AU2019100136B4 - Hydrogen-based compositions - Google Patents
Hydrogen-based compositions Download PDFInfo
- Publication number
- AU2019100136B4 AU2019100136B4 AU2019100136A AU2019100136A AU2019100136B4 AU 2019100136 B4 AU2019100136 B4 AU 2019100136B4 AU 2019100136 A AU2019100136 A AU 2019100136A AU 2019100136 A AU2019100136 A AU 2019100136A AU 2019100136 B4 AU2019100136 B4 AU 2019100136B4
- Authority
- AU
- Australia
- Prior art keywords
- gas
- carbon dioxide
- hydrogen
- composition
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 102
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 title claims abstract description 65
- 239000001257 hydrogen Substances 0.000 title abstract description 33
- 229910052739 hydrogen Inorganic materials 0.000 title abstract description 33
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims abstract description 128
- 239000007789 gas Substances 0.000 claims abstract description 79
- 229910002092 carbon dioxide Inorganic materials 0.000 claims abstract description 64
- 239000001569 carbon dioxide Substances 0.000 claims abstract description 50
- 235000013361 beverage Nutrition 0.000 claims abstract description 19
- 239000003125 aqueous solvent Substances 0.000 claims abstract description 14
- 230000036542 oxidative stress Effects 0.000 claims description 8
- 241000124008 Mammalia Species 0.000 claims description 7
- 210000004027 cell Anatomy 0.000 claims description 5
- 210000003463 organelle Anatomy 0.000 claims description 3
- 210000001519 tissue Anatomy 0.000 claims description 3
- 230000037406 food intake Effects 0.000 claims description 2
- 210000000056 organ Anatomy 0.000 claims description 2
- 241001465754 Metazoa Species 0.000 abstract description 11
- 230000008901 benefit Effects 0.000 abstract description 9
- 239000003814 drug Substances 0.000 abstract description 9
- 230000007407 health benefit Effects 0.000 abstract description 5
- 230000000699 topical effect Effects 0.000 abstract description 5
- 238000001802 infusion Methods 0.000 abstract description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 38
- 210000003491 skin Anatomy 0.000 description 25
- 238000000034 method Methods 0.000 description 15
- 102000012004 Ghrelin Human genes 0.000 description 13
- 101800001586 Ghrelin Proteins 0.000 description 13
- GNKDKYIHGQKHHM-RJKLHVOGSA-N ghrelin Chemical compound C([C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CN)COC(=O)CCCCCCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C1=CC=CC=C1 GNKDKYIHGQKHHM-RJKLHVOGSA-N 0.000 description 13
- 239000007788 liquid Substances 0.000 description 12
- 150000003839 salts Chemical class 0.000 description 12
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 10
- 239000000546 pharmaceutical excipient Substances 0.000 description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 8
- 150000003254 radicals Chemical class 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 239000002253 acid Substances 0.000 description 6
- 238000009472 formulation Methods 0.000 description 6
- 208000035475 disorder Diseases 0.000 description 5
- 235000000346 sugar Nutrition 0.000 description 5
- 239000008399 tap water Substances 0.000 description 5
- 235000020679 tap water Nutrition 0.000 description 5
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 4
- 230000004071 biological effect Effects 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 238000005868 electrolysis reaction Methods 0.000 description 4
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 4
- -1 manganese, aluminum salts Chemical class 0.000 description 4
- 210000003205 muscle Anatomy 0.000 description 4
- 230000003647 oxidation Effects 0.000 description 4
- 238000007254 oxidation reaction Methods 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 239000003642 reactive oxygen metabolite Substances 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 241000894007 species Species 0.000 description 4
- 239000004094 surface-active agent Substances 0.000 description 4
- BFSVOASYOCHEOV-UHFFFAOYSA-N 2-diethylaminoethanol Chemical compound CCN(CC)CCO BFSVOASYOCHEOV-UHFFFAOYSA-N 0.000 description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 3
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 3
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 3
- 241000282412 Homo Species 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 3
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 3
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 3
- 230000003078 antioxidant effect Effects 0.000 description 3
- 235000006708 antioxidants Nutrition 0.000 description 3
- 230000003796 beauty Effects 0.000 description 3
- YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 description 3
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 description 3
- 239000003085 diluting agent Substances 0.000 description 3
- MSJMDZAOKORVFC-SEPHDYHBSA-L disodium fumarate Chemical compound [Na+].[Na+].[O-]C(=O)\C=C\C([O-])=O MSJMDZAOKORVFC-SEPHDYHBSA-L 0.000 description 3
- HHLFWLYXYJOTON-UHFFFAOYSA-N glyoxylic acid Chemical compound OC(=O)C=O HHLFWLYXYJOTON-UHFFFAOYSA-N 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 230000001965 increasing effect Effects 0.000 description 3
- 229910052500 inorganic mineral Inorganic materials 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 235000010755 mineral Nutrition 0.000 description 3
- 239000011707 mineral Substances 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 229920001610 polycaprolactone Polymers 0.000 description 3
- KYKNRZGSIGMXFH-ZVGUSBNCSA-M potassium bitartrate Chemical compound [K+].OC(=O)[C@H](O)[C@@H](O)C([O-])=O KYKNRZGSIGMXFH-ZVGUSBNCSA-M 0.000 description 3
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 3
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 3
- LWIHDJKSTIGBAC-UHFFFAOYSA-K potassium phosphate Substances [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 239000001488 sodium phosphate Substances 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 208000011580 syndromic disease Diseases 0.000 description 3
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 3
- JYTUSYBCFIZPBE-QOKIMYEXSA-N (2r,3r,4r,5r)-2,3,5,6-tetrahydroxy-4-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexanoic acid Chemical compound OC(=O)[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O JYTUSYBCFIZPBE-QOKIMYEXSA-N 0.000 description 2
- OBCUSTCTKLTMBX-VIFPVBQESA-N (2s)-2-acetyloxy-2-phenylacetic acid Chemical compound CC(=O)O[C@H](C(O)=O)C1=CC=CC=C1 OBCUSTCTKLTMBX-VIFPVBQESA-N 0.000 description 2
- AAWZDTNXLSGCEK-LNVDRNJUSA-N (3r,5r)-1,3,4,5-tetrahydroxycyclohexane-1-carboxylic acid Chemical compound O[C@@H]1CC(O)(C(O)=O)C[C@@H](O)C1O AAWZDTNXLSGCEK-LNVDRNJUSA-N 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 2
- NCXUNZWLEYGQAH-UHFFFAOYSA-N 1-(dimethylamino)propan-2-ol Chemical compound CC(O)CN(C)C NCXUNZWLEYGQAH-UHFFFAOYSA-N 0.000 description 2
- HXKKHQJGJAFBHI-UHFFFAOYSA-N 1-aminopropan-2-ol Chemical compound CC(O)CN HXKKHQJGJAFBHI-UHFFFAOYSA-N 0.000 description 2
- BYACHAOCSIPLCM-UHFFFAOYSA-N 2-[2-[bis(2-hydroxyethyl)amino]ethyl-(2-hydroxyethyl)amino]ethanol Chemical compound OCCN(CCO)CCN(CCO)CCO BYACHAOCSIPLCM-UHFFFAOYSA-N 0.000 description 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 2
- JCBPETKZIGVZRE-UHFFFAOYSA-N 2-aminobutan-1-ol Chemical compound CCC(N)CO JCBPETKZIGVZRE-UHFFFAOYSA-N 0.000 description 2
- PMUNIMVZCACZBB-UHFFFAOYSA-N 2-hydroxyethylazanium;chloride Chemical compound Cl.NCCO PMUNIMVZCACZBB-UHFFFAOYSA-N 0.000 description 2
- KIIBBJKLKFTNQO-WHFBIAKZSA-N 5-hydroxyectoine Chemical compound CC1=N[C@H](C(O)=O)[C@@H](O)CN1 KIIBBJKLKFTNQO-WHFBIAKZSA-N 0.000 description 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 2
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- AAWZDTNXLSGCEK-UHFFFAOYSA-N Cordycepinsaeure Natural products OC1CC(O)(C(O)=O)CC(O)C1O AAWZDTNXLSGCEK-UHFFFAOYSA-N 0.000 description 2
- QXKAIJAYHKCRRA-BXXZVTAOSA-N D-ribonic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)C(O)=O QXKAIJAYHKCRRA-BXXZVTAOSA-N 0.000 description 2
- 102000016942 Elastin Human genes 0.000 description 2
- 108010014258 Elastin Proteins 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 2
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- UEZVMMHDMIWARA-UHFFFAOYSA-N Metaphosphoric acid Chemical compound OP(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-N 0.000 description 2
- OPKOKAMJFNKNAS-UHFFFAOYSA-N N-methylethanolamine Chemical compound CNCCO OPKOKAMJFNKNAS-UHFFFAOYSA-N 0.000 description 2
- BELBBZDIHDAJOR-UHFFFAOYSA-N Phenolsulfonephthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 BELBBZDIHDAJOR-UHFFFAOYSA-N 0.000 description 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 239000004115 Sodium Silicate Substances 0.000 description 2
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 2
- SLINHMUFWFWBMU-UHFFFAOYSA-N Triisopropanolamine Chemical compound CC(O)CN(CC(C)O)CC(C)O SLINHMUFWFWBMU-UHFFFAOYSA-N 0.000 description 2
- 244000098338 Triticum aestivum Species 0.000 description 2
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 2
- IAJILQKETJEXLJ-RSJOWCBRSA-N aldehydo-D-galacturonic acid Chemical compound O=C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-RSJOWCBRSA-N 0.000 description 2
- IAJILQKETJEXLJ-QTBDOELSSA-N aldehydo-D-glucuronic acid Chemical compound O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-QTBDOELSSA-N 0.000 description 2
- 239000004411 aluminium Substances 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- YPPRKFXMPDSDJV-UHFFFAOYSA-J aluminum;sodium;2-hydroxypropanoate Chemical compound [Na+].[Al+3].CC(O)C([O-])=O.CC(O)C([O-])=O.CC(O)C([O-])=O.CC(O)C([O-])=O YPPRKFXMPDSDJV-UHFFFAOYSA-J 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- CBTVGIZVANVGBH-UHFFFAOYSA-N aminomethyl propanol Chemical compound CC(C)(N)CO CBTVGIZVANVGBH-UHFFFAOYSA-N 0.000 description 2
- 229910021529 ammonia Inorganic materials 0.000 description 2
- 239000001099 ammonium carbonate Substances 0.000 description 2
- SOIFLUNRINLCBN-UHFFFAOYSA-N ammonium thiocyanate Chemical compound [NH4+].[S-]C#N SOIFLUNRINLCBN-UHFFFAOYSA-N 0.000 description 2
- UBKBVPONTPMQQW-UHFFFAOYSA-N azane;2-hydroxyacetic acid Chemical compound [NH4+].OCC([O-])=O UBKBVPONTPMQQW-UHFFFAOYSA-N 0.000 description 2
- UNTBPXHCXVWYOI-UHFFFAOYSA-O azanium;oxido(dioxo)vanadium Chemical compound [NH4+].[O-][V](=O)=O UNTBPXHCXVWYOI-UHFFFAOYSA-O 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- OWMVSZAMULFTJU-UHFFFAOYSA-N bis-tris Chemical compound OCCN(CCO)C(CO)(CO)CO OWMVSZAMULFTJU-UHFFFAOYSA-N 0.000 description 2
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 2
- 229960005069 calcium Drugs 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 description 2
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 description 2
- OFNJDDJDXNMTHZ-UHFFFAOYSA-L calcium;2-aminoacetate Chemical compound [Ca+2].NCC([O-])=O.NCC([O-])=O OFNJDDJDXNMTHZ-UHFFFAOYSA-L 0.000 description 2
- STIAPHVBRDNOAJ-UHFFFAOYSA-N carbamimidoylazanium;carbonate Chemical compound NC(N)=N.NC(N)=N.OC(O)=O STIAPHVBRDNOAJ-UHFFFAOYSA-N 0.000 description 2
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- 235000017281 sodium acetate Nutrition 0.000 description 1
- 229910001388 sodium aluminate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- WBHQBSYUUJJSRZ-UHFFFAOYSA-M sodium bisulfate Chemical compound [Na+].OS([O-])(=O)=O WBHQBSYUUJJSRZ-UHFFFAOYSA-M 0.000 description 1
- 229910000342 sodium bisulfate Inorganic materials 0.000 description 1
- 229940031688 sodium c14-16 olefin sulfonate Drugs 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
- HLBBKKJFGFRGMU-UHFFFAOYSA-M sodium formate Chemical compound [Na+].[O-]C=O HLBBKKJFGFRGMU-UHFFFAOYSA-M 0.000 description 1
- 235000019254 sodium formate Nutrition 0.000 description 1
- 229940005573 sodium fumarate Drugs 0.000 description 1
- VILMUCRZVVVJCA-UHFFFAOYSA-M sodium glycolate Chemical compound [Na+].OCC([O-])=O VILMUCRZVVVJCA-UHFFFAOYSA-M 0.000 description 1
- 229940023144 sodium glycolate Drugs 0.000 description 1
- NGSFWBMYFKHRBD-UHFFFAOYSA-M sodium lactate Chemical compound [Na+].CC(O)C([O-])=O NGSFWBMYFKHRBD-UHFFFAOYSA-M 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 235000019983 sodium metaphosphate Nutrition 0.000 description 1
- 235000019795 sodium metasilicate Nutrition 0.000 description 1
- KKCBUQHMOMHUOY-UHFFFAOYSA-N sodium oxide Chemical compound [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 description 1
- 229910001948 sodium oxide Inorganic materials 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- 235000011006 sodium potassium tartrate Nutrition 0.000 description 1
- 229910000031 sodium sesquicarbonate Inorganic materials 0.000 description 1
- 235000018341 sodium sesquicarbonate Nutrition 0.000 description 1
- 229940074404 sodium succinate Drugs 0.000 description 1
- ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 description 1
- 239000001433 sodium tartrate Substances 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- 235000019832 sodium triphosphate Nutrition 0.000 description 1
- MRQYKJNZWPCFNB-UHFFFAOYSA-M sodium;icosanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCCCC([O-])=O MRQYKJNZWPCFNB-UHFFFAOYSA-M 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 210000000498 stratum granulosum Anatomy 0.000 description 1
- 229910001866 strontium hydroxide Inorganic materials 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 230000002889 sympathetic effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
- 229960004559 theobromine Drugs 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 235000013337 tricalcium citrate Nutrition 0.000 description 1
- WUUHFRRPHJEEKV-UHFFFAOYSA-N tripotassium borate Chemical compound [K+].[K+].[K+].[O-]B([O-])[O-] WUUHFRRPHJEEKV-UHFFFAOYSA-N 0.000 description 1
- YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical compound CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 description 1
- JEJAMASKDTUEBZ-UHFFFAOYSA-N tris(1,1,3-tribromo-2,2-dimethylpropyl) phosphate Chemical compound BrCC(C)(C)C(Br)(Br)OP(=O)(OC(Br)(Br)C(C)(C)CBr)OC(Br)(Br)C(C)(C)CBr JEJAMASKDTUEBZ-UHFFFAOYSA-N 0.000 description 1
- VXYADVIJALMOEQ-UHFFFAOYSA-K tris(lactato)aluminium Chemical compound CC(O)C(=O)O[Al](OC(=O)C(C)O)OC(=O)C(C)O VXYADVIJALMOEQ-UHFFFAOYSA-K 0.000 description 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 1
- 235000019801 trisodium phosphate Nutrition 0.000 description 1
- ZXGOACRTCPRVON-UHFFFAOYSA-K trisodium;2-sulfonatobutanedioate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(C([O-])=O)S([O-])(=O)=O ZXGOACRTCPRVON-UHFFFAOYSA-K 0.000 description 1
- 229960004418 trolamine Drugs 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
- 230000006438 vascular health Effects 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 229940071566 zinc glycinate Drugs 0.000 description 1
- UOXSXMSTSYWNMH-UHFFFAOYSA-L zinc;2-aminoacetate Chemical compound [Zn+2].NCC([O-])=O.NCC([O-])=O UOXSXMSTSYWNMH-UHFFFAOYSA-L 0.000 description 1
Classifications
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P39/06—Free radical scavengers or antioxidants
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/40—Effervescence-generating compositions
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
- A23L2/54—Mixing with gases
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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Abstract
The present invention relates to the general field of compositions formed from a substantially aqueous solvent and having hydrogen gases dissolved therein for use with humans and other animals. The composition may take the form of a medicament, a beverage, an infusion, or a topical. More particularly, the invention relates to compositions having a mixture of hydrogen gas and another dissolved gas such as carbon dioxide. The compositions may provide benefit to the recipient in the form of a health benefit or an aesthetic benefit for example.
Description
HYDROGEN-BASED COMPOSITIONS
FIELD OF THE INVENTION [001], The present invention relates to the general field of compositions formed from a substantially aqueous solvent and having hydrogen gases dissolved therein for use with humans and other animals. The composition may take the form of a medicament, a beverage, an infusion, or atopical. More particularly, the invention relates to compositions having a mixture of hydrogen gas and another dissolved gases. The compositions may provide benefit to the recipient in the form of a health benefit or an aesthetic benefit for example.
BACKGROUND TO THE INVENTION [002], Free radical chemical species in the body are well known to cause negative health effects when present in excessive amounts. Free radicals are typically reactive oxygen species (ROS) which may be found within a cell, within a cellular organelle, or in the interstitial fluid of a mammal. Such radicals are generated is the body endogenously often in accordance with a physiochemical or pathological state in the body.
[003], In nature, free radicals are neutralized by antioxidant molecules which may be endogenous in the body or ingested. A fine balance between free radical and antioxidant species is necessary for good health. In some circumstances free radicals overwhelm the body's ability to neutralize them, leading to a condition known as oxidative stress. Excess free radicals are therefore free to oxidise lipids, proteins, DNA and other biological molecules of the body. Oxidation can destroy or alter a critical biological function in a molecule thereby leading to disease.
[004], It is known in the art that “hydrogen water” may be used as a beverage to prevent the generation of excess ROS, and therefore oxidative stress. Hydrogen water is typically
2019100136 07 Feb 2019 prepared by the electrolysis of water such that the water is close to saturated with molecular hydrogen (to around 1.6 ppm). While useful, hydrogen water is expensive to make by electrolysis requiring large amounts of energy, and the process is generally not achievable in a domestic setting. Furthermore, electrolysis of water other than distilled water, results in chlorine gas formation due to the presence of salt. Typically, consumers purchase hydrogen water in commercial pre-packaged form.
[005], Furthermore, hydrogen water has a limited ability to provide a desired biological effects in the body given the low levels of saturation of the gas in water. In some circumstances, a desired biological effect may only be achieved by rapidly consuming large amounts of hydrogen water with hydrogen gas levels that are much higher than the typical saturation ( 1.6mg/L) at standard temperature and pressure (STP). In other circumstances, the desired effect is simply not achievable.
[006]. It is an aspect of the present invention to provide an improvement to prior art dietary compositions that seek to reduce oxidative stress in the body. It is a further aspect of the prior art to provide a useful alternative to prior art compositions.
[007], The discussion of documents, acts, materials, devices, articles and the like is included in this specification solely for the purpose of providing a context for the present invention. It is not suggested or represented that any or all of these matters formed part of the prior art base or were common general knowledge in the field relevant to the present invention as it existed before the priority date of each provisional claim of this application.
SUMMARY OF THE INVENTION [008], In a first aspect, but not necessarily the broadest aspect, the present invention provides a composition comprising a substantially aqueous solvent, the solvent having dissolved therein carbon dioxide gas and hydrogen gas. In some embodiments the hydrogen gas is above the amount achievable at saturation at standard temperature and pressure (STP) such as about 1.6mg/L. The carbon dioxide gas and hydrogen gas may be
2019100136 07 Feb 2019 present in the composition as a result of contacting the substantially aqueous solvent with a gas mixture comprising both carbon dioxide gas and hydrogen gas.
[009], In one embodiment of the first aspect, the hydrogen gas is present in an amount that is sufficient to confer a health benefit on a mammal that ingests the composition.
[010], In one embodiment of the first aspect, the health benefit is the reduction of oxidative stress on a subcellular compartment or organelle of a cell, or a cell, or a tissue or an organ of the mammal that ingested the composition. In other embodiments, the health benefit is an upregulation of ghrelin or ghrelin-like molecule in the animal.
[Oil], In one embodiment of the first aspect, the hydrogen gas is present in an amount of at least about 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%. 1.0%, 1.5%, 2.0%, 2.5%, 3.0%, 3.5%, 4.0%, 4.5% or 5% by volume.
[012], In one embodiment of the first aspect, the carbon dioxide gas is present in an amount of at least about 0.25, 0.5, 1.0,1.5, 2.0, 2.5, 3.0, 3.5,4.0, 4.5, 5.0, 5.5, 6.0, 6.5, 7.0, 7.5, 8.0, 8.5, 9.0, 9.5 or 10 volumes.
[013], In one embodiment of the first aspect, the dissolved carbon dioxide gas leaves the substantially aqueous solvent (optionally in the form of bubbles) when the composition is exposed to room temperature and/or atmospheric pressure or STP.
[014], In one embodiment of the first aspect, the composition is present in a substantially hydrogen gas impermeable container, wherein a headspace comprising carbon dioxide gas and hydrogen gas at a supra-atmospheric pressure is present within the container so as to inhibit the dissolution of carbon dioxide gas and hydrogen gas.
[015], In one embodiment of the first aspect, the supra-atmospheric pressure is sufficient so as to allow dissolution of the carbon dioxide gas and/or hydrogen gas in an amount of
2019100136 07 Feb 2019 greater than about 1%, 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, or 100% compared with the amount of the carbon dioxide gas and/or hydrogen gas that is dissolved under conditions of atmospheric pressure and at the same temperature.
[016], In one embodiment of the first aspect, the container is fabricated from a metal.
[017], In one embodiment ofthe first aspect, the container is a can, abottle, or ajar.
[018], In one embodiment of the first aspect, the can has a ring-pull opening, or the bottle has a screw cap, or the jar has a screw cap.
[019], In one embodiment of the first aspect, the can, bottle or jar is configured to contain a gas at a pressure of at least about 50, 100, 150, 200, 250, or 300 kPa.
[020], In one embodiment of the first aspect, the composition is formulated as a beverage, a medicament, an infusion, or a topical.
[021], In a second aspect, the present invention provides a reusable container configured to contain a pressurized gas, the container comprising a mixture of hydrogen gas and carbon dioxide gas, and a port suitable for connection to a gas input of a domestic beverage dispensing apparatus capable of carbonating a substantially aqueous solvent.
[022], In one embodiment of the second aspect, the beverage dispensing apparatus is a Soda Stream™ apparatus or similar.
[023], In one embodiment of the second aspect, the reusable container is configured to be emptied and refilled with a mixture of hydrogen gas and carbon dioxide gas.
2019100136 07 Feb 2019 [024], In one embodiment of the first aspect, the reusable container has a weight (when filled with hydrogen gas and carbon dioxide gas) of less than about 10, 9, 8 ,7, 6, 5, 4, 3, 2 or 1 kg.
[025], In a third aspect, the present invention provides a system for the preparation of a composition, the system comprising: the reusable container of any embodiment if the second aspect, and a domestic beverage dispensing apparatus capable of carbonating a substantially aqueous solvent.
[026], In a fourth aspect, the present invention provides a method for the preparation of a composition, the method comprising the steps of: providing a substantially aqueous solvent, and contacting the substantially aqueous solvent with carbon dioxide gas and hydrogen gas so as to dissolve the carbon dioxide gas and hydrogen gas in the substantially aqueous solvent.
[027], In one embodiment of the fourth aspect, the method is configured to produce the composition of any embodiment of the first aspect.
[028], In one embodiment of the fourth aspect, the step of contacting is performed by a domestic beverage dispensing apparatus capable of carbonating a substantially aqueous solvent.
[029], In one embodiment of the fourth aspect the beverage dispensing apparatus is a Soda
Stream™ apparatus or similar.
[030], In a fifth aspect, the present invention provides a method for preventing or treating a disorder associated with oxidative stress and/or a deficiency of ghrelin or a ghrelin-like molecule, the method comprising the step of administering to a subject in need thereof an effective amount of a composition according to any embodiment of the first aspect.
[031], In a sixth aspect, the present invention provides a method of manufacturing a medicament or a functional food for preventing or treating a disorder associated with
2019100136 07 Feb 2019 oxidative stress and/or a deficiency of ghrelin or a ghrelin-like molecule, the method combining the step of adding a pharmaceutically acceptable excipient or a food additive to the composition of any embodiment of the first aspect.
DETAILED DESCRIPTION OF THE INVENTION AND PREFERRED EMBODIMENTS THEREOF [032], After considering this description it will be apparent to one skilled in the art how the invention is implemented in various alternative embodiments and alternative applications. However, although various embodiments of the present invention will be described herein, it is understood that these embodiments are presented by way of example only, and not limitation. As such, this description of various alternative embodiments should not be construed to limit the scope or breadth of the present invention. Furthermore, statements of advantages or other aspects apply to specific exemplary embodiments, and not necessarily to all embodiments covered by the claims.
[033], Throughout the description and the claims of this specification the word comprise and variations of the word, such as comprising and comprises is not intended to exclude other additives, components, integers or steps.
[034], Reference throughout this specification to “one embodiment” or “an embodiment” means that a particular feature, structure or characteristic described in connection with the embodiment is included in at least one embodiment of the present invention. Thus, appearances of the phrases “in one embodiment” or “in an embodiment” in various places throughout this specification are not necessarily all referring to the same embodiment, but may.
[035], The present invention is predicated at least in part on the inventors’ discovery that a composition comprising dissolved molecular (H2) hydrogen gas in combination with dissolved carbon dioxide gas (CO2) is advantageous for use by a human (or other mammal) in so far as the combination of dissolved gases is capable of exerting desirable biological effects in a recipient subject.
2019100136 07 Feb 2019 [036], It has been found firstly that the carbon dioxide and hydrogen act together (and in some circumstances may act synergistically) to increase levels of ghrelin in the recipient. Ghrelin is an endogenous hormone which regulates energy balance, amongst other physiological processes. Ghrelin signals the availability of nutrients in the digestive tract to the central nervous system, acting mainly through hypothalamic mediators. The hormone promotes both neuro-endocrine and inflammatory signals which may act to increase skeletal muscle growth, decreases protein breakdown, and increases lipolysis. Thus beverages or medicaments comprising both hydrogen and carbon dioxide may be used to improve body composition by increasing ratio of muscle to fat.
[037], An increases in the level of ghrelin may also be used in clinical applications to treat or prevent sarcopenia, Parkinson’s disease, cachexia in chronic heart failure, COPD, cancer, endstage- renal-disease or cystic fibrosis, frailty in elderly, gastrointestinal motility disorders (e.g., gastroparesis, functional dyspepsia, postoperative ileus), after curative gastrectomy, anorexia nervosa, growth hormone deficient patients, alcohol craving, sleepwake regulation (as noted in major depression), or sympathetic nervous activity in obesity.
[038], Animal research and some clinical studies have shown that ghrelin may have neuroprotective and cognitive enhancing activities, positive impacts on vascular health, anti-inflammatory activities useful in autoimmune disorders, and is markedly hepatoprotective.
[039], As will be appreciated, water is generally saturable by any given gas species. Thus, where hydrogen gas alone is used, only a limited upregulation of ghrelin in the recipient is possible because the water has become saturate with hydrogen. The addition of a second gas species (i.e. carbon dioxide) as a ghrelin upregulator allows for the composition to have an even greater ability to stimulate ghrelin production in the recipient. Thus, for a given volume of composition the present invention (comprising use of carbon dioxide and hydrogen) is able to induce higher levels of ghrelin than a composition having only a single
2019100136 07 Feb 2019 dissolved gas species. Accordingly, an improved clinical effect may be noted where compositions of the present invention are administered to a recipient.
[040], The present invention may be embodied in a method for the treatment or prophylaxis of a condition for which increased levels of gherlin are efficacious. The condition may be any of those listed supra, or indeed any other condition known at the filing date of this application to be preventable or treatable by increasing the endogenous levels of gherlin or a gherlin-like molecule in the body. A condition treatable or preventable by the method may be discovered at some time in the future, with such conditions being included within the ambit of the present methods.
[041], In some circumstances, the present compositions may be used in respect of nonmedical conditions so as to improve a subject’s appearance, appetite, body composition (e.g. fat to muscle ratio), mood or other parameter.
[042], A further finding is that compositions of the present invention may be prepared economically and freshly in the home using a domestic carbonation apparatus, such as a by way of a soda syphon, of which many types are already known to the skilled person. Exemplary type of soda siphon are of the variety marketed by SodaStream International Limited (Israel). Thus, to achieve the beneficial biological effects provided by the combination of hydrogen and carbon dioxide a consumer may purchase a small capacity gas cylinder (such as a soda bulb having sufficient gas for a single bottle of composition, or a larger cylinder for preparing multiple bottles) and inject the combination of gases into water. The resultant water (being a composition of the present invention) may be immediately consumed, or sealed so as to preserve at least to some extent the dissolved gases for a period of time for later consumption.
[043], Dependent on the intended use of the inventive composition, various formulations may be provided.
2019100136 07 Feb 2019 [044], Where the intended use is as an ingestible composition, the composition may be formulated as a liquid medicament or a beverage. In that regard, any one of more of the following additives may be used: a sugar, a sweetener, a colorant, a flavouring agent, a flavour enhancer, an aroma, a stabilizer, a pH adjusting agent, a preservative, a thickener, a pH buffering agent, or a salt. The skilled person having the benefit of the present specification is amply enabled to formulate a beverage based on a desired commercial use. Such formulations may be for the purpose of providing a “functional food” with regard to the general aim of upregulating ghrelin levels in the body, or providing some other desirable biological response in the subject’s body. In that regard, functional additives may be added such as a vitamin, a mineral, a protein, a probiotic, or a prebiotic.
[045], The beverage may be packaged in a vessel that is substantially impermeable to hydrogen, such that the gas remains in solution and therefore available to the subject upon ingestion. An aluminium can may be a cost effective vessel in that regard.
[046], For domestic applications, a screw cap aluminium or stainless steel vessel may be used to prevent escape of hydrogen.
[047], In some embodiments, the headspace within the vessel overlying the composition comprises hydrogen gas under pressure (and optionally also carbon dioxide gas under pressure) so as to maintain desirable amounts of the gas in solution. The vessel may be sealed in a pressurized atmosphere, or alternatively gas leaving solution and entering the headspace may provide the required pressure.
[048], Where the intended use is as a topical, the composition may be formulated so as to be applied to the skin by spraying, wiping, dabbing of other skin-contacting method. Low viscosity compositions will be preferred for spray applications. The topical compositions may be formulated with a humectant or other agent to inhibit evaporation from the skin surface. The carbon dioxide present in the composition slightly lowers the pH (to between about 3 and 4) due to the presence of carbonic acid. It is proposed that the acid pH of the composition dislodges dirt and dead skin cells from the stratum corneum layer of the skin,
2019100136 07 Feb 2019 thereby facilitating the passage of hydrogen into the deeper skin layers such as the stratum granulosum and even the dermis. Once in these deeper layers, the hydrogen acts as a scavenger of ROS, thereby decreasing the oxidative stress in the tissues. An improved appearance or tone in the skin may result, in part due to the protection from oxidation of molecules such as collagen and elastin which give the skin a youthful appearance. With ongoing use, the composition may further prevent oxidation of collagen and elastin to slow ageing the skins appearance.
[049], In the context of a topical dermatological composition, the composition may be prepared de novo in the home or in a beauty salon by contacting both hydrogen gas and carbon dioxide gas from a small cylinder to a substantially aqueous solvent, such as water.
[050], The solvent may be pre-formulated or the composition post-formulated to contain one or more dermatologically acceptable excipients.
[051], As used herein, the term dermatologically acceptable excipient includes without limitation any adjuvant, carrier, glidant, diluent, preservative, dye/colorant, flavor enhancer, surfactant, wetting agent, dispersing agent, suspending agent, stabilizer, isotonic agent, solvent, or emulsifier, including those approved by the United States Food and Drug Administration as being acceptable for dermatological or therapeutic use on humans, or which are known, or are suitable for use in dermatological compositions.
[052], A dermatologically acceptable excipient may be a buffer or a salt. As required, and with the benefit of the present specification the skilled person is enabled to decide whether or not any buffer or salt is required to provide a required pH or ionic strength for the composition. Acceptable salts include those salts which retain the biological effectiveness of the dissolved hydrogen and carbon dioxide, and which are not biologically or otherwise undesirable. Salts maybe prepared from addition of an inorganic base or an organic base to the free acid. Salts derived from inorganic bases include, but are not limited to, the sodium, potassium, lithium, ammonium, calcium, magnesium, iron, zinc, copper, manganese, aluminum salts and the like. Preferred inorganic salts are the ammonium, sodium,
2019100136 07 Feb 2019 potassium, calcium, and magnesium salts. Salts derived from organic bases include, but are not limited to, salts of primary, secondary, and tertiary amines, substituted amines including naturally occurring substituted amines, cyclic amines and basic ion exchange resins, such as ammonia, isopropylamine, trimethylamine, diethylamine, triethylamine, tripropylamine, diethanolamine, ethanolamine, 2-dimethylaminoethanol, 2diethylaminoethanol, dicyclohexylamine, lysine, arginine, histidine, caffeine, procaine, hydrabamine, choline, betaine, benethamine, benzathine, ethylenediamine, glucosamine, methylglucamine, theobromine, triethanolamine, tromethamine, purines, piperazine, piperidine, N-ethylpiperidine, polyamine resins and the like.
[053], The composition is preferably formulated so as to be on the acidic side of neutral to assist the role of carbon dioxide as means for removal of dirt and dead skin cells. The pH value may be adjusted to about 4.0 to 6.0 using an acid, such as a food acid. The acid for adjusting the pH value can be any conventionally used organic or inorganic acid or mixtures thereof, and may be citric acid.
[054], Useful excipients for adjusting pH, buffering or otherwise altering the ionic conditions of a composition include (byname, CAS No., ELINCS No); 1 ,6-hexanediamine 124-09-4 ,204-679-6; 2-aminobutanol, 96-20-8, 202-488-2; acetic acid, 64-19-7, 200-5807; acetyl mandelic acid, 51019-43-3 / 7322-88-5; adipic acid, 124-04-9, 204-673-3; alstonia scholaris bark extract, 91745-20-9, 294-689-7; aluminum glycinate, 13682-92-3 / 41354-48-7; aluminum lactate, 18917-91 -4, 242-670-9; aluminum triformate, 7360-534,230-898-1 ; aminoethyl propanediol, 1 15-70-8,204-101 -2; aminomethyl propanediol, 1 15-69-5, 204-100-7 ; aminomethyl propanol, 124-68-5, 204-709-8; aminopropanediol, 616-30-8, 210-475-8; ammonia, 7664-41 -7; 231 -635-3; ammonium acetate 631 -61 -8, 21 1 -162-9; ammonium bicarbonate, 1066-33-7,213-91 1 -5; ammonium carbamate, 1 1 1 1 -78-0, 214-185-2; ammonium carbonate, 10361 -29-2,233-786-0; ammonium chloride, 12125-02-9,235-186-4; ammonium glycolate 35249-89-9; ammonium hydroxide, 133621 -6, 215-647-6; ammonium lactate, 515-98-0, 208-214-8; ammonium molybdate 1205485-2; ammonium nitrate 6484-52-2, 229-347-8; ammonium phosphate, 7722-76-1 , 231 764-5; ammonium thiocyanate, 1762-95-4, 217-175-6; ammonium vanadate, 7803-55-6,
2019100136 07 Feb 2019
232-261 -3; ascorbic acid, 50-81 -7/62624-30-0,200-066-2/263-644-3; azelaic acid, 12399-9; 204-669; babassu acid; bakuhan; benzilic acid, 76-93-7,200-993-2; bis-hydroxy ethyl tromethamine, 6976-37-0, 230-237-7; bismuth citrate, 813-93-4, 212-390-1 ; boric acid, 10043-35-3/ 1 1 1 13-50-1 , 233-139-2 / 234-343-4; butyl diethanolamine, 102-79-4,203055-0; calcium carbonate, 471 -34-1 , 207-439-9; calcium citrate 813-94-5, 212-391 -7; calcium dihydrogen phosphate, 7758-23-8, 231 -837-1 ; calcium glycinate, 35947-07-0, 252-809-5; calcium hydroxide, 1305-62-0; 215-137-3; calcium lactate, 814-80-2,212-4067; calcium oxide, 1305-78-8,215-138-9; calcium phosphate, 7758-23-8 / 10103-46-5,231 -837-1 / 233-283-6; citric acid 77-92-9 / 5949-29-1 , 201 -069-1 ; clay minerals; copper glycinate, 32817-15-5, 251 -238-9; diammonium citrate, 3012-65-5, 221 -146-3; diammonium phosphate, 7783-28-0, 231 -987-8; dibutyl ethanolamine, 102-81 -8, 203057-1 , diethyl ethanolamine, 100-37-8, 202-845-2; dimethyl isopropanolamine, 108-16-7, 203-556-4; dimethyl mea, 108-01 -0,203-542-8; dioleoyl edetolmonium methosulfate, 1 1 1030-96-7; dioleyl phosphate, 14450-07-8,238-431 -3; dipotassium phosphate, 7758-1 1 4, 231 -834-5; disodium fumarate, 17013-01 -3, 241 -087-7; disodium phosphate, 755879-4 / 7782-85-6, 231 -448-7; disodium pyrophosphate, 7758-16-9, 231 -835-0; disodium tartrate ,868-18-8, 212-773-3; ethanolamine, 141 -43-5, 205-483-3; ethanolamine HCL, 2002-24-6, 217-900-6; ethyl ethanolamine, 1 10-73-6, 203-797-5; fumaric acid, 1 10-178, 203-743-0; galacturonic acid, 685-73-4, 21 1 -682-6; glucoheptonic acid, 23351 -51 -1 , 245-601 -0; gluconic acid, 526-95-4, 208-401 -4; glucuronic acid, 576-37-4; 209-401 -7; glutaric acid, 1 10-94-1 , 203-817-2; glycine, 56-40-6, 200-272-2; glycolic acid, 79-14-1 201 -180-5; glyoxylic acid, 298-12-4, 206-058-5; guanidine carbonate, 593-85-1 , 209813-7; guanidine HCI, 50-01 -1 , 200-002-3; hydrobromic acid, 10035-10-6, 233-1 13-0; hydrochloric acid, 7647-01 -0, 231 -595-7; hydroxyectoin, 165542-15-4, 442-870-8; hydroxyethylpiperazine ethane sulfonic acid, 7365-45-9, 230-907-9; imidazole, 288-32-4, 206-019-2; isobutyric acid, 79-31 -2, 201 -195-7; isopropanolamine, 78-96-6, 201 -162-7; isopropylamine 75-31 -0200-860-9; lactic acid, 50-21 -5, 200-018-0; lactobionic acid, 9682-2,202-538-3; lauryl p-cresol ketoxime, 50652-76-1 ; lithium carbonate, 554-13-2, 209062-5; lithium hydroxide, 1310-65-2, 215-183-4; magnesium acetate, 142-72-3, 205-5549; magnesium carbonate hydroxide, 12125-28-9,235-192-7; magnesium glycinate, 1478368-7, 238-852-2; magnesium hydroxide, 1309-42-8, 215-170-3; magnesium lactate,
2019100136 07 Feb 2019
18917-93-6, 242-671 -4; magnesium oxide, 1309-48-4, 215-171 -9; maleic acid, 1 10-167, 203-742-5; malic acid, 97-67-6, 202-601 -5; malonic acid, 141 -82-2, 205-503-0; maltobionic acid 534-42-9; mea-borate, 10377-81 -8, 233-829-3; metaphosphoric acid, 37267-86-0, 253-433-4; methoxy peg-100/polyepsilon caprolactone ethylhexanoate; methoxypeg-100/polyepsilon caprolactone palmitate; methoxy peg-1 14/polyepsilon caprolactone; methylethanolamine, 109-83-1 , 203-710-0, monosodium citrate, 18996-355, 242-734-6; mudstone powder; paecilomyces japonica/g rape/cucumber juice extract ferment filtrate; pentapotassium triphosphate, 13845-36-8, 237-574-9; pentasodium triphosphate, 7758-29-4, 231 -838-7; phenolsulfonphthalein, 143-74-8, 205-609-7; phenyl mercuric borate, 102-98-7, 203-068-1 ; phosphonobutanetricarboxylic acid, 37971 -36-1 , 253-733-5; phosphoric acid, 7664-38-2, 231 -633-2; phosphorus pentoxide, 1314-56-3, 215-236-1 ; potassium bicarbonate, 298-14-6, 206-059-0; potassium biphthalate, 877-247, 212-889-4; potassium bitartrate, 868-14-4, 212-769-1 ; potassium borate, 1332-77-0, 215-575-5; potassium carbonate, 584-08-7, 209-529-3; potassium citrate, 866-84-2, 212755-5; potassium hydroxide, 1310-58-3,215-181 -3; potassium lactate, 996-31 -6/8589578-9, 213-631 -3 / 288-752-8; potassium magnesium aspartate, 67528-13-6; potassium oxide, 12136-45-7, 235-227-6; potassium phosphate, 7778-77-0/ 16068-46-5,231 -913-4 / 240-213-8; potassium sodium tartrate, 304-59-6, 206-156-8; potassium tartrate, 921 -539, 213-067-8; propane tricarboxylic acid, 99-14-9 / 51750-56-2, 202-733-3 ; quinic acid, 77-95-2 / 562-73-2 / 36413-60-2, 201 -072-8 / 209-233-4; ribonic acid, 17812-24-7; sebacic acid, 111 -20-6, 203-845-5; sesquiethoxytriethanolamine; sh-decapeptide-7; sodium acetate, 127-09-3, 204-823-8; sodium aluminate, 1302-42-7, 215-100-1 ; sodium aluminum lactate, 68953-69-5, 273-223-6; sodium arachidate; sodium aspartate, 1709093-6 / 3792-50-5, 241 -155-6 / 223-264-0; sodium bicarbonate, 144-55-8, 205-633-8; sodium bisulfate, 7681 -38-1 ,231 -665-7; sodium borate, 1330-43-4/ 1303-96-4 215-5404; sodium butoxyethoxy acetate, 67990-17-4, 268-040-3 ; sodium calcium boron phosphate; sodium calcium copper phosphate; sodium calcium zinc phosphate; sodium carbonate, 497-19-8, 207-838-8; sodium citrate, 68-04-2 / 6132-04-3, 200-675-3; sodium esylate, 5324-47-0, 226-194-9; sodium formate, 141 -53-7, 205-488-0; sodium fumarate 5873-57-4 / 7704-73-6, 227-535-4 / 231 -725-2; sodium glycolate, 2836-32-0, 220-624-9; sodium humate, 68131 -04-4; sodium hydroxide, 1310-73-2, 215-185-5; sodium lactate,
2019100136 07 Feb 2019
72-17-3 / 867-56-1 ,200-772-0/212-762-3; sodium metaphosphate, 10361 -03-2/ 5081316-6, 233-782-9 / 256-779-4; sodium metasilicate, 6834-92-0, 229-912-9; sodium oxide, 1313-59-3,215-208-9; sodium phosphate, 7558-80-7/7632-05-5,231 -449-2/231 -5585; sodium sesquicarbonate, 533-96-0, 208-580-9; sodium silicate, 1344-09-8, 215-687-4; sodium succinate, 2922-54-5, 220-871 -2; sodium trimetaphosphate, 7785-84-4, 232-0883; strontium hydroxide 18480-07-4/ 131 1 -10-0,242-367-1 ; succinic acid, 1 10-15-6;
203- 740-4 sulfuric acid, 7664-93-9, 231 -639-5; tartaric acid, 133-37-9 / 147-71 -7 / 8769-4 ,205-105-7 / 205-695-6 / 201 -766-0; taurine, 107-35-7, 203-483-8; teadiricinoleate/ipdi copolymer, 351425-02-0; tea-hydroiodide 7601 -53-8, 231 -508-2; teasulfate, 7376-31 -0, 230-934-6; tetrahydroxyethyl ethylenediamine, 140-07-8, 205-396-0; tetrapotassium pyrophosphate, 7320-34-5, 230-785-7; tetrasodium pyrophosphate, 772288-5,231 -767-1 ; triethanolamine, 102-71 -6, 203-049-8; triisopropanolamine, 122-20-3,
204- 528-4; trisodium phosphate; 7601 -54-9,231 -509-8; trisodium sulfosuccinate, 1341959-5, 236-524-3; triticum vulgare protein, 100684-25-1 , 309-696-3; triticum vulgare seed extract, 84012-44-2, 281 -689-7; tromethamine, 77-86-1 , 201 -064-4; urea, 57-13-6, 200315-5; uric acid, 69-93-2, 200-720-7; zinc carbonate hydroxide, 150607-22-0; zinc glycinate, 14281 -83-5, 238-173-1 ; zinc hexametaphosphate, 13566-15-9, 236-967-2; and zinc magnesium aspartate.
[055], Where a surfactant is included as an excipient, the surfactant can be any conventionally used anionic, cationic, nonionic, zwitterionic or amphetoric surfactant or mixtures thereof, and may be a sodium C14-16 olefin sulfonate.
[056], In some embodiments, the composition is formulated as an ingestible medicament and in such form may comprise one or pharmaceutically acceptable excipients or additional biologically active agents. The composition of the present invention may be formulated for oral administration by compounding to form an emulsion, suspension, elixir, syrup, or any other liquid form suitable capable of retaining hydrogen gas and carbon dioxide gas in solution.
2019100136 07 Feb 2019 [057], It will be appreciated that compositions suitable for other routes of administration such as transdermal, buccal, intrathecal, rectal, nasal, and the like are not excluded from the present invention however for reasons of convenience at least orally ingestible compositions are generally preferred. The medicament may be in the form of a liquid, a syrup, a suspension, or a slurry.
[058], The present compositions are typically implemented by the user by spreading, gently rubbing or massaging the composition onto the skin of an animal. In the context of the present invention the term animal is intended to include without limitation any mammal such as a human, primate, domestic animal, beast of burden, zoo animal, agriculturally or economically significant animal. As will be appreciated, given the aesthetic and functional advantages of the present compositions as disclosed herein it is the primary intention that the compositions are formulated so as to be useful in application to humans, and in particular the skin of the face or upper torso.
[059], The skin may be wetted prior to application of the composition. Typically, the skin is left untouched so as to allow for the penetration of active ingredients into the skin.
[060], The composition may be used in a dermatologically effective amount, which refers to that amount which, when administered dermatologically (i.e., topically) to an animal, is sufficient to effect the desired effect. The amount of composition which constitutes a dermatologically effective amount may vary depending on, the condition of the skin and the need for improvement, and the age of the animal to be treated, but can be determined routinely by one of ordinary skill in the art having regard to his own knowledge and to this disclosure.
[061], The present compositions may be formulated as a spray, a cream (with an aqueous or non-aqueous base, or a mixed base - oil in water or water in oil), a foam, a foaming solution, a lotion, a balm, a soap, a serum, or a cleanser.
2019100136 07 Feb 2019 [062], The present invention is not limited to compositions produced in the home as described. For example, the compositions may be prepared industrially and packaged into a bottle, can, jar or similar for dispatch to a retail outlet. The hydrogen may be added to the water by electrolysis or any other means.
[063], Furthermore, the carbon dioxide may be added by means other than gas contact methods, such as natural carbonation as a result of fermentation. For example, the beverage may be formulated as a “kombucha”, being a probiotic-fermented tea beverage, combining tea, water, sugar and kombucha bacteria cultures and yeast. The bacteria and yeast ferment the sugar, yielding an effervescent drink that is low in sugar. The beverages often incorporate herb and fruit flavors to provide a variety of tastes.
[064], Alternatively or additionally, the use of salts such as sodium bicarbonate with an acid such as citric acid may be used to create a carbon dioxide effervescence.
[065], Compositions having various levels of hydrogen and carbon dioxide gas are recited in the summary of invention section herein are independently selectable. For some applications, the composition may comprise a relatively high amount of carbon dioxide and a relatively low amount of hydrogen, or a relatively low amount of carbon dioxide and a relatively high amount of hydrogen. In this context, the relativity of the amount is with regard to the saturable amount of the gas concerned.
[066]. As used herein, the term “treatment”, “treat” or “treating” as used herein means alleviating, inhibiting, slowing or arresting the development, reversing and/or relieving a condition related to alcohol consumption (directly caused by alcohol consumption, or secondary to alcohol consumption) including any disease, disorder, state, syndrome, symptom or aesthetic condition to which such term is associated. It is not intended that these terms are used to indicate a complete cure of the condition.
[067]. The term “prophylaxis”, “prevent” or “prevention” as used herein means preventing of the development of, or alleviating to some extent, a condition related to alcohol consumption (directly caused by alcohol consumption, or secondary to alcohol consumption) including any disease,
2019100136 07 Feb 2019 disorder, state, syndrome, symptom or aesthetic condition to which such term is associated. It is not intended that these terms are used to indicate a complete prevention of the condition.
[068]. The term effective amount” as used herein means an amount of the active compound(s) as described herein sufficient to effect beneficial or desired results for treating or preventing a condition, including any disease, disorder, state, syndrome, symptom of aesthetic condition to which such term is associated. An effective amount may be administered by way of one or more doses.
[069]. The term “pharmaceutically acceptable” as used herein means the carrier, diluent, and /or excipients used in the composition must be compatible with the other ingredients of the formulation, and not deleterious to the recipient thereof.
[070]. The term “pharmaceutically acceptable excipient” as used herein means a non-toxic, inert solid, semi-solid, diluent, encapsulating material or formulation auxiliary of any type. Some examples of materials which can serve as pharmaceutically acceptable excipient are sugars such as lactose, glucose, and sucrose; sweetening, flavoring, colouring and perfuming agents; preservatives according to the judgment of the formulator.
[071 ]. The present invention will now be more fully described by reference to the following nonlimiting Examples.
EXAMPLE 1: Formulation of a functional beverage composition, and use thereofin a subject to improve muscle to fat ratio.
[072], A composition is prepared using Reverse Osmosis permeate water as a solvent, to produce a beverage with both molecular hydrogen gas and carbon dioxide, in different quantities of each present in the water beverage.
[073]. The water, to which are added 1.472 g/L mineral mixture (Calcium Sulfate Dihydrate, 327mg/L, Calcium Carbonate 364.2mg/L, Magnesium Sulfate 663.6mg/L, Potassium Bicarbonate 3.48 mg/L, Potassium Chloride 3.6 mg/L and Sodium Chloride 109 mg/L) and placed in either a pressure vessel that can be pressurized with a standard blended gas mixture of both H2 and CO2 or using a domestic carbonator such as a SodaStream.
2019100136 07 Feb 2019 [074]. One method of carbonating is forced carbonation, a process that is often used in beer making and involves knowing liquid temperature and maintaining constant gas pressure till equilibrium of gas occurs between headspace and the liquid in a sealed pressure resistant vessel. The tables for forced carbonation are publicly available.
[075]. Forced carbonation of the mineralized water in this example, is carried out when the mineralized water is kept at 4 degrees Celsius throughout carbonation. The temperature of a liquid when lower than room temperature makes carbonation easier to achieve since the liquid can store more gas. The gas pressure used for carbonation (psi) is above STP and higher, to achieve levels of carbonation of 1.47 volume, 1.9 volumes, 3.1 volumes etc. using a gas mixture with the following blend of gasses: 2%v/v H2 and 98% v/v CO2.
[076]. Table 1 shows the composition of hydrogen and carbon dioxide gas in the mineralized water, at different levels of carbonation at equilibrium.
[077]. Table 1: Effects of carbonation on mineralized water at 10 C, at different headspace pressures till equilibrium is reached using a hydrogen: carbon dioxide gas mixture of 2% H2 & 98% CO2
Carbonation Temperature (° C) | Carbonation Pressure (psi) | Total gas volume in water | H2 Gas volume In water | CO2 Gas volume In water |
10 | 5 | 1.5 | 0.03 | 1.47 |
10 | 10 | 1.9 | 0.038 | 1.862 |
10 | 25 | 3.1 | 0.062 | 3.038 |
Table 2: Effects of carbonation on mineralized water at 10 C, at different headspace pressure, till equilibrium is reached using a hydrogen: carbon dioxide gas mixture of 4% H2 & 96% CO2
Carbonation Temperature (° C) | Carbonation Pressure (psi) | Total gas volume in water | H2 Gas volume In water | CO2 Gas volume In water |
10 | 5 | 1.5 | 0.06 | 1.44 |
2019100136 07 Feb 2019
10 | 10 | 1.9 | 0.076 | 1.824 |
10 | 25 | 3.1 | 0.124 | 2.976 |
[078]. It is clear from this example that both CO2 levels and H2 gas levels, although dosed as a mixture, can be changed to suit the liquid requirements.
[079]. In another example, a SodaStream home carbonator was used to carbonate tap water that was chilled in a domestic refrigerator for several hours. In this example, the recommended gas pressure cylinder which was filled with carbon dioxide, was emptied and refilled with a gas mixture of 4% hydrogen gas and 96% carbon dioxide gas and used to carbonate the chilled tap water. In this example, carbonation at 4g/L carbon dioxide was obtained with an average molecular hydrogen gas amount of 150ppm.
[080]. In other examples using the SodaStream, natural juice, colas, lemonade could all be carbonated, obtaining therapeutic levels of both hydrogen and carbon dioxide in the liquids. Using a gas mixture of 0.25% H2 v/v in 99.75% CO2 and carbonating to obtain 0.5g/L CO2 in the liquid, the H2 was nearly that of saturation i.e. 1.3ppm. In this instance, the liquid treated did not appear effervescent, nor did it taste effervescent. This was then the lowest combination of hydrogen gas in carbon dioxide gas used. Such a low level of carbonation is suitable for “still” beverages such as wine, where carbonation or effervescence is not required but hydrogen is desirable. The addition of hydrogen and carbon dioxide at this low level of addition prolonged the shelflife of wine against oxidation when compared to the same wine without hydrogen addition.
[081]. A composition produced according to any method of this example is consumed in moderate amounts (such as 300 mL) daily to achieve the desired alteration to muscle:fat ratio in the subject.
EXAMPLE 2: Formulation of a dermatological composition, and use thereof in a subject to improve the appearance of skin [082]. In an example of producing a dermatological composition to improve the skin, a SodaStream home carbonator was used to carbonate tap water. In this example, tap water was chilled in a domestic refrigerator for several hours before being carbonated using a gas cylinder filled with a blend of hydrogen gas (4%) and carbon dioxide gas (96%) until a carbonation level of
2019100136 07 Feb 2019 g/L CO2 were reached. In this example, the water contained just below 5 g/L carbon dioxide and an average molecular hydrogen gas amount of 200 ppm.
[083]. This gasified solution was then placed in a bowl and the subjects face was repeatedly immerged into the effervescent water bath whilst bubbles escaped the liquid and interacted with the skin. After about 15 minutes, the candidate felt her face was clean and refreshed and the oily pre-treated skin has vanished to a silkier facade.
[084]. This similar example was repeated using a IL aerosol can filled with hydrogen gas (3%) and CO2 gas (97%). In this instance, the disposable aerosol can was attached to a diffuser apparatus that was placed in a bowl to be used to treat the face of the subject. In this instance, blended gas was released into the bowl of tap water and the bubbles were continuous throughout the 15-minute duration face bath. In this instant, the effects on the skin according to the users was more pronounced.
[085]. This same concept of diffusing the blended gas was also tested in a bath which allowed the subject to emerge themselves in without sinking their head and furthermore, it was used to soak the subject’s feet. In both these instances, satisfaction was gained.
[086]. Subjects that were regularly using sparkling mineral water for face bathing, noted significant satisfaction when hydrogen was included into the skin baths.
[087]. In some instances, other ingredients were added to their baths which did not deter from the fundamental hydrogen combined with carbon dioxide benefit. It appears that the carbon dioxide evolving from the liquid solution in such skin baths, physically scrubs the skin to remove deposits that may block the skin pores. Furthermore, the carbonation with CO2 gas optimizes the pH of the water to that close to the skin pH, giving the skin natural replenishment and hydration.
[088]. The addition of hydrogen in the bath quickly diffused through the skin that is being scrubbed, giving a localized, deep anti-oxidant beauty treatment as well as then being absorbed into the blood stream for more systemic beauty effects.
2019100136 07 Feb 2019 [089]. In another instant, a blend of H2 gas (2%) in CO2 (98%) was applied directly to a surgical wound three times daily for 10 days. The wound healed much faster and more completely in that time of exposure, as described by the surgeon who operated.
[090], Those skilled in the art will appreciate that the invention described herein is susceptible to further variations and modifications other than those specifically described. It is understood that the invention comprises all such variations and modifications which fall within the spirit and scope of the present invention.
[091], While the invention has been disclosed in connection with the preferred embodiments shown and described in detail, various modifications and improvements thereon will become readily apparent to those skilled in the art.
[092], Accordingly, the spirit and scope of the present invention is not to be limited by the foregoing examples, but is to be understood in the broadest sense allowable by law.
Claims (5)
- CLAIMS:1. A reusable container configured to contain a pressurized gas, the container comprising a pressurized gas mixture of hydrogen gas and carbon dioxide gas, and a port suitable for connection to a gas input of a domestic beverage dispensing apparatus capable of carbonating a substantially aqueous solvent.
- 2. The reusable container of claim 1, wherein the hydrogen gas is present in an amount sufficient so as to be capable of producing a substantially aqueous composition that upon ingestion by a mammal reduces oxidative stress on a subcellular compartment or organelle of a cell, or a cell, or a tissue or an organ of the mammal.
- 3. The reusable container of claim 1 or claim 2, wherein the hydrogen gas is present in an amount of at least about 0.25% (v/v).
- 4. The reusable container of any one of claims 1 to 3, wherein the carbon dioxide gas is present in an amount sufficient so as to be capable of producing a substantially aqueous composition having dissolved carbon dioxide gas leaves the substantially aqueous solvent (optionally in the form of bubbles) when the composition is exposed to room temperature and/or atmospheric pressure and/or standard temperature and pressure.
- 5. The reusable container of any one of claims 1 to 4, wherein the carbon dioxide gas is present in an amount of at least about 96% (v/v).
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AU2019900340 | 2019-02-04 | ||
AU2019900340A AU2019900340A0 (en) | 2019-02-04 | Hydrogen-based compositions |
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AU2019100136A4 AU2019100136A4 (en) | 2019-03-14 |
AU2019100136B4 true AU2019100136B4 (en) | 2019-07-25 |
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