AU2020392094A1 - Methods for activation and expansion of tumor infiltrating lymphocytes - Google Patents

Methods for activation and expansion of tumor infiltrating lymphocytes Download PDF

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Publication number
AU2020392094A1
AU2020392094A1 AU2020392094A AU2020392094A AU2020392094A1 AU 2020392094 A1 AU2020392094 A1 AU 2020392094A1 AU 2020392094 A AU2020392094 A AU 2020392094A AU 2020392094 A AU2020392094 A AU 2020392094A AU 2020392094 A1 AU2020392094 A1 AU 2020392094A1
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tils
population
expanded
expansion
gene
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Micah BENSON
Nicholas John COLLETTI
Michael Schlabach
Noah Jacob TUBO
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KSQ Therapeutics Inc
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KSQ Therapeutics Inc
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
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    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • A—HUMAN NECESSITIES
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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  • General Engineering & Computer Science (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
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  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2020392094A 2019-11-25 2020-11-24 Methods for activation and expansion of tumor infiltrating lymphocytes Pending AU2020392094A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962940035P 2019-11-25 2019-11-25
US62/940,035 2019-11-25
US202063081539P 2020-09-22 2020-09-22
US63/081,539 2020-09-22
PCT/US2020/062094 WO2021108455A1 (en) 2019-11-25 2020-11-24 Methods for activation and expansion of tumor infiltrating lymphocytes

Publications (1)

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AU2020392094A1 true AU2020392094A1 (en) 2022-06-23

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AU2020392094A Pending AU2020392094A1 (en) 2019-11-25 2020-11-24 Methods for activation and expansion of tumor infiltrating lymphocytes

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US (1) US20240376428A1 (enExample)
EP (1) EP4065233A4 (enExample)
JP (2) JP2023502780A (enExample)
KR (1) KR20220119038A (enExample)
CN (1) CN115003387A (enExample)
AU (1) AU2020392094A1 (enExample)
CA (1) CA3162272A1 (enExample)
WO (1) WO2021108455A1 (enExample)

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WO2020180882A1 (en) 2019-03-05 2020-09-10 Nkarta, Inc. Cd19-directed chimeric antigen receptors and uses thereof in immunotherapy
US12365871B2 (en) 2020-04-28 2025-07-22 Lyell Immunopharma, Inc. Methods for culturing cells
WO2021252804A1 (en) 2020-06-12 2021-12-16 Nkarta, Inc. Genetically modified natural killer cells for cd70-directed cancer immunotherapy
CN116948964A (zh) 2020-11-19 2023-10-27 苏州沙砾生物科技有限公司 肿瘤浸润淋巴细胞的培养方法及其用途
US20240360410A1 (en) * 2021-08-03 2024-10-31 Suzhou Grit Biotechnology Co., Ltd. Modified tumor infiltrating lymphocyte and use thereof
KR20240052771A (ko) * 2021-09-08 2024-04-23 케이에스큐 세러퓨틱스 인코포레이티드 림프구 효력 검정
WO2023125772A1 (zh) * 2021-12-30 2023-07-06 苏州沙砾生物科技有限公司 一种修饰的肿瘤浸润淋巴细胞及其用途
CN118525084A (zh) * 2022-01-19 2024-08-20 苏州沙砾生物科技有限公司 肿瘤浸润淋巴细胞在疾病治疗中的用途
EP4469068A4 (en) * 2022-01-28 2026-05-13 Abelzeta Inc TUMOR-INFILTRATING LYMPHOCYTE ENRICHEMENT PROCESS
EP4471128A4 (en) * 2022-01-29 2026-03-04 Suzhou Grit Biotechnology Co Ltd Modified tumor infiltrating lymphocyte and use thereof
JP2025508050A (ja) * 2022-03-07 2025-03-21 ンカルタ・インコーポレイテッド Ｃｄ７０指向性がん免疫療法のための多重遺伝子編集細胞
CN117417894A (zh) * 2023-09-15 2024-01-19 毕诺济(上海)生物技术有限公司 敲除Roquin-1和/或Regnase-1基因的肿瘤浸润淋巴细胞及其应用
WO2025092690A1 (zh) * 2023-10-30 2025-05-08 苏州沙砾生物科技有限公司 一种修饰的细胞及其用途

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JPWO2010098429A1 (ja) * 2009-02-27 2012-09-06 国立大学法人大阪大学 免疫アジュバント組成物、及びその利用
EP2711418B1 (en) * 2012-09-25 2017-08-23 Miltenyi Biotec GmbH Method for polyclonal stimulation of T cells by flexible nanomatrices
US20170224731A1 (en) * 2014-06-10 2017-08-10 Monash University Method of producing leukocytes using ptpn2 inhibition for adoptive cell transfer
ES2808914T3 (es) * 2014-09-04 2021-03-02 Stemcell Tech Inc Complejos de anticuerpo solubles para la activación y expansión de linfocitos T o células NK
CN107567461A (zh) * 2014-12-29 2018-01-09 诺华股份有限公司 制备嵌合抗原受体表达细胞的方法
AU2016249005B2 (en) * 2015-04-17 2022-06-16 Novartis Ag Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells
WO2017087768A1 (en) * 2015-11-18 2017-05-26 Duke University Targeted delivery of interleukin-10 to tumor infiltrating lymphocytes
TWI788307B (zh) * 2016-10-31 2023-01-01 美商艾歐凡斯生物治療公司 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞
MA50871A (fr) * 2017-05-10 2020-03-18 Iovance Biotherapeutics Inc Expansion de lymphocytes infiltrant des tumeurs à partir de tumeurs liquides et leurs utilisations thérapeutiques
KR20200130826A (ko) * 2018-03-15 2020-11-20 케이에스큐 세러퓨틱스 인코포레이티드 개선된 면역요법을 위한 유전자-조절 조성물 및 방법
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Publication number Publication date
CA3162272A1 (en) 2021-06-03
JP2023502780A (ja) 2023-01-25
JP2025159098A (ja) 2025-10-17
EP4065233A1 (en) 2022-10-05
CN115003387A (zh) 2022-09-02
KR20220119038A (ko) 2022-08-26
WO2021108455A1 (en) 2021-06-03
EP4065233A4 (en) 2024-07-10
US20240376428A1 (en) 2024-11-14

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