AU529068B2 - 1,2,3,5-tetrahydroimidazothienopyrimidin-2-ones - Google Patents

1,2,3,5-tetrahydroimidazothienopyrimidin-2-ones

Info

Publication number
AU529068B2
AU529068B2 AU49735/79A AU4973579A AU529068B2 AU 529068 B2 AU529068 B2 AU 529068B2 AU 49735/79 A AU49735/79 A AU 49735/79A AU 4973579 A AU4973579 A AU 4973579A AU 529068 B2 AU529068 B2 AU 529068B2
Authority
AU
Australia
Prior art keywords
dec
compound
alkyl group
hydrogen atom
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU49735/79A
Other languages
English (en)
Other versions
AU4973579A (en
Inventor
Shinichiro Ashida
Fumiyoshi Ishikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Publication of AU4973579A publication Critical patent/AU4973579A/en
Application granted granted Critical
Publication of AU529068B2 publication Critical patent/AU529068B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU49735/79A 1978-08-11 1979-08-09 1,2,3,5-tetrahydroimidazothienopyrimidin-2-ones Ceased AU529068B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP9783278A JPS5527105A (en) 1978-08-11 1978-08-11 Imidazothienopyrimidinones compound
JP9783278 1978-08-11

Publications (2)

Publication Number Publication Date
AU4973579A AU4973579A (en) 1980-02-14
AU529068B2 true AU529068B2 (en) 1983-05-26

Family

ID=14202683

Family Applications (1)

Application Number Title Priority Date Filing Date
AU49735/79A Ceased AU529068B2 (en) 1978-08-11 1979-08-09 1,2,3,5-tetrahydroimidazothienopyrimidin-2-ones

Country Status (16)

Country Link
US (1) US4284773A (enExample)
EP (1) EP0008408B1 (enExample)
JP (1) JPS5527105A (enExample)
AU (1) AU529068B2 (enExample)
CA (1) CA1116597A (enExample)
CS (1) CS219256B2 (enExample)
DE (1) DE2961552D1 (enExample)
DK (1) DK153844C (enExample)
ES (1) ES483289A1 (enExample)
GR (1) GR73839B (enExample)
IL (1) IL57923A (enExample)
MX (1) MX6242E (enExample)
PH (1) PH15530A (enExample)
SU (1) SU880252A3 (enExample)
YU (1) YU41170B (enExample)
ZA (1) ZA793909B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4287340A (en) * 1979-08-27 1981-09-01 Warner-Lambert Company Dihydro-oxo-pyrido[1,2-a]thienopyrimidine compounds
ZW11781A1 (en) * 1980-06-27 1982-01-20 Hoffmann La Roche Pyrimidine derivatives
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US8304420B2 (en) 2006-11-28 2012-11-06 Shire Llc Substituted quinazolines for reducing platelet count
WO2008151257A2 (en) 2007-06-04 2008-12-11 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
GB0808950D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
ES2627848T3 (es) 2008-06-04 2017-07-31 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
MX357121B (es) 2011-03-01 2018-06-27 Synergy Pharmaceuticals Inc Star Proceso de preparacion de agonistas c de guanilato ciclasa.
EP2958577A2 (en) 2013-02-25 2015-12-30 Synergy Pharmaceuticals Inc. Guanylate cyclase receptor agonists for use in colonic cleansing
EP2968439A2 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
PL3004138T3 (pl) 2013-06-05 2024-07-29 Bausch Health Ireland Limited Ultra-oczyszczeni agoniści peptydowi cyklazy guanylanowej C, sposób ich uzyskiwania i ich zastosowanie
CA2920856C (en) 2013-08-09 2026-03-03 Ardelyx, Inc. Ph modulating compounds for inhibiting gastrointestinal phosphate uptake
JP2022533251A (ja) 2019-05-21 2022-07-21 アルデリックス， インコーポレイテッド 患者において血清リン酸塩を低下させるための組み合わせ

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3890321A (en) * 1971-09-20 1975-06-17 Pfizer 6-aryl-5-ethyl-pyrimidin-4-ol compounds useful as intermediates and bronchodilators
US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
DE2411273A1 (de) * 1974-03-06 1975-09-18 Schering Ag Neue thieno eckige klammer auf 2,3-d eckige klammer zu pyrimidinone und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
DE2961552D1 (en) 1982-02-04
MX6242E (es) 1985-01-28
JPS5527105A (en) 1980-02-27
IL57923A0 (en) 1979-11-30
DK153844C (da) 1989-01-30
JPS627914B2 (enExample) 1987-02-19
AU4973579A (en) 1980-02-14
US4284773A (en) 1981-08-18
YU194779A (en) 1983-10-31
PH15530A (en) 1983-02-09
GR73839B (enExample) 1984-05-04
CS219256B2 (en) 1983-03-25
SU880252A3 (ru) 1981-11-07
EP0008408A1 (en) 1980-03-05
EP0008408B1 (en) 1981-12-09
DK153844B (da) 1988-09-12
IL57923A (en) 1982-09-30
YU41170B (en) 1986-12-31
ES483289A1 (es) 1980-09-01
CA1116597A (en) 1982-01-19
ZA793909B (en) 1980-10-29
DK336779A (da) 1980-02-12

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