AU4488800A - Novel cyanine and indocyanine dye bioconjugates for biomedical applications - Google Patents
Novel cyanine and indocyanine dye bioconjugates for biomedical applicationsInfo
- Publication number
- AU4488800A AU4488800A AU44888/00A AU4488800A AU4488800A AU 4488800 A AU4488800 A AU 4488800A AU 44888/00 A AU44888/00 A AU 44888/00A AU 4488800 A AU4488800 A AU 4488800A AU 4488800 A AU4488800 A AU 4488800A
- Authority
- AU
- Australia
- Prior art keywords
- therapy
- imaging
- detection
- dye
- useful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000002560 therapeutic procedure Methods 0.000 abstract 5
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 238000001514 detection method Methods 0.000 abstract 3
- 239000000975 dye Substances 0.000 abstract 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000002059 diagnostic imaging Methods 0.000 abstract 2
- 238000003384 imaging method Methods 0.000 abstract 2
- 239000000863 peptide conjugate Substances 0.000 abstract 2
- 230000005856 abnormality Effects 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 230000002349 favourable effect Effects 0.000 abstract 1
- 239000012216 imaging agent Substances 0.000 abstract 1
- NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 abstract 1
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13506099P | 1999-05-20 | 1999-05-20 | |
| US60135060 | 1999-05-20 | ||
| US09325769 | 1999-06-04 | ||
| US09/325,769 US6217848B1 (en) | 1999-05-20 | 1999-06-04 | Cyanine and indocyanine dye bioconjugates for biomedical applications |
| PCT/US2000/011060 WO2000071162A2 (en) | 1999-05-20 | 2000-04-26 | Cyanine and indocyanine dye bioconjugates for biomedical applications |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU4488800A true AU4488800A (en) | 2000-12-12 |
Family
ID=26832945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU44888/00A Abandoned AU4488800A (en) | 1999-05-20 | 2000-04-26 | Novel cyanine and indocyanine dye bioconjugates for biomedical applications |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6217848B1 (enExample) |
| EP (2) | EP2058007A3 (enExample) |
| JP (1) | JP2003500367A (enExample) |
| AT (1) | ATE435662T1 (enExample) |
| AU (1) | AU4488800A (enExample) |
| CA (1) | CA2373475C (enExample) |
| DE (1) | DE60042522D1 (enExample) |
| DK (1) | DK1178830T3 (enExample) |
| ES (1) | ES2329542T3 (enExample) |
| PT (1) | PT1178830E (enExample) |
| WO (1) | WO2000071162A2 (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7175953B2 (en) * | 1999-04-09 | 2007-02-13 | Institute Fuer Diagnostik Forschung | Short-warp peptide-dye conjugate as contrast agent for optical diagnostic |
| US6630570B1 (en) * | 1999-04-09 | 2003-10-07 | Insitut für Diagnostikforschung GmbH | Short-chain peptide-dye conjugates as contrast media for optical diagnosis |
| US20050182434A1 (en) * | 2000-08-11 | 2005-08-18 | National Research Council Of Canada | Method and apparatus for performing intra-operative angiography |
| US6180085B1 (en) * | 2000-01-18 | 2001-01-30 | Mallinckrodt Inc. | Dyes |
| US6190641B1 (en) * | 2000-01-18 | 2001-02-20 | Mallinckrodt Inc. | Indocyanine dyes |
| US7230088B2 (en) * | 2001-07-03 | 2007-06-12 | Mallinckrodt, Inc. | Compounds for dual photodiagnosis and therapy |
| US7790144B2 (en) * | 2000-01-18 | 2010-09-07 | Mallinckrodt Inc. | Receptor-avid exogenous optical contrast and therapeutic agents |
| US7351807B2 (en) * | 2000-01-18 | 2008-04-01 | Mallinckrodt Inc. | Cyanine-sulfenates for dual phototherapy |
| US20030017164A1 (en) * | 2001-07-03 | 2003-01-23 | Mallinckrodt Inc. | Dye-azide compounds for dual phototherapy |
| US6673334B1 (en) * | 2000-10-16 | 2004-01-06 | Mallinkcrodt, Inc. | Light sensitive compounds for instant determination of organ function |
| US7556797B2 (en) * | 2000-10-16 | 2009-07-07 | Mallinckrodt Inc. | Minimally invasive physiological function monitoring agents |
| US6838074B2 (en) | 2001-08-08 | 2005-01-04 | Bristol-Myers Squibb Company | Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent |
| US20030105300A1 (en) * | 2001-10-17 | 2003-06-05 | Mallinckrodt Inc. | Tumor targeted photodiagnostic-phototherapeutic agents |
| IL148921A0 (en) * | 2002-03-26 | 2002-09-12 | Peptor Ltd | Photo active backbone cyclized somatostatin analogs for optical imaging and photodynamic therapy |
| US20040022731A1 (en) * | 2002-04-26 | 2004-02-05 | Alexei Bogdanov | In vivo imaging of apoptosis |
| US6658143B2 (en) * | 2002-04-29 | 2003-12-02 | Amersham Biosciences Corp. | Ray-based image analysis for biological specimens |
| US7580185B2 (en) | 2002-08-28 | 2009-08-25 | Carl Zeiss Surgical Gmbh | Microscopy system, microscopy method and a method of treating an aneurysm |
| US7303741B2 (en) * | 2002-09-23 | 2007-12-04 | General Electric Company | Systems and methods for high-resolution in vivo imaging of biochemical activity in a living organism |
| US7226577B2 (en) | 2003-01-13 | 2007-06-05 | Bracco Imaging, S. P. A. | Gastrin releasing peptide compounds |
| DE10302787A1 (de) * | 2003-01-24 | 2004-08-12 | Schering Ag | Hydrophile, Thiol-reaktive Cyaninfarbstoffe und deren Konjugate mit Biomolekülen für die Fluoreszenzdiagnostik |
| WO2004080483A1 (en) * | 2003-03-10 | 2004-09-23 | Mpa Technologies, Inc. | Targeted agents for both photodiagnosis and photodynamic therapy |
| WO2005000218A2 (en) * | 2003-05-31 | 2005-01-06 | Washington University | Macrocyclic cyanine and indocyanine bioconjugates provide improved biomedical applications |
| NO20035681D0 (no) * | 2003-12-18 | 2003-12-18 | Amersham Health As | Optisk avbildning av lungekreft |
| NO20035682D0 (no) * | 2003-12-18 | 2003-12-18 | Amersham Health As | Optisk avbildning av ösofagkreft og Barretts ösofag |
| NO20035683D0 (no) * | 2003-12-18 | 2003-12-18 | Amersham Health As | Optisk avbildning av prostatakreft |
| DE102004022628A1 (de) * | 2004-05-07 | 2005-12-15 | Sensient Imaging Technologies Gmbh | FRET-Bioassay |
| US7585492B2 (en) * | 2004-05-18 | 2009-09-08 | Siemens Aktiengesellschaft | Biomolecular contrast agents for therapy success and dose monitoring in radiation therapy with proton or ion beams |
| US20050272967A1 (en) * | 2004-05-18 | 2005-12-08 | Siemens Aktiengesellschaft | Biomolecular contrast agents with multiple signal variance for therapy planning and control in radiation therapy with proton or ion beams |
| US20050259779A1 (en) * | 2004-05-18 | 2005-11-24 | Siemens Aktiengesellschaft | Biomolecular contrast agents for therapy optimization in radiation therapy with proton or ion beams |
| US20060239916A1 (en) * | 2005-01-07 | 2006-10-26 | Kai Licha | Use of cyanine dyes for the diagnosis of proliferative diseases |
| US20070122344A1 (en) | 2005-09-02 | 2007-05-31 | University Of Rochester Medical Center Office Of Technology Transfer | Intraoperative determination of nerve location |
| US20080161744A1 (en) | 2006-09-07 | 2008-07-03 | University Of Rochester Medical Center | Pre-And Intra-Operative Localization of Penile Sentinel Nodes |
| GB0714202D0 (en) * | 2007-07-20 | 2007-08-29 | Ge Healthcare Bio Sciences Ab | Isoelectric point markers |
| US8406860B2 (en) | 2008-01-25 | 2013-03-26 | Novadaq Technologies Inc. | Method for evaluating blush in myocardial tissue |
| US20090214436A1 (en) | 2008-02-18 | 2009-08-27 | Washington University | Dichromic fluorescent compounds |
| EP2100621A1 (en) | 2008-03-10 | 2009-09-16 | mivenion GmbH | Polyether polyol dendron conjugates with effector molecules for biological targeting |
| US10219742B2 (en) | 2008-04-14 | 2019-03-05 | Novadaq Technologies ULC | Locating and analyzing perforator flaps for plastic and reconstructive surgery |
| EP2687235A3 (en) | 2008-05-02 | 2014-11-05 | Novadaq Technologies Inc. | Methods for production and use of substance-loaded erythrocytes (S-LES) for observation and treatment of microvascular hemodynamics |
| US9433700B2 (en) | 2009-04-27 | 2016-09-06 | Medibeacon Inc. | Tissue sealant compositions, vascular closure devices, and uses thereof |
| US10492671B2 (en) | 2009-05-08 | 2019-12-03 | Novadaq Technologies ULC | Near infra red fluorescence imaging for visualization of blood vessels during endoscopic harvest |
| CN102573925B (zh) * | 2009-10-05 | 2015-08-05 | 佳能株式会社 | 光声成像用造影剂和使用所述光声成像用造影剂的光声成像方法 |
| WO2012054749A1 (en) | 2010-10-20 | 2012-04-26 | Li-Cor, Inc. | Cyanine dyes and their conjugates |
| WO2012123916A2 (en) | 2011-03-15 | 2012-09-20 | Ramot At Tel-Aviv University Ltd. | Activatable fluorogenic compounds and uses thereof as near infrared probes |
| DK2774625T3 (en) * | 2011-09-05 | 2017-06-12 | Hiroshi Maeda | POLYMER TYPE FLUORESCING MOLECULE PROBE |
| EP3553075B1 (en) | 2012-01-23 | 2025-01-08 | Washington University | Goggle imaging systems and methods |
| EP2863801B8 (en) | 2012-06-21 | 2024-06-12 | Stryker Corporation | Quantification and analysis of angiography and perfusion |
| ES2628529T3 (es) * | 2012-10-24 | 2017-08-03 | Tintes de cianina-azaindolina sustituidos con hidroxamato, y bioconjugados de los mismos | |
| KR101440109B1 (ko) | 2013-01-29 | 2014-09-12 | 부경대학교 산학협력단 | 위장관암의 림프절 전이 검출용 광음향 단층촬영 시스템 |
| AU2015327665B2 (en) | 2014-09-29 | 2018-09-27 | Stryker European Operations Limited | Imaging a target fluorophore in a biological material in the presence of autofluorescence |
| AU2014408488B2 (en) | 2014-10-09 | 2019-07-18 | Stryker European Operations Limited | Quantification of absolute blood flow in tissue using fluorescence-mediated photoplethysmography |
| US10806804B2 (en) * | 2015-05-06 | 2020-10-20 | Washington University | Compounds having RD targeting motifs and methods of use thereof |
| WO2018145193A1 (en) | 2017-02-10 | 2018-08-16 | Novadaq Technologies ULC | Open-field handheld fluorescence imaging systems and methods |
| EP4072598A4 (en) | 2019-12-13 | 2024-02-21 | Washington University | Near infrared fluorescent dyes, formulations and related methods |
| WO2023227601A1 (en) | 2022-05-23 | 2023-11-30 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Near-infrared fluorescent heptamethine dye conjugates with favorable bleaching properties |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5745457A (en) * | 1980-09-02 | 1982-03-15 | Fuji Photo Film Co Ltd | Microimmunological measuring method |
| JP3147992B2 (ja) * | 1992-05-29 | 2001-03-19 | イビデン株式会社 | 免疫測定用標識試薬 |
| JP3354975B2 (ja) * | 1992-10-06 | 2002-12-09 | イビデン株式会社 | 蛍光標識試薬および蛍光免疫測定法 |
| US5453505A (en) | 1994-06-30 | 1995-09-26 | Biometric Imaging, Inc. | N-heteroaromatic ion and iminium ion substituted cyanine dyes for use as fluorescence labels |
| DE4445065A1 (de) * | 1994-12-07 | 1996-06-13 | Diagnostikforschung Inst | Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung |
| US5962424A (en) * | 1995-02-21 | 1999-10-05 | Arch Development Corporation | Methods and compositions for targeting selectins |
| DE19602295C2 (de) * | 1996-01-23 | 2003-08-14 | Deutsches Krebsforsch | Verwendung eines Konjugats aus einer zur Fluoreszenz-fähigen Verbindung, Cyanurchlorid oder einem Derivat davon als Linker und einem Protein |
| WO1997033620A2 (de) * | 1996-03-15 | 1997-09-18 | Pulsion Verw. Gmbh & Co. Medical Systems Kg | Verbindungen zur behandlung von tumoren |
| DE19649971A1 (de) * | 1996-11-19 | 1998-05-28 | Diagnostikforschung Inst | Optische Diagnostika zur Diagnostik neurodegenerativer Krankheiten mittels Nahinfrarot-Strahlung (NIR-Strahlung) |
| WO1998048846A1 (en) | 1997-04-29 | 1998-11-05 | Nycomed Imaging As | Light imaging contrast agents |
| ES2213899T3 (es) | 1997-04-29 | 2004-09-01 | Amersham Health As | Agentes de contraste utilizados en tecnicas de formacion de imagen en base a la luz. |
| WO1999051284A2 (en) * | 1998-04-03 | 1999-10-14 | Mallinckrodt Inc. | Non-covalent bioconjugates useful for diagnosis and therapy |
| EP1131099A2 (en) * | 1999-01-15 | 2001-09-12 | Light Sciences Corporation | Noninvasive vascular therapy |
| US6602274B1 (en) * | 1999-01-15 | 2003-08-05 | Light Sciences Corporation | Targeted transcutaneous cancer therapy |
| WO2000041725A2 (en) * | 1999-01-15 | 2000-07-20 | Light Sciences Corporation | Therapeutic compositions for metabolic bone disorders or bone metastases |
-
1999
- 1999-06-04 US US09/325,769 patent/US6217848B1/en not_active Expired - Fee Related
-
2000
- 2000-04-26 DK DK00926343T patent/DK1178830T3/da active
- 2000-04-26 CA CA2373475A patent/CA2373475C/en not_active Expired - Lifetime
- 2000-04-26 AT AT00926343T patent/ATE435662T1/de not_active IP Right Cessation
- 2000-04-26 PT PT00926343T patent/PT1178830E/pt unknown
- 2000-04-26 WO PCT/US2000/011060 patent/WO2000071162A2/en not_active Ceased
- 2000-04-26 AU AU44888/00A patent/AU4488800A/en not_active Abandoned
- 2000-04-26 ES ES00926343T patent/ES2329542T3/es not_active Expired - Lifetime
- 2000-04-26 JP JP2000619463A patent/JP2003500367A/ja active Pending
- 2000-04-26 EP EP08075854A patent/EP2058007A3/en not_active Withdrawn
- 2000-04-26 EP EP00926343A patent/EP1178830B1/en not_active Expired - Lifetime
- 2000-04-26 DE DE60042522T patent/DE60042522D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1178830A2 (en) | 2002-02-13 |
| CA2373475A1 (en) | 2000-11-30 |
| DE60042522D1 (de) | 2009-08-20 |
| PT1178830E (pt) | 2009-09-02 |
| ES2329542T3 (es) | 2009-11-27 |
| EP1178830B1 (en) | 2009-07-08 |
| EP2058007A3 (en) | 2009-05-27 |
| US6217848B1 (en) | 2001-04-17 |
| DK1178830T3 (da) | 2009-10-12 |
| WO2000071162A3 (en) | 2001-07-05 |
| CA2373475C (en) | 2012-10-23 |
| EP2058007A2 (en) | 2009-05-13 |
| ATE435662T1 (de) | 2009-07-15 |
| JP2003500367A (ja) | 2003-01-07 |
| WO2000071162A2 (en) | 2000-11-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |