AU2019207457B2 - C3b binding polypeptide - Google Patents

C3b binding polypeptide Download PDF

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Publication number
AU2019207457B2
AU2019207457B2 AU2019207457A AU2019207457A AU2019207457B2 AU 2019207457 B2 AU2019207457 B2 AU 2019207457B2 AU 2019207457 A AU2019207457 A AU 2019207457A AU 2019207457 A AU2019207457 A AU 2019207457A AU 2019207457 B2 AU2019207457 B2 AU 2019207457B2
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ser
gly
ile
thr
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AU2019207457A1 (en
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Paul Bishop
Simon Clark
Richard Unwin
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Complement Therapeutics Ltd
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Complement Therapeutics Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2019207457A 2018-01-15 2019-01-15 C3b binding polypeptide Active AU2019207457B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2024203142A AU2024203142B2 (en) 2018-01-15 2024-05-13 C3b binding polypeptide

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1800620.5 2018-01-15
GBGB1800620.5A GB201800620D0 (en) 2018-01-15 2018-01-15 C3b Binding Polypeptide
PCT/EP2019/050949 WO2019138137A1 (en) 2018-01-15 2019-01-15 C3b binding polypeptide

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2024203142A Division AU2024203142B2 (en) 2018-01-15 2024-05-13 C3b binding polypeptide

Publications (2)

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AU2019207457A1 AU2019207457A1 (en) 2020-08-27
AU2019207457B2 true AU2019207457B2 (en) 2024-02-15

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AU2019207457A Active AU2019207457B2 (en) 2018-01-15 2019-01-15 C3b binding polypeptide
AU2024203142A Active AU2024203142B2 (en) 2018-01-15 2024-05-13 C3b binding polypeptide

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AU2024203142A Active AU2024203142B2 (en) 2018-01-15 2024-05-13 C3b binding polypeptide

Country Status (8)

Country Link
US (3) US11524050B2 (https=)
EP (2) EP3740498A1 (https=)
JP (2) JP7505980B2 (https=)
CN (2) CN111788219A (https=)
AU (2) AU2019207457B2 (https=)
CA (1) CA3088476A1 (https=)
GB (1) GB201800620D0 (https=)
WO (1) WO2019138137A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201800620D0 (en) 2018-01-15 2018-02-28 Univ Manchester C3b Binding Polypeptide
GB201821082D0 (en) * 2018-12-21 2019-02-06 Gyroscope Therapeutics Ltd Combination of complement factors i and h, and vector encoding thereof
EP4048318A4 (en) * 2019-10-23 2023-11-22 Gemini Therapeutics Sub, Inc. METHOD FOR TREATING PATIENTS WITH CFH MUTATIONS USING RECOMBINANT CFH PROTEINS
GB202006789D0 (en) 2020-05-07 2020-06-24 Univ Manchester Detection of complement proteins
WO2022058447A1 (en) 2020-09-16 2022-03-24 The University Of Manchester Complementome assay
GB202107586D0 (en) 2021-05-27 2021-07-14 Complement Therapeutics Ltd Inhibitory nucleic acids for Factor H family proteins
GB202203627D0 (en) 2022-03-16 2022-04-27 Univ Manchester Agents for treating complement-related disorders
AU2024206379A1 (en) 2023-01-05 2025-07-24 Complement Therapeutics Limited Agents and methods for treating complement diseases

Citations (4)

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WO2018002131A1 (en) * 2016-06-28 2018-01-04 Universität Ulm Complement inhibitors and uses thereof
WO2018224663A1 (en) * 2017-06-09 2018-12-13 The University Of Manchester C3b inactivating polypeptide

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Publication number Publication date
AU2024203142B2 (en) 2026-02-05
US20230321184A1 (en) 2023-10-12
WO2019138137A1 (en) 2019-07-18
AU2019207457A1 (en) 2020-08-27
JP2024123077A (ja) 2024-09-10
US12383600B2 (en) 2025-08-12
EP4512822A2 (en) 2025-02-26
US20230310545A1 (en) 2023-10-05
CN119120483A (zh) 2024-12-13
US12544423B2 (en) 2026-02-10
US20210145933A1 (en) 2021-05-20
EP3740498A1 (en) 2020-11-25
AU2024203142A1 (en) 2024-06-06
JP2021511030A (ja) 2021-05-06
EP4512822A3 (en) 2025-04-30
US11524050B2 (en) 2022-12-13
JP7505980B2 (ja) 2024-06-25
GB201800620D0 (en) 2018-02-28
CN111788219A (zh) 2020-10-16
CA3088476A1 (en) 2019-07-18

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