AU2019341284B2 - Crystalline forms of 6- (1-acryloylpiperidin-4-yl) -2- (4-phenoxyphenyl) nicotinamide - Google Patents

Crystalline forms of 6- (1-acryloylpiperidin-4-yl) -2- (4-phenoxyphenyl) nicotinamide Download PDF

Info

Publication number
AU2019341284B2
AU2019341284B2 AU2019341284A AU2019341284A AU2019341284B2 AU 2019341284 B2 AU2019341284 B2 AU 2019341284B2 AU 2019341284 A AU2019341284 A AU 2019341284A AU 2019341284 A AU2019341284 A AU 2019341284A AU 2019341284 B2 AU2019341284 B2 AU 2019341284B2
Authority
AU
Australia
Prior art keywords
type
xrpd
shows
purity
week
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2019341284A
Other languages
English (en)
Other versions
AU2019341284A1 (en
Inventor
Xiangyang Chen
Zuopeng WANG
Liqin YU
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beijing Innocare Pharma Tech Co Ltd
Original Assignee
Beijing Innocare Pharma Tech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Innocare Pharma Tech Co Ltd filed Critical Beijing Innocare Pharma Tech Co Ltd
Publication of AU2019341284A1 publication Critical patent/AU2019341284A1/en
Application granted granted Critical
Publication of AU2019341284B2 publication Critical patent/AU2019341284B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2019341284A 2018-09-18 2019-09-18 Crystalline forms of 6- (1-acryloylpiperidin-4-yl) -2- (4-phenoxyphenyl) nicotinamide Active AU2019341284B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862732994P 2018-09-18 2018-09-18
US62/732,994 2018-09-18
PCT/CN2019/106433 WO2020057549A1 (en) 2018-09-18 2019-09-18 Crystalline forms of 6- (1-acryloylpiperidin-4-yl) -2- (4-phenoxyphenyl) nicotinamide

Publications (2)

Publication Number Publication Date
AU2019341284A1 AU2019341284A1 (en) 2021-04-15
AU2019341284B2 true AU2019341284B2 (en) 2024-09-05

Family

ID=69888278

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2019341284A Active AU2019341284B2 (en) 2018-09-18 2019-09-18 Crystalline forms of 6- (1-acryloylpiperidin-4-yl) -2- (4-phenoxyphenyl) nicotinamide

Country Status (11)

Country Link
US (1) US11945792B2 (https=)
EP (1) EP3853217B1 (https=)
JP (1) JP2022501351A (https=)
KR (1) KR20210060501A (https=)
CN (2) CN112654607B (https=)
AU (1) AU2019341284B2 (https=)
CA (1) CA3111114A1 (https=)
ES (1) ES2951420T3 (https=)
MX (1) MX2021003064A (https=)
SG (1) SG11202102116XA (https=)
WO (1) WO2020057549A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115894440B (zh) * 2022-10-27 2024-10-22 都创(重庆)医药科技有限公司 奥布替尼化合物的晶型及其制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015048662A2 (en) * 2013-09-30 2015-04-02 X-Rx Discovery, Inc. Substituted nicotinimide inhibitors of btk and their preparation and use in the treatment of cancer, inflammation and autoimmune disease

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015028662A1 (en) 2013-08-30 2015-03-05 Consejo Superior De Investigaciones Cientificas (Csic) Compositions and methods for characterization and amelioration of rheumatoid arthritis
SG11201704808VA (en) * 2014-12-18 2017-07-28 Principia Biopharma Inc Treatment of pemphigus
US20180193274A1 (en) * 2014-12-24 2018-07-12 Principia Biopharma Inc. Compositions for ileo-jejunal drug delivery

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015048662A2 (en) * 2013-09-30 2015-04-02 X-Rx Discovery, Inc. Substituted nicotinimide inhibitors of btk and their preparation and use in the treatment of cancer, inflammation and autoimmune disease

Also Published As

Publication number Publication date
JP2022501351A (ja) 2022-01-06
CN116496247A (zh) 2023-07-28
AU2019341284A1 (en) 2021-04-15
CN112654607B (zh) 2023-01-13
CA3111114A1 (en) 2020-03-26
EP3853217A1 (en) 2021-07-28
WO2020057549A1 (en) 2020-03-26
EP3853217B1 (en) 2023-06-07
US11945792B2 (en) 2024-04-02
CN112654607A (zh) 2021-04-13
KR20210060501A (ko) 2021-05-26
SG11202102116XA (en) 2021-04-29
ES2951420T3 (es) 2023-10-20
US20210188801A1 (en) 2021-06-24
MX2021003064A (es) 2021-05-27
EP3853217A4 (en) 2022-05-04

Similar Documents

Publication Publication Date Title
KR102522895B1 (ko) Jak 키나아제 억제제 바이설페이트의 결정형 및 이의 제조방법
CN109311832B (zh) 沃替西汀的帕莫酸盐及其晶型
US10150770B2 (en) Crystal form of bisulfate of JAK inhibitor and preparation method therefor
US20040229777A1 (en) Crystalline phases of a potent HCV inhibitor
RU2593750C2 (ru) Полиморф рифаксимина и способ его получения
CN103360391B (zh) 阿哌沙班新晶型及其制备方法
TR201816244T4 (tr) Epidermal büyüme faktörü reseptörü kinaz inhibitörü tuzları.
US20130317061A1 (en) Crystalline Salts of a Potent HCV Inhibitor
CN112805065B (zh) 磺酰胺结构的激酶抑制剂的新盐酸盐形式
AU2019341284B2 (en) Crystalline forms of 6- (1-acryloylpiperidin-4-yl) -2- (4-phenoxyphenyl) nicotinamide
CN111393399B (zh) 麦考酚酸的前体药物及其制备方法
RS82504A (sr) Izostrukturni pseudopolimorfi 9-deokso-9a-aza-9a-metil-9a-homoeritromicin a
CN108203449A (zh) 一种新型可逆性质子泵抑制剂及其制备方法和用途
JP2013184902A (ja) リファキシミン含有結晶
CN102762550B (zh) Xa因子抑制剂的盐和结晶形式
HK40048993B (en) Crystalline forms of 6-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl) nicotinamide
HK40048993A (en) Crystalline forms of 6-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl) nicotinamide
HK40096475A (zh) 6-(1-丙烯醯基哌啶-4-基)-2-(4-苯氧基苯基)尼克醯胺的晶型
TWI876245B (zh) (2R, 3S)-2-(3-(4,5-二氯-1H-苯并[d]咪唑-1-基)丙基)哌啶-3-醇的新穎酸加成鹽及晶形
CN106866657A (zh) 一种麦角新碱的制备方法
CN115073489B (zh) 一种噻吩骈吡啶酮类化合物、制备方法及一种抗真菌药物
KR20180124400A (ko) 사쿠비트릴 결합체, 이의 제조방법 및 이를 포함하는 약학 조성물
KR20180124428A (ko) 결정형 사쿠비트릴 헤미나트륨염, 이의 제조방법 및 이를 포함하는 약학 조성물

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)