AU2018366342A1 - Method for preparing Baricitinib - Google Patents
Method for preparing Baricitinib Download PDFInfo
- Publication number
- AU2018366342A1 AU2018366342A1 AU2018366342A AU2018366342A AU2018366342A1 AU 2018366342 A1 AU2018366342 A1 AU 2018366342A1 AU 2018366342 A AU2018366342 A AU 2018366342A AU 2018366342 A AU2018366342 A AU 2018366342A AU 2018366342 A1 AU2018366342 A1 AU 2018366342A1
- Authority
- AU
- Australia
- Prior art keywords
- compound
- mixture
- added
- reacted
- baricitinib
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- XUZMWHLSFXCVMG-UHFFFAOYSA-N CCS(N(C1)CC1(CC#N)[n]1ncc(-c2ncnc3c2cc[nH]3)c1)(=O)=O Chemical compound CCS(N(C1)CC1(CC#N)[n]1ncc(-c2ncnc3c2cc[nH]3)c1)(=O)=O XUZMWHLSFXCVMG-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201711334329.1 | 2017-12-13 | ||
CN201711334329.1A CN108129482A (zh) | 2017-12-13 | 2017-12-13 | 一种巴瑞替尼的制备方法 |
CN201810667443.4A CN108586465B (zh) | 2017-12-13 | 2018-06-25 | 一种巴瑞替尼的制备方法 |
CN201810667443.4 | 2018-06-25 | ||
PCT/CN2018/094160 WO2019114258A1 (fr) | 2017-12-13 | 2018-07-03 | Procédé de préparation de baricitinib |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2018366342A1 true AU2018366342A1 (en) | 2019-07-04 |
Family
ID=62389618
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2018102141A Active AU2018102141A4 (en) | 2017-12-13 | 2018-07-03 | Method for preparing Baricitinib |
AU2018366342A Pending AU2018366342A1 (en) | 2017-12-13 | 2018-07-03 | Method for preparing Baricitinib |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2018102141A Active AU2018102141A4 (en) | 2017-12-13 | 2018-07-03 | Method for preparing Baricitinib |
Country Status (3)
Country | Link |
---|---|
CN (2) | CN108129482A (fr) |
AU (2) | AU2018102141A4 (fr) |
WO (1) | WO2019114258A1 (fr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108129482A (zh) * | 2017-12-13 | 2018-06-08 | 江苏中邦制药有限公司 | 一种巴瑞替尼的制备方法 |
WO2021053690A1 (fr) * | 2019-09-17 | 2021-03-25 | Natco Pharma Limited | Procédé amélioré pour la préparation de baricitinib |
CN111362853A (zh) * | 2020-04-27 | 2020-07-03 | 安徽大学 | 一种3-氧杂氮杂环丁烷-1-羧酸叔丁酯的制备方法 |
CN112898306B (zh) * | 2021-02-02 | 2022-04-08 | 山东四环药业股份有限公司 | 一种巴瑞替尼的制备方法 |
CN115124537A (zh) * | 2022-07-13 | 2022-09-30 | 山东大学 | 一种jak抑制剂巴瑞替尼的制备方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3035395A1 (de) * | 1980-09-19 | 1982-05-06 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von pyrazol |
UA98639C2 (en) * | 2007-02-28 | 2012-06-11 | Лео Фарма А/С | Phosphodiesterase inhibitors |
RS55263B1 (sr) * | 2008-03-11 | 2017-02-28 | Incyte Holdings Corp | Derivati azetidina i ciklobutana kao jak inhibitori |
EP3227298A4 (fr) * | 2014-12-05 | 2018-05-23 | Sun Pharmaceutical Industries Ltd | Procédé de synthèse de baricitinib et d'un intermédiaire de celui-ci |
US10526350B2 (en) * | 2015-02-02 | 2020-01-07 | Sun Pharmaceutical Industries Limited | Process for the preparation of baricitinib and an intermediate thereof |
AR104918A1 (es) * | 2015-06-19 | 2017-08-23 | Lilly Co Eli | Procesos e intermediarios para la preparación de {1-(etilsulfonil)-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]azetidin-3-il}acetonitrilo |
CN105294699B (zh) * | 2015-12-04 | 2019-06-11 | 上海勋和医药科技有限公司 | 巴瑞替尼的制备方法 |
CN105541891B (zh) * | 2016-02-04 | 2017-11-28 | 东南大学 | 巴瑞替尼的中间体及其制备方法及由该中间体制备巴瑞替尼的方法 |
CN106496195B (zh) * | 2016-10-18 | 2019-03-08 | 杭州科巢生物科技有限公司 | 巴瑞替尼及其中间体的合成方法 |
CN106946917B (zh) * | 2017-03-20 | 2019-06-11 | 杭州科巢生物科技有限公司 | 一种jak抑制剂巴瑞替尼及其中间体的新合成方法 |
CN107176955B (zh) * | 2017-03-24 | 2019-04-09 | 南京优科制药有限公司 | 一种巴瑞替尼的制备方法 |
CN107739328B (zh) * | 2017-11-22 | 2020-03-20 | 海化生命(厦门)科技有限公司 | 用于合成巴瑞替尼的关键中间体1的制备方法 |
CN108129482A (zh) * | 2017-12-13 | 2018-06-08 | 江苏中邦制药有限公司 | 一种巴瑞替尼的制备方法 |
-
2017
- 2017-12-13 CN CN201711334329.1A patent/CN108129482A/zh not_active Withdrawn
-
2018
- 2018-06-25 CN CN201810667443.4A patent/CN108586465B/zh active Active
- 2018-07-03 AU AU2018102141A patent/AU2018102141A4/en active Active
- 2018-07-03 WO PCT/CN2018/094160 patent/WO2019114258A1/fr active Application Filing
- 2018-07-03 AU AU2018366342A patent/AU2018366342A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CN108586465B (zh) | 2020-06-02 |
CN108586465A (zh) | 2018-09-28 |
AU2018102141A4 (en) | 2019-10-03 |
CN108129482A (zh) | 2018-06-08 |
WO2019114258A1 (fr) | 2019-06-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
DA3 | Amendments made section 104 |
Free format text: THE NATURE OF THE AMENDMENT IS: APPLICATION IS TO PROCEED UNDER THE NUMBER 2018102141 |