AU2020235102B2 - Point of care concentration analyzer - Google Patents

Point of care concentration analyzer

Info

Publication number
AU2020235102B2
AU2020235102B2 AU2020235102A AU2020235102A AU2020235102B2 AU 2020235102 B2 AU2020235102 B2 AU 2020235102B2 AU 2020235102 A AU2020235102 A AU 2020235102A AU 2020235102 A AU2020235102 A AU 2020235102A AU 2020235102 B2 AU2020235102 B2 AU 2020235102B2
Authority
AU
Australia
Prior art keywords
cartridge
sample
chamber
wash
mixing chamber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2020235102A
Other languages
English (en)
Other versions
AU2020235102A1 (en
Inventor
Jeffrey J. BISHOP
Michele Gilbert
John David JOLLY
Erich Kyger
Richard Livingston
Luis H. MONSALVE
Brian W. NOLAND
Robert ONORATO
William E. Ortyn
Danni WANG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novilux LLC
Original Assignee
Novilux LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novilux LLC filed Critical Novilux LLC
Publication of AU2020235102A1 publication Critical patent/AU2020235102A1/en
Application granted granted Critical
Publication of AU2020235102B2 publication Critical patent/AU2020235102B2/en
Priority to AU2026203879A priority Critical patent/AU2026203879A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
    • B08B3/04—Cleaning involving contact with liquid
    • B08B3/10—Cleaning involving contact with liquid with additional treatment of the liquid or of the object being cleaned, e.g. by heat, by electricity or by vibration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F21/00—Dissolving
    • B01F21/40—Dissolving characterised by the state of the material being dissolved
    • B01F21/402—Dissolving characterised by the state of the material being dissolved characterised by the configuration, form or shape of the solid material, e.g. in the form of tablets or blocks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F29/00—Mixers with rotating receptacles
    • B01F29/30—Mixing the contents of individual packages or containers, e.g. by rotating tins or bottles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F29/00—Mixers with rotating receptacles
    • B01F29/60—Mixers with rotating receptacles rotating about a horizontal or inclined axis, e.g. drum mixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/25—Mixers with loose mixing elements, e.g. loose balls in a receptacle
    • B01F33/251—Mixers with loose mixing elements, e.g. loose balls in a receptacle using balls as loose mixing element
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3017—Mixing chamber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/40—Mixers using gas or liquid agitation, e.g. with air supply tubes
    • B01F33/405—Mixers using gas or liquid agitation, e.g. with air supply tubes in receptacles having guiding conduits therein, e.g. for feeding the gas to the bottom of the receptacle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/30—Driving arrangements; Transmissions; Couplings; Brakes
    • B01F35/33—Transmissions; Means for modifying the speed or direction of rotation
    • B01F35/331—Transmissions; Means for modifying the speed or direction of rotation alternately changing the speed of rotation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/71725—Feed mechanisms characterised by the means for feeding the components to the mixer using centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L13/00—Cleaning or rinsing apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
    • B08B9/02—Cleaning pipes or tubes or systems of pipes or tubes
    • B08B9/027—Cleaning the internal surfaces; Removal of blockages
    • B08B9/032—Cleaning the internal surfaces; Removal of blockages by the mechanical action of a moving fluid, e.g. by flushing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302—Apparatus specially adapted for immunological test procedures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N35/00069—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/60—Analysis of geometric attributes
    • G06T7/62—Analysis of geometric attributes of area, perimeter, diameter or volume
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/04—Exchange or ejection of cartridges, containers or reservoirs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0663—Whole sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B2209/00—Details of machines or methods for cleaning hollow articles
    • B08B2209/02—Details of apparatuses or methods for cleaning pipes or tubes
    • B08B2209/027—Details of apparatuses or methods for cleaning pipes or tubes for cleaning the internal surfaces
    • B08B2209/032—Details of apparatuses or methods for cleaning pipes or tubes for cleaning the internal surfaces by the mechanical action of a moving fluid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F11/00—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
    • G01F11/28—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with stationary measuring chambers having constant volume during measurement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00158—Elements containing microarrays, i.e. "biochip"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements
    • G01N2035/00564—Handling or washing solid phase elements, e.g. beads
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements
    • G01N2035/00564—Handling or washing solid phase elements, e.g. beads
    • G01N2035/00574—Means for distributing beads
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30101—Blood vessel; Artery; Vein; Vascular

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Clinical Laboratory Science (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Theoretical Computer Science (AREA)
  • Medical Informatics (AREA)
  • Quality & Reliability (AREA)
  • Radiology & Medical Imaging (AREA)
  • Geometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mechanical Engineering (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Fluid Mechanics (AREA)
AU2020235102A 2019-03-12 2020-03-12 Point of care concentration analyzer Active AU2020235102B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2026203879A AU2026203879A1 (en) 2019-03-12 2026-05-19 Point of care concentration analyzer

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962817433P 2019-03-12 2019-03-12
US62/817,433 2019-03-12
PCT/US2020/022399 WO2020186062A1 (en) 2019-03-12 2020-03-12 Point of care concentration analyzer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2026203879A Division AU2026203879A1 (en) 2019-03-12 2026-05-19 Point of care concentration analyzer

Publications (2)

Publication Number Publication Date
AU2020235102A1 AU2020235102A1 (en) 2021-09-30
AU2020235102B2 true AU2020235102B2 (en) 2026-02-19

Family

ID=72427660

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2020235102A Active AU2020235102B2 (en) 2019-03-12 2020-03-12 Point of care concentration analyzer
AU2026203879A Pending AU2026203879A1 (en) 2019-03-12 2026-05-19 Point of care concentration analyzer

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2026203879A Pending AU2026203879A1 (en) 2019-03-12 2026-05-19 Point of care concentration analyzer

Country Status (10)

Country Link
US (1) US20220168735A1 (enExample)
EP (2) EP4635598A3 (enExample)
JP (3) JP7496368B2 (enExample)
KR (2) KR20260048540A (enExample)
CN (2) CN114258321B (enExample)
AU (2) AU2020235102B2 (enExample)
CA (1) CA3133265A1 (enExample)
ES (1) ES3047957T3 (enExample)
MX (3) MX2021010984A (enExample)
WO (1) WO2020186062A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021079701A1 (ja) * 2019-10-25 2021-04-29 パナソニックＩｐマネジメント株式会社 計数方法、計数装置、及びプログラム
FR3128290A1 (fr) * 2021-10-15 2023-04-21 Biomerieux Procédé de fabrication d'une carte d'analyse biologique comprenant une chambre de pré-traitement munie de corps solides
EP4520433A4 (en) * 2022-05-06 2026-03-04 Seegene Inc Nucleic acid detection cassette
KR20240059057A (ko) * 2022-10-27 2024-05-07 주식회사 클리노믹스 미세유체 분리 및 분석용 통합카트리지
KR20240059058A (ko) * 2022-10-27 2024-05-07 주식회사 클리노믹스 원심분리장치용 카트리지 및 이를 포함하는 원심분리 장치
US12643104B2 (en) 2022-10-28 2026-06-02 Seegene, Inc. Cartridge for detecting target analyte
KR102921590B1 (ko) * 2022-10-28 2026-02-03 주식회사 씨젠 타깃 분석물 검출 카트리지
JP2026508400A (ja) * 2023-03-06 2026-03-10 ノヴィラクス エルエルシー 診療現場濃度分析器
CN117619219B (zh) * 2024-01-23 2024-05-10 天津市中环天佳电子有限公司 一种原料混合装置
US20250353008A1 (en) * 2024-05-15 2025-11-20 Summa Finland Oy An analyzer and a sensor disc assembly for the analyzer
WO2026057181A1 (en) * 2024-09-12 2026-03-19 Osaid Mohammad Sedimentation devices for separating particles from fluids and methods of use thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009111316A2 (en) * 2008-02-29 2009-09-11 Northwestern University Barriers for facilitating biological reactions
US20160195523A1 (en) * 2014-01-27 2016-07-07 Fannin Innovation Studio, Inc. Discontinuous fluidic systems for point-of-care analyte measurement

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5627041A (en) * 1994-09-02 1997-05-06 Biometric Imaging, Inc. Disposable cartridge for an assay of a biological sample
US20020025583A1 (en) * 1995-08-31 2002-02-28 Stoughton L. Ellsworth Analytical rotor and method for detecting analytes in liquid samples
JP3098970B2 (ja) * 1997-02-07 2000-10-16 日本碍子株式会社 タンパクのペプチド溶離免疫測定方法
US7026131B2 (en) * 2000-11-17 2006-04-11 Nagaoka & Co., Ltd. Methods and apparatus for blood typing with optical bio-discs
CA2469931A1 (en) * 2001-12-11 2003-07-03 Astrazeneca Ab Machine and method for processing biomolecules
US20050221281A1 (en) * 2003-01-08 2005-10-06 Ho Winston Z Self-contained microfluidic biochip and apparatus
WO2005001429A2 (en) * 2003-06-27 2005-01-06 Nagaoka & Co., Ltd. Fluidic circuits, methods and apparatus for use of whole blood samples in colorimetric assays
US20080226500A1 (en) * 2004-01-15 2008-09-18 Mitsuhiro Shikida Chemical Analytic Apparatus and Chemical Analytic Method
EP1917525B1 (en) * 2005-06-28 2017-12-27 Samsung Electronics Co., Ltd. BlO DRIVE APPARATUS, AND ASSAY METHOD USING THE SAME
US8637317B2 (en) * 2006-04-18 2014-01-28 Advanced Liquid Logic, Inc. Method of washing beads
EP1894617B1 (en) * 2006-08-31 2013-08-14 Samsung Electronics Co., Ltd. Method of mixing at least two kinds of fluids in centrifugal micro-fluid treating substrate
SE530392C2 (sv) * 2007-02-21 2008-05-20 Gyros Patent Ab Förfarande för blandning av alikvoter i en mikrokanalstruktur
US8852948B2 (en) * 2007-08-29 2014-10-07 Cem Corporation Colorimetric protein analysis method
AU2008352940B2 (en) 2007-12-19 2014-06-05 Singulex, Inc. Scanning analyzer for single molecule detection and methods of use
US9289765B2 (en) * 2008-09-23 2016-03-22 Samsung Electronics Co., Ltd. Micro-fluidic device and sample testing apparatus using the same
JP2010158235A (ja) * 2008-12-09 2010-07-22 Ngk Insulators Ltd Ｄｎａアレイ内蔵カートリッジ、分析装置及びｄｎａアレイ内蔵カートリッジの使用方法
CA2750900C (en) * 2009-01-30 2017-03-28 Gen-Probe Incorporated Systems and methods for detecting a signal and applying thermal energy to a signal transmission element
DE102010041621B4 (de) * 2010-09-29 2016-11-03 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Verfahren zum Transport magnetischer Partikel
US20120214224A1 (en) * 2011-02-01 2012-08-23 Chan Eugene Y Flow based clinical analysis
US9389229B2 (en) * 2012-07-18 2016-07-12 Theranos, Inc. Methods for detecting and measuring aggregation
JP2016509206A (ja) * 2012-12-21 2016-03-24 マイクロニクス， インコーポレイテッド 携帯型蛍光検出システムおよびマイクロアッセイカートリッジ
US10545161B2 (en) * 2013-03-11 2020-01-28 Cue Health Inc. Systems and methods for detection and quantification of analytes
CN112782393B (zh) * 2013-03-11 2024-11-19 克忧健康公司 用于检测和量化分析物的系统和方法
US11072812B2 (en) * 2013-03-15 2021-07-27 Promega Corporation Substrates for covalent tethering of proteins to functional groups or solid surfaces
IL227276A0 (en) 2013-07-01 2014-03-06 Parasight Ltd A method and system for preparing a monolayer of cells, particularly suitable for diagnosis
US20160178520A1 (en) 2014-12-17 2016-06-23 Singulex, Inc. Multiplexed Single Molecule Analyzer
CN204816573U (zh) * 2015-07-03 2015-12-02 艾康生物技术(杭州)有限公司 生物样品反应盒
CN105021544B (zh) * 2015-07-03 2018-02-02 艾康生物技术(杭州)有限公司 检测系统
WO2017070571A2 (en) * 2015-10-23 2017-04-27 Landers James P Devices, systems and methods for sample detection
EP3173149A1 (en) 2015-11-26 2017-05-31 Roche Diagnostics GmbH Determining a quantity of an analyte in a blood sample
JP6792568B2 (ja) * 2015-12-24 2020-11-25 Ｐｈｃホールディングス株式会社 試料分析用基板、試料分析装置、試料分析システムおよび試料分析システム用プログラム
CN105785054A (zh) * 2016-05-13 2016-07-20 绍兴普施康生物科技有限公司 降钙素原定量检测的化学发光微流控盘片及其使用方法
JP6829950B2 (ja) * 2016-05-31 2021-02-17 シスメックス株式会社 分析方法、分析装置および分析システム
JP6457451B2 (ja) * 2016-06-30 2019-01-23 シスメックス株式会社 検出装置および検出方法
JP6635897B2 (ja) * 2016-08-30 2020-01-29 シスメックス株式会社 試料分析用カートリッジ及びその製造方法、並びにその利用
JP7252899B2 (ja) * 2016-12-01 2023-04-05 ノベル マイクロデバイシズ，インク． 複雑な試料処理の為の自動ポイント・オブ・ケア装置及びその使用方法
JP6434114B1 (ja) * 2017-11-30 2018-12-05 シスメックス株式会社 測定方法および測定装置

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009111316A2 (en) * 2008-02-29 2009-09-11 Northwestern University Barriers for facilitating biological reactions
US20160195523A1 (en) * 2014-01-27 2016-07-07 Fannin Innovation Studio, Inc. Discontinuous fluidic systems for point-of-care analyte measurement

Also Published As

Publication number Publication date
CN114258321A (zh) 2022-03-29
EP3938077A1 (en) 2022-01-19
EP3938077C0 (en) 2025-09-10
MX2025009080A (es) 2025-09-02
JP2025100731A (ja) 2025-07-03
KR20210138640A (ko) 2021-11-19
MX2021010984A (es) 2021-10-13
JP7717906B2 (ja) 2025-08-04
MX2026004100A (es) 2026-05-04
EP3938077A4 (en) 2023-05-03
EP3938077B1 (en) 2025-09-10
WO2020186062A1 (en) 2020-09-17
EP4635598A2 (en) 2025-10-22
CA3133265A1 (en) 2020-09-17
CN117538550A (zh) 2024-02-09
AU2026203879A1 (en) 2026-06-04
EP4635598A3 (en) 2025-12-24
KR20260048540A (ko) 2026-04-10
CN114258321B (zh) 2023-09-15
JP7496368B2 (ja) 2024-06-06
JP2024100994A (ja) 2024-07-26
AU2020235102A1 (en) 2021-09-30
ES3047957T3 (en) 2025-12-05
US20220168735A1 (en) 2022-06-02
JP2022525133A (ja) 2022-05-11
KR102915035B1 (ko) 2026-01-22

Similar Documents

Publication Publication Date Title
EP3938077B1 (en) Point of care concentration analyzer and method of mixing
KR101722548B1 (ko) 원심력기반의 미세유동장치 및 이를 이용한 유체시료 내 분석대상물질 검출방법
JP5685538B2 (ja) 分析物を検出するためのキットおよび装置
KR101519379B1 (ko) 원심력 기반의 미세유동장치 및 이를 이용한 면역분석방법
CN101939648B (zh) 生物靶标的免疫磁性捕获和成像
US9682375B2 (en) Fluid sample analysis system
US12339233B2 (en) Optical detection of a substance in fluid
BR112014032304B1 (pt) Método e sistema para a determinação quantitativa ou qualitativa de um componente alvo em uma amostra líquida, e, dispositivo microfluídico
JP2009186459A (ja) 高速な粒子検出分析
US12263481B2 (en) Microchip for analyzing fluids
JP2013238420A (ja) 試料分析装置及び試料分析方法
US20240299938A1 (en) Point of Care Concentration Analyzer
WO2025155756A1 (en) Devices for biological analysis
JP6590697B2 (ja) サンプル処理及び細胞計数のための方法及びデバイス
HK40071881A (en) Point of care concentration analyzer
HK40071881B (en) Point of care concentration analyzer
CN112384802A (zh) 用于测定样品中颗粒浓度的装置和方法
HK1225407A1 (zh) 具有隔离围栏的微流体装置及用它测试生物微目标的方法

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)