AU496753B2 - Pyrrolidine, piperidine and azepidine prostaglandin analogues - Google Patents

Pyrrolidine, piperidine and azepidine prostaglandin analogues

Info

Publication number
AU496753B2
AU496753B2 AU87107/75A AU8710775A AU496753B2 AU 496753 B2 AU496753 B2 AU 496753B2 AU 87107/75 A AU87107/75 A AU 87107/75A AU 8710775 A AU8710775 A AU 8710775A AU 496753 B2 AU496753 B2 AU 496753B2
Authority
AU
Australia
Prior art keywords
hydrogen
compound
compound according
hydroxy
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU87107/75A
Other languages
English (en)
Other versions
AU8710775A (en
Inventor
Cassidy And Gordon Wootton Frederick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of AU8710775A publication Critical patent/AU8710775A/en
Application granted granted Critical
Publication of AU496753B2 publication Critical patent/AU496753B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
AU87107/75A 1974-11-29 1975-11-28 Pyrrolidine, piperidine and azepidine prostaglandin analogues Expired AU496753B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB51733/74A GB1524818A (en) 1974-11-29 1974-11-29 12-azaprostaglandins

Publications (2)

Publication Number Publication Date
AU8710775A AU8710775A (en) 1977-06-02
AU496753B2 true AU496753B2 (en) 1978-10-26

Family

ID=10461163

Family Applications (2)

Application Number Title Priority Date Filing Date
AU87107/75A Expired AU496753B2 (en) 1974-11-29 1975-11-28 Pyrrolidine, piperidine and azepidine prostaglandin analogues
AU39427/78A Expired AU526356B2 (en) 1974-11-29 1978-08-30 Amino acid intermediates for the preparation of prosta- glandin analogues

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU39427/78A Expired AU526356B2 (en) 1974-11-29 1978-08-30 Amino acid intermediates for the preparation of prosta- glandin analogues

Country Status (19)

Country Link
US (1) US4299970A (enExample)
JP (1) JPS51125278A (enExample)
AT (1) AT359216B (enExample)
AU (2) AU496753B2 (enExample)
BE (1) BE835989A (enExample)
CA (1) CA1088062A (enExample)
CH (2) CH626325A5 (enExample)
DE (1) DE2552312A1 (enExample)
DK (1) DK539775A (enExample)
ES (1) ES443081A1 (enExample)
FI (2) FI790726A7 (enExample)
FR (2) FR2313043A1 (enExample)
GB (1) GB1524818A (enExample)
HU (2) HU174537B (enExample)
IE (1) IE41877B1 (enExample)
NL (1) NL7513903A (enExample)
NO (2) NO753935L (enExample)
SE (2) SE413505B (enExample)
ZA (1) ZA757121B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU183046B (en) * 1976-06-03 1984-04-28 Wellcome Found Process for producing hydanthoine derivatives
IL53559A0 (en) 1976-12-18 1978-03-10 Beecham Group Ltd Novel prostaglandin analogues their preparation and pharmaceutical compositions containing them
DE2965098D1 (en) * 1978-06-15 1983-05-05 Beecham Group Plc 1.2.4-triazolidine-3.5-dione derivatives, process for their preparation and pharmaceutical compositions containing them
AU4806979A (en) * 1978-06-15 1979-12-20 Beecham Group Limited 1,2,4 triazole derivatives
IL58384A0 (en) * 1978-10-14 1980-01-31 Beecham Group Ltd 12-aza analogues of prostcyclin their preparation and pharmaceutical composition containing them
US6211226B1 (en) * 1998-12-17 2001-04-03 Alcon Laboratories, Inc. 11-Aza prostaglandins for the treatment of glaucoma and ocular hypertension
AU2003237520B2 (en) * 2002-06-10 2009-01-08 Laboratoires Serono Sa Gamma lactams as prostaglandin agonists and use thereof
US7053085B2 (en) * 2003-03-26 2006-05-30 Merck & Co. Inc. EP4 receptor agonist, compositions and methods thereof
US7179820B2 (en) * 2003-06-06 2007-02-20 Allergan, Inc. Piperidinyl prostaglandin E analogs
US6747037B1 (en) * 2003-06-06 2004-06-08 Allergan, Inc. Piperidinyl prostaglandin E analogs
WO2006061366A1 (en) * 2004-12-06 2006-06-15 Laboratoires Serono S.A. Pyrrolidin-2-one derivatives for use as dp1 receptor agonists
WO2023212495A1 (en) * 2022-04-29 2023-11-02 Zymergen Inc. Novel bio-based compound, method of forming the compound, and adhesive compositions containing the novel compound

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2343769A (en) * 1941-09-27 1944-03-07 Du Pont Aliphatic aminoacyl compound and method for preparing same
US2582257A (en) * 1950-09-15 1952-01-15 Parke Davis & Co Esters and methods for obtaining the same
NZ182264A (en) * 1975-10-25 1979-01-11 Beecham Group Ltd 2-carboxyalkyl-1-hydroxyalkyl-pyrrolidin-3,5-dione or-piperidin-3,6-dione derivatives prarmaceutical compostions
US4201864A (en) * 1975-10-25 1980-05-06 Beecham Group Limited Oxy-alkylamino acids and esters
NZ182263A (en) * 1975-10-25 1979-01-11 Beecham Group Ltd 2-carboxyalkyl-4,4-dimethyl-1-hydroxy-alkyl-pyrrolidin-3,5-dione derivativesand pharmaceutical compositions

Also Published As

Publication number Publication date
AU8710775A (en) 1977-06-02
CH629748A5 (de) 1982-05-14
ATA898375A (de) 1980-03-15
GB1524818A (en) 1978-09-13
IE41877B1 (en) 1980-04-09
SE7513255L (sv) 1976-05-31
DE2552312A1 (de) 1976-08-12
BE835989A (fr) 1976-05-26
CA1088062A (en) 1980-10-21
SE7809907L (sv) 1978-09-20
AT359216B (de) 1980-10-27
NO783765L (no) 1976-06-01
SE413505B (sv) 1980-06-02
FI790726A7 (fi) 1981-01-01
NO753935L (enExample) 1976-06-01
IE41877L (en) 1976-05-29
FI753341A7 (enExample) 1976-05-30
FR2313043A1 (fr) 1976-12-31
AU526356B2 (en) 1983-01-06
US4299970A (en) 1981-11-10
HU174537B (hu) 1980-02-28
DK539775A (da) 1976-05-30
HU176752B (en) 1981-05-28
ES443081A1 (es) 1977-05-01
ZA757121B (en) 1976-10-27
JPS51125278A (en) 1976-11-01
FR2379510A1 (fr) 1978-09-01
CH626325A5 (enExample) 1981-11-13
FR2379510B1 (enExample) 1982-10-29
AU3942778A (en) 1980-03-06
NL7513903A (nl) 1976-06-01
FR2313043B1 (enExample) 1982-08-13

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