AU2018266640B2 - Compounds and methods for treating bacterial infections - Google Patents

Compounds and methods for treating bacterial infections Download PDF

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Publication number
AU2018266640B2
AU2018266640B2 AU2018266640A AU2018266640A AU2018266640B2 AU 2018266640 B2 AU2018266640 B2 AU 2018266640B2 AU 2018266640 A AU2018266640 A AU 2018266640A AU 2018266640 A AU2018266640 A AU 2018266640A AU 2018266640 B2 AU2018266640 B2 AU 2018266640B2
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AU
Australia
Prior art keywords
int
mmol
oxo
methanopyrazolo
methyl
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AU2018266640A
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AU2018266640A1 (en
Inventor
Janelle Comita-Prevoir
Thomas Francois Durand-Reville
Satenig GULER
Jan Romero
Mark Sylvester
Ruben Tommasi
Camilo VELEZ-VEGA
Xiaoyun Wu
Jing Zhang
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Entasis Therapeutics Inc
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Entasis Therapeutics Inc
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Publication of AU2018266640A1 publication Critical patent/AU2018266640A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2018266640A 2017-05-08 2018-05-08 Compounds and methods for treating bacterial infections Active AU2018266640B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762502867P 2017-05-08 2017-05-08
US62/502,867 2017-05-08
PCT/US2018/031593 WO2018208769A1 (en) 2017-05-08 2018-05-08 Compounds and methods for treating bacterial infections

Publications (2)

Publication Number Publication Date
AU2018266640A1 AU2018266640A1 (en) 2019-11-07
AU2018266640B2 true AU2018266640B2 (en) 2022-03-03

Family

ID=62223332

Family Applications (1)

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AU2018266640A Active AU2018266640B2 (en) 2017-05-08 2018-05-08 Compounds and methods for treating bacterial infections

Country Status (27)

Country Link
US (1) US11046694B2 (https=)
EP (1) EP3630111B1 (https=)
JP (1) JP7058322B2 (https=)
KR (1) KR102611447B1 (https=)
CN (1) CN110709081B (https=)
AU (1) AU2018266640B2 (https=)
CY (1) CY1125340T1 (https=)
DK (1) DK3630111T3 (https=)
EA (1) EA038393B1 (https=)
ES (1) ES2907858T3 (https=)
HR (1) HRP20220231T1 (https=)
HU (1) HUE057592T2 (https=)
IL (1) IL270380B (https=)
LT (1) LT3630111T (https=)
MA (1) MA48743A (https=)
MX (1) MX385203B (https=)
MY (1) MY201377A (https=)
NZ (1) NZ758200A (https=)
PE (1) PE20200333A1 (https=)
PH (1) PH12019502509A1 (https=)
PL (1) PL3630111T3 (https=)
PT (1) PT3630111T (https=)
SG (1) SG11201909443YA (https=)
SI (1) SI3630111T1 (https=)
SM (1) SMT202200110T1 (https=)
TW (1) TWI791018B (https=)
WO (1) WO2018208769A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11905286B2 (en) 2018-08-09 2024-02-20 Antabio Sas Diazabicyclooctanones as inhibitors of serine beta-lactamases
EP3833665B1 (en) 2018-08-09 2023-07-19 Antabio SAS Diazabicyclooctanones as inhibitors of serine beta-lactamases
CN111675641B (zh) * 2020-06-04 2023-09-08 宁夏农林科学院农业资源与环境研究所（宁夏土壤与植物营养重点实验室） 单环β-内酰胺类化合物、单环内酰胺类化合物盐及其制备方法
CN115605480B (zh) 2021-05-07 2024-04-05 宁夏农林科学院 磺酰脒取代的化合物及其作为β-内酰胺酶抑制剂的用途
US11814385B2 (en) 2021-06-25 2023-11-14 University Of South Florida Small molecule inhibitors targeting Clostridioides difficile sporulation
AU2024346059A1 (en) * 2023-09-19 2026-04-02 Entasis Therapeutics Inc. Compounds and methods for treating bacterial infections

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US20090018329A1 (en) * 2002-12-06 2009-01-15 Novexel Novel heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors
US20100093784A1 (en) * 2008-10-10 2010-04-15 Novexel Novel heterocyclic nitrogenous compounds, their preparation and their use as antibacterial medicaments
WO2014141132A1 (en) * 2013-03-14 2014-09-18 Naeja Pharmaceutical Inc. NEW HETEROCYCLIC COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS AND β-LACTAMASE INHIBITORS

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CZ282567B6 (cs) 1993-12-29 1997-08-13 Pfizer Inc. Diazabicyklické sloučeniny a farmaceutické prostředky na jejich bázi
FR2812635B1 (fr) 2000-08-01 2002-10-11 Aventis Pharma Sa Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens
FR2825705B1 (fr) 2001-06-08 2005-05-20 Aventis Pharma Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens
FR2835186B1 (fr) 2002-01-28 2006-10-20 Aventis Pharma Sa Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
FR2848210B1 (fr) 2002-12-06 2007-10-19 Aventis Pharma Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens et inhibiteurs de beta-lactamases
US7507727B2 (en) * 2003-04-07 2009-03-24 Cylene Pharmaceuticals, Inc. Substituted quinobenzoxazine analogs and methods of using thereof
FR2914923B1 (fr) 2007-04-12 2013-06-14 Novexel Nouveaux composes heterocycliques azotes,leur preparation et leur utilisation comme medicaments antibacteriens.
WO2009091856A2 (en) 2008-01-18 2009-07-23 Merck & Co., Inc. Beta-lactamase inhibitors
FR2930553B1 (fr) 2008-04-29 2010-05-21 Novexel Composes azabicycliques, leur preparation et leur utilisation comme medicaments, notamment inhibiteurs de beta-lactamases
EP2921559A1 (en) 2008-06-19 2015-09-23 Astra Zeneca Holding France Use of (1r,2s,5r) 1,6-diazabicyclo [3.2.1]octane-2-carboxamide, 7-oxo-6-(sulfooxy)-, monosodium salt as a diagnostic reagent for detecting serine beta-lactamases
FR2936798B1 (fr) 2008-10-03 2012-09-28 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens.
FR2936951B1 (fr) 2008-10-10 2010-12-03 Novexel Nouvelles combinaisons de composes heterocycliques azotes antibacteriens avec d'autres composes antibacteriens et leur utilisation comme medicaments
FR2951171A1 (fr) 2009-10-09 2011-04-15 Novexel Nouveau sel de sodium d'un compose azabicyclique sous forme enantiomere cristallisee et nouvelles formes polymorphes et pseudopolymorphes ainsi que leur preparation
WO2013014497A1 (en) 2011-07-26 2013-01-31 Wockhardt Limited Pharmaceutical compositions comprising beta-lactam antibiotic, sulbactam and beta-lactamase inhibitor
NZ616806A (en) 2011-07-26 2015-03-27 Wockhardt Ltd Pharmaceutical compositions comprising sulbactam and beta-lactamase inhibitor
MX348974B (es) 2011-08-27 2017-07-04 Wockhardt Ltd Derivados 1,6 - diazabiciclo [3,2,1] octan-7-ona y su uso en el tratamiento de infecciones bacterianas.
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EP2814483A2 (en) 2012-02-15 2014-12-24 Rempex Pharmaceuticals, Inc. Methods of treating bacterial infections
WO2013149136A1 (en) 2012-03-30 2013-10-03 Cubist Pharmaceuticals, Inc. ISOXAZOLE β-LACTAMASE INHIBITORS
US8969570B2 (en) 2012-03-30 2015-03-03 Cubist Pharmaceuticals, Inc. Beta-lactamase inhibitors
US8916709B2 (en) 2012-03-30 2014-12-23 Cubist Pharmaceuticals, Inc. 1,2,4-oxadiazole and 1,2,4-thiadiazole β-lactamase inhibitors
US8940897B2 (en) 2012-03-30 2015-01-27 Cubist Pharmaceuticals, Inc. 1,3,4-oxadiazole and 1,3,4-thiadiazole β-lactamase inhibitors
AR090539A1 (es) * 2012-04-02 2014-11-19 Astrazeneca Ab COMPUESTOS INHIBIDORES DE b LACTAMASA
HUE046893T2 (hu) 2012-05-30 2020-04-28 Meiji Seika Pharma Co Ltd Új ß-laktamáz inhibitor és eljárás elõállítására
RU2614418C2 (ru) 2012-08-25 2017-03-28 Вокхардт Лимитед Производные 1,6-диазабицикло[3.2.1]октан-7-она и их применение для лечения бактериальных инфекций
US20150258072A1 (en) 2012-09-03 2015-09-17 Wockhardt Limited Antibacterial compositions
EP2953626A1 (en) 2013-02-06 2015-12-16 Astrazeneca AB Combination therapy for the treatment of nosocomial pneumonia
JP6764862B2 (ja) 2014-11-17 2020-10-07 エンタシス・セラピューティックス・リミテッド 耐性細菌感染症の治療のための併用療法
DK3512851T3 (en) 2016-09-16 2022-10-17 Entasis Therapeutics Ltd Beta-lactamase inhibitor compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090018329A1 (en) * 2002-12-06 2009-01-15 Novexel Novel heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors
US20100093784A1 (en) * 2008-10-10 2010-04-15 Novexel Novel heterocyclic nitrogenous compounds, their preparation and their use as antibacterial medicaments
WO2014141132A1 (en) * 2013-03-14 2014-09-18 Naeja Pharmaceutical Inc. NEW HETEROCYCLIC COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS AND β-LACTAMASE INHIBITORS

Also Published As

Publication number Publication date
MA48743A (fr) 2020-04-08
MY201377A (en) 2024-02-21
HUE057592T2 (hu) 2022-05-28
SI3630111T1 (sl) 2022-05-31
HRP20220231T1 (hr) 2022-04-29
ES2907858T3 (es) 2022-04-26
SMT202200110T1 (it) 2022-05-12
KR20200005586A (ko) 2020-01-15
EP3630111B1 (en) 2021-11-24
MX385203B (es) 2025-03-14
WO2018208769A1 (en) 2018-11-15
JP7058322B2 (ja) 2022-04-21
NZ758200A (en) 2025-12-19
CY1125340T1 (el) 2024-02-16
EP3630111A1 (en) 2020-04-08
TW201843152A (zh) 2018-12-16
BR112019023130A2 (pt) 2020-05-26
CA3059773A1 (en) 2018-11-15
CN110709081A (zh) 2020-01-17
CN110709081B (zh) 2023-09-22
PH12019502509A1 (en) 2020-07-13
PE20200333A1 (es) 2020-02-14
AU2018266640A1 (en) 2019-11-07
JP2020519687A (ja) 2020-07-02
DK3630111T3 (en) 2022-03-14
TWI791018B (zh) 2023-02-01
PL3630111T3 (pl) 2022-05-23
EA201992370A1 (ru) 2020-03-10
MX2019013291A (es) 2020-01-15
KR102611447B1 (ko) 2023-12-06
US11046694B2 (en) 2021-06-29
SG11201909443YA (en) 2019-11-28
IL270380B (en) 2022-06-01
LT3630111T (lt) 2022-03-10
PT3630111T (pt) 2022-03-01
US20200165251A1 (en) 2020-05-28
EA038393B1 (ru) 2021-08-20

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