AU542529B2 - 3,4-bis-substituted 1,2,5-oxadiazole 2-oxides - Google Patents

3,4-bis-substituted 1,2,5-oxadiazole 2-oxides

Info

Publication number
AU542529B2
AU542529B2 AU78558/81A AU7855881A AU542529B2 AU 542529 B2 AU542529 B2 AU 542529B2 AU 78558/81 A AU78558/81 A AU 78558/81A AU 7855881 A AU7855881 A AU 7855881A AU 542529 B2 AU542529 B2 AU 542529B2
Authority
AU
Australia
Prior art keywords
oxadiazole
oxides
bis
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU78558/81A
Other languages
English (en)
Other versions
AU7855881A (en
Inventor
Rudi Beyerle
Helmut Bohm
Melitta Just
Piero A. Martorana
Anton Mogilev
Rolf Eberhard Nilz
Karl Schonafinger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Cassella AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cassella AG filed Critical Cassella AG
Publication of AU7855881A publication Critical patent/AU7855881A/en
Application granted granted Critical
Publication of AU542529B2 publication Critical patent/AU542529B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/08—1,2,5-Oxadiazoles; Hydrogenated 1,2,5-oxadiazoles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Materials For Photolithography (AREA)
AU78558/81A 1980-12-18 1981-12-16 3,4-bis-substituted 1,2,5-oxadiazole 2-oxides Ceased AU542529B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE30477306 1980-12-18
DE19803047730 DE3047730A1 (de) 1980-12-18 1980-12-18 3,4-bis-substituierte 1,2,5-oxdiazol-2-oxide, verfahren zu ihrer herstellung, ihre verwendung und sie enthaltende pharmazeutische zubereitungen

Publications (2)

Publication Number Publication Date
AU7855881A AU7855881A (en) 1982-06-24
AU542529B2 true AU542529B2 (en) 1985-02-21

Family

ID=6119497

Family Applications (1)

Application Number Title Priority Date Filing Date
AU78558/81A Ceased AU542529B2 (en) 1980-12-18 1981-12-16 3,4-bis-substituted 1,2,5-oxadiazole 2-oxides

Country Status (28)

Country Link
US (1) US4356178A (OSRAM)
EP (1) EP0054872B1 (OSRAM)
JP (1) JPS57123173A (OSRAM)
KR (1) KR880000543B1 (OSRAM)
AR (1) AR227697A1 (OSRAM)
AT (1) ATE10094T1 (OSRAM)
AU (1) AU542529B2 (OSRAM)
CA (1) CA1157019A (OSRAM)
CS (1) CS219863B2 (OSRAM)
DD (1) DD201897A5 (OSRAM)
DE (2) DE3047730A1 (OSRAM)
DK (1) DK150597C (OSRAM)
ES (1) ES508086A0 (OSRAM)
FI (1) FI813666L (OSRAM)
GR (1) GR81375B (OSRAM)
HK (1) HK51385A (OSRAM)
HU (1) HU183751B (OSRAM)
IE (1) IE52034B1 (OSRAM)
IL (1) IL64563A (OSRAM)
NO (1) NO814045L (OSRAM)
NZ (1) NZ199272A (OSRAM)
PH (1) PH18051A (OSRAM)
PL (1) PL128564B1 (OSRAM)
PT (1) PT74129B (OSRAM)
RO (1) RO84099B (OSRAM)
SG (1) SG21285G (OSRAM)
SU (1) SU1093246A3 (OSRAM)
ZA (1) ZA818726B (OSRAM)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4507485A (en) * 1984-01-23 1985-03-26 Bristol-Myers Company 3,4-Disubstituted-1,2,5-oxadiazoles having histamine H2 -receptor antagonist activity
DE4217794A1 (de) * 1992-05-29 1993-12-02 Cassella Ag Phenylfuroxane
DE4218582A1 (de) * 1992-06-05 1993-12-09 Cassella Ag Pyridyl-1,2,5-oxadiazol-carbonamid-2-oxide
DE4218979A1 (de) * 1992-06-10 1993-12-16 Cassella Ag Pyrimidofuroxane
DE4220264A1 (de) * 1992-06-20 1993-12-23 Cassella Ag Phenyl-1,2,5-oxadiazol-carbonamid-2-oxide
DE4223800A1 (de) * 1992-07-20 1994-01-27 Cassella Farbwerke Mainkur Ag Verwendung von 1.2.5-Oxadiazol-2-oxiden zur Behandlung erektiler Dysfunktionen
DE4307105A1 (de) * 1993-03-06 1994-09-08 Cassella Ag Hydroxymethylfurazancarbonsäurederivate
US5460669A (en) * 1993-06-28 1995-10-24 Thiokol Corporation 3-nitramino-4-nitrofurazan and salts thereof
DE4401150A1 (de) * 1994-01-17 1995-07-20 Cassella Ag Furazancarbonsäurederivate
AU2006259368A1 (en) 2005-06-15 2006-12-28 Hydra Biosciences, Inc. Modulators of sperm hypermotility and uses thereof
WO2025244913A1 (en) * 2024-05-24 2025-11-27 Purdue Research Foundation One-pot synthesis of disubstituted furoxans

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4089867A (en) * 1976-11-11 1978-05-16 Texaco Inc. Preparation of diacylfurazan oxides

Also Published As

Publication number Publication date
IL64563A0 (en) 1982-03-31
AU7855881A (en) 1982-06-24
FI813666A7 (fi) 1982-06-19
AR227697A1 (es) 1982-11-30
EP0054872B1 (de) 1984-10-31
DK150597B (da) 1987-04-06
PT74129A (de) 1982-01-01
PT74129B (de) 1983-05-16
IE812976L (en) 1982-06-18
US4356178A (en) 1982-10-26
EP0054872A1 (de) 1982-06-30
ZA818726B (en) 1982-11-24
SG21285G (en) 1985-09-13
SU1093246A3 (ru) 1984-05-15
KR830007596A (ko) 1983-11-04
CS219863B2 (en) 1983-03-25
NO814045L (no) 1982-06-21
PH18051A (en) 1985-03-13
RO84099B (ro) 1984-06-30
IE52034B1 (en) 1987-05-27
IL64563A (en) 1985-02-28
KR880000543B1 (ko) 1988-04-13
ES8300101A1 (es) 1982-10-01
FI813666L (fi) 1982-06-19
JPS57123173A (en) 1982-07-31
DE3047730A1 (de) 1982-07-15
ATE10094T1 (de) 1984-11-15
DK533881A (da) 1982-06-19
DE3167001D1 (en) 1984-12-06
HK51385A (en) 1985-07-12
JPH0223551B2 (OSRAM) 1990-05-24
GR81375B (OSRAM) 1984-12-11
DK150597C (da) 1987-10-26
PL128564B1 (en) 1984-02-29
CA1157019A (en) 1983-11-15
HU183751B (en) 1984-05-28
RO84099A (ro) 1984-05-12
ES508086A0 (es) 1982-10-01
NZ199272A (en) 1984-03-16
PL234257A1 (OSRAM) 1982-08-02
DD201897A5 (de) 1983-08-17

Similar Documents

Publication Publication Date Title
AU545756B2 (en) Alpha-alkyl-alpha-phenyl-1h-1,2,4-triazole-1-ethanols
AU544294B2 (en) 25-hydroxy-26,26,27,27,27,-hexa fluorocholecalciferol
AU7312581A (en) Antinflammatory 4,5-diaryl-alpha-polyfluoroalkyl-1h- imidazole-2-methanamines
AU4973579A (en) 1,2,3,5-tetrahydroimidazothienopyrimidin-2-ones
AU546022B2 (en) Combi-equipment
AU7338081A (en) 1,2,4-triazolylpropenol derivatives
AU544637B2 (en) 4,1-benzoxazepines
AU7855881A (en) 3,4-bis-substituted 1,2,5-oxadiazole 2-oxides
AU548426B2 (en) 3-amino-(1,2,4)-triazoles
AU8553282A (en) 1(1,2,4-triazoyl/1,3-diazoyl)-2-hydroxy-(n)-phenyl-alkanes
AU5118979A (en) 2,6-diaminoebularines
AU547929B2 (en) 3,3-dimethylindolin-2-ones
AU2435784A (en) 8,10-dideazaminopterins
AU541703B2 (en) 1,1-diacetoxyethane
AU536493B2 (en) Substituted pyrazinyl-1,2,4-oxadiazoles
AU560079B2 (en) 1,8-dihydroxy-10-acyl-9-anthrones
AU546548B2 (en) 1,2,4-triazolylethylenes
AU531892B2 (en) 1,1-dioxopenicillanoyloxymethyl 6-(-2-amino-2-phenyl- acetamido)penicillanates
AU536894B2 (en) 4,9 - dioxonaphto-triazoles
AU2806184A (en) Tetrahydrothiopyran-3,5,-dione-4-carboxamides
AU548045B2 (en) 2,3-dihydropyrans
AU551883B2 (en) 2,5-bis-perfluoroalkyl-3,4-dicarbonylalkoxypyrroles
AU1176983A (en) 2,3-dihydro-1h-pyrrolizines
AU7301081A (en) 2-iodoacetylimino-3-methyl-5-trifluoromethyl 1,4- thiadiazol-4-ine
AU7744681A (en) 2,3-dihydro-4-pyrone derivatives