AU585131B2 - New aryl-substituted (N-piperidinyl)methyl- and (N-piperazinyl)methylazoles having antipsychotic properties - Google Patents

New aryl-substituted (N-piperidinyl)methyl- and (N-piperazinyl)methylazoles having antipsychotic properties

Info

Publication number
AU585131B2
AU585131B2 AU69247/87A AU6924787A AU585131B2 AU 585131 B2 AU585131 B2 AU 585131B2 AU 69247/87 A AU69247/87 A AU 69247/87A AU 6924787 A AU6924787 A AU 6924787A AU 585131 B2 AU585131 B2 AU 585131B2
Authority
AU
Australia
Prior art keywords
piperazinyl
piperidinyl
substituted
methyl
methylazoles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU69247/87A
Other languages
English (en)
Other versions
AU6924787A (en
Inventor
Cornelis G. Kruse
Marinus T.M. Tulp
Johannes A.M. Van Der Heyden
Ineke Van Wijngaarden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duphar International Research BV
Original Assignee
Duphar International Research BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duphar International Research BV filed Critical Duphar International Research BV
Publication of AU6924787A publication Critical patent/AU6924787A/en
Application granted granted Critical
Publication of AU585131B2 publication Critical patent/AU585131B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
AU69247/87A 1986-02-27 1987-02-25 New aryl-substituted (N-piperidinyl)methyl- and (N-piperazinyl)methylazoles having antipsychotic properties Ceased AU585131B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL8600488 1986-02-27
NL8600488 1986-02-27

Publications (2)

Publication Number Publication Date
AU6924787A AU6924787A (en) 1987-09-03
AU585131B2 true AU585131B2 (en) 1989-06-08

Family

ID=19847632

Family Applications (1)

Application Number Title Priority Date Filing Date
AU69247/87A Ceased AU585131B2 (en) 1986-02-27 1987-02-25 New aryl-substituted (N-piperidinyl)methyl- and (N-piperazinyl)methylazoles having antipsychotic properties

Country Status (15)

Country Link
US (2) US4772604A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0241053B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPH0798800B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE82281T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU585131B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1279645C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3782525T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK93087A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2052545T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR3006689T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE61724B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL81669A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ219380A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PH (1) PH22783A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA871335B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE82281T1 (de) * 1986-02-27 1992-11-15 Duphar Int Res Aryl-substituierte(n-piperidinyl)methyl und (npiperazinyl)methylazole mit antipsychotischer wirkung.
US4992441A (en) * 1987-10-14 1991-02-12 Mcneilab, Inc. 1-[[5-[[4-substituted-1-piperazinyl]methyl]-pyrrol-2-yl or furan-2-yl]methyl-2-piperidinones useful in treating schizophrenia
FR2672052B1 (fr) * 1991-01-28 1995-05-24 Esteve Labor Dr Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments.
GB9021453D0 (en) * 1990-10-03 1990-11-14 Wyeth John & Brother Ltd Piperazine derivatives
US5159083A (en) * 1990-12-28 1992-10-27 Neurogen Corporation Certain aminomethyl phenylimidazole derivatives; a class of dopamine receptor subtype specific ligands
FR2673628B1 (fr) * 1991-03-07 1993-07-09 Esteve Labor Dr Procede de preparation de derives d'aryl (ou heteroaryl)-piperazinyl-butyl-azoles.
US5569659A (en) * 1991-09-11 1996-10-29 Mcneilab, Inc. 4-arylpiperazines and 4-arylpiperidines
IE914218A1 (en) * 1991-09-11 1993-03-24 Mcneilab Inc Novel 4-arylpiperazines and 4-arylpiperidines
JPH05255089A (ja) * 1991-12-18 1993-10-05 Sanwa Kagaku Kenkyusho Co Ltd 抗ウイルス剤
FR2692264B1 (fr) * 1992-06-12 1994-08-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
US5523299A (en) * 1992-08-06 1996-06-04 Smithkline Beecham Plc 5-(2-oxyphenyl)-pyrrole derivatives as dopamine D3 receptor antagonists
US5314885A (en) * 1992-09-11 1994-05-24 Mcneilab, Inc. Cyclic benzylamino, benzylamido, and benzylimido antipsychotic agents
GB9305644D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
GB9306578D0 (en) * 1993-03-30 1993-05-26 Merck Sharp & Dohme Therapeutic agents
GB9307400D0 (en) * 1993-04-08 1993-06-02 Smithkline Beecham Plc Compounds
JPH08511789A (ja) * 1993-06-25 1996-12-10 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー フェニルピロール誘導体およびドーパミンｄ３拮抗薬としてのそれらの使用
GB9315800D0 (en) * 1993-07-30 1993-09-15 Smithkline Beecham Plc Compounds
GB9315801D0 (en) * 1993-07-30 1993-09-15 Smithkline Beecham Plc Compounds
GB9320855D0 (en) * 1993-10-09 1993-12-01 Smithkline Beecham Plc Compounds
GB9325827D0 (en) * 1993-12-17 1994-02-23 Smithkline Beecham Plc Compounds
GB9402197D0 (en) * 1994-02-04 1994-03-30 Smithkline Beecham Plc Compounds
GB9403199D0 (en) * 1994-02-19 1994-04-13 Smithkline Beecham Plc Compounds
US5478934A (en) * 1994-11-23 1995-12-26 Yuan; Jun Certain 1-substituted aminomethyl imidazole and pyrrole derivatives: novel dopamine receptor subtype specific ligands
WO1996016057A1 (en) * 1994-11-23 1996-05-30 Neurogen Corporation Certain 1-substituted aminomethyl imidazole and pyrrole derivatives; novel dopamine receptor subtype specific ligands
GB9512129D0 (en) * 1995-06-15 1995-08-16 Smithkline Beecham Plc Compounds
EP0839144B1 (en) * 1995-07-13 2001-09-19 Knoll GmbH Piperazine derivatives as therapeutic agents
ATE340173T1 (de) * 1996-03-29 2006-10-15 Duphar Int Res Piperazin- und piperidin- derivate
EP0946508B1 (en) 1996-12-23 2009-09-23 Bristol-Myers Squibb Pharma Company NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS
CA2278677A1 (en) * 1997-01-27 1998-07-30 Daiichi Pharmaceutical Co., Ltd. Pyrazole derivatives
US6169086B1 (en) 1997-01-27 2001-01-02 Daiichi Pharmaceutical Co., Ltd. Pyrazole derivatives
TW530054B (en) * 1997-09-24 2003-05-01 Duphar Int Res New piperazine and piperidine compounds
ATE381549T1 (de) 2000-07-04 2008-01-15 Kyoyu Agri Co Ltd Benzoxazol-derivative, verfahren zu ihrer herstellung und herbizide
EP1408976B3 (en) 2001-07-20 2010-08-25 Psychogenics Inc. Treatment for attention-deficit hyperactivity disorder
US7589199B2 (en) * 2002-06-12 2009-09-15 Chemocentryx, Inc. Substituted piperazines
US7842693B2 (en) * 2002-06-12 2010-11-30 Chemocentryx, Inc. Substituted piperazines
US20050256130A1 (en) * 2002-06-12 2005-11-17 Chemocentryx, Inc. Substituted piperazines
ES2329356T3 (es) 2002-06-12 2009-11-25 Chemocentryx, Inc. Derivados de piperazina 1-arilo-4-sustituidos utilizados como antagonistas de ccr1 para el tratamiento de enfermedades inflamatorias e inmunitarias.
CA2558211C (en) * 2004-03-03 2013-09-03 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
US7435831B2 (en) * 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
BRPI0405418A (pt) * 2004-09-02 2006-05-02 Univ Rio De Janeiro uso de derivados n-fenilperazìnicos e composições farmacêuticas contendo os mesmos
TW200800946A (en) * 2005-08-15 2008-01-01 Astrazeneca Ab Substituted piperazines as metabotropic glutamate receptor antagonists
KR100654328B1 (ko) 2005-08-26 2006-12-08 한국과학기술연구원 피페라지닐알킬피라졸계 ｔ-타입 칼슘 채널 억제 화합물 및이의 제조방법
US9066903B2 (en) 2006-02-28 2015-06-30 The United States Of America As Represented By The Department Of Veterans Affairs Pharmacological treatment of Parkinson's disease
CN103570705B (zh) * 2012-07-18 2017-01-25 中国医学科学院医药生物技术研究所 取代的n‑((1＇,3＇‑杂唑‑4＇‑基)‑甲基)‑4‑苯甲酰基六氢吡啶类化合物及其用途
EP3083563A1 (en) * 2013-12-20 2016-10-26 Laboratorios Del. Dr. Esteve, S.A. Piperazine derivatives having multimodal activity against pain
MX2016006603A (es) * 2013-12-20 2016-09-06 Esteve Labor Dr Compuestos piperidinicos con actividad multimodal contra el dolor.

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3407199A (en) * 1966-01-18 1968-10-22 Endo Lab Tertiaryamino ethyl or propyl pyrrol-2-yl ketones
DE2261351A1 (de) * 1972-12-15 1974-06-20 Merck Patent Gmbh Pyrazolderivate und verfahren zu ihrer herstellung
DE2526469A1 (de) * 1975-06-13 1976-12-30 Bayer Ag 1-substituierte pyrazolderivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4032526A (en) * 1975-10-02 1977-06-28 American Cyanamid Company 1,2-dimethyl-3 or 5-piperazinyl-pyrazolium salts
US4123529A (en) * 1976-04-23 1978-10-31 Lilly Industries Limited Phenylpiperazine derivatives
DE2747531A1 (de) * 1977-10-22 1979-04-26 Basf Ag Substituierte 3-aminopyrazole
FR2537133A1 (fr) * 1982-12-07 1984-06-08 Rhone Poulenc Sante Nouveaux derives de la (piperazinyl-1)-5 pyrrolidine, leur preparation et les medicaments qui les contiennent
DK169601B1 (da) * 1983-10-17 1994-12-19 Duphar Int Res Piperazinderivater og farmaceutisk præparat indeholdende et sådant derivat, samt piperazinderivater med mellemproduktanvendelse
US4562189A (en) * 1984-10-09 1985-12-31 American Cyanamid Company Pyrazolylpiperazines
DE3442860A1 (de) * 1984-11-24 1986-05-28 Kali-Chemie Pharma Gmbh, 3000 Hannover 5-alkyl-1-phenyl-2-piperazinoalkylpyrazolin-3- on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
ATE82281T1 (de) * 1986-02-27 1992-11-15 Duphar Int Res Aryl-substituierte(n-piperidinyl)methyl und (npiperazinyl)methylazole mit antipsychotischer wirkung.

Also Published As

Publication number Publication date
JPH0798800B2 (ja) 1995-10-25
EP0241053B1 (en) 1992-11-11
EP0241053A1 (en) 1987-10-14
PH22783A (en) 1988-12-12
NZ219380A (en) 1990-06-26
JPS62205058A (ja) 1987-09-09
IE61724B1 (en) 1994-11-30
DE3782525T2 (de) 1993-05-27
DE3782525D1 (de) 1992-12-17
US4772604A (en) 1988-09-20
ATE82281T1 (de) 1992-11-15
ZA871335B (en) 1987-09-30
DK93087A (da) 1987-08-28
IE870466L (en) 1987-08-27
DK93087D0 (da) 1987-02-24
ES2052545T3 (es) 1994-07-16
IL81669A (en) 1990-11-29
US4874770A (en) 1989-10-17
IL81669A0 (en) 1987-09-16
AU6924787A (en) 1987-09-03
GR3006689T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-06-30
CA1279645C (en) 1991-01-29

Similar Documents

Publication Publication Date Title
AU585131B2 (en) New aryl-substituted (N-piperidinyl)methyl- and (N-piperazinyl)methylazoles having antipsychotic properties
CA2000786A1 (en) 3-piperidinyl-1,2-benzisoxazoles
AU4148789A (en) Novel hydrogen phosphonodithioate compositions
BG101714A (en) Improvements in the function of the endometrium or in functions related to it
AU7219987A (en) Process and composition for the removal of hydrogen sulfide from gaseous streams
AU583196B2 (en) Detergent composition and process for its production
GB8816608D0 (en) Glass composition & batch blend for production
EP0192988A3 (en) Process for solubilization, purification and characterization of protein from insoluble protein aggregates or complexes and compositions of matter therefrom
ZA888033B (en) Process,modified rubbers and rubber compositions
WO1987004430A3 (en) Fused benzazepines
AU3350089A (en) Antihypertensive hyperimmune milk, production, composition, and use
AU2351688A (en) Vulcanizable fluororubber composition
MY129947A (en) Novel substituted thienopyrans as antihypertensive agents.
IL74138A (en) 4,6,6a,7,8,12b-hexahydro-indolo(4,3-ab)phenanthridines,their production and pharmaceutical compositions containing them
EP0325719A3 (en) Melt stable polyetherimide-poly-carbonate blends
AU585122B2 (en) Improved fuel composition
AU586402B2 (en) Gunnable refractory composition
ZA878797B (en) Process for the thermal conversion of heavy petroleum fractions and refining residues,in the presence of oxygen compounds of sulfur and nitrogen and compositions containing these compounds
AU596688B2 (en) Process for the production of low carbon silicon
GR3001505T3 (en) Process for the preparation of polysulphurized olefin compositions with a high sulphur and very low chlorine content
IL83777A (en) Purified enzyme deacetoxy cephalosporin c synthetase,process for its preparation and stabilized compositions containing said enzyme
AU599133B2 (en) Novel substituted (4.2.0.)bicyclooctane derivatives with valuable therapeutic properties
AU6169990A (en) Biocontrol compositions
AU5221690A (en) Novel compositions useful as lubricants
AU6750890A (en) Polymer blend composition

Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired