AU2513592A

AU2513592A - Hepatitis c assay utilizing recombinant antigens to ns1

Hepatitis c assay utilizing recombinant antigens to ns1

Info

Publication number: AU2513592A
Authority: AU; Australia
Prior art keywords: ala; val; leu; gly; arg
Prior art date: 1991-08-21
Legal status : Abandoned

Application number

AU25135/92A

Other languages

English (en)

Inventor

Stephen H. Dailey

Suresh M. Desai

Sushil G. Devare

Current Assignee

Abbott Laboratories

Original Assignee

Abbott Laboratories

Priority date

1991-08-21

Filing date

1992-08-21

Publication date

1993-03-16

1992-08-21 Application filed by Abbott Laboratories filed Critical Abbott Laboratories

1993-03-16 Publication of AU2513592A publication Critical patent/AU2513592A/en

Status Abandoned legal-status Critical Current

Links

239000000427 antigen Substances 0.000 title claims description 182
108091007433 antigens Proteins 0.000 title claims description 175
102000036639 antigens Human genes 0.000 title claims description 175
238000003556 assay Methods 0.000 title claims description 74
208000006454 hepatitis Diseases 0.000 title description 12
231100000283 hepatitis Toxicity 0.000 title description 9
108090000765 processed proteins & peptides Proteins 0.000 claims description 96
102000004196 processed proteins & peptides Human genes 0.000 claims description 81
229920001184 polypeptide Polymers 0.000 claims description 78
102000007056 Recombinant Fusion Proteins Human genes 0.000 claims description 38
108010008281 Recombinant Fusion Proteins Proteins 0.000 claims description 38
238000002360 preparation method Methods 0.000 claims description 25
238000002809 confirmatory assay Methods 0.000 claims description 20
239000007787 solid Substances 0.000 claims description 19
239000003153 chemical reaction reagent Substances 0.000 claims description 17
238000001514 detection method Methods 0.000 claims description 14
230000000536 complexating effect Effects 0.000 claims description 9
239000012530 fluid Substances 0.000 claims description 9
238000006386 neutralization reaction Methods 0.000 claims description 5
238000003018 immunoassay Methods 0.000 claims description 3
241000711549 Hepacivirus C Species 0.000 description 298
150000001413 amino acids Chemical class 0.000 description 206
229940024606 amino acid Drugs 0.000 description 180
235000001014 amino acid Nutrition 0.000 description 180
BYXHQQCXAJARLQ-ZLUOBGJFSA-N Ala-Ala-Ala Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(O)=O BYXHQQCXAJARLQ-ZLUOBGJFSA-N 0.000 description 117
241000588724 Escherichia coli Species 0.000 description 84
108010013746 3-deoxy-manno-octulosonate cytidyltransferase Proteins 0.000 description 70
238000007423 screening assay Methods 0.000 description 59
108090000623 proteins and genes Proteins 0.000 description 54
LMPKCSXZJSXBBL-NHCYSSNCSA-N Arg-Gln-Val Chemical compound [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(O)=O LMPKCSXZJSXBBL-NHCYSSNCSA-N 0.000 description 52
108020004414 DNA Proteins 0.000 description 47
108010005233 alanylglutamic acid Proteins 0.000 description 46
102000037865 fusion proteins Human genes 0.000 description 46
108020001507 fusion proteins Proteins 0.000 description 46
239000012634 fragment Substances 0.000 description 44
102000004169 proteins and genes Human genes 0.000 description 44
238000000034 method Methods 0.000 description 43
235000018102 proteins Nutrition 0.000 description 42
239000000523 sample Substances 0.000 description 41
VPZXBVLAVMBEQI-UHFFFAOYSA-N glycyl-DL-alpha-alanine Natural products OC(=O)C(C)NC(=O)CN VPZXBVLAVMBEQI-UHFFFAOYSA-N 0.000 description 40
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COYHRQWNJDJCNA-NUJDXYNKSA-N Thr-Thr-Thr Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O COYHRQWNJDJCNA-NUJDXYNKSA-N 0.000 description 39
239000002585 base Substances 0.000 description 39
JBCLFWXMTIKCCB-UHFFFAOYSA-N H-Gly-Phe-OH Natural products NCC(=O)NC(C(O)=O)CC1=CC=CC=C1 JBCLFWXMTIKCCB-UHFFFAOYSA-N 0.000 description 38
239000013612 plasmid Substances 0.000 description 38
108010013835 arginine glutamate Proteins 0.000 description 35
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SUENWIFTSTWUKD-AVGNSLFASA-N Pro-Leu-Val Chemical compound [H]N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(O)=O SUENWIFTSTWUKD-AVGNSLFASA-N 0.000 description 34
239000013598 vector Substances 0.000 description 34
RMWAOBGCZZSJHE-UMNHJUIQSA-N Glu-Val-Pro Chemical compound CC(C)[C@@H](C(=O)N1CCC[C@@H]1C(=O)O)NC(=O)[C@H](CCC(=O)O)N RMWAOBGCZZSJHE-UMNHJUIQSA-N 0.000 description 33
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HFZNNDWPHBRNPV-KZVJFYERSA-N Pro-Ala-Thr Chemical compound [H]N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(O)=O HFZNNDWPHBRNPV-KZVJFYERSA-N 0.000 description 32
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108010073969 valyllysine Proteins 0.000 description 32
ODWSTKXGQGYHSH-FXQIFTODSA-N Ala-Arg-Ala Chemical compound C[C@H](N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(O)=O ODWSTKXGQGYHSH-FXQIFTODSA-N 0.000 description 31
YCRAFFCYWOUEOF-DLOVCJGASA-N Ala-Phe-Ser Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)C)CC1=CC=CC=C1 YCRAFFCYWOUEOF-DLOVCJGASA-N 0.000 description 31
YUIGJDNAGKJLDO-JYJNAYRXSA-N Arg-Arg-Tyr Chemical compound [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O YUIGJDNAGKJLDO-JYJNAYRXSA-N 0.000 description 31
HZZIFFOVHLWGCS-KKUMJFAQSA-N Asn-Phe-Leu Chemical compound [H]N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(O)=O HZZIFFOVHLWGCS-KKUMJFAQSA-N 0.000 description 31
QHHVSXGWLYEAGX-GUBZILKMSA-N Asp-His-Gln Chemical compound C1=C(NC=N1)C[C@@H](C(=O)N[C@@H](CCC(=O)N)C(=O)O)NC(=O)[C@H](CC(=O)O)N QHHVSXGWLYEAGX-GUBZILKMSA-N 0.000 description 31
FAUPLTGRUBTXNU-FXQIFTODSA-N Asp-Pro-Ser Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(O)=O FAUPLTGRUBTXNU-FXQIFTODSA-N 0.000 description 31
VNTGPISAOMAXRK-CIUDSAMLSA-N Gln-Pro-Ser Chemical compound [H]N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(O)=O VNTGPISAOMAXRK-CIUDSAMLSA-N 0.000 description 31
ULZCYBYDTUMHNF-IUCAKERBSA-N Gly-Leu-Glu Chemical compound NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(O)=O ULZCYBYDTUMHNF-IUCAKERBSA-N 0.000 description 31
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108010065920 Insulin Lispro Proteins 0.000 description 31
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SOYWRINXUSUWEQ-DLOVCJGASA-N Glu-Val-Val Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](N)CCC(O)=O SOYWRINXUSUWEQ-DLOVCJGASA-N 0.000 description 29
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