AU2019227770B2 - Methyllactam ring compound and medicinal use thereof - Google Patents

Methyllactam ring compound and medicinal use thereof Download PDF

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Publication number
AU2019227770B2
AU2019227770B2 AU2019227770A AU2019227770A AU2019227770B2 AU 2019227770 B2 AU2019227770 B2 AU 2019227770B2 AU 2019227770 A AU2019227770 A AU 2019227770A AU 2019227770 A AU2019227770 A AU 2019227770A AU 2019227770 B2 AU2019227770 B2 AU 2019227770B2
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AU
Australia
Prior art keywords
compound
acid
formula
reaction mixture
salt
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AU2019227770A
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AU2019227770A1 (en
Inventor
Tomoya Miura
Yoshinori TAMATANI
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Shionogi and Co Ltd
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Shionogi and Co Ltd
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Assigned to SHIONOGI & CO., LTD. reassignment SHIONOGI & CO., LTD. Request to Amend Deed and Register Assignors: JAPAN TOBACCO INC.
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2019227770A 2018-03-01 2019-02-28 Methyllactam ring compound and medicinal use thereof Active AU2019227770B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2018036307 2018-03-01
JP2018-036307 2018-03-01
PCT/JP2019/007799 WO2019168096A1 (ja) 2018-03-01 2019-02-28 メチルラクタム環化合物及びその医薬用途

Publications (2)

Publication Number Publication Date
AU2019227770A1 AU2019227770A1 (en) 2020-07-09
AU2019227770B2 true AU2019227770B2 (en) 2023-10-05

Family

ID=67806229

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2019227770A Active AU2019227770B2 (en) 2018-03-01 2019-02-28 Methyllactam ring compound and medicinal use thereof

Country Status (21)

Country Link
US (3) US11014910B2 (https=)
EP (1) EP3760624A4 (https=)
JP (3) JP7206132B2 (https=)
KR (1) KR102795351B1 (https=)
CN (1) CN111757877B (https=)
AR (1) AR114418A1 (https=)
AU (1) AU2019227770B2 (https=)
BR (1) BR112020016788A2 (https=)
CA (1) CA3087859A1 (https=)
CL (1) CL2020002199A1 (https=)
IL (1) IL276311B2 (https=)
MA (1) MA52427A (https=)
MX (1) MX2020009070A (https=)
MY (1) MY205197A (https=)
PE (1) PE20210123A1 (https=)
PH (1) PH12020551340A1 (https=)
SA (1) SA520420037B1 (https=)
SG (1) SG11202007120UA (https=)
TW (1) TWI805699B (https=)
WO (1) WO2019168096A1 (https=)
ZA (1) ZA202004600B (https=)

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* Cited by examiner, † Cited by third party
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TWI805699B (zh) * 2018-03-01 2023-06-21 日商日本煙草產業股份有限公司 甲基內醯胺環化合物及其用途
EP3778593A4 (en) 2018-04-04 2021-12-22 Japan Tobacco Inc. HETEROARYL-SUBSTITUTED PYRAZOLE COMPOUND AND ITS MEDICAL USE
JP7760370B2 (ja) * 2019-09-04 2025-10-27 日本たばこ産業株式会社 慢性腎臓病の治療又は予防方法
US20230119894A1 (en) * 2019-09-04 2023-04-20 Japan Tobacco Inc. Therapeutic or prophylactic method for diabetes using combination medicine
CA3175131A1 (en) 2020-03-19 2021-09-23 Chihiro Okuma Treatment or prevention method for chronic heart failure

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JP2007332034A (ja) * 2005-06-08 2007-12-27 Japan Tobacco Inc 複素環化合物
WO2013031922A1 (ja) * 2011-08-31 2013-03-07 日本たばこ産業株式会社 ピラゾール化合物及びその医薬用途

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FR2665898B1 (fr) 1990-08-20 1994-03-11 Sanofi Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
JPH04247081A (ja) 1991-02-01 1992-09-03 Takeda Chem Ind Ltd ５員複素環酸アミド類
FR2692575B1 (fr) 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
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JP2006182648A (ja) 2003-04-08 2006-07-13 Dai Ichi Seiyaku Co Ltd ７員複素環誘導体
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KR101450356B1 (ko) 2006-11-24 2014-10-15 에이씨 이뮨 에스.에이. 알츠하이머와 같은 아밀로이드 또는 아밀로이드-유사 단백질과 관련된 질환의 치료를 위한 ｎ-(메틸)-1ｈ-피라졸-3-아민, ｎ-(메틸)-피리딘-2-아민 및 ｎ-(메틸)-티아졸-2-아민 유도체
EP2121619A2 (en) 2006-11-24 2009-11-25 AC Immune S.A. Compounds for the treatment of diseases associated with amyloid or amyloid-like proteins
TW200901974A (en) 2007-01-16 2009-01-16 Wyeth Corp Compounds, compositions, and methods of making and using them
JP5583003B2 (ja) * 2007-04-02 2014-09-03 セラコス・インコーポレイテッド ベンジルグルコシド誘導体およびその用途
WO2009091813A1 (en) 2008-01-14 2009-07-23 Wyeth Compounds useful as alpha7 nicotinic acetylcholine receptor agonists
EP2349484A2 (en) 2008-07-15 2011-08-03 Novartis AG Heteroaryl derivatives as dgat1 inhibitors
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KR102727059B1 (ko) * 2015-02-16 2024-11-05 더 유니버서티 어브 퀸슬랜드 설포닐우레아와 관련 화합물 및 그 용도
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TWI805699B (zh) * 2018-03-01 2023-06-21 日商日本煙草產業股份有限公司 甲基內醯胺環化合物及其用途
EP3778593A4 (en) 2018-04-04 2021-12-22 Japan Tobacco Inc. HETEROARYL-SUBSTITUTED PYRAZOLE COMPOUND AND ITS MEDICAL USE

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* Cited by examiner, † Cited by third party
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JP2007332034A (ja) * 2005-06-08 2007-12-27 Japan Tobacco Inc 複素環化合物
WO2007034279A2 (en) * 2005-09-19 2007-03-29 Pfizer Products Inc. C3a antagonists and pharmaceutical compositions thereof
WO2013031922A1 (ja) * 2011-08-31 2013-03-07 日本たばこ産業株式会社 ピラゾール化合物及びその医薬用途
EP2784074A1 (en) * 2011-08-31 2014-10-01 Japan Tobacco, Inc. Pyrazole compound and use thereof for medical purposes

Also Published As

Publication number Publication date
CL2020002199A1 (es) 2020-12-18
JP2023026566A (ja) 2023-02-24
MA52427A (fr) 2021-01-06
SA520420037B1 (ar) 2024-07-28
TWI805699B (zh) 2023-06-21
CN111757877A (zh) 2020-10-09
EP3760624A4 (en) 2021-11-03
PH12020551340A1 (en) 2021-05-31
US20190352284A1 (en) 2019-11-21
WO2019168096A1 (ja) 2019-09-06
MY205197A (en) 2024-10-07
US11014910B2 (en) 2021-05-25
CA3087859A1 (en) 2019-09-06
AU2019227770A1 (en) 2020-07-09
RU2020131756A (ru) 2022-03-28
TW202000660A (zh) 2020-01-01
BR112020016788A2 (pt) 2021-01-12
AR114418A1 (es) 2020-09-02
ZA202004600B (en) 2022-03-30
JP2019151627A (ja) 2019-09-12
IL276311A (en) 2020-09-30
JP2025026615A (ja) 2025-02-21
MX2020009070A (es) 2020-10-08
KR102795351B1 (ko) 2025-04-16
IL276311B2 (en) 2023-10-01
IL276311B1 (en) 2023-06-01
US20240174646A1 (en) 2024-05-30
EP3760624A1 (en) 2021-01-06
CN111757877B (zh) 2023-10-27
JP7206132B2 (ja) 2023-01-17
SG11202007120UA (en) 2020-08-28
KR20200128033A (ko) 2020-11-11
PE20210123A1 (es) 2021-01-19
US20220064148A1 (en) 2022-03-03

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Owner name: SHIONOGI & CO., LTD.

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