AU2019301070B2 - Fusion constructs and methods of using thereof - Google Patents

Fusion constructs and methods of using thereof

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Publication number
AU2019301070B2
AU2019301070B2 AU2019301070A AU2019301070A AU2019301070B2 AU 2019301070 B2 AU2019301070 B2 AU 2019301070B2 AU 2019301070 A AU2019301070 A AU 2019301070A AU 2019301070 A AU2019301070 A AU 2019301070A AU 2019301070 B2 AU2019301070 B2 AU 2019301070B2
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Australia
Prior art keywords
seq
fusion protein
sequence
tgf
antibody
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AU2019301070A
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AU2019301070A1 (en
Inventor
ChangHung CHEN
Simon METENOU
Helen SABZEVARI
Rutul R. SHAH
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Precigen Inc
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Precigen Inc
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
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    • C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
    • C12Y305/04004—Adenosine deaminase (3.5.4.4)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/70503—Immunoglobulin superfamily
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10041—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Wood Science & Technology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Hematology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2019301070A 2018-07-09 2019-07-09 Fusion constructs and methods of using thereof Active AU2019301070B2 (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201862695623P 2018-07-09 2018-07-09
US201862695627P 2018-07-09 2018-07-09
US62/695,623 2018-07-09
US62/695,627 2018-07-09
US201962863710P 2019-06-19 2019-06-19
US62/863,710 2019-06-19
US201962864367P 2019-06-20 2019-06-20
US62/864,367 2019-06-20
US201962866420P 2019-06-25 2019-06-25
US62/866,420 2019-06-25
PCT/US2019/041085 WO2020014285A2 (en) 2018-07-09 2019-07-09 Fusion constructs and methods of using thereof

Publications (2)

Publication Number Publication Date
AU2019301070A1 AU2019301070A1 (en) 2021-01-21
AU2019301070B2 true AU2019301070B2 (en) 2025-09-11

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AU2019301070A Active AU2019301070B2 (en) 2018-07-09 2019-07-09 Fusion constructs and methods of using thereof

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US (2) US11535669B2 (enExample)
EP (1) EP3820496A4 (enExample)
JP (2) JP7617839B2 (enExample)
KR (1) KR20210042909A (enExample)
CN (2) CN112672753B (enExample)
AU (1) AU2019301070B2 (enExample)
CA (1) CA3105750A1 (enExample)
IL (1) IL279965A (enExample)
SG (1) SG11202100208VA (enExample)
WO (1) WO2020014285A2 (enExample)
ZA (3) ZA202100390B (enExample)

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CN112672753B (zh) 2018-07-09 2025-07-08 普瑞赛格恩公司 融合构建体及其使用方法
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