AU2018309718B2 - Antifungal agents with enhanced activity in acidic pH - Google Patents

Antifungal agents with enhanced activity in acidic pH Download PDF

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Publication number
AU2018309718B2
AU2018309718B2 AU2018309718A AU2018309718A AU2018309718B2 AU 2018309718 B2 AU2018309718 B2 AU 2018309718B2 AU 2018309718 A AU2018309718 A AU 2018309718A AU 2018309718 A AU2018309718 A AU 2018309718A AU 2018309718 B2 AU2018309718 B2 AU 2018309718B2
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Australia
Prior art keywords
compound
pharmaceutically acceptable
acceptable salt
administered
subject
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AU2018309718A
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English (en)
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AU2018309718A1 (en
Inventor
David A. ANGULO GONZALEZ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scynexis Inc
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SCYNEXIS Inc
Scynexis Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=63209698&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2018309718(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by SCYNEXIS Inc, Scynexis Inc filed Critical SCYNEXIS Inc
Publication of AU2018309718A1 publication Critical patent/AU2018309718A1/en
Application granted granted Critical
Publication of AU2018309718B2 publication Critical patent/AU2018309718B2/en
Priority to AU2024227501A priority Critical patent/AU2024227501A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Gynecology & Obstetrics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Reproductive Health (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2018309718A 2017-08-04 2018-07-31 Antifungal agents with enhanced activity in acidic pH Active AU2018309718B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2024227501A AU2024227501A1 (en) 2017-08-04 2024-10-21 Antifungal agents with enhanced activity in acidic pH

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762541370P 2017-08-04 2017-08-04
US62/541,370 2017-08-04
PCT/US2018/044619 WO2019028034A1 (en) 2017-08-04 2018-07-31 Antifungal agents with enhanced activity in acidic ph

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2024227501A Division AU2024227501A1 (en) 2017-08-04 2024-10-21 Antifungal agents with enhanced activity in acidic pH

Publications (2)

Publication Number Publication Date
AU2018309718A1 AU2018309718A1 (en) 2020-02-27
AU2018309718B2 true AU2018309718B2 (en) 2024-07-25

Family

ID=63209698

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2018309718A Active AU2018309718B2 (en) 2017-08-04 2018-07-31 Antifungal agents with enhanced activity in acidic pH
AU2024227501A Pending AU2024227501A1 (en) 2017-08-04 2024-10-21 Antifungal agents with enhanced activity in acidic pH

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2024227501A Pending AU2024227501A1 (en) 2017-08-04 2024-10-21 Antifungal agents with enhanced activity in acidic pH

Country Status (26)

Country Link
US (3) US11534433B2 (https=)
EP (3) EP4732902A2 (https=)
JP (1) JP7214714B2 (https=)
KR (1) KR102807716B1 (https=)
CN (2) CN111093655A (https=)
AU (2) AU2018309718B2 (https=)
BR (1) BR112020002290A2 (https=)
CA (1) CA3071940A1 (https=)
CY (1) CY1125690T1 (https=)
DK (1) DK3661503T3 (https=)
EA (1) EA202090445A1 (https=)
ES (1) ES2932658T3 (https=)
FI (1) FI3661503T3 (https=)
HR (1) HRP20221414T1 (https=)
HU (1) HUE060508T2 (https=)
LT (1) LT3661503T (https=)
MA (1) MA49751B1 (https=)
MD (1) MD3661503T2 (https=)
MX (1) MX2020001399A (https=)
PL (1) PL3661503T3 (https=)
PT (1) PT3661503T (https=)
RS (1) RS63746B1 (https=)
SI (1) SI3661503T1 (https=)
SM (1) SMT202200461T1 (https=)
TW (1) TWI805600B (https=)
WO (1) WO2019028034A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112021016876A2 (pt) * 2019-02-27 2021-11-03 Scynexis Inc Métodos para tratar e para prevenir pneumonia por pneumocystis, métodos para tratar e para prevenir pneumonia por pneumocystis jirovecii, preparação de um medicamento para tratar ou prevenir pneumonia por pneumocystis jirovecii, e, uso de um composto
AU2020276595B2 (en) * 2019-05-16 2025-12-04 Scynexis, Inc. Antifungal Agents for Candida Auris Decolonization
WO2022140646A1 (en) * 2020-12-26 2022-06-30 Mycovia Pharmaceuticals, Inc Dosing regimen for oteseconazole

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756472A (en) 1996-01-31 1998-05-26 Merck & Co., Inc. Antifungal agent obtained from hormonema
JP5245057B2 (ja) 2006-04-03 2013-07-24 メルク・シャープ・アンド・ドーム・コーポレーション 抗真菌剤
WO2010019204A1 (en) 2008-08-12 2010-02-18 Merck Sharp & Dohme Corp. Antifungal agents
KR101686075B1 (ko) * 2008-08-12 2016-12-13 싸이넥시스, 인크. 항균제
HRP20220544T1 (hr) 2015-01-19 2022-08-05 Scynexis, Inc. Nove soli i polimorfi scy-078
MA49889A (fr) * 2017-04-10 2020-06-24 Scynexis Inc Agents antifongiques utilisés en association

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DANBY C.S. et al. "Effect of pH on in vitro susceptibility of Candida glabrata and Candida albicans to 11 antifungal agents and implications for clinical use", ANTIMICROBROBIAL AGENTS && CHEMOTHERAPY (2012), vol. 56, pages 1403-1406 *
HELOU, S. 25 April 2017. Retrieved from the Internet: *
SCYNEXIS: 5 October 2016, Retrieved from the Internet *

Also Published As

Publication number Publication date
EP3661503B1 (en) 2022-09-07
BR112020002290A2 (pt) 2020-09-08
US20200390751A1 (en) 2020-12-17
EP4732902A2 (en) 2026-04-29
US20260000656A1 (en) 2026-01-01
JP2020529999A (ja) 2020-10-15
KR20200044823A (ko) 2020-04-29
MD3661503T2 (ro) 2023-01-31
HRP20221414T1 (hr) 2023-01-20
EA202090445A1 (ru) 2020-06-23
TW201919476A (zh) 2019-06-01
CA3071940A1 (en) 2019-02-07
FI3661503T3 (fi) 2022-12-15
HUE060508T2 (hu) 2023-03-28
MA49751B1 (fr) 2022-12-30
SMT202200461T1 (it) 2023-01-13
EP4169514B1 (en) 2026-01-28
US11534433B2 (en) 2022-12-27
ES2932658T3 (es) 2023-01-23
SI3661503T1 (sl) 2023-01-31
RS63746B1 (sr) 2022-12-30
CN118542868A (zh) 2024-08-27
CY1125690T1 (el) 2026-02-25
LT3661503T (lt) 2022-12-12
EP4169514A1 (en) 2023-04-26
PT3661503T (pt) 2022-12-13
KR102807716B1 (ko) 2025-05-13
PL3661503T3 (pl) 2023-01-09
EP3661503A1 (en) 2020-06-10
CN111093655A (zh) 2020-05-01
WO2019028034A1 (en) 2019-02-07
US20230364067A1 (en) 2023-11-16
MA49751A (fr) 2020-06-10
AU2024227501A1 (en) 2024-11-07
EP4169514C0 (en) 2026-01-28
MX2020001399A (es) 2020-08-06
JP7214714B2 (ja) 2023-01-30
TWI805600B (zh) 2023-06-21
AU2018309718A1 (en) 2020-02-27
DK3661503T3 (da) 2022-12-12

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