AU2018258663B2 - Treatment of HER2 positive cancers - Google Patents

Treatment of HER2 positive cancers Download PDF

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Publication number
AU2018258663B2
AU2018258663B2 AU2018258663A AU2018258663A AU2018258663B2 AU 2018258663 B2 AU2018258663 B2 AU 2018258663B2 AU 2018258663 A AU2018258663 A AU 2018258663A AU 2018258663 A AU2018258663 A AU 2018258663A AU 2018258663 B2 AU2018258663 B2 AU 2018258663B2
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cancer
her2
tucatinib
dose
trastuzumab
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AU2018258663A
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AU2018258663A1 (en
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Scott Peterson
Luke Walker
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Seagen Inc
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Seagen Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/542—Mucosal route oral/gastrointestinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2018258663A 2017-04-28 2018-04-27 Treatment of HER2 positive cancers Active AU2018258663B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2022241509A AU2022241509B2 (en) 2017-04-28 2022-09-28 Treatment of HER2 positive cancers

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762491872P 2017-04-28 2017-04-28
US62/491,872 2017-04-28
PCT/US2018/029899 WO2018201016A1 (en) 2017-04-28 2018-04-27 Treatment of her2 positive cancers

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2022241509A Division AU2022241509B2 (en) 2017-04-28 2022-09-28 Treatment of HER2 positive cancers

Publications (2)

Publication Number Publication Date
AU2018258663A1 AU2018258663A1 (en) 2019-11-14
AU2018258663B2 true AU2018258663B2 (en) 2022-08-04

Family

ID=62165692

Family Applications (2)

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AU2018258663A Active AU2018258663B2 (en) 2017-04-28 2018-04-27 Treatment of HER2 positive cancers
AU2022241509A Active AU2022241509B2 (en) 2017-04-28 2022-09-28 Treatment of HER2 positive cancers

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2022241509A Active AU2022241509B2 (en) 2017-04-28 2022-09-28 Treatment of HER2 positive cancers

Country Status (13)

Country Link
US (3) US11207324B2 (enExample)
EP (1) EP3615067A1 (enExample)
JP (2) JP7328151B2 (enExample)
KR (1) KR102845148B1 (enExample)
CN (1) CN111032082B (enExample)
AU (2) AU2018258663B2 (enExample)
BR (1) BR112019022280A2 (enExample)
CA (1) CA3060407A1 (enExample)
EA (1) EA201992573A1 (enExample)
MA (1) MA49059A (enExample)
SG (1) SG11201909676WA (enExample)
WO (1) WO2018201016A1 (enExample)
ZA (1) ZA201907225B (enExample)

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TW202042820A (zh) * 2019-01-28 2020-12-01 美商西雅圖遺傳學股份有限公司 以妥卡替尼（Ｔｕｃａｔｉｎｉｂ）治療乳癌之方法
AU2019450366B2 (en) * 2019-06-11 2026-01-08 Board Of Regents, The University Of Texas System Use of an RXR agonist in treating Her2+ cancers
KR20220086627A (ko) * 2019-10-21 2022-06-23 시아겐 인크. 카페시타빈 및 트라스투주맙과 조합으로 투카티닙을 사용하여 her2 양성 유방암을 치료하는 방법
CA3159770A1 (en) * 2019-11-15 2021-05-20 Seagen Inc. Methods of treating her2 positive breast cancer with tucatinib in combination with an anti-her2 antibody-drug conjugate
KR20230027068A (ko) * 2020-05-29 2023-02-27 시아겐 인크. 트라스투주맙 및 옥살리플라틴-기반 화학요법과 병용하여 투카티닙을 이용하는 her2 양성 암의 치료 방법
JP2023537676A (ja) * 2020-07-29 2023-09-05 シージェン インコーポレイテッド トラスツズマブ、タキサン及びｖｅｇｆｒ－２アンタゴニストと組み合わせたツカチニブによりｈｅｒ２陽性癌を治療する方法
IL301405A (en) * 2020-09-28 2023-05-01 Seagen Inc Methods for treating solid tumors driven by HER2 alterations with toctinib in combination with an anti-HER2 antibody
IL303350A (en) 2020-12-04 2023-08-01 Macrogenics Inc Preparations containing an antibody against HER2/NEU and their use
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Also Published As

Publication number Publication date
KR102845148B1 (ko) 2025-08-20
KR20200014298A (ko) 2020-02-10
CA3060407A1 (en) 2018-11-01
AU2022241509B2 (en) 2025-02-20
JP2023145689A (ja) 2023-10-11
SG11201909676WA (en) 2019-11-28
MA49059A (fr) 2021-03-24
US20200188401A1 (en) 2020-06-18
US12048698B2 (en) 2024-07-30
CN111032082B (zh) 2025-01-07
JP2020517696A (ja) 2020-06-18
US11666572B2 (en) 2023-06-06
JP7328151B2 (ja) 2023-08-16
US20220168303A1 (en) 2022-06-02
EA201992573A1 (ru) 2020-04-06
AU2018258663A1 (en) 2019-11-14
EP3615067A1 (en) 2020-03-04
US20230390290A1 (en) 2023-12-07
ZA201907225B (en) 2023-11-29
BR112019022280A2 (pt) 2020-05-19
WO2018201016A1 (en) 2018-11-01
AU2022241509A1 (en) 2022-10-27
CN111032082A (zh) 2020-04-17
US11207324B2 (en) 2021-12-28

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