ES3047957T3 - Point of care concentration analyzer and method of mixing - Google Patents

Point of care concentration analyzer and method of mixing

Info

Publication number
ES3047957T3
ES3047957T3 ES20770261T ES20770261T ES3047957T3 ES 3047957 T3 ES3047957 T3 ES 3047957T3 ES 20770261 T ES20770261 T ES 20770261T ES 20770261 T ES20770261 T ES 20770261T ES 3047957 T3 ES3047957 T3 ES 3047957T3
Authority
ES
Spain
Prior art keywords
cartridge
chamber
sample
disclosures
mixing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES20770261T
Other languages
English (en)
Spanish (es)
Inventor
William Ortyn
Brian Noland
Jeffrey Bishop
Richard Livingston
Robert Onorato
Michele Gilbert
Danni Wang
Erich Kyger
John Jolly
Luis Monsalve
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novilux LLC
Original Assignee
Novilux LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novilux LLC filed Critical Novilux LLC
Application granted granted Critical
Publication of ES3047957T3 publication Critical patent/ES3047957T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
    • B08B3/04—Cleaning involving contact with liquid
    • B08B3/10—Cleaning involving contact with liquid with additional treatment of the liquid or of the object being cleaned, e.g. by heat, by electricity or by vibration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F21/00—Dissolving
    • B01F21/40—Dissolving characterised by the state of the material being dissolved
    • B01F21/402—Dissolving characterised by the state of the material being dissolved characterised by the configuration, form or shape of the solid material, e.g. in the form of tablets or blocks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01F29/60—Mixers with rotating receptacles rotating about a horizontal or inclined axis, e.g. drum mixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01F33/25—Mixers with loose mixing elements, e.g. loose balls in a receptacle
    • B01F33/251—Mixers with loose mixing elements, e.g. loose balls in a receptacle using balls as loose mixing element
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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Clinical Laboratory Science (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Theoretical Computer Science (AREA)
  • Medical Informatics (AREA)
  • Quality & Reliability (AREA)
  • Radiology & Medical Imaging (AREA)
  • Geometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mechanical Engineering (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Fluid Mechanics (AREA)
ES20770261T 2019-03-12 2020-03-12 Point of care concentration analyzer and method of mixing Active ES3047957T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962817433P 2019-03-12 2019-03-12
PCT/US2020/022399 WO2020186062A1 (en) 2019-03-12 2020-03-12 Point of care concentration analyzer

Publications (1)

Publication Number Publication Date
ES3047957T3 true ES3047957T3 (en) 2025-12-05

Family

ID=72427660

Family Applications (1)

Application Number Title Priority Date Filing Date
ES20770261T Active ES3047957T3 (en) 2019-03-12 2020-03-12 Point of care concentration analyzer and method of mixing

Country Status (10)

Country Link
US (1) US20220168735A1 (enExample)
EP (2) EP4635598A3 (enExample)
JP (3) JP7496368B2 (enExample)
KR (2) KR20260048540A (enExample)
CN (2) CN114258321B (enExample)
AU (2) AU2020235102B2 (enExample)
CA (1) CA3133265A1 (enExample)
ES (1) ES3047957T3 (enExample)
MX (3) MX2021010984A (enExample)
WO (1) WO2020186062A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021079701A1 (ja) * 2019-10-25 2021-04-29 パナソニックIpマネジメント株式会社 計数方法、計数装置、及びプログラム
FR3128290A1 (fr) * 2021-10-15 2023-04-21 Biomerieux Procédé de fabrication d'une carte d'analyse biologique comprenant une chambre de pré-traitement munie de corps solides
EP4520433A4 (en) * 2022-05-06 2026-03-04 Seegene Inc Nucleic acid detection cassette
KR20240059057A (ko) * 2022-10-27 2024-05-07 주식회사 클리노믹스 미세유체 분리 및 분석용 통합카트리지
KR20240059058A (ko) * 2022-10-27 2024-05-07 주식회사 클리노믹스 원심분리장치용 카트리지 및 이를 포함하는 원심분리 장치
US12643104B2 (en) 2022-10-28 2026-06-02 Seegene, Inc. Cartridge for detecting target analyte
KR102921590B1 (ko) * 2022-10-28 2026-02-03 주식회사 씨젠 타깃 분석물 검출 카트리지
JP2026508400A (ja) * 2023-03-06 2026-03-10 ノヴィラクス エルエルシー 診療現場濃度分析器
CN117619219B (zh) * 2024-01-23 2024-05-10 天津市中环天佳电子有限公司 一种原料混合装置
US20250353008A1 (en) * 2024-05-15 2025-11-20 Summa Finland Oy An analyzer and a sensor disc assembly for the analyzer
WO2026057181A1 (en) * 2024-09-12 2026-03-19 Osaid Mohammad Sedimentation devices for separating particles from fluids and methods of use thereof

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5627041A (en) * 1994-09-02 1997-05-06 Biometric Imaging, Inc. Disposable cartridge for an assay of a biological sample
US20020025583A1 (en) * 1995-08-31 2002-02-28 Stoughton L. Ellsworth Analytical rotor and method for detecting analytes in liquid samples
JP3098970B2 (ja) * 1997-02-07 2000-10-16 日本碍子株式会社 タンパクのペプチド溶離免疫測定方法
US7026131B2 (en) * 2000-11-17 2006-04-11 Nagaoka & Co., Ltd. Methods and apparatus for blood typing with optical bio-discs
CA2469931A1 (en) * 2001-12-11 2003-07-03 Astrazeneca Ab Machine and method for processing biomolecules
US20050221281A1 (en) * 2003-01-08 2005-10-06 Ho Winston Z Self-contained microfluidic biochip and apparatus
WO2005001429A2 (en) * 2003-06-27 2005-01-06 Nagaoka & Co., Ltd. Fluidic circuits, methods and apparatus for use of whole blood samples in colorimetric assays
US20080226500A1 (en) * 2004-01-15 2008-09-18 Mitsuhiro Shikida Chemical Analytic Apparatus and Chemical Analytic Method
EP1917525B1 (en) * 2005-06-28 2017-12-27 Samsung Electronics Co., Ltd. BlO DRIVE APPARATUS, AND ASSAY METHOD USING THE SAME
US8637317B2 (en) * 2006-04-18 2014-01-28 Advanced Liquid Logic, Inc. Method of washing beads
EP1894617B1 (en) * 2006-08-31 2013-08-14 Samsung Electronics Co., Ltd. Method of mixing at least two kinds of fluids in centrifugal micro-fluid treating substrate
SE530392C2 (sv) * 2007-02-21 2008-05-20 Gyros Patent Ab Förfarande för blandning av alikvoter i en mikrokanalstruktur
US8852948B2 (en) * 2007-08-29 2014-10-07 Cem Corporation Colorimetric protein analysis method
AU2008352940B2 (en) 2007-12-19 2014-06-05 Singulex, Inc. Scanning analyzer for single molecule detection and methods of use
CN102027367B (zh) * 2008-02-29 2016-03-23 西北大学 促进生物反应的屏障
US9289765B2 (en) * 2008-09-23 2016-03-22 Samsung Electronics Co., Ltd. Micro-fluidic device and sample testing apparatus using the same
JP2010158235A (ja) * 2008-12-09 2010-07-22 Ngk Insulators Ltd Dnaアレイ内蔵カートリッジ、分析装置及びdnaアレイ内蔵カートリッジの使用方法
CA2750900C (en) * 2009-01-30 2017-03-28 Gen-Probe Incorporated Systems and methods for detecting a signal and applying thermal energy to a signal transmission element
DE102010041621B4 (de) * 2010-09-29 2016-11-03 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Verfahren zum Transport magnetischer Partikel
US20120214224A1 (en) * 2011-02-01 2012-08-23 Chan Eugene Y Flow based clinical analysis
US9389229B2 (en) * 2012-07-18 2016-07-12 Theranos, Inc. Methods for detecting and measuring aggregation
JP2016509206A (ja) * 2012-12-21 2016-03-24 マイクロニクス, インコーポレイテッド 携帯型蛍光検出システムおよびマイクロアッセイカートリッジ
US10545161B2 (en) * 2013-03-11 2020-01-28 Cue Health Inc. Systems and methods for detection and quantification of analytes
CN112782393B (zh) * 2013-03-11 2024-11-19 克忧健康公司 用于检测和量化分析物的系统和方法
US11072812B2 (en) * 2013-03-15 2021-07-27 Promega Corporation Substrates for covalent tethering of proteins to functional groups or solid surfaces
IL227276A0 (en) 2013-07-01 2014-03-06 Parasight Ltd A method and system for preparing a monolayer of cells, particularly suitable for diagnosis
CA2937975A1 (en) * 2014-01-27 2015-07-30 Brevitest Technologies, Llc Discontinuous fluidic systems for point-of-care analyte measurement
US20160178520A1 (en) 2014-12-17 2016-06-23 Singulex, Inc. Multiplexed Single Molecule Analyzer
CN204816573U (zh) * 2015-07-03 2015-12-02 艾康生物技术(杭州)有限公司 生物样品反应盒
CN105021544B (zh) * 2015-07-03 2018-02-02 艾康生物技术(杭州)有限公司 检测系统
WO2017070571A2 (en) * 2015-10-23 2017-04-27 Landers James P Devices, systems and methods for sample detection
EP3173149A1 (en) 2015-11-26 2017-05-31 Roche Diagnostics GmbH Determining a quantity of an analyte in a blood sample
JP6792568B2 (ja) * 2015-12-24 2020-11-25 Phcホールディングス株式会社 試料分析用基板、試料分析装置、試料分析システムおよび試料分析システム用プログラム
CN105785054A (zh) * 2016-05-13 2016-07-20 绍兴普施康生物科技有限公司 降钙素原定量检测的化学发光微流控盘片及其使用方法
JP6829950B2 (ja) * 2016-05-31 2021-02-17 シスメックス株式会社 分析方法、分析装置および分析システム
JP6457451B2 (ja) * 2016-06-30 2019-01-23 シスメックス株式会社 検出装置および検出方法
JP6635897B2 (ja) * 2016-08-30 2020-01-29 シスメックス株式会社 試料分析用カートリッジ及びその製造方法、並びにその利用
JP7252899B2 (ja) * 2016-12-01 2023-04-05 ノベル マイクロデバイシズ,インク. 複雑な試料処理の為の自動ポイント・オブ・ケア装置及びその使用方法
JP6434114B1 (ja) * 2017-11-30 2018-12-05 シスメックス株式会社 測定方法および測定装置

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