AU2018359018B2 - Peptide antibiotics - Google Patents

Peptide antibiotics Download PDF

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Publication number
AU2018359018B2
AU2018359018B2 AU2018359018A AU2018359018A AU2018359018B2 AU 2018359018 B2 AU2018359018 B2 AU 2018359018B2 AU 2018359018 A AU2018359018 A AU 2018359018A AU 2018359018 A AU2018359018 A AU 2018359018A AU 2018359018 B2 AU2018359018 B2 AU 2018359018B2
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AU
Australia
Prior art keywords
dab
group
leu
compound
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2018359018A
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English (en)
Other versions
AU2018359018A1 (en
Inventor
Bernd Becker
Mark Blaskovich
Matthew Cooper
Alysha ELLIOTT
Alejandra Gallardo-Godoy
Karl Hansford
Craig Muldoon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Queensland UQ
Original Assignee
University of Queensland UQ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2017904465A external-priority patent/AU2017904465A0/en
Application filed by University of Queensland UQ filed Critical University of Queensland UQ
Publication of AU2018359018A1 publication Critical patent/AU2018359018A1/en
Application granted granted Critical
Publication of AU2018359018B2 publication Critical patent/AU2018359018B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C07K7/62—Polymyxins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
AU2018359018A 2017-11-02 2018-11-02 Peptide antibiotics Active AU2018359018B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2017904465A AU2017904465A0 (en) 2017-11-02 Peptide antibiotics
AU2017904465 2017-11-02
PCT/AU2018/051194 WO2019084628A1 (en) 2017-11-02 2018-11-02 Peptide antibiotics

Publications (2)

Publication Number Publication Date
AU2018359018A1 AU2018359018A1 (en) 2020-05-14
AU2018359018B2 true AU2018359018B2 (en) 2022-11-24

Family

ID=66331139

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2018359018A Active AU2018359018B2 (en) 2017-11-02 2018-11-02 Peptide antibiotics

Country Status (6)

Country Link
US (1) US11279733B2 (https=)
EP (1) EP3704135A4 (https=)
JP (1) JP2021501783A (https=)
CN (1) CN111527100A (https=)
AU (1) AU2018359018B2 (https=)
WO (1) WO2019084628A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021247978A1 (en) * 2020-06-05 2021-12-09 The Rockefeller University Antibacterial synthetic-bioinformatic natural products and uses thereof
US20250346633A1 (en) * 2021-04-27 2025-11-13 The Rockefeller University Macolacins and methods of use thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0471453A2 (en) * 1990-07-19 1992-02-19 Merck & Co. Inc. Cyclic HIV principal neutralizing determinant peptides
WO2002055543A2 (en) * 2001-01-16 2002-07-18 Univ Ramot Hybrid peptides for treatment of bacteremia and septicemia
WO2017189868A1 (en) * 2016-04-27 2017-11-02 Spero Opco Serine replacement polymyxin analogues useful as antibiotic potentiators

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3880994A (en) 1972-12-06 1975-04-29 Bristol Myers Co Antibiotic BU-1880
JPS5025795A (https=) 1973-07-10 1975-03-18
US4341768A (en) * 1981-04-03 1982-07-27 Bristol-Myers Company Antibiotic compounds
GB2128617A (en) * 1982-10-06 1984-05-02 Martti Vaara Polypeptides for use in antibacterial therapy
US20060004185A1 (en) * 2004-07-01 2006-01-05 Leese Richard A Peptide antibiotics and peptide intermediates for their prepartion
BRPI0715095B8 (pt) * 2006-08-11 2021-05-25 Northern Antibiotics Oy derivado de polimixina da fórmula geral (i); produto de combinação; composição farmacêutica; método para se sensibilizar bactérias gram-negativas a um agente antibacteriano; método para o desenvolvimento de antibióticos; método para a redução da toxicidade de polimixinas, octapeptinas naturais e seus derivados durante a aplicação das mesmas no tratamento de infecções em um indivíduo; método para melhorar as propriedades farmacocinéticas, de polimixinas, octapeptinas naturais e seus derivados; método para a sensibilização de bactérias gram-negativas clinicamente importantes a um complemento de mecanismo de defesa presente no soro; uso de um derivado; e processo para a preparação de um derivado de polimixina da fórmula (i).
US9096649B2 (en) * 2008-02-08 2015-08-04 Northern Antibiotics Ltd. Polymyxin derivatives and uses thereof
FI20085469A0 (fi) * 2008-02-08 2008-05-16 Northern Antibiotics Oy Polymyksiinijohdannaiset, joissa on lyhyt rasvahappohäntä, ja niiden käyttöjä
WO2010130007A1 (en) 2009-05-14 2010-11-18 Monash University Antimicrobial compounds
ES2374779B1 (es) 2010-03-10 2012-12-27 Universidad De Barcelona Compuestos péptidicos útiles como agentes antibacterianos.
WO2012168820A1 (en) 2011-06-08 2012-12-13 Pfizer Inc. Polymyxin derivatives useful as antibacterial agents
CA2855916A1 (en) * 2011-11-18 2013-05-23 Novacta Biosystems Limited Polymyxin derivatives
KR102354902B1 (ko) 2013-05-22 2022-01-24 에버레스트 메디신즈 (싱가포르) 피티이. 리미티드 폴리믹신 유도체 및 상이한 항생제와의 조합 요법에 있어서의 이들의 용도
MX359104B (es) 2014-03-11 2018-09-14 New Pharma Licence Holdings Ltd Derivados de polimixina y su uso en terapia de combinacion junto con diferentes antibioticos.
JP2017512818A (ja) * 2014-04-01 2017-05-25 モナシュ、ユニバーシティＭｏｎａｓｈ Ｕｎｉｖｅｒｓｉｔｙ 抗菌性化合物としてのポリミキシン誘導体
US12146004B2 (en) * 2014-11-26 2024-11-19 Spero Therapeutics, Inc. Polymyxin compounds and uses thereof
WO2016100578A2 (en) 2014-12-16 2016-06-23 Micurx Pharmaceuticals, Inc. Antimicrobial polymyxins for treatment of bacterial infections
EP3274361A1 (en) 2015-03-23 2018-01-31 Polyphor Ag Beta-hairpin peptidomimetics
EP3356387B1 (en) 2015-09-29 2024-06-26 Monash University Antimicrobial polymyxin derivative compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0471453A2 (en) * 1990-07-19 1992-02-19 Merck & Co. Inc. Cyclic HIV principal neutralizing determinant peptides
WO2002055543A2 (en) * 2001-01-16 2002-07-18 Univ Ramot Hybrid peptides for treatment of bacteremia and septicemia
WO2017189868A1 (en) * 2016-04-27 2017-11-02 Spero Opco Serine replacement polymyxin analogues useful as antibiotic potentiators

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
KNIGHT, M. et al, "Inhibitory Cyclic Analogues and Chlorambucil Derivatives of Bombesin-Like Peptides", Peptides, 1995, vol. 16, no. 6, pages 1109-1115 *
PARKER, W. et al, "EM49, A NEW PEPTIDE ANTIBIOTIC II. CHEMICAL CHARACTERIZATION", The Journal of Antibiotics, 1973, vol. 26, no. 8, pages 449-456 *
SATO, Y. et al, "Novel Des-Fatty Acyl-Polymyxin B Derivatives with Pseudomonas aeruginosa-Specific Antimicrobial Activity", Chemical and Pharmaceutical Bulletin, 2011, vol. 59, no. 5, pages 597-602 *
SWANSON, P. E. et al, "Characterization of Octapeptin-Membrane Interactions Using Spin-Labeled Octapeptin", Biochemistry, 1980, vol. 19, pages 3307-3314 *
VELKOV, T. et al, "A Novel Chemical Biology Approach for Mapping of Polymyxin Lipopeptide Antibody Binding Epitopes", ACS Infectious Diseases, 2016, vol. 2, pages 341-351 *
WEINSTEIN, J. et al, "Selective Reductive Cleavage of a Threonine Peptide Bond in Polymyxin Antibiotics", Annals of the New York Academy of Science, 1986, vol. 471, pages 321-323 *

Also Published As

Publication number Publication date
JP2021501783A (ja) 2021-01-21
EP3704135A4 (en) 2022-04-27
AU2018359018A1 (en) 2020-05-14
US20200361994A1 (en) 2020-11-19
EP3704135A1 (en) 2020-09-09
WO2019084628A1 (en) 2019-05-09
CN111527100A (zh) 2020-08-11
US11279733B2 (en) 2022-03-22

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