CN114401718A - 用于伤口愈合的yap抑制 - Google Patents

用于伤口愈合的yap抑制 Download PDF

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Publication number
CN114401718A
CN114401718A CN202080063651.9A CN202080063651A CN114401718A CN 114401718 A CN114401718 A CN 114401718A CN 202080063651 A CN202080063651 A CN 202080063651A CN 114401718 A CN114401718 A CN 114401718A
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CN
China
Prior art keywords
wound
skin
days
enf
yap
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080063651.9A
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English (en)
Chinese (zh)
Inventor
沙米克·马斯拉克
希瑟·伊丽莎白·德斯贾丁斯帕克
弥米·博雷利
迈克尔·弗朗西斯·戴维特
迈克尔·T·龙雅可
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
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Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leland Stanford Junior University filed Critical Leland Stanford Junior University
Publication of CN114401718A publication Critical patent/CN114401718A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN202080063651.9A 2019-07-26 2020-07-24 用于伤口愈合的yap抑制 Pending CN114401718A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962879369P 2019-07-26 2019-07-26
US62/879,369 2019-07-26
PCT/US2020/043420 WO2021021607A2 (en) 2019-07-26 2020-07-24 Yap inhibition for wound healing

Publications (1)

Publication Number Publication Date
CN114401718A true CN114401718A (zh) 2022-04-26

Family

ID=74229013

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080063651.9A Pending CN114401718A (zh) 2019-07-26 2020-07-24 用于伤口愈合的yap抑制

Country Status (10)

Country Link
US (1) US20220313658A1 (https=)
EP (1) EP4003334A4 (https=)
JP (1) JP2022541572A (https=)
KR (1) KR20220041154A (https=)
CN (1) CN114401718A (https=)
AU (1) AU2020320171B2 (https=)
BR (1) BR112022001196A2 (https=)
CA (1) CA3144185A1 (https=)
IL (1) IL289923A (https=)
WO (1) WO2021021607A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116602265A (zh) * 2023-05-25 2023-08-18 北京工业大学 一种用于建立瘢痕疙瘩动物模型的智能控制系统及方法
CN116694089A (zh) * 2022-09-19 2023-09-05 广州贝奥吉因生物科技股份有限公司 一种用于抑制瘢痕的水凝胶及其制备方法和应用

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102550631B1 (ko) * 2021-03-16 2023-07-03 (주)파인헬스케어 인공지능을 이용한 욕창 단계 평가 및 치료 추천을 제공하는 장치 및 방법
WO2023009439A1 (en) * 2021-07-30 2023-02-02 The Board Of Trustees Of The Leland Stanford Junior University Mechanotransduction disruption mediation in skin grafting methods and compositions for use in practicing the same
US20240366565A1 (en) * 2021-09-09 2024-11-07 The Board Of Trustees Of The Leland Stanford Junior University Use of Verteporfin to Modulate Wound Healing After an Ocular Surgical Procedure or Ocular Injury
CN114288474A (zh) * 2021-12-27 2022-04-08 湖北中部医疗科技有限公司 一种促毛囊再生用真皮层、人工皮肤及其制备方法
CA3248997A1 (en) * 2022-04-28 2023-11-02 The Board Of Trustees Of The Leland Stanford Junior University PIEZO-ELECTRIC INHIBITION FOR Wound Healing

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110217269A1 (en) * 2010-02-26 2011-09-08 Euroderm Gmbh Method of fostering the healing of skin wounds using cells of the root sheath, composition and preparation method
US20150157584A1 (en) * 2012-06-11 2015-06-11 The J. David Gladstone Institutes Inhibitors of hippo-yap signaling pathway

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2532906T5 (es) * 2002-10-25 2022-03-23 Foamix Pharmaceuticals Ltd Espuma cosmética y farmacéutica
GB0823265D0 (en) * 2008-12-20 2009-01-28 Convatec Technologies Inc Antimicrobial Composition
AU2011338530B2 (en) * 2010-12-06 2017-06-15 Follica, Inc. Methods for treating baldness and promoting hair growth
US9655967B2 (en) * 2011-12-09 2017-05-23 The Board Of Trustees Of The Leland Stanford Junior University Inhibition of focal adhesion kinase for control of scar tissue formation
KR101385196B1 (ko) * 2012-05-17 2014-04-14 주식회사 유니크메디케어 광 조사를 이용한 광감각제―펩타이드를 유효성분으로 포함하는 발모 개선 또는 촉진용 조성물 및 이를 이용한 방법
US20140086867A1 (en) * 2012-09-24 2014-03-27 Robert G. Matheny Systems, Compositions and Methods for the Treatment of Alopecia
IL248468A0 (en) * 2016-10-13 2017-01-31 Technion Res & Dev Foundation Use of caspase-3 inhibitors and caspase-3 activators in the manufacture of medicament for treating cancer and wound healing

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110217269A1 (en) * 2010-02-26 2011-09-08 Euroderm Gmbh Method of fostering the healing of skin wounds using cells of the root sheath, composition and preparation method
US20150157584A1 (en) * 2012-06-11 2015-06-11 The J. David Gladstone Institutes Inhibitors of hippo-yap signaling pathway

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SHAMIK MASCHARAK等: "Inhibition of Mechanotransduction Yields Regenerative Wound Healing by Engrailed1-negative Fibroblasts", PRS GLOBAL OPEN, pages 4 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116694089A (zh) * 2022-09-19 2023-09-05 广州贝奥吉因生物科技股份有限公司 一种用于抑制瘢痕的水凝胶及其制备方法和应用
CN116694089B (zh) * 2022-09-19 2024-03-26 广州贝奥吉因生物科技股份有限公司 一种用于抑制瘢痕的水凝胶及其制备方法和应用
CN116602265A (zh) * 2023-05-25 2023-08-18 北京工业大学 一种用于建立瘢痕疙瘩动物模型的智能控制系统及方法
CN116602265B (zh) * 2023-05-25 2024-05-14 北京工业大学 一种用于建立瘢痕疙瘩动物模型的智能控制系统及方法

Also Published As

Publication number Publication date
US20220313658A1 (en) 2022-10-06
WO2021021607A3 (en) 2021-04-08
BR112022001196A2 (pt) 2022-03-15
EP4003334A2 (en) 2022-06-01
KR20220041154A (ko) 2022-03-31
WO2021021607A2 (en) 2021-02-04
CA3144185A1 (en) 2021-02-04
AU2020320171B2 (en) 2025-05-29
IL289923A (en) 2022-03-01
EP4003334A4 (en) 2023-08-16
JP2022541572A (ja) 2022-09-26
AU2020320171A1 (en) 2022-02-17

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