AU2001295310A1 - Aromatic derivatives with hiv integrase inhibitory properties - Google Patents
Aromatic derivatives with hiv integrase inhibitory propertiesInfo
- Publication number
- AU2001295310A1 AU2001295310A1 AU2001295310A AU9531001A AU2001295310A1 AU 2001295310 A1 AU2001295310 A1 AU 2001295310A1 AU 2001295310 A AU2001295310 A AU 2001295310A AU 9531001 A AU9531001 A AU 9531001A AU 2001295310 A1 AU2001295310 A1 AU 2001295310A1
- Authority
- AU
- Australia
- Prior art keywords
- hiv integrase
- inhibitory properties
- aromatic derivatives
- integrase inhibitory
- aromatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
- C07C243/38—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002321348A CA2321348A1 (en) | 2000-09-27 | 2000-09-27 | Aromatic derivatives with hiv integrase inhibitory properties |
CA2321348 | 2000-09-27 | ||
PCT/CA2001/001367 WO2002026697A2 (en) | 2000-09-27 | 2001-09-25 | Aromatic derivatives with hiv integrase inhibitory properties |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001295310A1 true AU2001295310A1 (en) | 2002-04-08 |
Family
ID=4167266
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001295310A Abandoned AU2001295310A1 (en) | 2000-09-27 | 2001-09-25 | Aromatic derivatives with hiv integrase inhibitory properties |
Country Status (4)
Country | Link |
---|---|
US (1) | US6528655B1 (en) |
AU (1) | AU2001295310A1 (en) |
CA (1) | CA2321348A1 (en) |
WO (1) | WO2002026697A2 (en) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090124690A1 (en) * | 2000-04-03 | 2009-05-14 | Alberte Randall S | Generation of Combinatorial Synthetic Libraries and Screening for Novel Proadhesins and Nonadhesins |
CA2477604A1 (en) | 2002-03-13 | 2003-09-25 | Signum Biosciences, Inc. | Modulation of protein methylation and phosphoprotein phosphate |
CN1703395A (en) * | 2002-08-09 | 2005-11-30 | 特兰斯泰克制药公司 | Aryl and heteroaryl compounds and methods to modulate coagulation |
US7414045B2 (en) * | 2002-12-27 | 2008-08-19 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Substituted pyrimido[1,2-a]azepines useful as HIV integrase inhibitors |
US7230133B2 (en) | 2003-05-01 | 2007-06-12 | Bristol-Myers Squibb Company | Malonamides and malonamide derivatives as modulators of chemokine receptor activity |
US7405210B2 (en) | 2003-05-21 | 2008-07-29 | Osi Pharmaceuticals, Inc. | Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase |
JP2007501844A (en) | 2003-08-08 | 2007-02-01 | トランス テック ファーマ,インコーポレイテッド | Aryl and heteroaryl compounds, compositions and methods of use |
WO2005014534A1 (en) * | 2003-08-08 | 2005-02-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions, and methods of use |
US7208601B2 (en) * | 2003-08-08 | 2007-04-24 | Mjalli Adnan M M | Aryl and heteroaryl compounds, compositions, and methods of use |
EP1664154B1 (en) | 2003-09-12 | 2009-05-27 | Basf Se | Highly functional, highly branched or hyperbranched polycarbonates and the production and use hereof |
EP1725555B1 (en) | 2004-03-08 | 2010-10-06 | Prosidion Ltd. | Pyrrolopyridine-2-carboxylic acid hydrazides as inhibitors of glycogen phosphorylase |
DE602005013275D1 (en) | 2004-12-02 | 2009-04-23 | Prosidion Ltd | Pyrrolopyridine-2-KARBONSÄUREAMIDE |
EP1843734A4 (en) * | 2005-02-03 | 2008-09-10 | Signum Biosciences Inc | Compositions and methods for enhancing cognitive function |
US7923041B2 (en) | 2005-02-03 | 2011-04-12 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
AU2006299918A1 (en) * | 2005-10-13 | 2007-04-19 | Wyeth | Methods for preparing glutamic acid derivatives |
JP5401652B2 (en) | 2006-09-21 | 2014-01-29 | タイメッド バイオロジクス インコーポレイテッド | Protease inhibitor |
US8759327B2 (en) | 2007-04-16 | 2014-06-24 | The Regents Of The University Of Michigan | Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism |
US9120744B2 (en) * | 2007-04-16 | 2015-09-01 | The Regents Of The University Of Michigan | Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism |
AU2008266228A1 (en) * | 2007-06-13 | 2008-12-24 | Bristol-Myers Squibb Company | Dipeptide analogs as coagulation factor inhibitors |
CA2696321A1 (en) | 2007-08-15 | 2009-02-19 | Cytokinetics, Incorporated | Certain chemical entities, compositions, and methods |
EP2090606A1 (en) | 2008-02-15 | 2009-08-19 | Basf Se | Highly functional polyetherols, method for their manufacture and application thereof |
EP2161295A1 (en) | 2008-09-05 | 2010-03-10 | Basf Se | Highly functional polyetherols, method for their manufacture and application thereof |
CN101952347B (en) | 2008-02-15 | 2015-02-18 | 巴斯夫欧洲公司 | Highly functional polyetherols and the production and use thereof |
CN102014897B (en) | 2008-04-21 | 2015-08-05 | 西格纳姆生物科学公司 | Compound, compositions and its preparation method |
WO2011028740A1 (en) * | 2009-09-03 | 2011-03-10 | Glaxo Group Limited | ENaC BLOCKERS |
EP2444443A1 (en) | 2010-10-18 | 2012-04-25 | Basf Se | Highly functional polyetherols, method for their manufacture and application thereof |
US9085555B2 (en) | 2011-01-04 | 2015-07-21 | Novartis Ag | Complement pathway modulators and uses thereof |
EP2867227B1 (en) | 2012-06-28 | 2018-11-21 | Novartis AG | Complement pathway modulators and uses thereof |
CN104619698B (en) | 2012-06-28 | 2016-08-31 | 诺华股份有限公司 | Pyrrolidin derivatives and the purposes as complement pathway regulator thereof |
CN105121429B (en) | 2012-06-28 | 2017-12-12 | 诺华股份有限公司 | Complement pathway conditioning agent and its purposes |
US9388199B2 (en) | 2012-06-28 | 2016-07-12 | Novartis Ag | Pyrrolidine derivatives and their use as complement pathway modulators |
EP2867229B1 (en) | 2012-06-28 | 2017-07-26 | Novartis AG | Pyrrolidine derivatives and their use as complement pathway modulators |
EP2872503B1 (en) | 2012-07-12 | 2018-06-20 | Novartis AG | Complement pathway modulators and uses thereof |
US9718760B2 (en) | 2012-10-31 | 2017-08-01 | The Regents Of The University Of Michigan | Plasminogen activator inhibitor-1 inhibitors and methods of use thereof |
AU2018307807B2 (en) | 2017-07-27 | 2024-05-02 | Eastern Michigan University | Plasminogen activator inhibitor-1 (PAI-1) inhibitor and method of use |
WO2023028286A1 (en) * | 2021-08-27 | 2023-03-02 | Ut-Battelle, Llc | Covalent inhibitors of coronavirus papain-like protease |
CN114907344B (en) * | 2022-05-09 | 2023-06-30 | 山东大学 | Beta-carboline-1-propionic acid and indole derivatives, and preparation method and application thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2761687B1 (en) * | 1997-04-08 | 2000-09-15 | Centre Nat Rech Scient | QUINOLEIN DERIVATIVES, ESPECIALLY HAVING ANTIVIRAL PROPERTIES, THEIR PREPARATIONS AND THEIR BIOLOGICAL APPLICATIONS |
AU3366899A (en) * | 1998-03-27 | 1999-10-18 | Regents Of The University Of California, The | Novel hiv integrase inhibitors and hiv therapy based on drug combinations including integrase inhibitors |
WO2000024392A1 (en) * | 1998-10-26 | 2000-05-04 | Sumitomo Pharmaceuticals Company, Limited | β-AMYLOID FORMATION INHIBITORS |
AU3546100A (en) * | 1999-03-30 | 2000-10-23 | Pharmacor Inc. | Hydroxyphenyl derivatives with hiv integrase inhibitory properties |
US6362165B1 (en) * | 1999-03-30 | 2002-03-26 | Pharmacor Inc. | Hydroxyphenyl derivatives with HIV integrase inhibitory properties |
-
2000
- 2000-09-27 CA CA002321348A patent/CA2321348A1/en not_active Abandoned
-
2001
- 2001-09-25 AU AU2001295310A patent/AU2001295310A1/en not_active Abandoned
- 2001-09-25 WO PCT/CA2001/001367 patent/WO2002026697A2/en active Application Filing
- 2001-09-26 US US09/963,329 patent/US6528655B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2321348A1 (en) | 2002-03-27 |
US6528655B1 (en) | 2003-03-04 |
WO2002026697A3 (en) | 2002-05-16 |
WO2002026697A2 (en) | 2002-04-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU2001295310A1 (en) | Aromatic derivatives with hiv integrase inhibitory properties | |
AU2001238595A1 (en) | N-maleimidyl polymer derivatives | |
AU2002361992A1 (en) | 1,4-dihydro-1,4-diphenylpyridine derivatives | |
AU2001280099A1 (en) | 4-acylaminopyrazole derivatives | |
AU2001230584A1 (en) | 1h-imidazopyridine derivatives | |
AU2001280796A1 (en) | Electrowetting-driven micropumping | |
AU2002221047A1 (en) | Quinazolinone derivatives | |
AU2002221827A1 (en) | Novel lactame-substituted pyrazolopyridine derivatives | |
AU2002216028A1 (en) | Novel carbamate-substituted pyrazolopyridine derivatives | |
AU2002215218A1 (en) | Isoxazole derivatives | |
AU2001230026A1 (en) | 2,4-diaminothiazole derivatives | |
AU2001230537A1 (en) | Pyridoxazine derivatives | |
AU2001281802A1 (en) | 6-phenylpyrrolopyrimidinedione derivatives | |
AU6616400A (en) | Hiv integrase inhibitors | |
AU2001278790A1 (en) | 1h-imidazopyridine derivatives | |
AU3546100A (en) | Hydroxyphenyl derivatives with hiv integrase inhibitory properties | |
AU2002213978A1 (en) | Substituted C-cyclohexylmethylamine derivatives | |
AU2002212301A1 (en) | Diazacycloalkanedione derivatives | |
AU2002349675A1 (en) | Derivative having hiv integrase inhibitory activity | |
AU8009900A (en) | Hiv integrase inhibitors | |
AU2001258563A1 (en) | Chromatic-dispersion compensator | |
AU2002212959A1 (en) | Cycloalkylfluorosulfonamide derivatives | |
AU2002221099A1 (en) | Combination drugs | |
AU2002215212A1 (en) | 1-methylcarbapenem derivatives | |
AU2001289937A1 (en) | Substituted 1-aminobutan-3-ol derivatives |