AU2020320171B2 - YAP inhibition for wound healing - Google Patents

YAP inhibition for wound healing Download PDF

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Publication number
AU2020320171B2
AU2020320171B2 AU2020320171A AU2020320171A AU2020320171B2 AU 2020320171 B2 AU2020320171 B2 AU 2020320171B2 AU 2020320171 A AU2020320171 A AU 2020320171A AU 2020320171 A AU2020320171 A AU 2020320171A AU 2020320171 B2 AU2020320171 B2 AU 2020320171B2
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AU
Australia
Prior art keywords
wound
enfs
days
yap
skin
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AU2020320171A
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English (en)
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AU2020320171A1 (en
Inventor
Mimi BORRELLI
Michael Francis DAVITT
Heather Elizabeth DESJARDINS-PARK
Michael T. Longaker
Shamik MASCHARAK
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Leland Stanford Junior University
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Leland Stanford Junior University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2020320171A 2019-07-26 2020-07-24 YAP inhibition for wound healing Active AU2020320171B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962879369P 2019-07-26 2019-07-26
US62/879,369 2019-07-26
PCT/US2020/043420 WO2021021607A2 (en) 2019-07-26 2020-07-24 Yap inhibition for wound healing

Publications (2)

Publication Number Publication Date
AU2020320171A1 AU2020320171A1 (en) 2022-02-17
AU2020320171B2 true AU2020320171B2 (en) 2025-05-29

Family

ID=74229013

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2020320171A Active AU2020320171B2 (en) 2019-07-26 2020-07-24 YAP inhibition for wound healing

Country Status (10)

Country Link
US (1) US20220313658A1 (https=)
EP (1) EP4003334A4 (https=)
JP (1) JP2022541572A (https=)
KR (1) KR20220041154A (https=)
CN (1) CN114401718A (https=)
AU (1) AU2020320171B2 (https=)
BR (1) BR112022001196A2 (https=)
CA (1) CA3144185A1 (https=)
IL (1) IL289923A (https=)
WO (1) WO2021021607A2 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102550631B1 (ko) * 2021-03-16 2023-07-03 (주)파인헬스케어 인공지능을 이용한 욕창 단계 평가 및 치료 추천을 제공하는 장치 및 방법
WO2023009439A1 (en) * 2021-07-30 2023-02-02 The Board Of Trustees Of The Leland Stanford Junior University Mechanotransduction disruption mediation in skin grafting methods and compositions for use in practicing the same
US20240366565A1 (en) * 2021-09-09 2024-11-07 The Board Of Trustees Of The Leland Stanford Junior University Use of Verteporfin to Modulate Wound Healing After an Ocular Surgical Procedure or Ocular Injury
CN114288474A (zh) * 2021-12-27 2022-04-08 湖北中部医疗科技有限公司 一种促毛囊再生用真皮层、人工皮肤及其制备方法
CA3248997A1 (en) * 2022-04-28 2023-11-02 The Board Of Trustees Of The Leland Stanford Junior University PIEZO-ELECTRIC INHIBITION FOR Wound Healing
CN116694089B (zh) * 2022-09-19 2024-03-26 广州贝奥吉因生物科技股份有限公司 一种用于抑制瘢痕的水凝胶及其制备方法和应用
CN116602265B (zh) * 2023-05-25 2024-05-14 北京工业大学 一种用于建立瘢痕疙瘩动物模型的智能控制系统及方法

Family Cites Families (9)

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ES2532906T5 (es) * 2002-10-25 2022-03-23 Foamix Pharmaceuticals Ltd Espuma cosmética y farmacéutica
GB0823265D0 (en) * 2008-12-20 2009-01-28 Convatec Technologies Inc Antimicrobial Composition
DE102010009572A1 (de) * 2010-02-26 2011-09-01 Euroderm Gmbh Verfahren zum Begünstigen der Heilung von Hautwunden unter Verwendung der Zellen der Haarwurzelscheide, Präparat und Herstellverfahren
AU2011338530B2 (en) * 2010-12-06 2017-06-15 Follica, Inc. Methods for treating baldness and promoting hair growth
US9655967B2 (en) * 2011-12-09 2017-05-23 The Board Of Trustees Of The Leland Stanford Junior University Inhibition of focal adhesion kinase for control of scar tissue formation
KR101385196B1 (ko) * 2012-05-17 2014-04-14 주식회사 유니크메디케어 광 조사를 이용한 광감각제―펩타이드를 유효성분으로 포함하는 발모 개선 또는 촉진용 조성물 및 이를 이용한 방법
EP2858635A1 (en) * 2012-06-11 2015-04-15 The Regents of The University of California Inhibitors of hippo-yap signaling pathway
US20140086867A1 (en) * 2012-09-24 2014-03-27 Robert G. Matheny Systems, Compositions and Methods for the Treatment of Alopecia
IL248468A0 (en) * 2016-10-13 2017-01-31 Technion Res & Dev Foundation Use of caspase-3 inhibitors and caspase-3 activators in the manufacture of medicament for treating cancer and wound healing

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Barnes, L.D.; et al. "The effect of photodynamic therapy on squamous cell carcinoma in a murine model: Evaluation of time between intralesional injection to laser irradiation." Vet. J. 2009, 180, 60-65. *
Oku, Y.; et al. "Small molecules inhibiting the nuclear localization of YAP/TAZfor chemotherapeutics and chemosensitizers against breast cancers." FEBS Open Bio 2015, 5, 1, 542-549. DOI: 10.1016/j.fob.2015.06.007 *
Scott, L.J. & Goa, K.L. "Verteporfin" Drugs & Aging 2000, 16, 2, 139-146. *
Shamik, M.; et al. Conference Abstract, PLASTIC SURGERY RESEARCH COUNCIL, 64th Annual Meeting, 2 May 2019. https://ps-rc.org/meeting/abstracts/2019/5.cgi# *

Also Published As

Publication number Publication date
US20220313658A1 (en) 2022-10-06
WO2021021607A3 (en) 2021-04-08
BR112022001196A2 (pt) 2022-03-15
EP4003334A2 (en) 2022-06-01
KR20220041154A (ko) 2022-03-31
WO2021021607A2 (en) 2021-02-04
CA3144185A1 (en) 2021-02-04
IL289923A (en) 2022-03-01
CN114401718A (zh) 2022-04-26
EP4003334A4 (en) 2023-08-16
JP2022541572A (ja) 2022-09-26
AU2020320171A1 (en) 2022-02-17

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