CA3091711A1 - Anti-lambda myeloma antigen (lma) binding proteins to treat lma-expressing cancer and autoimmune disorders - Google Patents
Anti-lambda myeloma antigen (lma) binding proteins to treat lma-expressing cancer and autoimmune disorders Download PDFInfo
- Publication number
- CA3091711A1 CA3091711A1 CA3091711A CA3091711A CA3091711A1 CA 3091711 A1 CA3091711 A1 CA 3091711A1 CA 3091711 A CA3091711 A CA 3091711A CA 3091711 A CA3091711 A CA 3091711A CA 3091711 A1 CA3091711 A1 CA 3091711A1
- Authority
- CA
- Canada
- Prior art keywords
- seq
- binding protein
- lma
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3061—Blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2018900534A AU2018900534A0 (en) | 2018-02-20 | Composition and method | |
| AU2018900534 | 2018-02-20 | ||
| PCT/AU2019/050137 WO2019161443A1 (en) | 2018-02-20 | 2019-02-20 | Anti-lambda myeloma antigen (lma) binding proteins to treat lma-expressing cancer and autoimmune disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3091711A1 true CA3091711A1 (en) | 2019-08-29 |
Family
ID=67686653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3091711A Pending CA3091711A1 (en) | 2018-02-20 | 2019-02-20 | Anti-lambda myeloma antigen (lma) binding proteins to treat lma-expressing cancer and autoimmune disorders |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11447571B2 (https=) |
| EP (1) | EP3755724A4 (https=) |
| JP (2) | JP7490559B2 (https=) |
| KR (1) | KR102824611B1 (https=) |
| CN (1) | CN111918879B (https=) |
| AU (2) | AU2019225446B2 (https=) |
| BR (1) | BR112020017018A2 (https=) |
| CA (1) | CA3091711A1 (https=) |
| SG (1) | SG11202007925SA (https=) |
| WO (1) | WO2019161443A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20250326864A1 (en) * | 2022-06-13 | 2025-10-23 | Paradox Immunotherapeutics Inc. | Monoclonal antibodies targeting conformation-specific epitopes of immunoglobulin light chains of the lambda subclass |
| WO2025236034A1 (en) * | 2024-05-13 | 2025-11-20 | HaemaLogiX Ltd | Anti-lma binding proteins |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ548921A (en) | 2004-02-27 | 2008-09-26 | Immune System Therapeutics Ltd | Target for B-cell disorders |
| US20100187181A1 (en) * | 2009-01-29 | 2010-07-29 | Sortwell Edwin T | Method for Dispersing and Aggregating Components of Mineral Slurries |
| WO2010115238A1 (en) * | 2009-04-07 | 2010-10-14 | Immune System Therapeutics Ltd | Method for treating immune disorders |
| GB201203938D0 (en) * | 2012-03-06 | 2012-04-18 | Binding Site Group The Ltd | Assay system |
-
2019
- 2019-02-20 BR BR112020017018-6A patent/BR112020017018A2/pt unknown
- 2019-02-20 CN CN201980012636.9A patent/CN111918879B/zh active Active
- 2019-02-20 EP EP19758107.7A patent/EP3755724A4/en active Pending
- 2019-02-20 US US16/970,991 patent/US11447571B2/en active Active
- 2019-02-20 SG SG11202007925SA patent/SG11202007925SA/en unknown
- 2019-02-20 KR KR1020207027033A patent/KR102824611B1/ko active Active
- 2019-02-20 WO PCT/AU2019/050137 patent/WO2019161443A1/en not_active Ceased
- 2019-02-20 CA CA3091711A patent/CA3091711A1/en active Pending
- 2019-02-20 AU AU2019225446A patent/AU2019225446B2/en active Active
- 2019-02-20 JP JP2020544005A patent/JP7490559B2/ja active Active
-
2021
- 2021-04-06 AU AU2021202092A patent/AU2021202092A1/en not_active Abandoned
-
2022
- 2022-08-12 US US17/819,483 patent/US12435158B2/en active Active
-
2024
- 2024-05-15 JP JP2024079382A patent/JP7798956B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3755724A1 (en) | 2020-12-30 |
| JP2021514369A (ja) | 2021-06-10 |
| CN111918879A (zh) | 2020-11-10 |
| US20230174675A1 (en) | 2023-06-08 |
| JP2024100838A (ja) | 2024-07-26 |
| CN111918879B (zh) | 2024-10-15 |
| JP7798956B2 (ja) | 2026-01-14 |
| SG11202007925SA (en) | 2020-09-29 |
| US12435158B2 (en) | 2025-10-07 |
| US20210230309A1 (en) | 2021-07-29 |
| WO2019161443A1 (en) | 2019-08-29 |
| EP3755724A4 (en) | 2022-03-23 |
| BR112020017018A2 (pt) | 2020-12-29 |
| AU2021202092A1 (en) | 2021-04-29 |
| AU2019225446A1 (en) | 2020-10-08 |
| KR102824611B1 (ko) | 2025-06-24 |
| US11447571B2 (en) | 2022-09-20 |
| KR20210005553A (ko) | 2021-01-14 |
| JP7490559B2 (ja) | 2024-05-27 |
| AU2019225446B2 (en) | 2021-01-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20231211 |
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| MFA | Maintenance fee for application paid |
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| U00 | Fee paid |
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| U11 | Full renewal or maintenance fee paid |
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| D15 | Examination report completed |
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| MFA | Maintenance fee for application paid |
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| U00 | Fee paid |
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| P11 | Amendment of application requested |
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| P13 | Application amended |
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