AU2020358000B2 - Antagonists of the muscarinic acetylcholine receptor M4 - Google Patents
Antagonists of the muscarinic acetylcholine receptor M4Info
- Publication number
- AU2020358000B2 AU2020358000B2 AU2020358000A AU2020358000A AU2020358000B2 AU 2020358000 B2 AU2020358000 B2 AU 2020358000B2 AU 2020358000 A AU2020358000 A AU 2020358000A AU 2020358000 A AU2020358000 A AU 2020358000A AU 2020358000 B2 AU2020358000 B2 AU 2020358000B2
- Authority
- AU
- Australia
- Prior art keywords
- compound
- pharmaceutically acceptable
- pyran
- tetrahydro
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962910863P | 2019-10-04 | 2019-10-04 | |
| US62/910,863 | 2019-10-04 | ||
| PCT/US2020/053942 WO2021067696A1 (en) | 2019-10-04 | 2020-10-02 | Antagonists of the muscarinic acetylcholine receptor m4 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2020358000A1 AU2020358000A1 (en) | 2022-04-07 |
| AU2020358000B2 true AU2020358000B2 (en) | 2026-05-28 |
Family
ID=75337550
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2020358000A Active AU2020358000B2 (en) | 2019-10-04 | 2020-10-02 | Antagonists of the muscarinic acetylcholine receptor M4 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US12319701B2 (enExample) |
| EP (1) | EP4037677B1 (enExample) |
| JP (1) | JP7572734B2 (enExample) |
| AU (1) | AU2020358000B2 (enExample) |
| CA (1) | CA3155864A1 (enExample) |
| ES (1) | ES3057371T3 (enExample) |
| WO (1) | WO2021067696A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3651762B1 (en) | 2017-07-12 | 2024-07-03 | Vanderbilt University | Antagonists of the muscarinic acetylcholine receptor m4 |
| JP7270989B2 (ja) | 2017-10-20 | 2023-05-11 | ヴァンダービルト ユニバーシティー | ムスカリン性アセチルコリン受容体ｍ４のアンタゴニスト |
| CA3180717A1 (en) * | 2020-04-24 | 2021-10-28 | Vanderbilt University | Condensed substituted hydropyrroles as antagonists of the muscarinic acetylcholine receptor m4 |
| US20240174655A1 (en) * | 2021-04-02 | 2024-05-30 | Vanderbilt University | Indazole derivatives as antagonists of the muscarinic acetylcholine receptor m4 |
| WO2022261427A1 (en) * | 2021-06-11 | 2022-12-15 | Vanderbilt University | (4-(6-((2-octahydrocyclopenta[c]pyrrol-5-yl)amino)pyridazin-3-yl)phenyl)(imino)(methyl)-lambda6- sulfanone derivatives and similar compounds as muscarinic acetylcholine receptor m4 antagonists for the treatment of neurodegenerative disorders |
| CA3226995A1 (en) | 2021-07-21 | 2023-01-26 | Nico Therapeutics, Inc. | Annulated pyridazine compound |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019079783A1 (en) * | 2017-10-20 | 2019-04-25 | Vanderbilt University | ANTAGONISTS OF THE MUSCARINIC RECEPTOR OF ACETYLCHOLINE M4 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7560551B2 (en) | 2006-01-23 | 2009-07-14 | Amgen Inc. | Aurora kinase modulators and method of use |
| EA018128B1 (ru) | 2006-01-23 | 2013-05-30 | Амген Инк. | Модуляторы аурора киназы, способы их получения и их применение |
| EP2038289A2 (en) * | 2006-04-21 | 2009-03-25 | Amgen Inc. | Thieno-[2,3-d]pyrimidine and thieno-pyridazine compounds and methods of use |
| WO2011149995A1 (en) * | 2010-05-25 | 2011-12-01 | Abbott Laboratories | Novel substituted octahydrocyclopenta [c]pyrrol-4-amines as calcium channel blockers |
| WO2015027204A1 (en) * | 2013-08-23 | 2015-02-26 | Vanderbilt University | Substituted thieno[2,3-b]pyridine-2-carboxamide analogs as positive allosteric modulators of the muscarinic acetylcholine receptor m4 |
| BR112018016689A2 (pt) * | 2016-02-16 | 2019-02-12 | Univ Vanderbilt | moduladores alostéricos positivos do receptor muscarínico de acetilcolina m1 |
| PL3507289T3 (pl) | 2016-09-02 | 2021-01-25 | Suven Life Sciences Limited | Dodatnie allosteryczne modulatory receptora muskarynowego m1 |
| EP3651762B1 (en) | 2017-07-12 | 2024-07-03 | Vanderbilt University | Antagonists of the muscarinic acetylcholine receptor m4 |
| ES2982890T3 (es) * | 2017-10-31 | 2024-10-18 | Univ Vanderbilt | Antagonistas del receptor muscarínico de acetilcolina M4 |
| CA3090130A1 (en) * | 2018-02-02 | 2019-08-08 | Vanderbilt University | Antagonists of the muscarinic acetylcholine receptor m4 |
| WO2021119254A1 (en) | 2019-12-10 | 2021-06-17 | Vanderbilt University | Antagonists of the muscarinic acetylcholine receptor m4 |
| AU2020402978A1 (en) | 2019-12-10 | 2022-06-23 | Vanderbilt University | Antagonists of the muscarinic acetylcholine receptor M4 |
| US20230183219A1 (en) | 2020-04-24 | 2023-06-15 | Vanderbilt University | Condensed substituted hydropyrroles as antagonists of the muscarinic acetylcholine receptor m4 |
| CA3180717A1 (en) | 2020-04-24 | 2021-10-28 | Vanderbilt University | Condensed substituted hydropyrroles as antagonists of the muscarinic acetylcholine receptor m4 |
| CA3199786A1 (en) | 2020-11-18 | 2022-05-27 | Vanderbilt University | Antagonists of the muscarinic acetylcholine receptor m4 |
| CN116669737A (zh) | 2020-12-22 | 2023-08-29 | 范德堡大学 | 毒蕈碱型乙酰胆碱受体m4的拮抗剂 |
| JP2024500880A (ja) | 2020-12-22 | 2024-01-10 | ヴァンダービルト ユニヴァーシティ | ムスカリン性アセチルコリン受容体ｍ４のアンタゴニスト |
| US20240174655A1 (en) | 2021-04-02 | 2024-05-30 | Vanderbilt University | Indazole derivatives as antagonists of the muscarinic acetylcholine receptor m4 |
| US20240228468A1 (en) | 2021-04-05 | 2024-07-11 | Vanderbilt University | N-(6-((octahydrocyclopenta[c]pyrrol-5-yi)amino)pyridazin-3-yl)phenyl)carboxamide and (6- ((octahydrocyclopenta[c]pyrrol-5-yl)amino)pyridazin-3-yl)benzamide derivatives as machr m4 antagonists for the treatment of neurodegenerative disorders |
| WO2022261427A1 (en) | 2021-06-11 | 2022-12-15 | Vanderbilt University | (4-(6-((2-octahydrocyclopenta[c]pyrrol-5-yl)amino)pyridazin-3-yl)phenyl)(imino)(methyl)-lambda6- sulfanone derivatives and similar compounds as muscarinic acetylcholine receptor m4 antagonists for the treatment of neurodegenerative disorders |
-
2020
- 2020-10-02 US US17/766,341 patent/US12319701B2/en active Active
- 2020-10-02 ES ES20873262T patent/ES3057371T3/es active Active
- 2020-10-02 JP JP2022520473A patent/JP7572734B2/ja active Active
- 2020-10-02 AU AU2020358000A patent/AU2020358000B2/en active Active
- 2020-10-02 EP EP20873262.8A patent/EP4037677B1/en active Active
- 2020-10-02 WO PCT/US2020/053942 patent/WO2021067696A1/en not_active Ceased
- 2020-10-02 CA CA3155864A patent/CA3155864A1/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019079783A1 (en) * | 2017-10-20 | 2019-04-25 | Vanderbilt University | ANTAGONISTS OF THE MUSCARINIC RECEPTOR OF ACETYLCHOLINE M4 |
Non-Patent Citations (1)
| Title |
|---|
| WOOD ET AL.: "Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 26, 2016, pages 3029 - 3033, * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2022550459A (ja) | 2022-12-01 |
| EP4037677A4 (en) | 2023-05-03 |
| EP4037677B1 (en) | 2025-09-24 |
| US20240083907A1 (en) | 2024-03-14 |
| WO2021067696A1 (en) | 2021-04-08 |
| US12319701B2 (en) | 2025-06-03 |
| AU2020358000A1 (en) | 2022-04-07 |
| EP4037677A1 (en) | 2022-08-10 |
| JP7572734B2 (ja) | 2024-10-24 |
| CA3155864A1 (en) | 2021-04-08 |
| ES3057371T3 (en) | 2026-03-02 |