AU2022294563A1 - Method for producing cerebral cortical cell preparation derived from human pluripotent stem cells - Google Patents
Method for producing cerebral cortical cell preparation derived from human pluripotent stem cells Download PDFInfo
- Publication number
- AU2022294563A1 AU2022294563A1 AU2022294563A AU2022294563A AU2022294563A1 AU 2022294563 A1 AU2022294563 A1 AU 2022294563A1 AU 2022294563 A AU2022294563 A AU 2022294563A AU 2022294563 A AU2022294563 A AU 2022294563A AU 2022294563 A1 AU2022294563 A1 AU 2022294563A1
- Authority
- AU
- Australia
- Prior art keywords
- cell
- cerebral
- cells
- culture
- cell aggregate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0619—Neurons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/38—Vitamins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/42—Notch; Delta; Jagged; Serrate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases [EC 2.]
- C12N2501/727—Kinases (EC 2.7.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2513/00—3D culture
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Neurosurgery (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Developmental Biology & Embryology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163211622P | 2021-06-17 | 2021-06-17 | |
| US63/211,622 | 2021-06-17 | ||
| PCT/JP2022/024226 WO2022265086A1 (ja) | 2021-06-17 | 2022-06-16 | ヒト多能性幹細胞由来大脳皮質細胞製剤の製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2022294563A1 true AU2022294563A1 (en) | 2024-01-18 |
Family
ID=84527112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2022294563A Pending AU2022294563A1 (en) | 2021-06-17 | 2022-06-16 | Method for producing cerebral cortical cell preparation derived from human pluripotent stem cells |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20240279602A1 (https=) |
| EP (1) | EP4357449A4 (https=) |
| JP (1) | JPWO2022265086A1 (https=) |
| KR (1) | KR20240034191A (https=) |
| CN (1) | CN117769591A (https=) |
| AU (1) | AU2022294563A1 (https=) |
| CA (1) | CA3224178A1 (https=) |
| IL (1) | IL309344A (https=) |
| WO (1) | WO2022265086A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025225695A1 (ja) * | 2024-04-26 | 2025-10-30 | 株式会社Racthera | 細胞凝集体の保存方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| CA2277278A1 (en) | 1997-01-10 | 1998-07-16 | Life Technologies, Inc. | Embryonic stem cell serum replacement |
| US6280718B1 (en) | 1999-11-08 | 2001-08-28 | Wisconsin Alumni Reasearch Foundation | Hematopoietic differentiation of human pluripotent embryonic stem cells |
| WO2002101057A1 (fr) | 2001-06-08 | 2002-12-19 | Dnavec Research Inc. | Transfert genique dans des cellules souches embryonnaires de primate a l'aide d'un virus de l'immunodeficience simienne de pseudo type vsv-g utilise comme vecteur |
| JP2008099662A (ja) | 2006-09-22 | 2008-05-01 | Institute Of Physical & Chemical Research | 幹細胞の培養方法 |
| US20100087486A1 (en) | 2008-05-30 | 2010-04-08 | Hiroshi Nakamura | Methods for using tgf-b receptor inhibitors or activin-like kinase (alk) 5 inhibitors a-83-01 and sb-431542 to treat eye disease and wound healing conditions |
| ES2732730T3 (es) | 2013-11-22 | 2019-11-25 | Riken | Método para producir telencéfalo o tejido progenitor del mismo |
| TWI810142B (zh) | 2014-10-24 | 2023-08-01 | 日商住友製藥股份有限公司 | 神經組織的製造方法 |
| US10626368B2 (en) | 2015-04-14 | 2020-04-21 | Kyoto University | Method for inducing cerebral cortex neurons |
| WO2017083705A1 (en) * | 2015-11-13 | 2017-05-18 | The Johns Hopkins University | Cell culture system and method of use thereof |
| US20220145247A1 (en) * | 2019-02-11 | 2022-05-12 | Miltenyi Biotec B.V. & Co. KG | Generation of human pluripotent stem cell derived artificial tissue structures without three dimensional matrices |
| JP7364208B2 (ja) * | 2019-06-21 | 2023-10-18 | 独立行政法人国立病院機構 | 前脳型の神経前駆細胞の製造方法、分化用培地、及び、前脳型の神経前駆細胞 |
-
2022
- 2022-06-16 JP JP2023530419A patent/JPWO2022265086A1/ja active Pending
- 2022-06-16 AU AU2022294563A patent/AU2022294563A1/en active Pending
- 2022-06-16 WO PCT/JP2022/024226 patent/WO2022265086A1/ja not_active Ceased
- 2022-06-16 EP EP22825074.2A patent/EP4357449A4/en active Pending
- 2022-06-16 CN CN202280042648.8A patent/CN117769591A/zh active Pending
- 2022-06-16 CA CA3224178A patent/CA3224178A1/en active Pending
- 2022-06-16 US US18/569,736 patent/US20240279602A1/en active Pending
- 2022-06-16 IL IL309344A patent/IL309344A/en unknown
- 2022-06-16 KR KR1020247001757A patent/KR20240034191A/ko active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20240279602A1 (en) | 2024-08-22 |
| JPWO2022265086A1 (https=) | 2022-12-22 |
| CA3224178A1 (en) | 2022-12-22 |
| WO2022265086A1 (ja) | 2022-12-22 |
| EP4357449A1 (en) | 2024-04-24 |
| IL309344A (en) | 2024-02-01 |
| KR20240034191A (ko) | 2024-03-13 |
| CN117769591A (zh) | 2024-03-26 |
| EP4357449A4 (en) | 2025-09-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7023820B2 (ja) | 多分化能細胞および多能性細胞の分化を方向付けることによって発生させる皮質介在ニューロンおよびその他のニューロン細胞 | |
| CN110573610B (zh) | 视网膜色素上皮细胞的制备方法 | |
| JP6499084B2 (ja) | 終脳又はその前駆組織の製造方法 | |
| KR102920569B1 (ko) | 안구 세포의 분화를 위한 방법 및 이의 용도 | |
| CN105658788B (zh) | 多巴胺能神经元的制备方法 | |
| CN110662832A (zh) | 由间介中胚层细胞分化诱导肾祖细胞的方法和由多能干细胞分化诱导肾祖细胞的方法 | |
| JP2008099662A (ja) | 幹細胞の培養方法 | |
| JPWO2020100481A1 (ja) | 脳オルガノイドの製造方法 | |
| CN108350421A (zh) | 用于制备视网膜色素上皮细胞的方法 | |
| US12545892B2 (en) | Application of TGF-B inhibitor in inducing neural stem cells and organoid formation | |
| JPWO2016039317A1 (ja) | 小脳前駆組織の製造方法 | |
| CN112601814A (zh) | 包含嗅神经细胞或其前体细胞的细胞团块及其制备方法 | |
| AU2020234344A1 (en) | Method for evaluating quality of transplant neural retina, and transplant neural retina sheet | |
| US12590954B2 (en) | Neural stem cell-induced differential medium and induction differentiation method | |
| CN105392881A (zh) | 体细胞基于小分子转化为神经嵴细胞 | |
| JP2026042046A (ja) | 細胞凝集体、細胞凝集体の混合物及びそれらの製造方法 | |
| AU2022294563A1 (en) | Method for producing cerebral cortical cell preparation derived from human pluripotent stem cells | |
| JPWO2017141900A1 (ja) | 多能性幹細胞の神経幹細胞への分化用培地及びその使用 | |
| HK40104497A (en) | Method for producing cerebral cortical cell preparation derived from human pluripotent stem cells | |
| WO2019167398A1 (ja) | 薬剤評価方法 | |
| US20240158745A1 (en) | Methods of generating oligodendrocyte progenitor cells and use thereof | |
| AU2024233447A1 (en) | Methods and compositions for in vitro haematopoiesis and lymphopoiesis | |
| WO2022020798A1 (en) | Methods of differentiating neurons and identification of disease phenotypes thereof | |
| CN121343902A (zh) | 离体的大脑皮层中间神经元前体细胞群及其制备方法和用途 | |
| HK40064426A (en) | Method for evaluating quality of transplant neural retina, and transplant neural retina sheet |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC1 | Assignment before grant (sect. 113) |
Owner name: RATHERA CO., LTD. Free format text: FORMER APPLICANT(S): KYOTO UNIVERSITY; SUMITOMO PHARMA CO., LTD. Owner name: KYOTO UNIVERSITY Free format text: FORMER APPLICANT(S): KYOTO UNIVERSITY; SUMITOMO PHARMA CO., LTD. |
|
| TH | Corrigenda |
Free format text: IN VOL 59 , NO 40 , PAGE(S) 5430 UNDER THE HEADING ASSIGNMENTS BEFORE GRANT, SECTION 113 - 2022 CORRECT THE NAME OF THE ASSIGNEE TO READ: KYOTO UNIVERSITY AND RACTHERA CO., LTD. |