AU2019225446B2 - Anti-lambda myeloma antigen (LMA) binding proteins to treat LMA-expressing cancer and autoimmune disorders - Google Patents

Anti-lambda myeloma antigen (LMA) binding proteins to treat LMA-expressing cancer and autoimmune disorders Download PDF

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Publication number
AU2019225446B2
AU2019225446B2 AU2019225446A AU2019225446A AU2019225446B2 AU 2019225446 B2 AU2019225446 B2 AU 2019225446B2 AU 2019225446 A AU2019225446 A AU 2019225446A AU 2019225446 A AU2019225446 A AU 2019225446A AU 2019225446 B2 AU2019225446 B2 AU 2019225446B2
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seq
ser
leu
lma
amino acid
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AU2019225446A1 (en
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Rosanne Dunn
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Haemalogix Pty Ltd
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Haemalogix Pty Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2019225446A 2018-02-20 2019-02-20 Anti-lambda myeloma antigen (LMA) binding proteins to treat LMA-expressing cancer and autoimmune disorders Active AU2019225446B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2021202092A AU2021202092A1 (en) 2018-02-20 2021-04-06 Anti-lambda myeloma antigen (LMA) binding proteins to treat LMA-expressing cancer and autoimmune disorders

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2018900534A AU2018900534A0 (en) 2018-02-20 Composition and method
AU2018900534 2018-02-20
PCT/AU2019/050137 WO2019161443A1 (en) 2018-02-20 2019-02-20 Anti-lambda myeloma antigen (lma) binding proteins to treat lma-expressing cancer and autoimmune disorders

Related Child Applications (1)

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AU2021202092A Division AU2021202092A1 (en) 2018-02-20 2021-04-06 Anti-lambda myeloma antigen (LMA) binding proteins to treat LMA-expressing cancer and autoimmune disorders

Publications (2)

Publication Number Publication Date
AU2019225446A1 AU2019225446A1 (en) 2020-10-08
AU2019225446B2 true AU2019225446B2 (en) 2021-01-07

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AU2019225446A Active AU2019225446B2 (en) 2018-02-20 2019-02-20 Anti-lambda myeloma antigen (LMA) binding proteins to treat LMA-expressing cancer and autoimmune disorders
AU2021202092A Abandoned AU2021202092A1 (en) 2018-02-20 2021-04-06 Anti-lambda myeloma antigen (LMA) binding proteins to treat LMA-expressing cancer and autoimmune disorders

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AU2021202092A Abandoned AU2021202092A1 (en) 2018-02-20 2021-04-06 Anti-lambda myeloma antigen (LMA) binding proteins to treat LMA-expressing cancer and autoimmune disorders

Country Status (10)

Country Link
US (2) US11447571B2 (https=)
EP (1) EP3755724A4 (https=)
JP (2) JP7490559B2 (https=)
KR (1) KR102824611B1 (https=)
CN (1) CN111918879B (https=)
AU (2) AU2019225446B2 (https=)
BR (1) BR112020017018A2 (https=)
CA (1) CA3091711A1 (https=)
SG (1) SG11202007925SA (https=)
WO (1) WO2019161443A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20250326864A1 (en) * 2022-06-13 2025-10-23 Paradox Immunotherapeutics Inc. Monoclonal antibodies targeting conformation-specific epitopes of immunoglobulin light chains of the lambda subclass
WO2025236034A1 (en) * 2024-05-13 2025-11-20 HaemaLogiX Ltd Anti-lma binding proteins

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005082409A1 (en) * 2004-02-27 2005-09-09 Pacmab Limited Target for b-cell disorders
WO2010088388A1 (en) * 2009-01-29 2010-08-05 Sortwell & Co. Method for dispersing and aggregating components of mineral slurries
WO2010115238A1 (en) * 2009-04-07 2010-10-14 Immune System Therapeutics Ltd Method for treating immune disorders
WO2013132245A1 (en) * 2012-03-06 2013-09-12 The Binding Site Group Limited Method for characterising plasma cell associated diseases

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005082409A1 (en) * 2004-02-27 2005-09-09 Pacmab Limited Target for b-cell disorders
WO2010088388A1 (en) * 2009-01-29 2010-08-05 Sortwell & Co. Method for dispersing and aggregating components of mineral slurries
WO2010115238A1 (en) * 2009-04-07 2010-10-14 Immune System Therapeutics Ltd Method for treating immune disorders
WO2013132245A1 (en) * 2012-03-06 2013-09-12 The Binding Site Group Limited Method for characterising plasma cell associated diseases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ASVADI, P. et al., "IDENTIFICATION AND CHARACTERISATION OF LAMBDA MYELOMA ANTIGEN, LMA, AS A THERAPEUTIC TARGET IN LAMBDA MULTIPLE MYELOMA", HAEMATOLOGICA, vol. 98, no. 1, page 316 *

Also Published As

Publication number Publication date
CA3091711A1 (en) 2019-08-29
EP3755724A1 (en) 2020-12-30
JP2021514369A (ja) 2021-06-10
CN111918879A (zh) 2020-11-10
US20230174675A1 (en) 2023-06-08
JP2024100838A (ja) 2024-07-26
CN111918879B (zh) 2024-10-15
JP7798956B2 (ja) 2026-01-14
SG11202007925SA (en) 2020-09-29
US12435158B2 (en) 2025-10-07
US20210230309A1 (en) 2021-07-29
WO2019161443A1 (en) 2019-08-29
EP3755724A4 (en) 2022-03-23
BR112020017018A2 (pt) 2020-12-29
AU2021202092A1 (en) 2021-04-29
AU2019225446A1 (en) 2020-10-08
KR102824611B1 (ko) 2025-06-24
US11447571B2 (en) 2022-09-20
KR20210005553A (ko) 2021-01-14
JP7490559B2 (ja) 2024-05-27

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