AU2018226867B2 - ECM hydrogel for treating esophageal inflammation - Google Patents

ECM hydrogel for treating esophageal inflammation Download PDF

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Publication number
AU2018226867B2
AU2018226867B2 AU2018226867A AU2018226867A AU2018226867B2 AU 2018226867 B2 AU2018226867 B2 AU 2018226867B2 AU 2018226867 A AU2018226867 A AU 2018226867A AU 2018226867 A AU2018226867 A AU 2018226867A AU 2018226867 B2 AU2018226867 B2 AU 2018226867B2
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Australia
Prior art keywords
ecm
hydrogel
esophagus
esophageal
subject
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AU2018226867A
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AU2018226867A1 (en
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Stephen Francis Badylak
Juan Diego Naranjo Gutierrez
Lindsey Tamiko Saldin
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University of Pittsburgh
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University of Pittsburgh
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Priority to AU2024200617A priority Critical patent/AU2024200617B2/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2018226867A 2017-03-02 2018-03-02 ECM hydrogel for treating esophageal inflammation Active AU2018226867B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2024200617A AU2024200617B2 (en) 2017-03-02 2024-02-01 Ecm hydrogel for treating esophageal inflammation

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762465985P 2017-03-02 2017-03-02
US62/465,985 2017-03-02
PCT/US2018/020758 WO2018161028A1 (en) 2017-03-02 2018-03-02 Ecm hydrogel for treating esophageal inflammation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2024200617A Division AU2024200617B2 (en) 2017-03-02 2024-02-01 Ecm hydrogel for treating esophageal inflammation

Publications (2)

Publication Number Publication Date
AU2018226867A1 AU2018226867A1 (en) 2019-08-22
AU2018226867B2 true AU2018226867B2 (en) 2023-11-02

Family

ID=63371156

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2018226867A Active AU2018226867B2 (en) 2017-03-02 2018-03-02 ECM hydrogel for treating esophageal inflammation
AU2024200617A Active AU2024200617B2 (en) 2017-03-02 2024-02-01 Ecm hydrogel for treating esophageal inflammation

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2024200617A Active AU2024200617B2 (en) 2017-03-02 2024-02-01 Ecm hydrogel for treating esophageal inflammation

Country Status (9)

Country Link
US (4) US11213545B2 (https=)
EP (2) EP3589292B1 (https=)
JP (3) JP7203428B2 (https=)
KR (1) KR102745611B1 (https=)
CN (1) CN110352061A (https=)
AU (2) AU2018226867B2 (https=)
CA (1) CA3052489A1 (https=)
ES (2) ES2957291T3 (https=)
WO (1) WO2018161028A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3698815B1 (en) 2014-03-21 2024-02-21 University of Pittsburgh- Of the Commonwealth System of Higher Education Terminally sterilized hydrogel derived from extracellular matrix
ES2965061T3 (es) 2016-03-02 2024-04-10 Univ Pittsburgh Commonwealth Sys Higher Education Nanovesículas unidas a matriz y su uso
ES2957291T3 (es) 2017-03-02 2024-01-16 Univ Pittsburgh Commonwealth Sys Higher Education Hidrogel de ECM para el tratamiento de la inflamación esofágica
AU2018226871B2 (en) 2017-03-02 2023-08-10 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Extracellular matrix (ECM) hydrogel and soluble fraction thereof for the treatment of cancer
ES2945740T3 (es) 2017-05-05 2023-07-06 Univ Pittsburgh Commonwealth Sys Higher Education Aplicaciones oculares de vesículas unidas a matriz (MBV)
CN112805016A (zh) 2018-05-03 2021-05-14 联邦高等教育系统匹兹堡大学 包含il-33的基质结合囊泡(mbv)及其用途
CN115444993B (zh) 2018-06-21 2024-03-29 联邦高等教育系统匹兹堡大学 细胞外基质(ecm)水凝胶作为食管粘膜下流体垫的用途
ES2966711T3 (es) * 2018-06-21 2024-04-23 Univ Pittsburgh Commonwealth Sys Higher Education Hidrogel de matriz extracelular (ECM) como almohadilla líquida submucosa
CN115671410B (zh) 2018-06-21 2024-06-18 联邦高等教育系统匹兹堡大学 膀胱ecm水凝胶作为食管粘膜下层流体垫的用途
AU2020235627B2 (en) 2019-03-13 2026-01-08 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Acoustic extracellular matrix hydrogels and their use
CA3171384A1 (en) 2020-02-28 2021-09-02 Texas Medical Center Sprayable stimuli-responsive micro-hydrogels for adhesion prevention and enhanced tissue healing
WO2022108313A1 (ko) * 2020-11-17 2022-05-27 연세대학교 산학협력단 식도 오가노이드 배양 및 이식을 위한 탈세포 식도 조직 유래 지지체 및 이의 제조방법
EP4706694A1 (en) 2024-09-06 2026-03-11 Georgia Tech Research Corporation Hydrogels for cargo delivery to tubular epithelial structures

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018161034A1 (en) * 2017-03-02 2018-09-07 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Extracellular matrix (ecm) hydrogel and soluble fraction thereof for the treatment of cancer

Family Cites Families (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3155095A (en) 1961-02-07 1964-11-03 Adolph M Brown Anastomosis method and means
US4294241A (en) 1977-06-09 1981-10-13 Teruo Miyata Collagen skin dressing
US4582640A (en) 1982-03-08 1986-04-15 Collagen Corporation Injectable cross-linked collagen implant material
US4563350A (en) 1984-10-24 1986-01-07 Collagen Corporation Inductive collagen based bone repair preparations
US4978668A (en) 1986-09-02 1990-12-18 Purdue Research Foundation Treatment to reduce ischemic tissue injury
US4902508A (en) 1988-07-11 1990-02-20 Purdue Research Foundation Tissue graft composition
US4956178A (en) 1988-07-11 1990-09-11 Purdue Research Foundation Tissue graft composition
US5007927A (en) 1989-10-24 1991-04-16 Purdue Research Foundation Muscle-powered cardiac assist device
US5281422A (en) 1991-09-24 1994-01-25 Purdue Research Foundation Graft for promoting autogenous tissue growth
US5354274A (en) 1992-08-20 1994-10-11 Methodist Hospital Of Indiana, Inc. Device for oral administration of liquids
US6653291B1 (en) 1992-11-13 2003-11-25 Purdue Research Foundation Composition and method for production of transformed cells
US5641518A (en) 1992-11-13 1997-06-24 Purdue Research Foundation Method of repairing bone tissue
US5352463A (en) 1992-11-13 1994-10-04 Badylak Steven F Tissue graft for surgical reconstruction of a collagenous meniscus and method therefor
US5275826A (en) 1992-11-13 1994-01-04 Purdue Research Foundation Fluidized intestinal submucosa and its use as an injectable tissue graft
CA2188563C (en) 1994-04-29 2005-08-02 Andrew W. Buirge Stent with collagen
US6475232B1 (en) 1996-12-10 2002-11-05 Purdue Research Foundation Stent with reduced thrombogenicity
US5695998A (en) 1995-02-10 1997-12-09 Purdue Research Foundation Submucosa as a growth substrate for islet cells
US6485723B1 (en) 1995-02-10 2002-11-26 Purdue Research Foundation Enhanced submucosal tissue graft constructs
JPH11508151A (ja) 1995-04-07 1999-07-21 パーデュー・リサーチ・ファウンデーション 膀胱再建方法及び膀胱再建用組織グラフト
US5554389A (en) 1995-04-07 1996-09-10 Purdue Research Foundation Urinary bladder submucosa derived tissue graft
US5711969A (en) 1995-04-07 1998-01-27 Purdue Research Foundation Large area submucosal tissue graft constructs
CA2160647C (en) 1995-10-16 2002-05-28 Thomas William Garay Helical bearing anchor catcher
US5755791A (en) 1996-04-05 1998-05-26 Purdue Research Foundation Perforated submucosal tissue graft constructs
WO1998022158A2 (en) 1996-08-23 1998-05-28 Cook Biotech, Incorporated Graft prosthesis, materials and methods
AU731768B2 (en) 1996-09-16 2001-04-05 Purdue Research Foundation Composition and method for repairing neurological tissue
US6096347A (en) 1996-11-05 2000-08-01 Purdue Research Foundation Myocardial graft constructs
TW510803B (en) 1996-11-20 2002-11-21 Yasuhiko Shimizu Man-made esophagus and its manufacturing method
US6375989B1 (en) 1996-12-10 2002-04-23 Purdue Research Foundation Submucosa extracts
US6696270B2 (en) 1996-12-10 2004-02-24 Purdue Research Foundation Gastric submucosal tissue as a novel diagnostic tool
AU732726B2 (en) 1996-12-10 2001-04-26 Purdue Research Foundation Biomaterial derived from vertebrate liver tissue
WO1998025549A1 (en) 1996-12-10 1998-06-18 Purdue Research Foundation Artificial vascular valves
JP4074666B2 (ja) 1996-12-10 2008-04-09 クック バイオテック、インク. 精製粘膜下組織からの管状移植片
WO1998025636A1 (en) 1996-12-10 1998-06-18 Purdue Research Foundation Stomach submucosa derived tissue graft
EP1011699B1 (en) 1997-09-11 2001-12-05 Purdue Research Foundation Galactosidase modified submucosal tissue
US6264992B1 (en) 1998-02-27 2001-07-24 Purdue Research Foundation Submucosa as a growth substrate for cells
US6448076B2 (en) 1998-09-15 2002-09-10 The Regents Of The University Of Michigan Method for chemically acellularizing a biological tissue sample
AU759272B2 (en) 1998-12-01 2003-04-10 Medical College Of Ohio At Toledo Submucosa modulation of mammalian immune response
US6918396B1 (en) 1998-12-01 2005-07-19 Purdue Research Foundation Method for vocal cord reconstruction
US6576265B1 (en) 1999-12-22 2003-06-10 Acell, Inc. Tissue regenerative composition, method of making, and method of use thereof
US6579538B1 (en) 1999-12-22 2003-06-17 Acell, Inc. Tissue regenerative compositions for cardiac applications, method of making, and method of use thereof
EP1315796B1 (en) 2000-08-16 2006-07-12 Duke University Decellularized tissue engineered constructs and tissues
MXPA03004546A (es) * 2000-11-22 2003-09-10 Rxkinetix Inc Tratamiento de mucositis.
US7919121B2 (en) 2002-01-11 2011-04-05 Purdue Research Foundation Biomaterial derived from vertebrate liver tissue
WO2003059284A2 (en) 2002-01-11 2003-07-24 Purdue Research Foundation Composition and method for inhibiting hypersensitivity
JP2005524699A (ja) 2002-05-02 2005-08-18 パーデュー・リサーチ・ファウンデーション 血管新生が促進された移植片構成物
WO2003092604A2 (en) 2002-05-02 2003-11-13 Purdue Research Foundation Vascularization enhanced graft constructs
DE60333277D1 (de) 2002-05-02 2010-08-19 Purdue Research Foundation Transplantatkonstrukte mit verbesserter vaskularisierung
US7402319B2 (en) 2002-09-27 2008-07-22 Board Of Regents, The University Of Texas System Cell-free tissue replacement for tissue engineering
US20040187877A1 (en) 2002-12-04 2004-09-30 Badylak Stephen F. Method for repair of liver tissue
US20040191226A1 (en) 2002-12-04 2004-09-30 Badylak Stephen F. Method for repair of body wall
US20040176855A1 (en) 2003-03-07 2004-09-09 Acell, Inc. Decellularized liver for repair of tissue and treatment of organ deficiency
US20040175366A1 (en) 2003-03-07 2004-09-09 Acell, Inc. Scaffold for cell growth and differentiation
AU2004253508A1 (en) 2003-06-25 2005-01-13 Acell, Inc. Conditioned matrix compositions for tissue restoration
US7326571B2 (en) 2003-07-17 2008-02-05 Boston Scientific Scimed, Inc. Decellularized bone marrow extracellular matrix
US8741352B2 (en) 2003-08-25 2014-06-03 Cook Biotech Incorporated Graft materials containing ECM components, and methods for their manufacture
DE112004001553T5 (de) 2003-08-25 2006-08-10 Cook Biotech, Inc., West Lafayette Verpflanzungsmaterialien, die bioaktive Substanzen enthalten, und Methoden zu deren Herstellung
DE602005024942D1 (de) 2004-03-19 2011-01-05 Tamura Plastic Mfg Co Ltd Blende für ein kraftfahrzeug
US7905826B2 (en) 2004-11-03 2011-03-15 Cook Incorporated Methods for modifying vascular vessel walls
US8874204B2 (en) 2004-12-20 2014-10-28 Cardiac Pacemakers, Inc. Implantable medical devices comprising isolated extracellular matrix
US9138445B2 (en) 2005-03-09 2015-09-22 Cook Biotech Incorporated Medical graft materials with adherent extracellular matrix fibrous mass
AU2006265682A1 (en) 2005-07-01 2007-01-11 University Of Pittsburgh Wound healing polymeric networks
WO2007084278A2 (en) 2006-01-06 2007-07-26 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Extracellular matrix based gastroesophageal junction reinforcement device
US8241908B2 (en) 2006-05-16 2012-08-14 Becton, Dickinson And Company Extracellular matrix coated surface for culturing cells
US8535719B2 (en) 2006-07-07 2013-09-17 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Biohybrid elastomeric scaffolds and methods of use thereof
BRPI0717388A2 (pt) 2006-10-23 2013-10-15 Cook Biotech Inc Materiais ecm processados com melhores perfis de componentes
WO2008109407A2 (en) 2007-03-02 2008-09-12 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Extracellular matrix-derived gels and related methods
WO2009137755A2 (en) 2008-05-09 2009-11-12 University Of Pittsburgh- Commonwealth System Of Higher Education Biologic matrix for cardiac repair
US9277999B2 (en) 2009-02-27 2016-03-08 University of Pittsburgh—of the Commonwealth System of Higher Education Joint bioscaffolds
WO2011044443A2 (en) 2009-10-09 2011-04-14 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Matricryptic ecm peptides for tissue reconstruction
US9814744B2 (en) 2009-12-22 2017-11-14 University of Pittsburg—Of the Commonwealth System of Higher Education Decellularized adipose cell growth scaffold
WO2012024390A2 (en) 2010-08-17 2012-02-23 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Biohybrid composite scaffold
RU2602601C2 (ru) 2011-04-12 2016-11-20 Ново Нордиск А/С Дважды ацилированные производные glp-1
WO2013009595A2 (en) 2011-07-08 2013-01-17 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Injectable cns-derived ecm for tissue reconstruction
DK2953659T3 (da) 2013-02-08 2019-11-25 Acell Inc Fremgangsmåder til at fremstille bioaktive geler fra extracellulært matrixmateriale
ES2703785T3 (es) 2013-04-08 2019-03-12 Regentys Corp Método y composición para tratar una enfermedad inflamatoria intestinal sin colectomía
US9861662B2 (en) 2013-07-03 2018-01-09 University of Pittsburgh—of the Commonwealth System of Higher Education Bone-derived extra cellular matrix gel
ITMI20131924A1 (it) 2013-11-20 2015-05-21 Cosmo Technologies Ltd Emulsions or microemulsions for use in endoscopic mucosal resectioning and/or endoscopic submucosal dissection emulsioni o microemulsioni per uso nella resezione mucosale endoscopica e/o dissezione submucosale endoscopica
US10286119B2 (en) 2014-01-24 2019-05-14 University of Pittsburgh—of the Commonwealth System of Higher Education Extracellular matrix mesh coating
EP3698815B1 (en) 2014-03-21 2024-02-21 University of Pittsburgh- Of the Commonwealth System of Higher Education Terminally sterilized hydrogel derived from extracellular matrix
WO2015164728A1 (en) 2014-04-24 2015-10-29 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Fractionating extracellular matrix to modulate bioactivity and the host response
WO2017011299A1 (en) 2015-07-10 2017-01-19 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Methods of preparing ecm scaffolds and hydrogels from colon
EP3347063B1 (en) 2015-09-10 2025-11-19 University of Pittsburgh - of the Commonwealth System of Higher Education Bi-layer extra cellular matrix scaffolds and uses therefor
EP3349814B1 (en) 2015-09-18 2021-03-17 University of Pittsburgh- Of the Commonwealth System of Higher Education Non-gelling soluble extracellular matrix with biological activity
US11406736B2 (en) 2016-01-13 2022-08-09 University of Pittsburgh—Of the Commonwealth Systems of Higher Education Vascular extracellular matrix hydrogel
ES2965061T3 (es) 2016-03-02 2024-04-10 Univ Pittsburgh Commonwealth Sys Higher Education Nanovesículas unidas a matriz y su uso
US11389566B2 (en) 2016-03-14 2022-07-19 Regentys Corporation Method and composition for treating inflammatory bowel disease
ES2957291T3 (es) 2017-03-02 2024-01-16 Univ Pittsburgh Commonwealth Sys Higher Education Hidrogel de ECM para el tratamiento de la inflamación esofágica
US11389569B2 (en) 2017-04-03 2022-07-19 University of Pittsburgh—of the Commonwealth System of Higher Education Biodegradable, porous, thermally responsive injectable hydrogel as soft tissue defect filler
ES2945740T3 (es) 2017-05-05 2023-07-06 Univ Pittsburgh Commonwealth Sys Higher Education Aplicaciones oculares de vesículas unidas a matriz (MBV)
US12329883B2 (en) 2017-10-24 2025-06-17 Davol Inc. Soft tissue repair implants comprising hydroxybutyrate
CN112805016A (zh) 2018-05-03 2021-05-14 联邦高等教育系统匹兹堡大学 包含il-33的基质结合囊泡(mbv)及其用途

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018161034A1 (en) * 2017-03-02 2018-09-07 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Extracellular matrix (ecm) hydrogel and soluble fraction thereof for the treatment of cancer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TIMOTHY J. KEANE ET AL: "Tissue-Specific Effects of Esophageal Extracellular Matrix", TISSUE ENGINEERING PART A, vol. 21, no. 17-18, 1 September 2015 pages 2293 - 2300, *

Also Published As

Publication number Publication date
JP2020509048A (ja) 2020-03-26
EP4252842B1 (en) 2025-06-25
EP3589292A4 (en) 2020-12-09
US11707485B2 (en) 2023-07-25
ES2957291T3 (es) 2024-01-16
JP7203428B2 (ja) 2023-01-13
ES3039679T3 (en) 2025-10-23
JP7681909B2 (ja) 2025-05-23
EP4252842A2 (en) 2023-10-04
KR102745611B1 (ko) 2024-12-20
EP3589292A1 (en) 2020-01-08
KR20190120258A (ko) 2019-10-23
JP2023024578A (ja) 2023-02-16
US20200009187A1 (en) 2020-01-09
WO2018161028A1 (en) 2018-09-07
US12303533B2 (en) 2025-05-20
AU2018226867A1 (en) 2019-08-22
AU2024200617B2 (en) 2025-10-23
US11213545B2 (en) 2022-01-04
CN110352061A (zh) 2019-10-18
US20220249549A1 (en) 2022-08-11
JP2025019254A (ja) 2025-02-06
AU2024200617A1 (en) 2024-02-22
US20240189349A1 (en) 2024-06-13
CA3052489A1 (en) 2018-09-07
US20260053850A1 (en) 2026-02-26
EP4252842A3 (en) 2023-10-25
EP3589292B1 (en) 2023-08-23

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