AU2023249802A1 - Cells having solid tumor targeting backbone and use thereof - Google Patents

Cells having solid tumor targeting backbone and use thereof Download PDF

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Publication number
AU2023249802A1
AU2023249802A1 AU2023249802A AU2023249802A AU2023249802A1 AU 2023249802 A1 AU2023249802 A1 AU 2023249802A1 AU 2023249802 A AU2023249802 A AU 2023249802A AU 2023249802 A AU2023249802 A AU 2023249802A AU 2023249802 A1 AU2023249802 A1 AU 2023249802A1
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cell
receptor
seq
domain
cells
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AU2023249802A
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Chia-Wei Chang
Martin HOSKING
Tom Tong LEE
Eigen Peralta
Bahram Valamehr
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Fate Therapeutics Inc
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Fate Therapeutics Inc
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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AU2023249802A 2022-04-08 2023-04-07 Cells having solid tumor targeting backbone and use thereof Pending AU2023249802A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202263329364P 2022-04-08 2022-04-08
US63/329,364 2022-04-08
US202263380378P 2022-10-20 2022-10-20
US63/380,378 2022-10-20
PCT/US2023/065550 WO2023196994A1 (en) 2022-04-08 2023-04-07 Cells having solid tumor targeting backbone and use thereof

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AU2023249802A1 true AU2023249802A1 (en) 2024-10-24

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AU2023249802A Pending AU2023249802A1 (en) 2022-04-08 2023-04-07 Cells having solid tumor targeting backbone and use thereof

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US (2) US20250228943A1 (enExample)
EP (1) EP4504914A4 (enExample)
JP (2) JP7701453B2 (enExample)
KR (1) KR20250005097A (enExample)
CN (1) CN119256075A (enExample)
AU (1) AU2023249802A1 (enExample)
CA (1) CA3247423A1 (enExample)
IL (1) IL316101A (enExample)
MX (1) MX2024008227A (enExample)
WO (1) WO2023196994A1 (enExample)

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IL312565A (en) * 2021-11-08 2024-07-01 Fate Therapeutics Inc Engineered effector cells for trafficking of allogeneic cell therapies in solid tumors
WO2025101809A1 (en) * 2023-11-08 2025-05-15 Fate Therapeutics, Inc. Ipsc-derived t cells for solid tumor treatment

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