AU552147B2 - Quinoline derivatives - Google Patents

Quinoline derivatives

Info

Publication number
AU552147B2
AU552147B2 AU86118/82A AU8611882A AU552147B2 AU 552147 B2 AU552147 B2 AU 552147B2 AU 86118/82 A AU86118/82 A AU 86118/82A AU 8611882 A AU8611882 A AU 8611882A AU 552147 B2 AU552147 B2 AU 552147B2
Authority
AU
Australia
Prior art keywords
carbon atoms
group
alkyl
hydrogen
quinoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU86118/82A
Other languages
English (en)
Other versions
AU8611882A (en
Inventor
Daniel Humbert
Peter Francis Hunt
Odile Le Martret
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of AU8611882A publication Critical patent/AU8611882A/en
Application granted granted Critical
Publication of AU552147B2 publication Critical patent/AU552147B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Quinoline Compounds (AREA)
AU86118/82A 1981-07-17 1982-07-16 Quinoline derivatives Ceased AU552147B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8113957 1981-07-17
FR8113957A FR2509728A1 (fr) 1981-07-17 1981-07-17 Nouveaux derives de la quinoleine, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant

Publications (2)

Publication Number Publication Date
AU8611882A AU8611882A (en) 1983-01-20
AU552147B2 true AU552147B2 (en) 1986-05-22

Family

ID=9260604

Family Applications (1)

Application Number Title Priority Date Filing Date
AU86118/82A Ceased AU552147B2 (en) 1981-07-17 1982-07-16 Quinoline derivatives

Country Status (13)

Country Link
US (1) US4450167A (https=)
EP (1) EP0070767B1 (https=)
JP (1) JPS5818361A (https=)
KR (1) KR880002232B1 (https=)
AT (1) ATE12635T1 (https=)
AU (1) AU552147B2 (https=)
CA (1) CA1204441A (https=)
DE (1) DE3262985D1 (https=)
ES (1) ES8305335A1 (https=)
FI (1) FI77654C (https=)
FR (1) FR2509728A1 (https=)
HU (1) HU186561B (https=)
ZA (1) ZA824746B (https=)

Families Citing this family (37)

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FR2564832B1 (fr) * 1984-05-23 1987-05-15 Panmedica Sa Nouveaux n-acyl derives d'amino-acides et leurs esters, leur procede de preparation et medicaments les contenant
FR2566405B1 (fr) * 1984-06-25 1986-09-26 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2 par une fonction aminee, leur preparation, leur application comme medicaments, les compositions les renfermant et les intermediaires nouveaux obtenus
ZA854556B (en) * 1984-06-25 1986-08-27 Roussel Uclaf Derivatives of isoxazoloquinolinone,process and intermediates for preparation,use as medicaments,and compositions containing them
US4602014A (en) * 1984-07-09 1986-07-22 Ciba-Geigy Corporation Ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives as benzodiazepine receptor modulators
EP0172004B1 (en) * 1984-08-15 1990-03-21 The Boots Company PLC Quinolinones, process for their preparation and pharmaceutical compositions containing them
FR2585356B1 (fr) * 1985-07-25 1987-10-23 Roussel Uclaf Nouveaux derives de l'acide 4-oh quinoleine carboxylique substitues en 2 par deux fonctions hydroxyle eventuellement etherifiees ou esterifiees, leurs procedes de preparation, les nouveaux intermediaires obtenus, leur application comme medicaments et les compositions les renfermant
FR2593810B1 (fr) * 1986-01-24 1988-04-22 Sanofi Sa Derives de la quinoleine, leur procede de preparation, leur application a titre de medicaments et les compositions les renfermant
FR2593811B1 (fr) * 1986-01-24 1989-03-31 Sanofi Sa Derives alcoyl-1 oxo-4 dihydro-1,4 quinoleine carboxamide-3, leur procede de preparation, leur application a titre de medicaments et les compositions les renfermant
GB8610981D0 (en) * 1986-05-06 1986-06-11 Ici America Inc Quinoline amides
GB8610980D0 (en) * 1986-05-06 1986-06-11 Ici America Inc Heterocyclic fused tricyclic compounds
US5235054A (en) * 1992-07-15 1993-08-10 Pfizer Inc. 3-carboxaldehyde substituted quinolines and naphthyridines
HUP9904567A3 (en) 1996-06-20 2001-10-29 Univ Texas Use of azo, thioalkyl, thiocarbonyl derivatives substituted by fused heterocycles and/or phenyl group for the preparation of pharmaceutical compositions stimulating bone growth
DE19738616A1 (de) * 1997-09-04 1999-03-11 Clariant Gmbh 4-Hydroxychinolin-3-carbonsäure-Derivate als Lichtschutzmittel
JP2001524468A (ja) * 1997-11-21 2001-12-04 エヌピーエス ファーマシューティカルズ インコーポレーテッド 中枢神経系疾患を治療するための代謝調節型グルタミン酸受容体アンタゴニスト
US6429207B1 (en) * 1997-11-21 2002-08-06 Nps Pharmaceuticals, Inc. Metabotropic glutamate receptor antagonists and their use for treating central nervous system diseases
ES2227893T3 (es) * 1997-12-03 2005-04-01 Taisho Pharmaceutical Co., Ltd Derivados de 1,2-dihidro-2-oxoquinolina.
DE69831506T2 (de) * 1997-12-22 2006-06-29 Pharmacia & Upjohn Co. Llc, Kalamazoo 4-hydroxychinolin-3-carboxamide und hydrazide als antivirale wirkstoffe
BR9908321A (pt) 1998-02-26 2001-12-18 Neurogen Corp Composto
BR0010308A (pt) * 1999-05-06 2002-01-08 Neurogen Corp Composto, composição farmacêutica, uso de um composto, e, métodos para o tratamento de uma doença ou distúrbio associados com o agonismo patogênico, agonismo inverso ou antagonismo do receptor de gabaa, para localizar receptores de gabaa em uma amostra de tecido, para inibir a ligação de um composto de benzodiazepina a um receptor de gabaa e para alterar a atividade da transdução de sinal dos receptores de gabaa, e, composição farmacêutica embalada
RS56037B1 (sr) * 2004-06-24 2017-09-29 Vertex Pharma Modulatori atp-vezujućih kasetnih transportera
US8354427B2 (en) 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
EP1979367A2 (en) * 2005-12-24 2008-10-15 Vertex Pharmaceuticals Incorporated Quinolin-4-one derivatives as modulators of abc transporters
EP3219705B1 (en) 2005-12-28 2020-03-11 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of the amorphous form of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
US12458635B2 (en) 2008-08-13 2025-11-04 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
EP2349263B1 (en) * 2008-10-23 2014-04-23 Vertex Pharmaceuticals Inc. Modulators of cystic fibrosis transmembrane conductance regulator
PL2408750T3 (pl) 2009-03-20 2016-02-29 Vertex Pharma Sposób otrzymywania modulatorów błonowego regulatora przewodnictwa swoistego dla mukowiscydozy
MX2013002121A (es) * 2010-08-27 2013-04-03 Gruenenthal Gmbh Quinolina-3-carboxamidas sustituidas como moduladores de kcnq2/3.
TW201211007A (en) 2010-08-27 2012-03-16 Gruenenthal Gmbh Substituted 2-amino-quinoline-3-carboxamides as KCNQ2/3 modulators
DK2609083T3 (da) 2010-08-27 2015-03-30 Gruenenthal Gmbh Substituerede 2-oxy-quinolin-3-carboxamider som KCNQ2/3 modulatorer
SI2609086T1 (sl) 2010-08-27 2015-04-30 Gruenenthal Gmbh Substituirani 2-okso in 2-tiokso-dihidrokinolin-3-karboksamidi kot KCNQ2/3 modulatorji
MX2013002295A (es) 2010-09-01 2013-05-09 Gruenenthal Gmbh 1-oxo-dihidroisoquinolin-3-carboxamidas sustituidas como moduladores de kcnq2/3.
US8802700B2 (en) 2010-12-10 2014-08-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
JP2015511583A (ja) 2012-02-27 2015-04-20 バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated 薬学的組成物およびその投与
CN107250113B (zh) 2014-10-07 2019-03-29 弗特克斯药品有限公司 囊性纤维化跨膜传导调节蛋白的调节剂的共晶
US11505528B2 (en) 2017-08-04 2022-11-22 Axial Therapeutics, Inc. Inhibitors of microbially induced amyloid
GB202016245D0 (en) * 2020-10-13 2020-11-25 Univ College Cardiff Consultants Ltd Compounds

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR960299A (https=) * 1950-04-15
DE540697C (de) * 1925-08-11 1933-01-28 Chemische Ind Ges Verfahren zur Darstellung einseitig acylierter Diamine
US2504896A (en) * 1945-06-04 1950-04-18 Us Sec War Method of preparing intermediates suitable for conversion into nuclear substituted heterocyclic compounds
US2504875A (en) * 1945-06-04 1950-04-18 Us Sec War Method for producing 4-hydroxyquinolines
US2614121A (en) * 1946-03-01 1952-10-14 Charles C Price Process for making intermediates for producing basic compounds
US2798070A (en) * 1954-02-04 1957-07-02 Mcneilab Inc Quaternary quinoline carboxamide salts and method of preparing same
DE1908548A1 (de) * 1968-02-29 1970-11-05 Warner Lambert Co Chinolinderivate
US3755332A (en) * 1971-07-01 1973-08-28 Ciba Geigy Corp Substituted 4 indazolaminoquinolines
GB1433774A (en) * 1973-02-26 1976-04-28 Allen & Hanburys Ltd Heterocyclic compounds apparatus for conveying articles
FR2221126B2 (https=) * 1973-03-12 1977-01-28 Roussel Uclaf
CA1034124A (en) * 1973-05-11 1978-07-04 Ciba-Geigy Ag Process for the manufacture of new quinolines
CH578536A5 (en) * 1973-05-11 1976-08-13 Ciba Geigy Ag Quinoline-3-carboxylic acid derivs - with e.g. analgesic, antinociceptive, antiinflammatory and antiallergic props
FR2281761A1 (fr) * 1974-08-13 1976-03-12 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
JPS5291876A (en) * 1976-01-27 1977-08-02 Roussel Uclaf Novel derivatives of 33quinolinecarboxylic acid and medicine comprising same
FR2340735A1 (fr) * 1976-02-11 1977-09-09 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
DE2730061A1 (de) * 1977-07-02 1979-01-18 Bayer Ag Verfahren zur herstellung von chinolin-derivaten
FR2443467A1 (fr) * 1978-12-08 1980-07-04 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
DE2854190C2 (de) * 1978-12-15 1980-11-27 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von lasierenden Pigmentformen des Indanthrens und des chlorierten Indanthrone

Also Published As

Publication number Publication date
EP0070767B1 (fr) 1985-04-10
FI822509L (fi) 1983-01-18
FR2509728B1 (https=) 1985-03-01
DE3262985D1 (en) 1985-05-15
ES514053A0 (es) 1983-04-01
ES8305335A1 (es) 1983-04-01
EP0070767A1 (fr) 1983-01-26
HU186561B (en) 1985-08-28
ATE12635T1 (de) 1985-04-15
FI77654C (fi) 1989-04-10
FR2509728A1 (fr) 1983-01-21
US4450167A (en) 1984-05-22
FI822509A0 (fi) 1982-07-14
JPS5818361A (ja) 1983-02-02
KR840000501A (ko) 1984-02-22
CA1204441A (fr) 1986-05-13
AU8611882A (en) 1983-01-20
KR880002232B1 (ko) 1988-10-20
FI77654B (fi) 1988-12-30
ZA824746B (en) 1983-04-27

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