AU2020307673A1 - Chimeric antigen receptor with 4-1BB costimulatory domain - Google Patents

Chimeric antigen receptor with 4-1BB costimulatory domain Download PDF

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Publication number
AU2020307673A1
AU2020307673A1 AU2020307673A AU2020307673A AU2020307673A1 AU 2020307673 A1 AU2020307673 A1 AU 2020307673A1 AU 2020307673 A AU2020307673 A AU 2020307673A AU 2020307673 A AU2020307673 A AU 2020307673A AU 2020307673 A1 AU2020307673 A1 AU 2020307673A1
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Australia
Prior art keywords
cell
cancer
antigen
immune cell
car
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Pending
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AU2020307673A
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English (en)
Inventor
Young Gyoon CHANG
Jiwon Chung
Kwanghee Kim
Byoung S. Kwon
Hye Mi Lee
Jungyun Lee
Sae Rom Lee
Hyuntae SON
Bo-Rim YI
Eun Hye Yoo
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Eutilex Co Ltd
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Eutilex Co Ltd
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Publication date
Priority claimed from PCT/KR2019/010244 external-priority patent/WO2020032784A1/ko
Application filed by Eutilex Co Ltd filed Critical Eutilex Co Ltd
Publication of AU2020307673A1 publication Critical patent/AU2020307673A1/en
Pending legal-status Critical Current

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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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    • A61K2239/11—Antigen recognition domain
    • A—HUMAN NECESSITIES
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    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
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    • A—HUMAN NECESSITIES
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2319/00—Fusion polypeptide
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AU2020307673A 2019-06-27 2020-06-26 Chimeric antigen receptor with 4-1BB costimulatory domain Pending AU2020307673A1 (en)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US201962867503P 2019-06-27 2019-06-27
US62/867,503 2019-06-27
AUPCT/KR2019/010244 2019-08-12
PCT/KR2019/010244 WO2020032784A1 (ko) 2018-08-10 2019-08-12 Hla-dr에 결합하는 키메라 항원 수용체 및 car-t 세포
US16/715,462 US11013765B2 (en) 2018-08-10 2019-12-16 Chimeric antigen receptor that binds HLA-DR and CAR-T cell
US16/715,462 2019-12-16
US202062991493P 2020-03-18 2020-03-18
US62/991,493 2020-03-18
US202063004827P 2020-04-03 2020-04-03
US63/004,827 2020-04-03
US202063043237P 2020-06-24 2020-06-24
US63/043,237 2020-06-24
PCT/IB2020/056097 WO2020261231A1 (en) 2019-06-27 2020-06-26 Chimeric antigen receptor with 4-1bb costimulatory domain

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AU2020307673A1 true AU2020307673A1 (en) 2022-01-20

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AU2020307673A Pending AU2020307673A1 (en) 2019-06-27 2020-06-26 Chimeric antigen receptor with 4-1BB costimulatory domain

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EP (1) EP3990626A4 (https=)
JP (2) JP7829911B2 (https=)
CN (2) CN114080452B (https=)
AU (1) AU2020307673A1 (https=)
BR (1) BR112021026406A2 (https=)
CA (1) CA3144875A1 (https=)
MX (1) MX2021015967A (https=)
WO (1) WO2020261231A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3835320A4 (en) * 2018-08-10 2022-06-01 Eutilex Co., Ltd. Chimeric antigen receptor binding to hla-dr, and car-t cell
EP3962527A4 (en) 2019-04-30 2023-11-01 Senti Biosciences, Inc. CHIMERIC RECEPTORS AND METHODS OF USE THEREOF
KR102671410B1 (ko) * 2021-03-03 2024-06-04 진화섭 RANK 리간드(RANK ligand)에 특이적으로 결합하는 키메릭 항원 수용체 및 이의 용도
JP2025509769A (ja) * 2022-03-15 2025-04-11 ニューヨーク・ゲノム・センター，インコーポレーテッド 改善した免疫療法のための融合タンパク質を含む方法及び組成物
WO2025103439A1 (zh) * 2023-11-16 2025-05-22 广州瑞风生物科技有限公司 一种嵌合抗原受体及其应用

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050113564A1 (en) * 2003-11-05 2005-05-26 St. Jude Children's Research Hospital Chimeric receptors with 4-1BB stimulatory signaling domain
JP4331227B2 (ja) * 2004-07-09 2009-09-16 中外製薬株式会社 抗グリピカン３抗体
AU2013204922B2 (en) * 2012-12-20 2015-05-14 Celgene Corporation Chimeric antigen receptors
WO2014160627A1 (en) * 2013-03-25 2014-10-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-cd276 polypeptides, proteins, and chimeric antigen receptors
WO2015069922A2 (en) * 2013-11-06 2015-05-14 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Alk antibodies, conjugates, and chimeric antigen receptors, and their use
KR101605421B1 (ko) * 2014-03-05 2016-03-23 국립암센터 B 세포 림프종 세포를 특이적으로 인지하는 단일클론항체 및 이의 용도
MX383150B (es) * 2014-06-02 2025-03-13 Us Health Receptores quiméricos de antígeno que tienen como diana a cd-19.
US10195272B2 (en) * 2015-03-02 2019-02-05 The Nemours Foundation Adoptive t-cell therapy using FcεRI-based chimeric antigen receptors for treating IgE-mediated allergic diseases
JP7010473B2 (ja) * 2015-06-04 2022-02-10 ユニバーシティ オブ サザン カリフォルニア Ｌｙｍ－１およびｌｙｍ－２標的化ｃａｒ細胞免疫療法
CN114181960B (zh) * 2015-10-09 2024-08-23 美天施生物科技有限公司 嵌合抗原受体和使用方法
CN105906720A (zh) * 2016-05-16 2016-08-31 武汉汉密顿生物科技股份有限公司 靶向性嵌合抗原受体修饰的免疫细胞及其制备方法和应用
CN106279438B (zh) * 2016-08-24 2019-10-22 北京领柯生物科技有限公司 新型嵌合抗原受体及其用途
CN108165568B (zh) * 2016-12-07 2020-12-08 上海恒润达生生物科技有限公司 一种培养CD19CAR-iNKT细胞方法及用途
WO2018106993A1 (en) * 2016-12-09 2018-06-14 H. Lee Moffitt Cancer Center And Research Institute Inc. Tlr9-binding chimeric antigen receptors
WO2018132513A1 (en) * 2017-01-10 2018-07-19 The General Hospital Corporation T cells experessing a chimeric antigen receptor
JP2020508080A (ja) * 2017-02-21 2020-03-19 ユーティレックス カンパニー リミテッド Ｈｌａ−ｄｒ ｃａｒ−ｔ組成物ならびにその作製方法および使用方法
WO2018156711A1 (en) * 2017-02-22 2018-08-30 H. Lee Moffitt Cancer Center And Research Institute, Inc. Il13ra2-binding chimeric antigen receptors
CN108728459B (zh) * 2017-04-24 2023-08-04 上海恒润达生生物科技股份有限公司 靶向cd19的嵌合抗原受体并联合表达il-15的方法和用途
WO2018236909A1 (en) * 2017-06-20 2018-12-27 La Jolla Institute For Allergy And Immunology Engineered t-cell receptors and methods of their use in modulating inflammatory responses and treating atherosclerosis
US10442867B2 (en) * 2017-07-31 2019-10-15 Lentigen Technology, Inc. Compositions and methods for treating cancer with anti-CD19/CD20 immunotherapy
CN108715859B (zh) * 2018-05-31 2021-08-03 中国医学科学院血液病医院(中国医学科学院血液学研究所) 靶向cd22的嵌合抗原受体及其应用
JPWO2020017479A1 (ja) * 2018-07-17 2021-08-02 ノイルイミューン・バイオテック株式会社 抗ｇｐｃ３一本鎖抗体を含むｃａｒ

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