AU2018352699A1 - Pyrimidine TBK/IKKE inhibitor compounds and uses thereof - Google Patents

Info

Publication number

AU2018352699A1

AU2018352699A1 AU2018352699A AU2018352699A AU2018352699A1 AU 2018352699 A1 AU2018352699 A1 AU 2018352699A1 AU 2018352699 A AU2018352699 A AU 2018352699A AU 2018352699 A AU2018352699 A AU 2018352699A AU 2018352699 A1 AU2018352699 A1 AU 2018352699A1

Authority

AU

Australia

Prior art keywords

amino

pyrimidin

compound

yloxy

methoxy

Prior art date

2017-10-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
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• 150000001875 compounds Chemical class 0.000 title claims abstract description 299
• CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title claims description 5
• 239000003112 inhibitor Substances 0.000 title abstract description 10
• 101001043761 Homo sapiens Inhibitor of nuclear factor kappa-B kinase subunit epsilon Proteins 0.000 title 1
• 102100021857 Inhibitor of nuclear factor kappa-B kinase subunit epsilon Human genes 0.000 title 1
• 238000000034 method Methods 0.000 claims description 356
• -1 carrier Substances 0.000 claims description 72
• IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 50
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 48
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 41
• 150000003839 salts Chemical class 0.000 claims description 40
• 229910052757 nitrogen Inorganic materials 0.000 claims description 39
• 125000005842 heteroatom Chemical group 0.000 claims description 33
• 201000010099 disease Diseases 0.000 claims description 31
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 30
• 229910052717 sulfur Chemical group 0.000 claims description 30
• 239000011593 sulfur Chemical group 0.000 claims description 30
• 125000003118 aryl group Chemical group 0.000 claims description 29
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 29
• 239000001301 oxygen Chemical group 0.000 claims description 29
• 229910052760 oxygen Inorganic materials 0.000 claims description 29
• 125000001931 aliphatic group Chemical group 0.000 claims description 28
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 28
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• 150000004677 hydrates Chemical class 0.000 claims description 7
• JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 6
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