AU2018366342A1 - Method for preparing Baricitinib - Google Patents

Method for preparing Baricitinib Download PDF

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Publication number
AU2018366342A1
AU2018366342A1 AU2018366342A AU2018366342A AU2018366342A1 AU 2018366342 A1 AU2018366342 A1 AU 2018366342A1 AU 2018366342 A AU2018366342 A AU 2018366342A AU 2018366342 A AU2018366342 A AU 2018366342A AU 2018366342 A1 AU2018366342 A1 AU 2018366342A1
Authority
AU
Australia
Prior art keywords
compound
mixture
added
reacted
baricitinib
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AU2018366342A
Other languages
English (en)
Inventor
Shuang HUANG
Weisi LI
Jingyu TANG
Siqing WU
Qiang Xu
Jian Yang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
JIANGSU ZHONGBANG PHARMACEUTICAL CO Ltd
Original Assignee
JIANGSU ZHONGBANG PHARMACEUTICAL CO Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JIANGSU ZHONGBANG PHARMACEUTICAL CO Ltd filed Critical JIANGSU ZHONGBANG PHARMACEUTICAL CO Ltd
Publication of AU2018366342A1 publication Critical patent/AU2018366342A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2018366342A 2017-12-13 2018-07-03 Method for preparing Baricitinib Pending AU2018366342A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201711334329.1 2017-12-13
CN201711334329.1A CN108129482A (zh) 2017-12-13 2017-12-13 一种巴瑞替尼的制备方法
CN201810667443.4A CN108586465B (zh) 2017-12-13 2018-06-25 一种巴瑞替尼的制备方法
CN201810667443.4 2018-06-25
PCT/CN2018/094160 WO2019114258A1 (fr) 2017-12-13 2018-07-03 Procédé de préparation de baricitinib

Publications (1)

Publication Number Publication Date
AU2018366342A1 true AU2018366342A1 (en) 2019-07-04

Family

ID=62389618

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2018102141A Active AU2018102141A4 (en) 2017-12-13 2018-07-03 Method for preparing Baricitinib
AU2018366342A Pending AU2018366342A1 (en) 2017-12-13 2018-07-03 Method for preparing Baricitinib

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AU2018102141A Active AU2018102141A4 (en) 2017-12-13 2018-07-03 Method for preparing Baricitinib

Country Status (3)

Country Link
CN (2) CN108129482A (fr)
AU (2) AU2018102141A4 (fr)
WO (1) WO2019114258A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108129482A (zh) * 2017-12-13 2018-06-08 江苏中邦制药有限公司 一种巴瑞替尼的制备方法
WO2021053690A1 (fr) * 2019-09-17 2021-03-25 Natco Pharma Limited Procédé amélioré pour la préparation de baricitinib
CN111362853A (zh) * 2020-04-27 2020-07-03 安徽大学 一种3-氧杂氮杂环丁烷-1-羧酸叔丁酯的制备方法
CN112898306B (zh) * 2021-02-02 2022-04-08 山东四环药业股份有限公司 一种巴瑞替尼的制备方法
CN115124537A (zh) * 2022-07-13 2022-09-30 山东大学 一种jak抑制剂巴瑞替尼的制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3035395A1 (de) * 1980-09-19 1982-05-06 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von pyrazol
UA98639C2 (en) * 2007-02-28 2012-06-11 Лео Фарма А/С Phosphodiesterase inhibitors
RS55263B1 (sr) * 2008-03-11 2017-02-28 Incyte Holdings Corp Derivati azetidina i ciklobutana kao jak inhibitori
EP3227298A4 (fr) * 2014-12-05 2018-05-23 Sun Pharmaceutical Industries Ltd Procédé de synthèse de baricitinib et d'un intermédiaire de celui-ci
US10526350B2 (en) * 2015-02-02 2020-01-07 Sun Pharmaceutical Industries Limited Process for the preparation of baricitinib and an intermediate thereof
AR104918A1 (es) * 2015-06-19 2017-08-23 Lilly Co Eli Procesos e intermediarios para la preparación de {1-(etilsulfonil)-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]azetidin-3-il}acetonitrilo
CN105294699B (zh) * 2015-12-04 2019-06-11 上海勋和医药科技有限公司 巴瑞替尼的制备方法
CN105541891B (zh) * 2016-02-04 2017-11-28 东南大学 巴瑞替尼的中间体及其制备方法及由该中间体制备巴瑞替尼的方法
CN106496195B (zh) * 2016-10-18 2019-03-08 杭州科巢生物科技有限公司 巴瑞替尼及其中间体的合成方法
CN106946917B (zh) * 2017-03-20 2019-06-11 杭州科巢生物科技有限公司 一种jak抑制剂巴瑞替尼及其中间体的新合成方法
CN107176955B (zh) * 2017-03-24 2019-04-09 南京优科制药有限公司 一种巴瑞替尼的制备方法
CN107739328B (zh) * 2017-11-22 2020-03-20 海化生命(厦门)科技有限公司 用于合成巴瑞替尼的关键中间体1的制备方法
CN108129482A (zh) * 2017-12-13 2018-06-08 江苏中邦制药有限公司 一种巴瑞替尼的制备方法

Also Published As

Publication number Publication date
CN108586465B (zh) 2020-06-02
CN108586465A (zh) 2018-09-28
AU2018102141A4 (en) 2019-10-03
CN108129482A (zh) 2018-06-08
WO2019114258A1 (fr) 2019-06-20

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DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: APPLICATION IS TO PROCEED UNDER THE NUMBER 2018102141