AU2020290995B2 - Topical treatment of vitiligo by a JAK inhibitor - Google Patents

Topical treatment of vitiligo by a JAK inhibitor

Info

Publication number
AU2020290995B2
AU2020290995B2 AU2020290995A AU2020290995A AU2020290995B2 AU 2020290995 B2 AU2020290995 B2 AU 2020290995B2 AU 2020290995 A AU2020290995 A AU 2020290995A AU 2020290995 A AU2020290995 A AU 2020290995A AU 2020290995 B2 AU2020290995 B2 AU 2020290995B2
Authority
AU
Australia
Prior art keywords
week
vitiligo
patient
ruxolitinib
cream
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2020290995A
Other languages
English (en)
Other versions
AU2020290995A1 (en
Inventor
Kathleen Butler
Michael Howell
Fiona Kuo
Jim Lee
Kang Sun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Incyte Corp
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=73651112&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2020290995(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of AU2020290995A1 publication Critical patent/AU2020290995A1/en
Application granted granted Critical
Publication of AU2020290995B2 publication Critical patent/AU2020290995B2/en
Priority to AU2026200410A priority Critical patent/AU2026200410A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2020290995A 2019-06-10 2020-06-10 Topical treatment of vitiligo by a JAK inhibitor Active AU2020290995B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2026200410A AU2026200410A1 (en) 2019-06-10 2026-01-21 Topical treatment of vitiligo by a jak inhibitor

Applications Claiming Priority (25)

Application Number Priority Date Filing Date Title
US201962859495P 2019-06-10 2019-06-10
US201962859506P 2019-06-10 2019-06-10
US201962859584P 2019-06-10 2019-06-10
US201962859601P 2019-06-10 2019-06-10
US201962859532P 2019-06-10 2019-06-10
US62/859,532 2019-06-10
US62/859,584 2019-06-10
US62/859,601 2019-06-10
US62/859,506 2019-06-10
US62/859,495 2019-06-10
US201962894564P 2019-08-30 2019-08-30
US201962894581P 2019-08-30 2019-08-30
US201962894496P 2019-08-30 2019-08-30
US201962894541P 2019-08-30 2019-08-30
US201962894514P 2019-08-30 2019-08-30
US62/894,496 2019-08-30
US62/894,581 2019-08-30
US62/894,541 2019-08-30
US62/894,564 2019-08-30
US62/894,514 2019-08-30
US201962911845P 2019-10-07 2019-10-07
US62/911,845 2019-10-07
US202062967879P 2020-01-30 2020-01-30
US62/967,879 2020-01-30
PCT/US2020/036985 WO2020252012A1 (en) 2019-06-10 2020-06-10 Topical treatment of vitiligo by a jak inhibitor

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2026200410A Division AU2026200410A1 (en) 2019-06-10 2026-01-21 Topical treatment of vitiligo by a jak inhibitor

Publications (2)

Publication Number Publication Date
AU2020290995A1 AU2020290995A1 (en) 2022-04-07
AU2020290995B2 true AU2020290995B2 (en) 2025-12-11

Family

ID=73651112

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2020290995A Active AU2020290995B2 (en) 2019-06-10 2020-06-10 Topical treatment of vitiligo by a JAK inhibitor
AU2026200410A Pending AU2026200410A1 (en) 2019-06-10 2026-01-21 Topical treatment of vitiligo by a jak inhibitor

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2026200410A Pending AU2026200410A1 (en) 2019-06-10 2026-01-21 Topical treatment of vitiligo by a jak inhibitor

Country Status (10)

Country Link
US (4) US11602536B2 (cg-RX-API-DMAC10.html)
EP (1) EP3982971A4 (cg-RX-API-DMAC10.html)
JP (2) JP7532511B2 (cg-RX-API-DMAC10.html)
AU (2) AU2020290995B2 (cg-RX-API-DMAC10.html)
CA (1) CA3150975A1 (cg-RX-API-DMAC10.html)
IL (1) IL290637A (cg-RX-API-DMAC10.html)
MA (1) MA56215A (cg-RX-API-DMAC10.html)
TW (1) TW202112377A (cg-RX-API-DMAC10.html)
UA (1) UA130944C2 (cg-RX-API-DMAC10.html)
WO (1) WO2020252012A1 (cg-RX-API-DMAC10.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112020008850A2 (pt) 2017-11-03 2020-10-20 Aclaris Therapeutics, Inc. composto, composição farmacêutica e método para tratar uma doença mediada por jak1 e jak3
JP7591500B2 (ja) 2018-08-10 2024-11-28 アクラリス セラピューティクス，インコーポレイテッド ピロロピリミジンｉｔｋ阻害剤
US11602536B2 (en) * 2019-06-10 2023-03-14 Incyte Corporation Topical treatment of vitiligo by a JAK inhibitor
US20230364095A1 (en) * 2020-09-16 2023-11-16 Incyte Corporation Topical treatment of vitiligo
CN117279915A (zh) * 2021-02-18 2023-12-22 阿克拉瑞斯治疗股份有限公司 Jak1/3抑制剂的局部制剂及其用于特异性皮炎和其他皮肤病况的治疗的方法
JP2024509383A (ja) * 2021-02-18 2024-03-01 アクラリス セラピューティクス，インコーポレイテッド アトピー性皮膚炎及びその他の皮膚状態の治療のためのｊａｋ１／３阻害剤の局所製剤及びその使用方法
EP4389114A4 (en) * 2021-08-19 2025-09-03 Zhuhai United Laboratories Co Ltd LOCAL TOPICAL FORMULATION CONTAINING A JAK INHIBITOR OR A SALT THEREOF OR A CRYSTALLINE FORM THEREOF, PREPARATION METHOD THEREOF AND CORRESPONDING APPLICATION
CN115869321A (zh) 2021-09-28 2023-03-31 杭州中美华东制药有限公司 一种芦可替尼组合物及其制备方法

Citations (2)

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Publication number Priority date Publication date Assignee Title
WO2018200786A1 (en) * 2017-04-26 2018-11-01 Yale University Compositions and methods for treating vitiligo
US20190060311A1 (en) * 2017-08-24 2019-02-28 Aclaris Therapeutics, Inc. Compositions and methods for treatment of vitiligo

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ES2342240T3 (es) 1998-08-11 2010-07-02 Novartis Ag Derivados de isoquinolina con actividad que inhibe la angiogenia.
US6133031A (en) 1999-08-19 2000-10-17 Isis Pharmaceuticals Inc. Antisense inhibition of focal adhesion kinase expression
GB9905075D0 (en) 1999-03-06 1999-04-28 Zeneca Ltd Chemical compounds
GB0004890D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
CN100391958C (zh) 2001-09-19 2008-06-04 安万特医药股份有限公司 化合物
PT1441737E (pt) 2001-10-30 2006-12-29 Dana Farber Cancer Inst Inc Derivados de estrutura como inibidores da actividade do receptor de tirosina cinase flt3
PE20040522A1 (es) 2002-05-29 2004-09-28 Novartis Ag Derivados de diarilurea dependientes de la cinasa de proteina
GB0215676D0 (en) 2002-07-05 2002-08-14 Novartis Ag Organic compounds
JP2006502183A (ja) 2002-09-20 2006-01-19 アルコン，インコーポレイテッド ドライアイ障害の処置のためのサイトカイン合成インヒビターの使用
AR042052A1 (es) 2002-11-15 2005-06-08 Vertex Pharma Diaminotriazoles utiles como inhibidores de proteinquinasas
UA80767C2 (en) 2002-12-20 2007-10-25 Pfizer Prod Inc Pyrimidine derivatives for the treatment of abnormal cell growth
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RU2007123675A (ru) 2004-11-24 2008-12-27 Новартис АГ (CH) Комбинации ингибиторов jak
HUE028588T2 (hu) 2005-12-13 2016-12-28 Incyte Holdings Corp Heteroaril-szubsztituált pirrolo[2,3-b]piridinek és pirrolo[2,3-b]pirimidinek mint Janus-kináz inhibitorok
EP2740731B1 (en) 2007-06-13 2016-03-23 Incyte Holdings Corporation Crystalline salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile
EA202091303A3 (ru) 2010-05-21 2021-05-31 Инсайт Холдингс Корпорейшн Композиция ингибитора jak для местного применения
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WO2019191679A1 (en) 2018-03-30 2019-10-03 Incyte Corporation Biomarkers for inflammatory skin disease
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US20210030672A1 (en) 2019-06-10 2021-02-04 Incyte Corporation Topical treatment of vitiligo by a jak inhibitor
US11602536B2 (en) * 2019-06-10 2023-03-14 Incyte Corporation Topical treatment of vitiligo by a JAK inhibitor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018200786A1 (en) * 2017-04-26 2018-11-01 Yale University Compositions and methods for treating vitiligo
US20190060311A1 (en) * 2017-08-24 2019-02-28 Aclaris Therapeutics, Inc. Compositions and methods for treatment of vitiligo

Non-Patent Citations (2)

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DAVID ROSAMARIN: "Treatment of vitiligo with the topical Janus kinase inhibitor ruxolitinib: A 32-week open-label extension study with optional narrow-band ultraviolet B", 1 June 2018 (2018-06-01), pages 1205 - 1207 *
ROTHSTEIN, B ET AL.: "Treatment of vitiligo with the topical Janus kinase inhibitor ruxolitinib", 2015, JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, vol. 76, no. 6, 5 April 2017, pages 1054-1060, DOI: 10.1016/j.jaad.2017.02.049 *

Also Published As

Publication number Publication date
CA3150975A1 (en) 2020-12-17
AU2020290995A1 (en) 2022-04-07
US20200405627A1 (en) 2020-12-31
US20220409622A1 (en) 2022-12-29
US11590138B2 (en) 2023-02-28
UA130944C2 (uk) 2026-06-24
US12233067B2 (en) 2025-02-25
TW202112377A (zh) 2021-04-01
AU2026200410A1 (en) 2026-02-12
JP2022545568A (ja) 2022-10-27
US20230355628A1 (en) 2023-11-09
JP2024105436A (ja) 2024-08-06
EP3982971A4 (en) 2023-08-16
WO2020252012A1 (en) 2020-12-17
IL290637A (en) 2022-04-01
EP3982971A1 (en) 2022-04-20
MA56215A (fr) 2022-04-20
JP7532511B2 (ja) 2024-08-13
US20200383986A1 (en) 2020-12-10
US11602536B2 (en) 2023-03-14

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Legal Events

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NB Applications allowed - extensions of time section 223(2)

Free format text: THE TIME IN WHICH TO ENTER THE NATIONAL PHASE HAS BEEN EXTENDED TO 10 MAR 2022

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