AU2018306606B2 - Compounds and methods for the targeted degradation of Androgen Receptor - Google Patents

Compounds and methods for the targeted degradation of Androgen Receptor Download PDF

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AU2018306606B2
AU2018306606B2 AU2018306606A AU2018306606A AU2018306606B2 AU 2018306606 B2 AU2018306606 B2 AU 2018306606B2 AU 2018306606 A AU2018306606 A AU 2018306606A AU 2018306606 A AU2018306606 A AU 2018306606A AU 2018306606 B2 AU2018306606 B2 AU 2018306606B2
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AU2018306606A1 (en
Inventor
Michael Berlin
Xin Chen
Andrew P. Crew
Craig M. Crews
Hanqing Dong
Yimin Qian
Lawrence Snyder
Jing Wang
Kurt Zimmermann
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Arvinas Operations Inc
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Arvinas Operations Inc
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    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
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    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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AU2018306606A 2017-07-28 2018-07-27 Compounds and methods for the targeted degradation of Androgen Receptor Ceased AU2018306606B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15/663,273 US20170327469A1 (en) 2015-01-20 2017-07-28 Compounds and methods for the targeted degradation of androgen receptor
US15/663,273 2017-07-28
PCT/US2018/044051 WO2019023553A1 (fr) 2017-07-28 2018-07-27 Composés et procédés pour la dégradation ciblée du récepteur des androgènes

Publications (2)

Publication Number Publication Date
AU2018306606A1 AU2018306606A1 (en) 2020-02-06
AU2018306606B2 true AU2018306606B2 (en) 2021-04-22

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AU2018306606A Ceased AU2018306606B2 (en) 2017-07-28 2018-07-27 Compounds and methods for the targeted degradation of Androgen Receptor

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EP (1) EP3658548A1 (fr)
JP (1) JP2020528918A (fr)
KR (1) KR20200035435A (fr)
CN (1) CN111212835A (fr)
AU (1) AU2018306606B2 (fr)
BR (1) BR112020001825A2 (fr)
CA (1) CA3069544A1 (fr)
RU (1) RU2020108515A (fr)
WO (1) WO2019023553A1 (fr)

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WO2020132561A1 (fr) 2018-12-20 2020-06-25 C4 Therapeutics, Inc. Dégradation ciblée de protéines
US20220241424A1 (en) 2019-04-16 2022-08-04 Northwestern University Treatment of cancer
WO2020211822A1 (fr) * 2019-04-18 2020-10-22 成都海创药业有限公司 Classe de composés hétérocycliques chimériques bifonctionnels pour la dégradation ciblée de récepteurs des androgènes et utilisation associée
CN113811333B (zh) 2019-05-14 2024-03-12 诺维逊生物股份有限公司 靶向抗癌核激素受体的化合物
CN112574278B (zh) * 2019-09-29 2024-08-23 江西济民可信集团有限公司 作为蛋白降解剂杂环类化合物及其制备方法和医药应用
TW202131930A (zh) 2019-11-13 2021-09-01 美商諾維雪碧歐公司 抗癌核荷爾蒙受體標靶化合物
CN110903345A (zh) * 2019-11-27 2020-03-24 中国药科大学 靶向雄激素受体的小分子降解剂及其制备方法与应用
TW202146412A (zh) 2020-03-05 2021-12-16 美商C4醫藥公司 用於標靶降解brd9之化合物
CN113387930B (zh) * 2020-03-11 2022-07-12 苏州开拓药业股份有限公司 一种双官能化合物及其制备方法和用途
CN113582974B (zh) * 2020-04-30 2022-05-17 江西济民可信集团有限公司 一类作为蛋白降解剂的化合物及其制备方法和医药用途
CN111471054A (zh) * 2020-05-16 2020-07-31 长春中医药大学 一种降解铜离子转运蛋白Atox1和CCS的小分子抑制剂及其应用
CN111606868B (zh) * 2020-06-23 2023-02-17 温州大学新材料与产业技术研究院 一种双齿噁唑啉手性配体的制备方法
KR20220014952A (ko) 2020-07-29 2022-02-08 한국화학연구원 안드로겐 수용체의 저해 또는 분해용 화합물 및 이들의 의약 용도
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CA3069544A1 (fr) 2019-01-31
JP2020528918A (ja) 2020-10-01
RU2020108515A (ru) 2021-08-27
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