AU2020284406A1 - Composition for the protection and repair of the blood brain barrier - Google Patents
Composition for the protection and repair of the blood brain barrier Download PDFInfo
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- AU2020284406A1 AU2020284406A1 AU2020284406A AU2020284406A AU2020284406A1 AU 2020284406 A1 AU2020284406 A1 AU 2020284406A1 AU 2020284406 A AU2020284406 A AU 2020284406A AU 2020284406 A AU2020284406 A AU 2020284406A AU 2020284406 A1 AU2020284406 A1 AU 2020284406A1
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- NNNVXFKZMRGJPM-KHPPLWFESA-N sapienic acid Chemical compound CCCCCCCCC\C=C/CCCCC(O)=O NNNVXFKZMRGJPM-KHPPLWFESA-N 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 238000002603 single-photon emission computed tomography Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 238000006277 sulfonation reaction Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000000946 synaptic effect Effects 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 230000001839 systemic circulation Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 229940034208 thyroxine Drugs 0.000 description 1
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- UWHZIFQPPBDJPM-BQYQJAHWSA-N trans-vaccenic acid Chemical compound CCCCCC\C=C\CCCCCCCCCC(O)=O UWHZIFQPPBDJPM-BQYQJAHWSA-N 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 208000018726 traumatic encephalopathy Diseases 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- 230000003966 vascular damage Effects 0.000 description 1
- 230000009441 vascular protection Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
- 230000037314 wound repair Effects 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 239000002676 xenobiotic agent Substances 0.000 description 1
- 230000002034 xenobiotic effect Effects 0.000 description 1
- DTOSIQBPPRVQHS-UHFFFAOYSA-N α-Linolenic acid Chemical compound CCC=CCC=CCC=CCCCCCCCC(O)=O DTOSIQBPPRVQHS-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/717—Celluloses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/721—Dextrans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1905566A FR3096579B1 (fr) | 2019-05-27 | 2019-05-27 | composition pour la protection et la reparation de la barriere hematoencephalique (BHE) |
| FRFR1905566 | 2019-05-27 | ||
| PCT/EP2020/062081 WO2020239356A1 (fr) | 2019-05-27 | 2020-04-30 | Composition pour la protection et la reparation de la barriere hematoencephalique (bhe) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2020284406A1 true AU2020284406A1 (en) | 2022-01-06 |
Family
ID=68138337
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2020284406A Pending AU2020284406A1 (en) | 2019-05-27 | 2020-04-30 | Composition for the protection and repair of the blood brain barrier |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20220152089A1 (fr) |
| EP (1) | EP3976060A1 (fr) |
| JP (1) | JP2022534278A (fr) |
| KR (1) | KR20220042310A (fr) |
| CN (1) | CN114206354B (fr) |
| AU (1) | AU2020284406A1 (fr) |
| BR (1) | BR112021023737A2 (fr) |
| CA (1) | CA3141923A1 (fr) |
| FR (1) | FR3096579B1 (fr) |
| WO (1) | WO2020239356A1 (fr) |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4021066A1 (de) * | 1990-07-03 | 1992-01-09 | Hoechst Ag | Langzeitprophylaxe gegen erkrankungen, die durch viren oder durch unkonventionelle viren verursacht werden |
| FR2718025B1 (fr) * | 1994-03-30 | 1996-06-21 | Paris Val Marne Universite | Médicament et composition pharmaceutique pour le traitement des lésions du système nerveux. |
| US6573251B2 (en) * | 1994-03-30 | 2003-06-03 | Denis Barritault | Drug and pharmaceutical composition for the treatment of lesions of the nervous system and fractions enriched in heparan sulfate |
| FR2781485B1 (fr) | 1998-07-21 | 2003-08-08 | Denis Barritault | Polymeres biocompatibles leur procede de preparation et les compositions les contenant |
| CA2397016C (fr) * | 2000-01-10 | 2011-03-29 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Utilisation de conjugues de lipides dans le traitement de maladies |
| FR2832708B1 (fr) | 2001-11-29 | 2004-02-13 | Organes Tissus Regeneration Re | Procede de sulfonation de composes comprenant des groupements hydroxyle (oh) libres ou des amines primaires ou secondaires |
| ES2552106T3 (es) | 2003-10-28 | 2015-11-25 | Organes Tissus Régénération Réparation Remplacement | Polímeros biocompatibles para una composición médica |
| WO2008097563A1 (fr) | 2007-02-06 | 2008-08-14 | The Board Of Trustees Of The Leland Stanford Junior University | Procédés pour maintenir l'intégrité de la barrière sang-cerveau chez des sujets hypertendus à l'aide d'un inhibiteur de la protéine kinase c delta (pkc) |
| US8343942B2 (en) * | 2008-04-04 | 2013-01-01 | University Of Utah Research Foundation | Methods for treating interstitial cystitis |
| CN101632728B (zh) | 2008-07-21 | 2013-08-07 | 河北以岭医药研究院有限公司 | 一种中药组合物在制备保护血脑屏障的药物中的应用 |
| EP3097928A1 (fr) * | 2015-05-28 | 2016-11-30 | Organes Tissus Régénération Réparation Remplacement | Composition pour le traitement des lesions cerebrales |
| EP3097922A1 (fr) * | 2015-05-28 | 2016-11-30 | Denis Barritault | Composition pour le traitement des lesions tissulaires |
| CN105148276B (zh) | 2015-09-22 | 2018-11-20 | 深圳市第二人民医院 | 抑制Claudin-5降解阻止缺血性血脑屏障损伤的保护剂 |
| WO2018207792A1 (fr) | 2017-05-12 | 2018-11-15 | 花王株式会社 | Agent de protection de barrière hémato-encéphalique |
-
2019
- 2019-05-27 FR FR1905566A patent/FR3096579B1/fr active Active
-
2020
- 2020-04-30 KR KR1020217042420A patent/KR20220042310A/ko unknown
- 2020-04-30 EP EP20721621.9A patent/EP3976060A1/fr active Pending
- 2020-04-30 BR BR112021023737A patent/BR112021023737A2/pt unknown
- 2020-04-30 WO PCT/EP2020/062081 patent/WO2020239356A1/fr unknown
- 2020-04-30 US US17/595,818 patent/US20220152089A1/en active Pending
- 2020-04-30 CN CN202080047142.7A patent/CN114206354B/zh active Active
- 2020-04-30 CA CA3141923A patent/CA3141923A1/fr active Pending
- 2020-04-30 JP JP2021570515A patent/JP2022534278A/ja active Pending
- 2020-04-30 AU AU2020284406A patent/AU2020284406A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| BR112021023737A2 (pt) | 2022-02-01 |
| CN114206354A (zh) | 2022-03-18 |
| EP3976060A1 (fr) | 2022-04-06 |
| KR20220042310A (ko) | 2022-04-05 |
| US20220152089A1 (en) | 2022-05-19 |
| CN114206354B (zh) | 2023-12-29 |
| CA3141923A1 (fr) | 2020-12-03 |
| WO2020239356A1 (fr) | 2020-12-03 |
| FR3096579A1 (fr) | 2020-12-04 |
| JP2022534278A (ja) | 2022-07-28 |
| FR3096579B1 (fr) | 2023-05-05 |
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