AU2020100591A4 - External Rosmarinus Officinalis Ointment With Effects Of Refreshing Brain And Restoring Consciousness - Google Patents

External Rosmarinus Officinalis Ointment With Effects Of Refreshing Brain And Restoring Consciousness Download PDF

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AU2020100591A4
AU2020100591A4 AU2020100591A AU2020100591A AU2020100591A4 AU 2020100591 A4 AU2020100591 A4 AU 2020100591A4 AU 2020100591 A AU2020100591 A AU 2020100591A AU 2020100591 A AU2020100591 A AU 2020100591A AU 2020100591 A4 AU2020100591 A4 AU 2020100591A4
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rosmarinus officinalis
parts
essential oil
ointment
refreshing
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Shihong CENG
Yaling JIANG
Ke Li
Qiuwei LIU
Weiping Yin
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Zhengzhou University of Industrial Technology
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    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/55—Liquid-liquid separation; Phase separation
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Abstract

Abstract The present invention discloses an external rosmarinus officinalis ointment with the effects of refreshing the brain and restoring consciousness. The ointment is prepared from the following raw materials in parts by weight: 13 to 20 parts of rosmarinus officinalis plant essential oil, 4 to 6 parts of lavender essential oil, 80 to 120 parts of borneol, 8 to 14 parts of liquid paraffin, 8 to 14 parts of glycerol and 730 to 800 parts of vaseline. In the rosmarinus officinalis essential oil in the external ointment prepared by the present invention, an antibacterial and anti-inflammatory ingredient marked by thymol and the like accounts for 25.50 to 28.50% of the content of essential oil, and an L-camphor ingredient with the effects of refreshing the brain and restoring consciousness accounts for 12.00 to 15.00% of the content of the essential oil. The efficacies of refreshing the brain, restoring consciousness and protecting the skin are achieved. The external rosmarinus officinalis ointment has an acrid flavor, a mild property and pleasant fragrance, achieves the effects of refreshing the brain and restoring consciousness, realizes sterilization and insect killing, and is applicable to all user groups.

Description

Description
External Rosmarinus Officinalis Ointment with Effects of Refreshing Brain and Restoring Consciousness
Technical Field
The present invention relates to the field of external medicine, in particular to an external rosmarinus officinalis ointment with the effects of refreshing the brain and restoring consciousness.
Background Art
At present, there are many products with the effects of refreshing the brain and restoring consciousness on the market, but at the end, ingredients of the products with the effects of refreshing the brain and restoring consciousness are mainly four kinds of materials including caffeine, vitamin B, taurine and calcium orthophosphate, side effects are great, the effect is not obvious sufficiently, and the products are inconvenient to use. The ointment is mainly used for skin care, skin lubrication and local treatment, is commonly used for chronic skin diseases or may be used for preventing headache caused by mosquito bite and common cold, dizziness and carsickness discomfort. Products with functions of an ointment for refreshing the brain and restoring consciousness and functions of a skin care ointment mostly use extracted plant volatile oil as a raw material at home and abroad, for example, products such as Fengyoujing (essential balm) and Wanjingyou (cooling ointment) produced in China, and products such as Anshuyou (eucalyptus oil) produced in Australia have the two functions. For example, the Fengyoujing is light green clear oily liquid with special aroma and cold and acrid flavors. Due to the acrid flavor and irritation, the use by some special user groups such as children, pregnant women and elderly people is strictly restricted.
Rosmarinus officinalis (Rosmarinus officinalis L.) is also called as rosemary, and belongs to a spice plant in labiatae. The rosmarinus officinalis is mainly planted abundantly in the Mediterranean region. After 1981, the rosmarinus officinalis was introduced into China, and cultivated and domesticated successfully. The rosmarinus officinalis is an indispensable condiment in western food, and has a pleasant fragrance similar to camphor. Tender leaves of the rosmarinus officinalis may be directly eaten after being dressed with sauce. Meanwhile, the rosmarinus officinalis may be used as a condiment for vegetable stewing, soup cooking, barbecue and the like. Rosmarinus officinalis volatile oil has an acrid flavor and a mild property, achieves the prominent effects in aspects of calming the nerves, strengthening the spleens and nourishing the stomach, and also has the effects of sterilization, anti-oxidization and the like. The rosmarinus officinalis essential oil has been used as a spice for a long time, so that the rosmarinus officinalis essential oil is widely used in the fields of daily chemicals such as perfume, soaps and air fresheners. The present invention uses special effects of the extracted rosmarinus officinalis to develop and prepare a rosmarinus officinalis ointment preparation with the effects of refreshing the brain and restoring consciousness. Meanwhile, the rosmarinus officinalis ointment preparation is externally used on the skin, and has the effects of skin care and bacterium resistance. The product is about to be marketed, and is a product capable of replacing other identical plant essential oil with strong odor.
Summary of the Invention
The present invention is directed to provide an external rosmarinus officinalis ointment with the effects of refreshing the brain and restoring consciousness so as to solve a problem in the prior art. The ointment has dual effects of refreshing the brain and restoring consciousness, and caring the skin and resisting bacteria, is safe and effective, and may be applied to all user groups.
In order to achieve the objective, the present invention provides the following scheme:
the present invention provides an external rosmarinus officinalis ointment with the effects of refreshing the brain and restoring consciousness, and the ointment is prepared from the following raw materials in parts by weight:
to 20 parts of rosmarinus officinalis plant essential oil, 4 to 6 parts of lavender essential oil, 80 to 120 parts of borneol, 8 to 14 parts of liquid paraffin, 8 to 14 parts of glycerol and 730 to 800 parts of vaseline;
in the rosmarinus officinalis plant essential oil, an antibacterial and anti-inflammatory ingredient accounts for 25.50 to 28.50% of the content of essential oil, and an ingredient with the effects of refreshing the brain and restoring consciousness accounts for 12.00 to 15.00% of the content of the essential oil;
a preparation method of the external rosmarinus officinalis ointment with the effects of refreshing the brain and restoring consciousness comprises the following steps:
taking the following raw materials in parts by weight: 13 to 20 parts of rosmarinus officinalis plant essential oil, 4 to 6 parts of lavender essential oil, 80 to 120 parts of borneol, 8 to 14 parts of liquid paraffin, 8 to 14 parts of glycerol and 730 to 800 parts of vaseline for use; firstly, mixing the vaseline, the liquid paraffin and the glycerol; then, heating the mixture to a molten state; passing the mixture through a 120-mesh copper wire sieve screen for filtration while hot to obtain a mixed solution; next, raising the temperature of the mixed solution to 145 to 155°C for sterilization for 1 h; after a sterilized greasing substrate is naturally cooled to 60 to 65°C, adding the borneol while stirring; after the borneol is molten, performing natural cooling to 45 to 50°C; then, adding the rosmarinus officinalis essential oil and the lavender essential oil while stirring; and performing uniform stirring to obtain the external rosmarinus officinalis ointment with the effects of refreshing the brain and restoring consciousness after cooling;
an extraction method of the rosmarinus officinalis plant essential oil comprises the following steps:
step 1, weighing stems and leaves, dried in shade, of overground parts of the rosmarinus officinalis as a rosmarinus officinalis raw material, and after crushing, spraying a cellulase water solution onto the rosmarinus officinalis raw material;
step 2, putting the rosmarinus officinalis raw material treated in the step 1 into a distilling flask, and performing steam distillation for 3 to 5 h at a distillation speed of 1 to 2 drops/second to obtain rosmarinus officinalis volatile oil for use;
step 3, extracting the rosmarinus officinalis volatile oil obtained in the step 2 by ethyl acetate, collecting upper layer extraction liquid, then adding anhydrous sodium sulfate for drying, performing still standing for 12 to 20 h until the anhydrous sodium sulfate is dry and aggregates, performing filtration, collecting filter liquid, and removing a solvent from the filter liquid through reduced pressure distillation, so as to obtain rosmarinus officinalis natural essential oil;
a mass concentration of the cellulase water solution in the step 1 is 0.15%; and a vacuum degree of the reduced pressure distillation in the step 3 is 0.090 to 0.095 Mpa, and a water bath temperature is 45 to 52°C.
Further, in the extraction method of the rosmarinus officinalis natural essential oil, the consumption of the ethyl acetate in the step 3 is 1/3 of the weight of the rosmarinus officinalis volatile oil.
The present invention achieves the following technical effects:
in the rosmarinus officinalis essential oil in the external ointment prepared by the present invention, an antibacterial and anti-inflammatory ingredient marked by thymol and the like accounts for 25.50 to 28.50% of the content of essential oil, and an L-camphor ingredient with the effects of refreshing the brain and restoring consciousness accounts for 12.00 to 15.00% of the content of the essential oil; the efficacies of refreshing the brain, restoring consciousness and protecting the skin are achieved; and the external rosmarinus officinalis ointment has an acrid flavor, a mild property and pleasant fragrance, achieves the effects of refreshing the brain and restoring consciousness, realizes sterilization and insect killing, and is applicable to all user groups.
The external rosmarinus officinalis ointment with the effects of refreshing the brain and restoring consciousness provided by the present invention comprises medical ingredients of the rosmarinus officinalis volatile oil, has no irritation, a lubrication property and a good medicine release property, may form a closed oil film on the skin to achieve a protective effect on the skin, may promote a skin hydration effect, and is easy to remove. Detection indexes of the external ointment prepared by the present invention all reach quality standards, and a melting point of the external ointment reaches the quality standards of premium-grade products (a melting point is 45 to 60°C, and a volatile oil content is higher than or equal to 1.70%). A recipe and a preparation method process of the prevent invention may reduce product cost, also ensure the quality of products, and conform to the quality standards of the products.
Brief Description of the Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical schemes in the prior art, the drawings to be used in the embodiments will be briefly described hereafter. Obviously, the drawings depicted hereinafter are only some embodiments of the present invention, and those skilled in the art would obtain other drawings from the drawings herein without involving any inventive effort.
Fig. 1. Total ion flow chromatogram of the essential oil from rosmarinus officinalis.
Detailed Description of the Invention
Various exemplary embodiments of the present invention will be described in detail hereafter, which should not be considered as a limitation of the present invention, and should be understood as a more detailed description of certain aspects, features and embodiments of the present invention.
Embodiment 1:
An external rosmarinus officinalis ointment with the effects of refreshing the brain and restoring consciousness is prepared from the following raw materials in parts by weight: 13 parts of rosmarinus officinalis plant essential oil, 4 parts of lavender essential oil, 80 parts of borneol, 8 parts of liquid paraffin, 8 parts of glycerol and 730 parts of vaseline.
Rosmarinus officinalis natural essential oil is extracted by the following steps:
step 1, weighing stems and leaves, dried in shade, of overground parts of the rosmarinus officinalis as a rosmarinus officinalis raw material, and after crushing, spraying a cellulase water solution onto the rosmarinus officinalis raw material, wherein a mass concentration of the cellulase water solution is 0.15%;
step 2, putting the rosmarinus officinalis raw material treated in the step 1 into a distilling flask, and performing steam distillation for 3 h at a distillation speed of 1 to 2 drops/second to obtain rosmarinus officinalis volatile oil for use; and step 3, extracting the rosmarinus officinalis volatile oil obtained in the step 2 by ethyl acetate with the consumption accounting for 1/3 of the weight of the rosmarinus officinalis volatile oil, collecting upper layer extraction liquid, then adding anhydrous sodium sulfate for drying, performing still standing for 20 h until the anhydrous sodium sulfate is dry and aggregates, performing filtration, collecting filter liquid, and removing a solvent from the filter liquid through reduced pressure distillation under the conditions of a vacuum degree of the reduced pressure distillation being 0.095 MPa and a water bath temperature being 45°C, so as to obtain the rosmarinus officinalis natural essential oil.
The external rosmarinus officinalis ointment with the effects of refreshing the brain and restoring consciousness is prepared through the following steps:
taking the raw materials of the rosmarinus officinalis plant essential oil, the lavender essential oil,
2020100591 17 Apr 2020 the borneol, the liquid paraffin, the glycerol and the vaseline in parts by weight for use; firstly, mixing the vaseline, the liquid paraffin and the glycerol; then, heating the mixture to a molten state; passing the mixture through a 120-mesh copper wire sieve screen for filtration while hot to obtain a mixed solution; next, raising the temperature of the mixed solution to 150°C for 5 sterilization for 1 h; after a sterilized greasing substrate is naturally cooled to 65°C, adding the borneol while stirring; after the borneol is molten, performing natural cooling to 45°C; then, adding the rosmarinus officinalis essential oil and the lavender essential oil while stirring; and performing uniform stirring to obtain the external rosmarinus officinalis ointment with the effects of refreshing the brain and restoring consciousness after cooling.
The rosmarinus officinalis natural essential oil prepared by the present embodiment is subjected to chromatography identification, and an obtained total ion flow chromatogram and an obtained ingredient content table are shown in Fig. 1 and the table as follow, the essential oil content of the rosmarinus officinalis by extraction.
No RT percentage Name CAS Compatibility Molecular formula
1 10.8489 0.0986 4-methyl-3-Penten-2-one 000141-79-7 80 C6H10O
2 13.3342 9.2796 Eucalptol 000470-82-6 98 Ci0H18O
3 14.3918 0.0622 g-Terpinene 000099-85-4 96 C10H16
4 14.8149 0.0665 l-methyl-3-(l-methylethyl)-Benzene 000535-77-3 94 C1()H14
5 16.3308 6.0379 3-methyl-Cyclohexanone 000591-24-2 70 C7H12O
6 17.4883 0.0383 3-Hexen-lol 000544-12-7 93 C6H12O
7 20.0147 0.01072 l-Octen-3-ol 003391-86-4 78 C8Hi6O
8 20.2909 0.101 Bicyclo[2.2.2]oct-5-en-2-one 002220-40-8 64 CsHioO
9 23.3756 0.3221 2,7,7-trimethyl-Bicyclo[3.1.1]hept-2-en-6-one 473-06-3 90 CioH140
10 24.1747 13.6579 (lS)-Bicyclo[2.2.1]heptan-2-one,l,7,7-trimethyl- 000464-48-2 97 CioHi60
11 24.8151 1.2398 3,7-dimethyl-l,6-Octadien-3-ol 000078-70-6 97 Ci„H18O
12 25.1148 0.4827 cis-l-methyl-4-(l-methylethenyl)-Cyclohexanol 7299-41-4 90 CioHisO
13 25.9726 0.6471 Trans-l-methyl-4-(l-methylethenyl)-2-Cyclohexen-l-ol 029803-81-4 91 CioH18Q
14 26.3016 0.3111 5-methyl-2-(l-methylethenyl)- Cyclohexanol 007786-67-6 99 Ci0Hi8O
2020100591 17 Apr 2020
15 26.6306 1.582 Isopulegol 000089-79-2 95 CioHtsO
16 27.6765 0.213 (lS-endo)-l,7,7-trinethyl-Bicyclo[2.2.2.1]heptan-2-ol aceate 005655-61-8 98 C12H20O2
17 27.7176 0.1299 Acetic acid, l,7,7-trinethyl-Bicyclo[2.2.2.1]hept-2-yl ester 092618-89-8 98 C12H20O2
18 27.9762 0.246 Bornyl acetate 000076-49-3 93 C12H20O2
19 28.5402 4.4557 Terpinen-4-ol 000562-74-3 97 Ci0HlsO
20 29.7271 0.5329 Cis-l-methyl-4-(l-methylethyl)-2-Cyclohexen-l-ol 029803-82-5 70 CioH180
21 31.5074 0.1393 Pulegone 000089-82-7 96 CioHisO
22 34.892 18.202 Isobornyl formate 1200-67-5 86 C11H18O2
23 34.9916 2.7578 Endo-Borneol 000507-70-0 95 CioHisO
24 35.7378 24.1208 4,6,6-trimethyl-Bicyclo[3.1.1]hept-3-en-2-one 001196-01-6 98 CioH140
25 36.86 0.1892 3-methyl-6-(l-methylethyl)-2-Cyclohexen-l-one 000089-81-6 95 CioHi60
26 36.9012 0.1661 2-isopropyl-5-methyl-3-Cyclohexen-l-one 89-81-6 97 CioHtsO
27 37.1597 0.1088 (E)-3,7-dimethyl-2,6-Octadienal 000141-27-5 97 CioHisO
28 37.2008 0.1881 Citral 005392-40-5 95 Ck,H16O
29 37.7708 0.3131 cis-3- methyl-6-(l-methylethyl)- 2-Cyclohexen-l-ol 016721-38-3 80 CioH180
30 39.2925 0.9934 (R)-3,7-dimethy-6-Octen-l-ol 001117-61-9 97 C10H20O
31 41.1081 1.499 6,6-dimethyl-Bicyclo[3.1.1]hept-2-ene-2-nethanol 000515-00-4 94 C1(,H16O
32 41.8484 0.0689 (Z)-3,7- dimethyl-2,6- Octadien-l-ol 000106-25-2 96 CioHi8G
33 44.5747 0.2545 cis-2- methyl-5-(l-methylethyl)- 2-Cyclohexen-l-ol 001197-06-4 97 Ck)H16O
34 45.6852 1.5983 Geraniol 000106-24-1 86 CioHisO
35 47.8239 0.0379 Benzyl alcohol 000100-51-6 96 c7h8o
36 50.603 0.0774 Phenylethyl alcohol 000060-12-8 94 C8HioO
37 51.5901 0.2596 2,6,6-trimethyl-2,4-Cycloheptadien-l-one 000503-93-5 87 CioHuO
38 55.5091 0.139 2-Hevenoic acid 013419-69-7 97 C6H10O2
39 57.642 0.3378 Caryophyllene oxide 001139-30-6 87 C15H24O
40 58.5409 0.0718 4-(l-methylethyl)- 1-Cyclohexen-l-methanol 000536-59-4 89 C1(,H16O
41 58.7642 0.1052 Phenol 000108-95-2 93 c6h6o
2020100591 17 Apr 2020
42 59.3341 0.1221 2,6,6-trimethyl-l,3-Cyclohexadiene-l-carboxaldehyde 000116-26-7 86 CioH140
43 59.8159 0.0568 methyleugenol 000093-15-2 97 C11H14O2
44 65.5505 0.104 p-cynen-7-ol 000536-60-7 93 C10H14O
45 69.7574 0.7303 3-Allyl-6-methoxyphenol 000501-19-9 98 cI0h12o2
46 70.1804 0.5888 Thynol 000089-83-8 94 Ck,H14O
47 71.6493 0.1092 2-Methoxy-4-vinylphenol 007786-61-0 95 c9h10o2
48 72.0841 0.315 3-Methoxy-4-isopropylphenol 003228-02-2 97 C10H14O
49 72.6247 0.4763 2-Methoxy-5-(l-methylethyl)-Phenol 000499-75-2 97 C1„H14O
50 74.4285 0.1256 3,7-dimethyl-6-Octenoic acid 000502-47-6 97 CioHisCh
51 75.5448 0.1178 Hexadecanoic acid, nethyl ester 000112-39-0 96 C1?H34O2
52 80.6448 1.5379 Octadecanoic acid 000057-11-4 99 CisH36O2
53 82.055 0.139 3,4-dimethoxy-Benzoic acid nethyl ester 002150-38-1 98 CioHi204
54 82.4369 0.0754 Triethyl citrate 000077-93-0 87 Ci2H2o07
55 83.9939 2.1581 Cis-13-Octadecenoic acid 1000336-66-8 99 c18h34o2
Embodiment 2:
An external rosmarinus officinalis ointment with the effects of refreshing the brain and restoring consciousness is prepared from the following raw materials in parts by weight: 17 parts of rosmarinus officinalis plant essential oil, 5 parts of lavender essential oil, 100 parts of borneol, 11 parts of liquid paraffin, 11 parts of glycerol and 770 parts of vaseline.
Rosmarinus officinalis natural essential oil is extracted by the following steps:
step 1, weighing stems and leaves, dried in shade, of overground parts of the rosmarinus officinalis as a rosmarinus officinalis raw material, and after crushing, spraying a cellulase water solution onto the rosmarinus officinalis raw material, wherein a mass concentration of the cellulase water solution is 0.15%;
step 2, putting the rosmarinus officinalis raw material treated in the step 1 into a distilling flask, and performing steam distillation for 5 h at a distillation speed of 1 to 2 drops/second to obtain rosmarinus officinalis volatile oil for use; and step 3, extracting the rosmarinus officinalis volatile oil obtained in the step 2 by ethyl acetate with the consumption accounting for 1/3 of the weight of the rosmarinus officinalis volatile oil, collecting upper layer extraction liquid, then adding anhydrous sodium sulfate for drying, performing still standing for 16 h until the anhydrous sodium sulfate is dry and aggregates, performing filtration, collecting filter liquid, and removing a solvent from the filter liquid through reduced pressure distillation under the conditions of a vacuum degree of the reduced pressure distillation being 0.092 MPa and a water bath temperature being 50°C, so as to obtain the rosmarinus officinalis natural essential oil.
The external rosmarinus officinalis ointment with the effects of refreshing the brain and restoring consciousness is prepared through the following steps:
taking the raw materials of the rosmarinus officinalis plant essential oil, the lavender essential oil, the borneol, the liquid paraffin, the glycerol and the vaseline in parts by weight for use; firstly, mixing the vaseline, the liquid paraffin and the glycerol; then, heating the mixture to a molten state; passing the mixture through a 120-mesh copper wire sieve screen for filtration while hot to obtain a mixed solution; next, raising the temperature of the mixed solution to 155°C for sterilization for 1 h; after a sterilized greasing substrate is naturally cooled to 60°C, adding the borneol while stirring; after the borneol is molten, performing natural cooling to 50°C; then, adding the rosmarinus officinalis essential oil and the lavender essential oil while stirring; and performing uniform stirring to obtain the external rosmarinus officinalis ointment with the effects of refreshing the brain and restoring consciousness after cooling.
Embodiment 3:
An external rosmarinus officinalis ointment with the effects of refreshing the brain and restoring consciousness is prepared from the following raw materials in parts by weight: 20 parts of rosmarinus officinalis plant essential oil, 6 parts of lavender essential oil, 120 parts of borneol, 14 parts of liquid paraffin, 14 parts of glycerol and 800 parts of vaseline.
Rosmarinus officinalis natural essential oil is extracted by the following steps:
step 1, weighing stems and leaves, dried in shade, of overground parts of the rosmarinus officinalis as a rosmarinus officinalis raw material, and after crushing, spraying a cellulase water solution onto the rosmarinus officinalis raw material, wherein a mass concentration of the cellulase water
2020100591 17 Apr 2020 solution is 0.15%;
step 2, putting the rosmarinus officinalis raw material treated in the step 1 into a distilling flask, and performing steam distillation for 4 h at a distillation speed of 1 to 2 drops/second to obtain 5 rosmarinus officinalis volatile oil for use; and step 3, extracting the rosmarinus officinalis volatile oil obtained in the step 2 by ethyl acetate with the consumption accounting for 1/3 of the weight of the rosmarinus officinalis volatile oil, collecting upper layer extraction liquid, then adding anhydrous sodium sulfate for drying, 10 performing still standing for 12 h until the anhydrous sodium sulfate is dry and aggregates, performing filtration, collecting filter liquid, and removing a solvent from the filter liquid through reduced pressure distillation under the conditions of a vacuum degree of the reduced pressure distillation being 0.090 MPa and a water bath temperature being 52°C, so as to obtain the rosmarinus officinalis natural essential oil.
The external rosmarinus officinalis ointment with the effects of refreshing the brain and restoring consciousness is prepared through the following steps:
taking the raw materials of the rosmarinus officinalis plant essential oil, the lavender essential oil, 20 the borneol, the liquid paraffin, the glycerol and the vaseline in parts by weight for use; firstly, mixing the vaseline, the liquid paraffin and the glycerol; then, heating the mixture to a molten state; passing the mixture through a 120-mesh copper wire sieve screen for filtration while hot to obtain a mixed solution; next, raising the temperature of the mixed solution to 145°C for sterilization for 1 h; after a sterilized greasing substrate is naturally cooled to 62°C, adding the 25 borneol while stirring; after the borneol is molten, performing natural cooling to 48°C; then, adding the rosmarinus officinalis essential oil and the lavender essential oil while stirring; and performing uniform stirring to obtain the external rosmarinus officinalis ointment with the effects of refreshing the brain and restoring consciousness after cooling.
Through identification, 57 kinds of ingredients are identified from transparent liquid obtained after adding cellulase into rosmarinus officinalis leaves in the embodiment of the present invention and performing distillation and dehydration, and are much more than 35 kinds of ingredients reported in literature, wherein in the rosmarinus officinalis essential oil with the effects of refreshing the brain and restoring consciousness, the content of L-camphor is 12.00 to 15.00%, and an 35 antibacterial and anti-inflammatory ingredient marked by thymol and the like accounts for 25.50
2020100591 17 Apr 2020 to 28.50% of the content of essential oil.
Detection indexes of the external ointment prepared by the present invention all reach quality standards, and a melting point of the external ointment reaches the quality standards of 5 premium-grade products (the melting point is 45 to 60°C, and a volatile oil content is higher than or equal to 1.70%).
The foregoing embodiments are only intended to illustrate a preferred mode of the present invention but not to limit the scope of the present invention. Various variations and modifications 10 made to the technical scheme of the present invention by those skilled in the art without departing from the design spirit of the present invention shall fall within the protection scope determined by the claims of the present invention.

Claims (2)

Claims
1. An external rosmarinus officinalis ointment with the effects of refreshing the brain and restoring consciousness, characterized in that the ointment is prepared from the following raw materials in parts by weight:
13 to 20 parts of rosmarinus officinalis plant essential oil, 4 to 6 parts of lavender essential oil, 80 to 120 parts of borneol, 8 to 14 parts of liquid paraffin, 8 to 14 parts of glycerol and 730 to 800 parts of vaseline;
in the rosmarinus officinalis plant essential oil, an antibacterial and anti-inflammatory ingredient accounts for 25.50 to 28.50% of the content of essential oil, and an ingredient with the effects of refreshing the brain and restoring consciousness accounts for 12.00 to 15.00% of the content of the essential oil;
a preparation method of the external rosmarinus officinalis ointment with the effects of refreshing the brain and restoring consciousness comprises the following steps:
taking the following raw materials in parts by weight: 13 to 20 parts of rosmarinus officinalis plant essential oil, 4 to 6 parts of lavender essential oil, 80 to 120 parts of borneol, 8 to 14 parts of liquid paraffin, 8 to 14 parts of glycerol and 730 to 800 parts of vaseline for use; firstly, mixing the vaseline, the liquid paraffin and the glycerol; then, heating the mixture to a molten state; passing the mixture through a 120-mesh copper wire sieve screen for filtration while hot to obtain a mixed solution; next, raising the temperature of the mixed solution to 145 to 155°C for sterilization for 1 h; after a sterilized greasing substrate is naturally cooled to 60 to 65°C, adding the borneol while stirring; after the borneol is molten, performing natural cooling to 45 to 50°C; then, adding the rosmarinus officinalis essential oil and the lavender essential oil while stirring; and performing uniform stirring to obtain the external rosmarinus officinalis ointment with the effects of refreshing the brain and restoring consciousness after cooling;
an extraction method of the rosmarinus officinalis plant essential oil comprises the following steps:
step 1, weighing stems and leaves, dried in shade, of overground parts of the rosmarinus officinalis as a rosmarinus officinalis raw material, and after crushing, spraying a cellulase water solution onto the rosmarinus officinalis raw material;
step 2, putting the rosmarinus officinalis raw material treated in the step 1 into a distilling flask, and performing steam distillation for 3 to 5 h at a distillation speed of 1 to 2 drops/second to obtain rosmarinus officinalis volatile oil for use;
step 3, extracting the rosmarinus officinalis volatile oil obtained in the step 2 by ethyl acetate, collecting upper layer extraction liquid, then adding anhydrous sodium sulfate for drying, performing still standing for 12 to 20 h until the anhydrous sodium sulfate is dry and aggregates, performing filtration, collecting filter liquid, and removing a solvent from the filter liquid through reduced pressure distillation, so as to obtain the rosmarinus officinalis natural essential oil;
a mass concentration of the cellulase water solution in the step 1 is 0.15%; and a vacuum degree of the reduced pressure distillation in the step 3 is 0.090 to 0.095 Mpa, and a water bath temperature is 45 to 52°C.
2. The external rosmarinus officinalis ointment with the effects of refreshing the brain and restoring consciousness according to claim 1, characterized in that in the extraction method of the rosmarinus officinalis natural essential oil, the consumption of the ethyl acetate in the step 3 is 1/3 of the weight of the rosmarinus officinalis volatile oil.
AU2020100591A 2020-04-17 2020-04-17 External Rosmarinus Officinalis Ointment With Effects Of Refreshing Brain And Restoring Consciousness Ceased AU2020100591A4 (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115737713A (en) * 2022-12-28 2023-03-07 安徽工业大学 Atomized essential oil with refreshing function and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115737713A (en) * 2022-12-28 2023-03-07 安徽工业大学 Atomized essential oil with refreshing function and preparation method thereof
CN115737713B (en) * 2022-12-28 2023-11-28 安徽工业大学 Atomized essential oil with refreshing effect and preparation method thereof

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