AU2018243664B2 - Methods of treating T cell exhaustion by inhibiting or modulating T cell receptor signaling - Google Patents

Methods of treating T cell exhaustion by inhibiting or modulating T cell receptor signaling Download PDF

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AU2018243664B2
AU2018243664B2 AU2018243664A AU2018243664A AU2018243664B2 AU 2018243664 B2 AU2018243664 B2 AU 2018243664B2 AU 2018243664 A AU2018243664 A AU 2018243664A AU 2018243664 A AU2018243664 A AU 2018243664A AU 2018243664 B2 AU2018243664 B2 AU 2018243664B2
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AU2018243664A1 (en
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Rachel LYNN
Crystal Mackall
Tom J. WANDLESS
Evan WEBER
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Leland Stanford Junior University
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Leland Stanford Junior University
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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AU2018243664A 2017-03-31 2018-03-30 Methods of treating T cell exhaustion by inhibiting or modulating T cell receptor signaling Active AU2018243664B2 (en)

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Application Number Priority Date Filing Date Title
US201762479930P 2017-03-31 2017-03-31
US62/479,930 2017-03-31
PCT/US2018/025459 WO2018183888A2 (en) 2017-03-31 2018-03-30 Methods of treating t cell exhaustion by inhibiting or modulating t cell receptor signaling

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AU2018243664A1 AU2018243664A1 (en) 2019-10-17
AU2018243664B2 true AU2018243664B2 (en) 2024-02-01

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AU2018243664A Active AU2018243664B2 (en) 2017-03-31 2018-03-30 Methods of treating T cell exhaustion by inhibiting or modulating T cell receptor signaling
AU2018243571A Active AU2018243571B2 (en) 2017-03-31 2018-03-30 Methods of treating T cell exhaustion by inhibiting or modulating T cell receptor signaling
AU2024203919A Pending AU2024203919A1 (en) 2017-03-31 2024-06-07 Methods of treating T cell exhaustion by inhibiting or modulating T cell receptor signaling

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AU2024203919A Pending AU2024203919A1 (en) 2017-03-31 2024-06-07 Methods of treating T cell exhaustion by inhibiting or modulating T cell receptor signaling

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US (3) US11938153B2 (enExample)
EP (2) EP3600323A4 (enExample)
JP (6) JP7249287B2 (enExample)
CN (3) CN110603044B (enExample)
AU (3) AU2018243664B2 (enExample)
CA (2) CA3057372A1 (enExample)
WO (2) WO2018183888A2 (enExample)

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JP2021505604A (ja) * 2017-12-07 2021-02-18 ユリウス−マクシミリアン−ウニヴェルシテート・ヴュルツブルク ダサチニブ及び他のチロシンキナーゼ阻害剤を用いる遺伝子改変されたキメラ抗原受容体ｔ細胞の機能の制御及び調節
US20210393628A1 (en) * 2018-10-30 2021-12-23 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for modulating t cell exhaustion
MX2021005366A (es) 2018-11-08 2021-09-10 Juno Therapeutics Inc Metodos y combinaciones para el tratamiento y modulacion de celulas t.
EP3931216A4 (en) * 2019-03-01 2023-04-19 National University of Singapore MANIPULATED IMMUNE CELLS
CN110157680A (zh) * 2019-05-08 2019-08-23 浙江大学 提高嵌合抗原受体t细胞疗效和作用持久性的细胞培养方法
JP7505784B2 (ja) * 2019-08-01 2024-06-25 国立大学法人三重大学 Ｇｄ２結合性分子
CN115768879A (zh) 2020-04-28 2023-03-07 莱尔免疫制药公司 用于培养细胞的方法
AU2021292932A1 (en) * 2020-06-19 2023-01-05 Chugai Seiyaku Kabushiki Kaisha Anti-T cell antigen-binding molecule for use in combination with angiogenesis inhibitor
CN116322691A (zh) * 2020-09-24 2023-06-23 豪夫迈·罗氏有限公司 T细胞双特异性抗体相关不良反应的预防或减轻
WO2022094314A1 (en) * 2020-10-30 2022-05-05 The University Of North Carolina At Chapel Hill Dual targeting chimeric antigen receptors
WO2022210487A1 (ja) * 2021-03-29 2022-10-06 タカラバイオ株式会社 抗原に特異的な受容体を発現する免疫細胞の製造方法
EP4071248A1 (en) 2021-04-07 2022-10-12 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Means and methods for enhancing receptor-targeted gene transfer
EP4334443A1 (en) * 2021-05-07 2024-03-13 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH Method for constitutive malt1 protease activation
CN113533729B (zh) * 2021-06-15 2024-09-06 北京大学人民医院 一种鉴定aml患者骨髓中nk细胞耗竭的研究方法及其应用
EP4370541A1 (en) 2021-07-14 2024-05-22 2seventy bio, Inc. Engineered t cell receptors fused to binding domains from antibodies
CN115677861A (zh) * 2021-07-29 2023-02-03 上海科技大学 一种泛素偶联修饰的嵌合抗原受体及免疫细胞
WO2023077026A1 (en) 2021-10-28 2023-05-04 Lyell Immunopharma, Inc. Methods for culturing cells expressing ror1-binding protein
CA3234826A1 (en) 2021-10-28 2023-05-04 Lyell Immunopharma, Inc. Methods for culturing cells expressing c-jun
CN119546327A (zh) 2022-04-08 2025-02-28 再生元制药公司 多部分受体和信号传导复合物
KR20250036972A (ko) * 2022-06-13 2025-03-14 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 개선된 글리칸 의존성 키메라 항원 수용체 세포
GB202218144D0 (en) * 2022-12-02 2023-01-18 Univ Oxford Innovation Ltd Product
CN116121196B (zh) * 2022-12-23 2025-07-22 广州安捷生物医学技术有限公司 一种调控car-t细胞的方法与应用

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