AU2019300100B2 - Phenyl-N-quinoline derivatives for treating a RNA virus infection - Google Patents
Phenyl-N-quinoline derivatives for treating a RNA virus infection Download PDFInfo
- Publication number
- AU2019300100B2 AU2019300100B2 AU2019300100A AU2019300100A AU2019300100B2 AU 2019300100 B2 AU2019300100 B2 AU 2019300100B2 AU 2019300100 A AU2019300100 A AU 2019300100A AU 2019300100 A AU2019300100 A AU 2019300100A AU 2019300100 B2 AU2019300100 B2 AU 2019300100B2
- Authority
- AU
- Australia
- Prior art keywords
- group
- alkyl
- cycloalkyl
- atom
- alkyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18305910.4 | 2018-07-09 | ||
| EP18305910.4A EP3594206A1 (en) | 2018-07-09 | 2018-07-09 | Phenyl-n-quinoline derivatives for treating a rna virus infection |
| PCT/EP2019/068459 WO2020011810A1 (en) | 2018-07-09 | 2019-07-09 | Phenyl-n-quinoline derivatives for treating a rna virus infection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2019300100A1 AU2019300100A1 (en) | 2021-01-21 |
| AU2019300100B2 true AU2019300100B2 (en) | 2024-10-24 |
Family
ID=63035966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2019300100A Active AU2019300100B2 (en) | 2018-07-09 | 2019-07-09 | Phenyl-N-quinoline derivatives for treating a RNA virus infection |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US12084422B2 (enExample) |
| EP (2) | EP3594206A1 (enExample) |
| JP (2) | JP7504409B2 (enExample) |
| KR (1) | KR102758510B1 (enExample) |
| CN (1) | CN112566899B (enExample) |
| AU (1) | AU2019300100B2 (enExample) |
| BR (1) | BR112021000331A2 (enExample) |
| CU (1) | CU24674B1 (enExample) |
| MX (1) | MX2021000089A (enExample) |
| WO (1) | WO2020011810A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3594206A1 (en) * | 2018-07-09 | 2020-01-15 | Abivax | Phenyl-n-quinoline derivatives for treating a rna virus infection |
| EP3999493B1 (en) | 2019-07-19 | 2023-12-20 | Abivax | Aryl-n-aryl derivatives for treating a rna virus infection |
| BR112022018793A2 (pt) | 2020-03-20 | 2022-11-29 | Abivax | Uso de um composto de fórmula (i) ou (ii) para tratar ou previnir uma infecção por coronaviridae e condições relacionadas, composição farmacêutica e medicamento compreendendo os mesmos, uso de um mirna como um biomarcador de uma infecção por coronaviridae, e método para avaliar uma infecção por coronaviridae |
| EP3884946A1 (en) | 2020-03-25 | 2021-09-29 | Abivax | Compounds for treating or preventing a coronaviridae infection & methods and uses for assessing the occurrence of a coronaviridae infection |
| EP3881844A1 (en) | 2020-03-20 | 2021-09-22 | Abivax | Compounds for treating or preventing a coronaviridae infection & methods and uses for assessing the occurrence of a coronaviridae infection |
| IL326865A (en) * | 2023-08-30 | 2026-04-01 | Jiangsu Chia Tai Fenghai Pharmaceutical Co Ltd | Compound for regulating activity of microrna-124 |
| CN122514519A (zh) * | 2024-01-11 | 2026-08-04 | 豪夫迈·罗氏有限公司 | 杂芳基苯基醚衍生物 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015001518A1 (en) * | 2013-07-05 | 2015-01-08 | Splicos | Bicyclic compounds useful for treating diseases caused by retroviruses |
| WO2016135053A1 (en) * | 2015-02-23 | 2016-09-01 | Abivax | Methods for screening compounds for treating or preventing a viral infection or a virus-related condition |
| WO2016135055A1 (en) * | 2015-02-23 | 2016-09-01 | Abivax | Quinoline derivatives for use in the treatment or prevention of viral infection |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070244120A1 (en) | 2000-08-18 | 2007-10-18 | Jacques Dumas | Inhibition of raf kinase using substituted heterocyclic ureas |
| US7429599B2 (en) | 2000-12-06 | 2008-09-30 | Signal Pharmaceuticals, Llc | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK |
| FR2830862A1 (fr) | 2001-10-16 | 2003-04-18 | Lipha | Derives nitroso de la diphenylamine a fonction ether ou thioether, compositions pharmaceutiques les contenant et leur utilisation pour la preparation de medicaments |
| FR2836917B1 (fr) | 2002-03-11 | 2006-02-24 | Lipha | Derives nitroso de la diphenylamine, compositions pharmaceutiques les contenant en tant que medicaments utilisables dans le traitement des pathologies caracterisees par une situation de stress oxydatif |
| AP2006003552A0 (en) | 2003-08-21 | 2006-04-30 | Osi Pharm Inc | N3 - substituted imidazopyridine C-kit inhibitors. |
| FR2859474B1 (fr) | 2003-09-04 | 2006-01-13 | Centre Nat Rech Scient | Utilisation de composes derives d'indole pour la preparation d'un medicament utile pour le traitement de maladies genetiques resultant de l'alteration des processus d'epissage |
| ATE435222T1 (de) | 2003-12-18 | 2009-07-15 | Tibotec Pharm Ltd | Aminobenzimidazole und benzimidazole als inhibitoren der replikation von respiratory syncytial virus |
| FR2866647B1 (fr) * | 2004-02-20 | 2006-10-27 | Servier Lab | Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US20060069110A1 (en) | 2004-09-27 | 2006-03-30 | Andersen Denise L | Substituted heterocyclic compounds and methods of use |
| RU2410382C2 (ru) | 2005-03-17 | 2011-01-27 | Тиботек Фармасьютикалз Лтд | 1, 3-дигидробензимидазол-2-илиденовые амины в качестве ингибиторов репликации респираторного синцитиального вируса |
| US9409856B2 (en) | 2005-11-28 | 2016-08-09 | Gtx, Inc. | Estrogen receptor ligands and methods of use thereof |
| WO2007081517A2 (en) | 2005-12-21 | 2007-07-19 | Abbott Laboratories | Anti-viral compounds |
| WO2007076035A2 (en) | 2005-12-21 | 2007-07-05 | Abbott Laboratories | Anti-viral compounds |
| FR2901273B1 (fr) | 2006-05-19 | 2010-12-24 | Anaconda Pharma | Inhibiteurs du virus du papillome humain et les compositions pharmaceutiques les contenant |
| FR2926297B1 (fr) | 2008-01-10 | 2013-03-08 | Centre Nat Rech Scient | Molecules chimiques inhibitrices du mecanisme d'epissage pour traiter des maladies resultant d'anomalies d'epissage. |
| US20140187641A1 (en) | 2012-08-23 | 2014-07-03 | Gtx | Estrogen receptor ligands and methods of use thereof |
| CN102625804B (zh) | 2009-06-12 | 2015-04-08 | Abivax公司 | 用于治疗aids的化合物 |
| JP2011026251A (ja) | 2009-07-27 | 2011-02-10 | Kowa Co | ２−アリールアミノキノリン化合物及びこれを有効成分として含有するエリスロポエチン産生促進剤 |
| AU2011270994B2 (en) | 2010-06-24 | 2015-12-10 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compounds as phosphodiesterases (PDES) inhibitors |
| EP2465502A1 (en) * | 2010-12-15 | 2012-06-20 | Société Splicos | Compounds useful for treating AIDS |
| EP2505198A1 (en) | 2011-04-01 | 2012-10-03 | Société Splicos | Compounds for use as therapeutic agents affecting p53 expression and/or activity |
| WO2014164667A1 (en) | 2013-03-11 | 2014-10-09 | Georgetown University | Dengue and west nile virus protease inhibitors |
| RU2628800C2 (ru) | 2014-03-12 | 2017-08-22 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Амидные соединения, способы получения, применение в качестве средств для лечения и профилактики заболеваний, вызываемых рнк-содержащими вирусами |
| WO2016086153A2 (en) | 2014-11-26 | 2016-06-02 | Esanex, Inc. | Use of tetrahydro!ndazolylbeimzamide and tetrahydroindolylbenzamide derivatives for the treatment of human immunodeficiency virus (hiv) and acquired immune deficiency syndrome (aids) |
| WO2017158201A1 (en) | 2016-03-18 | 2017-09-21 | Ratiopharm Gmbh | Process for preparing quinolin-2-yl-phenylamine derivatives and their salts |
| EP3594206A1 (en) * | 2018-07-09 | 2020-01-15 | Abivax | Phenyl-n-quinoline derivatives for treating a rna virus infection |
-
2018
- 2018-07-09 EP EP18305910.4A patent/EP3594206A1/en not_active Ceased
-
2019
- 2019-07-09 CN CN201980045917.4A patent/CN112566899B/zh active Active
- 2019-07-09 JP JP2021500215A patent/JP7504409B2/ja active Active
- 2019-07-09 BR BR112021000331-2A patent/BR112021000331A2/pt active Search and Examination
- 2019-07-09 EP EP19737536.3A patent/EP3820852A1/en active Pending
- 2019-07-09 WO PCT/EP2019/068459 patent/WO2020011810A1/en not_active Ceased
- 2019-07-09 KR KR1020217001298A patent/KR102758510B1/ko active Active
- 2019-07-09 CU CU2021000006A patent/CU24674B1/es unknown
- 2019-07-09 AU AU2019300100A patent/AU2019300100B2/en active Active
- 2019-07-09 MX MX2021000089A patent/MX2021000089A/es unknown
- 2019-07-09 US US17/259,364 patent/US12084422B2/en active Active
-
2023
- 2023-10-17 JP JP2023179000A patent/JP7673362B2/ja active Active
-
2024
- 2024-05-10 US US18/660,578 patent/US12479802B2/en active Active
-
2025
- 2025-10-15 US US19/359,300 patent/US20260035348A1/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015001518A1 (en) * | 2013-07-05 | 2015-01-08 | Splicos | Bicyclic compounds useful for treating diseases caused by retroviruses |
| WO2016135053A1 (en) * | 2015-02-23 | 2016-09-01 | Abivax | Methods for screening compounds for treating or preventing a viral infection or a virus-related condition |
| WO2016135055A1 (en) * | 2015-02-23 | 2016-09-01 | Abivax | Quinoline derivatives for use in the treatment or prevention of viral infection |
Also Published As
| Publication number | Publication date |
|---|---|
| CN112566899A (zh) | 2021-03-26 |
| EP3594206A1 (en) | 2020-01-15 |
| CA3103867A1 (en) | 2020-01-16 |
| KR102758510B1 (ko) | 2025-01-22 |
| JP2024053563A (ja) | 2024-04-15 |
| WO2020011810A1 (en) | 2020-01-16 |
| JP7504409B2 (ja) | 2024-06-24 |
| US12084422B2 (en) | 2024-09-10 |
| JP7673362B2 (ja) | 2025-05-09 |
| CU24674B1 (es) | 2023-08-08 |
| EP3820852A1 (en) | 2021-05-19 |
| US12479802B2 (en) | 2025-11-25 |
| US20210309611A1 (en) | 2021-10-07 |
| AU2019300100A1 (en) | 2021-01-21 |
| US20260035348A1 (en) | 2026-02-05 |
| CN112566899B (zh) | 2024-01-30 |
| JP2021524481A (ja) | 2021-09-13 |
| BR112021000331A2 (pt) | 2021-04-06 |
| CU20210006A7 (es) | 2021-08-06 |
| KR20210052432A (ko) | 2021-05-10 |
| MX2021000089A (es) | 2021-03-25 |
| US20240308964A1 (en) | 2024-09-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) |