AU3546100A - Hydroxyphenyl derivatives with hiv integrase inhibitory properties - Google Patents

Hydroxyphenyl derivatives with hiv integrase inhibitory properties

Info

Publication number
AU3546100A
AU3546100A AU35461/00A AU3546100A AU3546100A AU 3546100 A AU3546100 A AU 3546100A AU 35461/00 A AU35461/00 A AU 35461/00A AU 3546100 A AU3546100 A AU 3546100A AU 3546100 A AU3546100 A AU 3546100A
Authority
AU
Australia
Prior art keywords
hiv integrase
inhibitory properties
integrase inhibitory
hydroxyphenyl derivatives
hydroxyphenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU35461/00A
Other languages
English (en)
Inventor
Gilles Sauve
Jocelyn Yelle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacor Inc
Original Assignee
Pharmacor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA 2267657 external-priority patent/CA2267657A1/fr
Application filed by Pharmacor Inc filed Critical Pharmacor Inc
Publication of AU3546100A publication Critical patent/AU3546100A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU35461/00A 1999-03-30 2000-03-27 Hydroxyphenyl derivatives with hiv integrase inhibitory properties Abandoned AU3546100A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US28056999A 1999-03-30 1999-03-30
CA2267657 1999-03-30
US09280569 1999-03-30
CA 2267657 CA2267657A1 (fr) 1999-03-30 1999-03-30 Derives hydroxyphenyliques ayant des proprietes inhibitrices de vih-integrase
PCT/CA2000/000327 WO2000059867A1 (fr) 1999-03-30 2000-03-27 Derives d'hydroxyphenyle possedant des proprietes inhibitrices de l'integrase du vih

Publications (1)

Publication Number Publication Date
AU3546100A true AU3546100A (en) 2000-10-23

Family

ID=25680873

Family Applications (1)

Application Number Title Priority Date Filing Date
AU35461/00A Abandoned AU3546100A (en) 1999-03-30 2000-03-27 Hydroxyphenyl derivatives with hiv integrase inhibitory properties

Country Status (3)

Country Link
EP (1) EP1165492A1 (fr)
AU (1) AU3546100A (fr)
WO (1) WO2000059867A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6362165B1 (en) 1999-03-30 2002-03-26 Pharmacor Inc. Hydroxyphenyl derivatives with HIV integrase inhibitory properties
US6313177B1 (en) 1999-04-30 2001-11-06 Pharmacor Inc. D-mannitol derivatives as HIV aspartyl protease inhibitors
CA2321348A1 (fr) 2000-09-27 2002-03-27 Blaise Magloire N'zemba Derives aromatiques ayant des proprietes inhibant l'integrase de l'hiv
WO2003082881A2 (fr) * 2002-03-28 2003-10-09 Procyon Biopharma Inc. Derives du pyridoxal-5-phosphate en tant qu'inhibiteurs de l'integrase du vih
JP2008538750A (ja) 2005-04-13 2008-11-06 アステックス、セラピューティックス、リミテッド 医薬化合物
US7754725B2 (en) 2006-03-01 2010-07-13 Astex Therapeutics Ltd. Dihydroxyphenyl isoindolymethanones
EP2073804B1 (fr) 2006-10-12 2017-09-13 Astex Therapeutics Limited Composes amides d'acide benzoique substitues par un groupe hydroxyle pour son utilisation dans le traitement de la douleur
US8779132B2 (en) 2006-10-12 2014-07-15 Astex Therapeutics Limited Pharmaceutical compounds
JP5528806B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
JP5528807B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
JP5721949B2 (ja) 2006-10-12 2015-05-20 アステックス、セラピューティックス、リミテッドＡｓｔｅｘ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ 複合薬剤
GB0620259D0 (en) 2006-10-12 2006-11-22 Astex Therapeutics Ltd Pharmaceutical compounds
GB0806527D0 (en) 2008-04-11 2008-05-14 Astex Therapeutics Ltd Pharmaceutical compounds
RU2554087C2 (ru) 2009-12-18 2015-06-27 Айденикс Фармасьютикалз, Инк. 5,5-конденсированные ариленовые или гетероариленовые ингибиторы вируса гепатита с
WO2017066965A1 (fr) * 2015-10-22 2017-04-27 The University Of Hong Kong Conjugué d'acide gallique-l-leucine pour la résolution de l'inflammation et du sepsis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6161794A (en) * 1993-01-17 1994-08-15 Schering Corporation Peptides having anti-hiv activity
AU4917397A (en) * 1996-10-31 1998-05-22 Merck & Co., Inc. Benzodiazepine hydrazide derivatives as inhibitors of hiv integrase
WO1998050347A1 (fr) * 1997-05-05 1998-11-12 The Regents Of The University Of California Naphtols utilisables dans des methodes antivirales

Also Published As

Publication number Publication date
EP1165492A1 (fr) 2002-01-02
WO2000059867A1 (fr) 2000-10-12

Similar Documents

Publication Publication Date Title
AU2001295310A1 (en) Aromatic derivatives with hiv integrase inhibitory properties
AU6314900A (en) Biarylurea derivatives
AU6714700A (en) Cyclopropylindole derivatives
AU5259100A (en) Medicament
AU2955200A (en) Cannula
AU1271201A (en) Azepinoindole derivatives, the production and use thereof
AU6616400A (en) Hiv integrase inhibitors
AU3546100A (en) Hydroxyphenyl derivatives with hiv integrase inhibitory properties
AU3118200A (en) Hiv integrase inhibitors
AU2623399A (en) 3-hydroxy-4-aryl-5-pyrazoline derivatives as herbicides
AU7947000A (en) Tricyclic fused-imidazole derivatives
AU8009900A (en) Hiv integrase inhibitors
AU3670000A (en) Novel thiazolobenzimidazole derivatives
AU5429000A (en) Novel bicyclonucleoside derivatives
AU7952800A (en) 2-alkoxybenzene derivatives
AU2692200A (en) Enteral sorbefacients
AU1304801A (en) Tricyclic azaindolizine derivatives having an SPLA2- inhibiting effect
AU1899501A (en) Novel 3-nitropyridine derivatives and the pharmaceutical compositions containingsaid derivatives
AU4081300A (en) Centroid integration
AU3714800A (en) Hiv therapy
AU4599500A (en) Safe
AU6262300A (en) Indolinylamide derivatives
AU1558300A (en) 1-cycloalkylpyrazoyl-benzoyl derivatives
AU7448300A (en) Novel pyridine derivatives
AU2028401A (en) 3-methyl-chromane or thiochromane derivatives

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase