AU2020226524A1 - Cancer-targeted, virus-encoded, regulatable T (CatVert) or NK cell (CatVern) linkers - Google Patents

Cancer-targeted, virus-encoded, regulatable T (CatVert) or NK cell (CatVern) linkers Download PDF

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Publication number
AU2020226524A1
AU2020226524A1 AU2020226524A AU2020226524A AU2020226524A1 AU 2020226524 A1 AU2020226524 A1 AU 2020226524A1 AU 2020226524 A AU2020226524 A AU 2020226524A AU 2020226524 A AU2020226524 A AU 2020226524A AU 2020226524 A1 AU2020226524 A1 AU 2020226524A1
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Australia
Prior art keywords
vector
cell
polynucleotide
sequence
antigen
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AU2020226524A
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Inventor
Dawn Chandler
Chun-Yu Chen
Timothy P. CRIPE
Mark CURRIER
Brian HUTZEN
Pin-Yi Wang
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Nationwide Childrens Hospital Inc
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Nationwide Childrens Hospital Inc
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    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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AU2020226524A 2019-02-20 2020-02-19 Cancer-targeted, virus-encoded, regulatable T (CatVert) or NK cell (CatVern) linkers Pending AU2020226524A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962808264P 2019-02-20 2019-02-20
US62/808,264 2019-02-20
PCT/US2020/018806 WO2020172259A1 (en) 2019-02-20 2020-02-19 Cancer-targeted, virus-encoded, regulatable t (catvert) or nk cell (catvern) linkers

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AU2020226524A1 true AU2020226524A1 (en) 2021-08-12

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US (1) US20220257760A1 (https=)
EP (1) EP3927750A4 (https=)
JP (2) JP7603013B2 (https=)
KR (1) KR20210128399A (https=)
CN (1) CN113646334B (https=)
AU (1) AU2020226524A1 (https=)
BR (1) BR112021015907A2 (https=)
CA (1) CA3129506A1 (https=)
IL (2) IL325850A (https=)
SG (1) SG11202108924RA (https=)
WO (1) WO2020172259A1 (https=)

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CN112794916B (zh) * 2021-04-08 2021-08-10 正大天晴药业集团南京顺欣制药有限公司 三特异性抗原结合构建体及构建方法和应用
JP2024516168A (ja) * 2021-04-22 2024-04-12 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド がんを治療するための組成物および方法
JP2024520444A (ja) 2021-05-24 2024-05-24 プロヴェンション・バイオ・インコーポレイテッド １型糖尿病を治療するための方法
JP2023176123A (ja) * 2022-05-31 2023-12-13 株式会社 光バイオ ウイルスベクター及びそれを含むがん細胞増殖抑制剤

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IL325850A (en) 2026-03-01
BR112021015907A2 (pt) 2021-11-03
CN113646334A (zh) 2021-11-12
WO2020172259A1 (en) 2020-08-27
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IL285617A (en) 2021-09-30
EP3927750A1 (en) 2021-12-29
US20220257760A1 (en) 2022-08-18
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