AU2018348796B2 - Zinc ionophores and uses thereof - Google Patents

Zinc ionophores and uses thereof Download PDF

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Publication number
AU2018348796B2
AU2018348796B2 AU2018348796A AU2018348796A AU2018348796B2 AU 2018348796 B2 AU2018348796 B2 AU 2018348796B2 AU 2018348796 A AU2018348796 A AU 2018348796A AU 2018348796 A AU2018348796 A AU 2018348796A AU 2018348796 B2 AU2018348796 B2 AU 2018348796B2
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AU
Australia
Prior art keywords
zinc
antibiotic
pharmaceutically acceptable
optionally substituted
pbt2
Prior art date
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AU2018348796A
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English (en)
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AU2018348796A1 (en
Inventor
Christopher MCDEVITT
Alastair Mcewan
Mark Von Itzstein
Mark Walker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Queensland UQ
Griffith University
Adelaide University
Original Assignee
University of Adelaide
University of Queensland UQ
Griffith University
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Publication date
Priority claimed from AU2017904135A external-priority patent/AU2017904135A0/en
Application filed by University of Adelaide, University of Queensland UQ, Griffith University filed Critical University of Adelaide
Publication of AU2018348796A1 publication Critical patent/AU2018348796A1/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2018348796A 2017-10-13 2018-10-12 Zinc ionophores and uses thereof Active AU2018348796B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2017904135A AU2017904135A0 (en) 2017-10-13 Compositions and their uses
AU2017904135 2017-10-13
PCT/AU2018/051116 WO2019071325A1 (en) 2017-10-13 2018-10-12 ZINC IONOPHORES AND USES THEREOF

Publications (2)

Publication Number Publication Date
AU2018348796A1 AU2018348796A1 (en) 2020-05-07
AU2018348796B2 true AU2018348796B2 (en) 2024-09-26

Family

ID=66100161

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2018348796A Active AU2018348796B2 (en) 2017-10-13 2018-10-12 Zinc ionophores and uses thereof

Country Status (6)

Country Link
US (1) US20200261440A1 (enExample)
EP (1) EP3694515A4 (enExample)
JP (2) JP7514763B2 (enExample)
CN (1) CN111787921A (enExample)
AU (1) AU2018348796B2 (enExample)
WO (1) WO2019071325A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3114742A1 (fr) * 2020-10-04 2022-04-08 Bruno Eto Composition pharmaceutique ou diététique pour bloquer la synthèse des peptides par les ribosomes.
TW202334089A (zh) 2021-11-02 2023-09-01 美商夫雷爾醫療公司 Ｐｐａｒｇ反向激動劑及其用途
CN116726145A (zh) * 2022-03-04 2023-09-12 海南普利制药股份有限公司 一种稳定的酯肽类药物组合物
EP4565234A1 (en) * 2022-08-01 2025-06-11 Griffith University Antibacterial compound pbt2
CN120695002A (zh) * 2025-06-24 2025-09-26 南方医科大学南方医院 Pbt2在制备抗白念珠菌生物膜药物中的应用

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5696083A (en) * 1992-11-10 1997-12-09 Olin Corporation Personal care composition containing pyrithione and polymyxin
WO2009140215A2 (en) * 2008-05-11 2009-11-19 Geraghty, Erin Method for treating drug-resistant bacterial and other infections with clioquinol, phanquinone, and related compounds
WO2009155088A1 (en) * 2008-05-30 2009-12-23 University Of Cincinnati Use of zinc chelators to inhibit biofilm formation
WO2014172435A1 (en) * 2013-04-16 2014-10-23 University Of Cincinnati Antimicrobial compositions of aminoglycosidic antibiotics and zinc ion chelators
WO2015049546A1 (en) * 2013-10-04 2015-04-09 Universitetet I Oslo Inhibitors of metallo-beta-lactamase (mbl) comprising a zinc chelating moiety
WO2016207183A1 (en) * 2015-06-23 2016-12-29 Janssen Pharmaceutica Nv Antimicrobial compositions comprising food approved antimicrobials and zinc pyrithione
WO2017053696A2 (en) * 2015-09-24 2017-03-30 University Of Florida Research Foundation, Incorporated Halogenated quinoline derivatives as antimicrobial agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002950217A0 (en) 2002-07-16 2002-09-12 Prana Biotechnology Limited 8- Hydroxy Quinoline Derivatives
HUE030264T2 (en) * 2005-06-28 2017-04-28 Janssen Pharmaceutica Nv Quinoline derivatives as antibacterial agents

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5696083A (en) * 1992-11-10 1997-12-09 Olin Corporation Personal care composition containing pyrithione and polymyxin
WO2009140215A2 (en) * 2008-05-11 2009-11-19 Geraghty, Erin Method for treating drug-resistant bacterial and other infections with clioquinol, phanquinone, and related compounds
WO2009155088A1 (en) * 2008-05-30 2009-12-23 University Of Cincinnati Use of zinc chelators to inhibit biofilm formation
WO2014172435A1 (en) * 2013-04-16 2014-10-23 University Of Cincinnati Antimicrobial compositions of aminoglycosidic antibiotics and zinc ion chelators
WO2015049546A1 (en) * 2013-10-04 2015-04-09 Universitetet I Oslo Inhibitors of metallo-beta-lactamase (mbl) comprising a zinc chelating moiety
WO2016207183A1 (en) * 2015-06-23 2016-12-29 Janssen Pharmaceutica Nv Antimicrobial compositions comprising food approved antimicrobials and zinc pyrithione
WO2017053696A2 (en) * 2015-09-24 2017-03-30 University Of Florida Research Foundation, Incorporated Halogenated quinoline derivatives as antimicrobial agents

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BLANCHARD CATLYN ET AL: "Zinc Pyrithione Improves the Antibacterial Activity of Silver Sulfadiazine Ointment", MSPHERE, vol. 1, no. 5, September 2016 (2016-09-01), pages - 16, XP002802337, ISSN: 2379-5042 *
CHIEM, K ET AL. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 59, no. 9, 13 July 2015, pages 5851 - 5853 *
DATABASE Pubchem Compound [online] 23 August 2007 (2007-08-23), ANONYMOUS: "8-Hydroxyquinoline ZINC Salt", XP055591238, retrieved from NCBI Database accession no. CID 16717640 *
LI YIJIA ET AL: "Inhibition of Aminoglycoside Acetyltransferase Resistance Enzymes by Metal Salts", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 59, no. 7, July 2015 (2015-07-01), pages 4148 - 4156, XP002802338, ISSN: 0066-4804 *
NGUYEN, M ET AL.: "Structures of the Copper and Zinc Complexes of PBT2, a Chelating Agent Evaluated as Potential Drug for Neurodegenerative Diseases", EUROPEAN JOURNAL INORGANIC CHEMISTRY, vol. 2017, no. 3, 4 November 2016, pages 600 - 608 *

Also Published As

Publication number Publication date
JP2020536966A (ja) 2020-12-17
AU2018348796A1 (en) 2020-05-07
JP2024073569A (ja) 2024-05-29
EP3694515A1 (en) 2020-08-19
US20200261440A1 (en) 2020-08-20
EP3694515A4 (en) 2021-04-21
JP7514763B2 (ja) 2024-07-11
CN111787921A (zh) 2020-10-16
WO2019071325A1 (en) 2019-04-18

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