AU2021281829A1 - Method of producing organoid derived from lung epithelial cell or lung cancer cell - Google Patents

Method of producing organoid derived from lung epithelial cell or lung cancer cell Download PDF

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Publication number
AU2021281829A1
AU2021281829A1 AU2021281829A AU2021281829A AU2021281829A1 AU 2021281829 A1 AU2021281829 A1 AU 2021281829A1 AU 2021281829 A AU2021281829 A AU 2021281829A AU 2021281829 A AU2021281829 A AU 2021281829A AU 2021281829 A1 AU2021281829 A1 AU 2021281829A1
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Prior art keywords
cells
cell
inhibitor
combination
organoid
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AU2021281829A
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English (en)
Inventor
Takashi Fujimura
Mitsuru Morimoto
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Otsuka Pharmaceutical Co Ltd
RIKEN
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Otsuka Pharmaceutical Co Ltd
RIKEN
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Publication of AU2021281829A1 publication Critical patent/AU2021281829A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/42—Respiratory system, e.g. lungs, bronchi or lung cells
    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0688—Cells from the lungs or the respiratory tract
    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
    • G—PHYSICS
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases [EC 2.]
    • C12N2501/727—Kinases (EC 2.7.)
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AU2021281829A 2020-05-27 2021-05-26 Method of producing organoid derived from lung epithelial cell or lung cancer cell Pending AU2021281829A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020-092303 2020-05-27
JP2020092303 2020-05-27
PCT/JP2021/019947 WO2021241621A1 (ja) 2020-05-27 2021-05-26 肺上皮細胞又は肺がん細胞からのオルガノイドの製造方法

Publications (1)

Publication Number Publication Date
AU2021281829A1 true AU2021281829A1 (en) 2023-02-02

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ID=78744588

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Application Number Title Priority Date Filing Date
AU2021281829A Pending AU2021281829A1 (en) 2020-05-27 2021-05-26 Method of producing organoid derived from lung epithelial cell or lung cancer cell

Country Status (9)

Country Link
US (1) US20230203450A1 (https=)
EP (1) EP4159277A4 (https=)
JP (1) JPWO2021241621A1 (https=)
KR (1) KR20230016653A (https=)
CN (1) CN115667496A (https=)
AU (1) AU2021281829A1 (https=)
CA (1) CA3185066A1 (https=)
TW (1) TW202200786A (https=)
WO (1) WO2021241621A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114292816B (zh) * 2022-03-10 2022-05-31 北京大橡科技有限公司 肺癌类器官培养液及其培养试剂组合和培养方法
CN115094022B (zh) * 2022-05-31 2023-07-28 创芯国际生物科技(广州)有限公司 肺癌成纤维细胞与肺癌类器官共培养模型的构建方法
WO2024019492A1 (ko) * 2022-07-20 2024-01-25 가톨릭대학교 산학협력단 폐 오가노이드를 이용한 covid-19 및 호흡기 질환 바이러스 감염 모델
US20260022347A1 (en) * 2022-07-27 2026-01-22 Keio University Treatment agent for lung adenocarcinomas
JPWO2024075838A1 (https=) * 2022-10-07 2024-04-11
IT202300008076A1 (it) * 2023-04-26 2024-10-26 Irccs Ospedale Policlinico San Martino Terreno di coltura per la propagazione di colture primarie di cellule epiteliali e relativo metodo di utilizzo
CN117467701B (zh) * 2023-09-27 2025-07-15 中国医学科学院医药生物技术研究所 一种过表达mr-1转基因肺腺癌小鼠模型的构建方法
WO2025065097A1 (en) * 2023-09-29 2025-04-03 Stemcell Technologies Canada Inc. Compositions and methods for improved generation of organoids

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2906643A1 (en) 2013-03-15 2014-09-25 The Jackson Laboratory Isolation of non-embryonic stem cells and uses thereof
GB201421092D0 (en) 2014-11-27 2015-01-14 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium
US20170285002A1 (en) * 2016-03-16 2017-10-05 Public University Corporation Yokohama City University Method for reconstituting tumor with microenvironment
JP7183175B2 (ja) * 2017-03-24 2022-12-05 ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク 分岐構造を有する肺芽オルガノイドの生成および肺疾患のモデリングのためのその使用
CN106967672B (zh) * 2017-03-24 2021-01-26 四川大学华西医院 一种肺及肺癌组织培养方法以及用其构建肺癌小鼠动物模型方法

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Publication number Publication date
JPWO2021241621A1 (https=) 2021-12-02
EP4159277A1 (en) 2023-04-05
US20230203450A1 (en) 2023-06-29
CN115667496A (zh) 2023-01-31
EP4159277A4 (en) 2024-07-03
KR20230016653A (ko) 2023-02-02
CA3185066A1 (en) 2021-12-02
TW202200786A (zh) 2022-01-01
WO2021241621A1 (ja) 2021-12-02

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DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE INVENTION TITLE TO READ METHOD OF PRODUCING ORGANOID DERIVED FROM LUNG EPITHELIAL CELL OR LUNG CANCER CELL