AU2020228296B2 - Administration of PD-1 inhibitors for treating skin cancer - Google Patents

Administration of PD-1 inhibitors for treating skin cancer

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Publication number
AU2020228296B2
AU2020228296B2 AU2020228296A AU2020228296A AU2020228296B2 AU 2020228296 B2 AU2020228296 B2 AU 2020228296B2 AU 2020228296 A AU2020228296 A AU 2020228296A AU 2020228296 A AU2020228296 A AU 2020228296A AU 2020228296 B2 AU2020228296 B2 AU 2020228296B2
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AU
Australia
Prior art keywords
antibody
cscc
seq
antigen
amino acid
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Active
Application number
AU2020228296A
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English (en)
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AU2020228296A1 (en
Inventor
Matthew G. Fury
Israel Lowy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Regeneron Pharmaceuticals Inc filed Critical Regeneron Pharmaceuticals Inc
Publication of AU2020228296A1 publication Critical patent/AU2020228296A1/en
Application granted granted Critical
Publication of AU2020228296B2 publication Critical patent/AU2020228296B2/en
Active legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU2020228296A 2019-02-28 2020-02-27 Administration of PD-1 inhibitors for treating skin cancer Active AU2020228296B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962811827P 2019-02-28 2019-02-28
US62/811,827 2019-02-28
PCT/US2020/020018 WO2020176699A1 (en) 2019-02-28 2020-02-27 Administration of pd-1 inhibitors for treating skin cancer

Publications (2)

Publication Number Publication Date
AU2020228296A1 AU2020228296A1 (en) 2021-10-14
AU2020228296B2 true AU2020228296B2 (en) 2025-10-02

Family

ID=70057261

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2020228296A Active AU2020228296B2 (en) 2019-02-28 2020-02-27 Administration of PD-1 inhibitors for treating skin cancer

Country Status (12)

Country Link
US (1) US20220259313A1 (https=)
EP (1) EP3930848A1 (https=)
JP (2) JP2022521800A (https=)
KR (1) KR20210134690A (https=)
CN (1) CN113490529A (https=)
AU (1) AU2020228296B2 (https=)
CA (1) CA3137361A1 (https=)
IL (1) IL285050A (https=)
MA (1) MA55084A (https=)
MX (1) MX2021010228A (https=)
SG (1) SG11202108089SA (https=)
WO (1) WO2020176699A1 (https=)

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TWI680138B (zh) * 2014-01-23 2019-12-21 美商再生元醫藥公司 抗ｐｄ-ｌ１之人類抗體
JP7126941B2 (ja) 2015-12-22 2022-08-29 リジェネロン・ファーマシューティカルズ・インコーポレイテッド がんを治療するための抗ｐｄ－１抗体と二重特異性抗ｃｄ２０／抗ｃｄ３抗体の組合せ
US12516382B2 (en) 2018-12-07 2026-01-06 Arizona Board Of Regents On Behalf Of The University Of Arizona Method of determining risk for skin cancer development and skin cancer therapeutic prevention by measuring PD-1/PD-L1 signaling pathway members
KR20230141869A (ko) * 2021-02-11 2023-10-10 리제너론 파마슈티칼스 인코포레이티드 신보조 요법으로서 pd-1 저해제의 투여에 의한 암 치료 방법
WO2024186917A2 (en) * 2023-03-06 2024-09-12 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions for pd-l1 inhibition and methods of use thereof

Citations (3)

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WO2017197263A1 (en) * 2016-05-13 2017-11-16 Regeneron Pharmaceuticals, Inc. Methods of treating skin cancer by administering a pd-1 inhibitor
US9987500B2 (en) * 2014-01-23 2018-06-05 Regeneron Pharmaceuticals, Inc. Human antibodies to PD-1
WO2018156494A1 (en) * 2017-02-21 2018-08-30 Regeneron Pharmaceuticals, Inc. Anti-pd-1 antibodies for treatment of lung cancer

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EP1210428B1 (en) 1999-08-23 2015-03-18 Dana-Farber Cancer Institute, Inc. Pd-1, a receptor for b7-4, and uses therefor
ES2350687T3 (es) 2002-07-03 2011-01-26 Ono Pharmaceutical Co., Ltd. Composiciones de inmunopotenciación.
CN1753912B (zh) 2002-12-23 2011-11-02 惠氏公司 抗pd-1抗体及其用途
RU2494107C2 (ru) 2005-05-09 2013-09-27 Оно Фармасьютикал Ко., Лтд. Моноклональные антитела человека к белку программируемой смерти 1 (pd-1) и способы лечения рака с использованием анти-pd-1-антител самостоятельно или в комбинации с другими иммунотерапевтическими средствами
CN104356236B (zh) 2005-07-01 2020-07-03 E.R.施贵宝&圣斯有限责任公司 抗程序性死亡配体1(pd-l1)的人单克隆抗体
HRP20131167T1 (hr) 2007-06-18 2014-01-03 Merck Sharp & Dohme B.V. Antitijela za humani receptor programirane smrti pd-1
WO2009114335A2 (en) 2008-03-12 2009-09-17 Merck & Co., Inc. Pd-1 binding proteins
CN102203132A (zh) 2008-08-25 2011-09-28 安普利穆尼股份有限公司 Pd-1拮抗剂的组合物和使用方法
KR101814408B1 (ko) 2008-09-26 2018-01-04 다나-파버 캔서 인스티튜트 인크. 인간 항-ｐｄ-１, ｐｄ-ｌ１, 및 ｐｄ-ｌ2 항체 및 그의 용도
AU2009333580B2 (en) 2008-12-09 2016-07-07 Genentech, Inc. Anti-PD-L1 antibodies and their use to enhance T-cell function
JP6240600B2 (ja) 2011-07-24 2017-11-29 キュアテク リミテッド ヒト化免疫モノクローナル抗体の変異体
HRP20201595T1 (hr) 2011-11-28 2020-12-11 Merck Patent Gmbh Anti-pd-l1 protutijela i njihova uporaba
WO2013181452A1 (en) 2012-05-31 2013-12-05 Genentech, Inc. Methods of treating cancer using pd-l1 axis binding antagonists and vegf antagonists
HK1204557A1 (en) 2012-05-31 2015-11-27 Sorrento Therapeutics, Inc. Antigen binding proteins that bind pd-l1
US9308236B2 (en) 2013-03-15 2016-04-12 Bristol-Myers Squibb Company Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions
TWI680138B (zh) 2014-01-23 2019-12-21 美商再生元醫藥公司 抗ｐｄ-ｌ１之人類抗體
US10435470B2 (en) 2014-08-05 2019-10-08 Cb Therapeutics, Inc. Anti-PD-L1 antibodies
CN108112254B (zh) 2015-03-13 2022-01-28 西托姆克斯治疗公司 抗-pdl1抗体、可活化的抗-pdl1抗体、及其使用方法
AR105654A1 (es) 2015-08-24 2017-10-25 Lilly Co Eli Anticuerpos pd-l1 (ligando 1 de muerte celular programada)
WO2017106656A1 (en) * 2015-12-17 2017-06-22 Novartis Ag Antibody molecules to pd-1 and uses thereof
JP7126941B2 (ja) * 2015-12-22 2022-08-29 リジェネロン・ファーマシューティカルズ・インコーポレイテッド がんを治療するための抗ｐｄ－１抗体と二重特異性抗ｃｄ２０／抗ｃｄ３抗体の組合せ
CN109310677A (zh) 2016-04-07 2019-02-05 凯莫森特里克斯股份有限公司 通过联合施用ccr1拮抗剂与pd-1抑制剂或pd-l1拮抗剂降低肿瘤负荷
US11603407B2 (en) 2017-04-06 2023-03-14 Regeneron Pharmaceuticals, Inc. Stable antibody formulation
AU2018287317B2 (en) * 2017-06-19 2024-06-20 Medicenna Therapeutics Inc. Uses and methods for IL-2 superagonists, agonists, and fusions thereof

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US9987500B2 (en) * 2014-01-23 2018-06-05 Regeneron Pharmaceuticals, Inc. Human antibodies to PD-1
WO2017197263A1 (en) * 2016-05-13 2017-11-16 Regeneron Pharmaceuticals, Inc. Methods of treating skin cancer by administering a pd-1 inhibitor
WO2018156494A1 (en) * 2017-02-21 2018-08-30 Regeneron Pharmaceuticals, Inc. Anti-pd-1 antibodies for treatment of lung cancer

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ANONYMOUS: "A Study to Compare the Administration of Pembrolizumab After Surgery Versus Administration Both Before and After Surgery for High-Risk Melanoma ", CLINICALTRIALS.GOV, 5 October 2018 (2018-10-05), pages 1 - 13, XP055919719 *
CASSLER NICOLE M ET AL: "Merkel Cell Carcinoma Therapeutic Update", CURRENT TREATMENT OPTIONS IN ONCOLOGY MAY 2005, SPRINGER US, BOSTON, vol. 17, no. 7, 4 June 2016 (2016-06-04), pages 1 - 18 *
EGGERMONT ALEXANDER M.M., BLANK CHRISTIAN U., MANDALA MARIO, LONG GEORGINA V., ATKINSON VICTORIA, DALLE STÉPHANE, HAYDON ANDREW, L: "Adjuvant Pembrolizumab versus Placebo in Resected Stage III Melanoma", *
MERCK SHARP & DOHME LLC: "History of Changes for Study: NCT03833167 Pembrolizumab Versus Placebo Following Surgery and Radiation in Participants With Locally Advanced Cutaneous Squamous Cell Carcinoma (MK-3475-630/KEYNOTE-630)" *
SANDRO V PORCEDDU, MICHAEL J VENESS , ALEXANDER GUMINSKI : "Nonmelanoma Cutaneous Head and Neck Cancer and Merkel Cell Carcinoma: Current Concepts, Advances, and Controversies", J CLIN ONCOL ., vol. 33, no. 29, 10 October 2015 (2015-10-10) *

Also Published As

Publication number Publication date
EP3930848A1 (en) 2022-01-05
WO2020176699A1 (en) 2020-09-03
JP2025041768A (ja) 2025-03-26
SG11202108089SA (en) 2021-08-30
AU2020228296A1 (en) 2021-10-14
IL285050A (en) 2021-09-30
US20220259313A1 (en) 2022-08-18
KR20210134690A (ko) 2021-11-10
CA3137361A1 (en) 2020-09-03
CN113490529A (zh) 2021-10-08
JP2022521800A (ja) 2022-04-12
MA55084A (fr) 2022-01-05
MX2021010228A (es) 2021-10-26

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