AU2017361539B2 - Buffered formulations of exendin (9-39) - Google Patents
Buffered formulations of exendin (9-39) Download PDFInfo
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- AU2017361539B2 AU2017361539B2 AU2017361539A AU2017361539A AU2017361539B2 AU 2017361539 B2 AU2017361539 B2 AU 2017361539B2 AU 2017361539 A AU2017361539 A AU 2017361539A AU 2017361539 A AU2017361539 A AU 2017361539A AU 2017361539 B2 AU2017361539 B2 AU 2017361539B2
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- Prior art keywords
- exendin
- liquid pharmaceutical
- pharmaceutical formulation
- formulation
- concentration
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 45
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
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- Hematology (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US201762517065P | 2017-06-08 | 2017-06-08 | |
| US62/517,065 | 2017-06-08 | ||
| PCT/US2017/062838 WO2018094404A1 (fr) | 2016-11-21 | 2017-11-21 | Formulations tamponnées d'exendine (9-39) |
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| CL (1) | CL2019001366A1 (fr) |
| IL (1) | IL266568B1 (fr) |
| WO (1) | WO2018094404A1 (fr) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP4049673A1 (fr) | 2007-01-08 | 2022-08-31 | The Trustees of the University of Pennsylvania | Antagonistes des récepteurs glp-1 pour l'utilisation dans le traitement de la hypoglycémie postprandiale or de l'hyperinsulinisme familial |
| EP3297654B1 (fr) | 2015-05-22 | 2021-07-07 | The Board of Trustees of the Leland Stanford Junior University | Traitement de l'hypoglycémie post-bariatrique avec l'exendine (9-39) |
| WO2017152014A1 (fr) | 2016-03-04 | 2017-09-08 | Eiger Biopharmaceuticals, Inc. | Traitement de l'hypoglycémie hyperinsulinémique avec des dérivés de l'exendine-4 |
| IL266568B1 (en) | 2016-11-21 | 2024-05-01 | Eiger Biopharmaceuticals Inc | Conditioned formulations of Exendin (39-9) |
| EP3628683A1 (fr) * | 2018-09-28 | 2020-04-01 | Zealand Pharma A/S | Formulations d'analogues de peptide-2 de type glucagon (glp-2) |
| EP3867266A4 (fr) | 2018-10-15 | 2022-07-13 | Eiger Biopharmaceuticals, Inc. | Avexitide pour le traitement de l'hypoglycémie hyperinsulinémique |
| WO2021231366A1 (fr) * | 2020-05-12 | 2021-11-18 | Regeneron Pharmaceuticals, Inc. | Anticorps antagonistes anti-glp1r et leurs procédés d'utilisation |
| WO2022271753A1 (fr) | 2021-06-21 | 2022-12-29 | Eiger Biopharmaceuticals, Inc. | Traitement de l'hyperinsulinisme congénital avec de l'avexitide |
| US11878036B2 (en) * | 2022-05-25 | 2024-01-23 | Neuvian LLC | Vaginal care compositions and methods of improving vaginal health |
| CN116606367A (zh) * | 2022-05-31 | 2023-08-18 | 南京盛德瑞尔医药科技有限公司 | 长效Exendin-9-39及其在低血糖治疗中的应用和作为治疗低血糖的药物 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1609478A1 (fr) * | 1999-01-14 | 2005-12-28 | Amylin Pharmaceuticals, Inc. | formulations de peptides agonistes de l'exendine |
| US20080269130A1 (en) * | 2007-01-08 | 2008-10-30 | Doris Stoffers | Methods and compositions for treating hypoglycemic disorders |
| US20100029554A1 (en) * | 2006-05-26 | 2010-02-04 | Amylin Pharmaceuticals, Inc. | Composition and Methods for Treatment of Congestive Heart Failure |
| WO2011109787A1 (fr) * | 2010-03-05 | 2011-09-09 | Conjuchem, Llc | Méthodes d'administration de peptides insulinotropes |
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| SK155694A3 (en) | 1992-06-15 | 1995-05-10 | Pfizer | Glucagon-like peptide, insulinotropin derivatives, method of their preparation, pharmaceutical agent containing and using these matters |
| US5424286A (en) | 1993-05-24 | 1995-06-13 | Eng; John | Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same |
| US20040092443A1 (en) | 1996-08-06 | 2004-05-13 | Yeda Research And Development Co., Ltd | Long-acting exendins and exendin agonists |
| EP2016950B1 (fr) | 1996-08-08 | 2011-01-05 | Amylin Pharmaceuticals, Inc. | Composition pharmaceutique comportant un peptide d'exendine-4 |
| US6268343B1 (en) | 1996-08-30 | 2001-07-31 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| US6458924B2 (en) | 1996-08-30 | 2002-10-01 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| US7235627B2 (en) | 1996-08-30 | 2007-06-26 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| JP4798814B2 (ja) | 1997-01-07 | 2011-10-19 | アミリン・ファーマシューティカルズ，インコーポレイテッド | 食物摂取低減用のエキセンジンおよびそのアゴニストの使用 |
| KR100574630B1 (ko) | 1998-01-30 | 2006-04-27 | 노보 노르디스크 에이/에스 | 주입 주사기 |
| CA2350887A1 (fr) | 1998-12-10 | 2000-06-15 | Agouron Pharmaceuticals, Inc. | Antagonistes non peptidiques du recepteur glp-1 et techniques d'utilisation |
| JP2002538084A (ja) | 1999-01-14 | 2002-11-12 | アミリン・ファーマシューティカルズ，インコーポレイテッド | グルカゴンを抑制する方法 |
| US6924264B1 (en) | 1999-04-30 | 2005-08-02 | Amylin Pharmaceuticals, Inc. | Modified exendins and exendin agonists |
| US6903074B1 (en) | 1999-06-04 | 2005-06-07 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. | Neuromedin b and somatostatin receptor agonists |
| US6495164B1 (en) | 2000-05-25 | 2002-12-17 | Alkermes Controlled Therapeutics, Inc. I | Preparation of injectable suspensions having improved injectability |
| US6479065B2 (en) | 2000-08-10 | 2002-11-12 | Alkermes Controlled Therapeutics, Inc. | Process for the preparation of polymer-based sustained release compositions |
| US6824822B2 (en) | 2001-08-31 | 2004-11-30 | Alkermes Controlled Therapeutics Inc. Ii | Residual solvent extraction method and microparticles produced thereby |
| SE0004462D0 (sv) | 2000-12-04 | 2000-12-04 | Pharmacia Ab | Novel method and use |
| WO2002066062A2 (fr) | 2001-02-01 | 2002-08-29 | Drucker Daniel J | Renforcement de l'activite de glp-2 |
| AU2002257132A1 (en) | 2001-04-06 | 2002-10-21 | The Trustees Of The University Of Pennsylvania | Erbb interface peptidomimetics and methods of use thereof |
| GB0113179D0 (en) * | 2001-05-31 | 2001-07-25 | Novartis Ag | Organic compounds |
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- 2017-11-21 JP JP2019527188A patent/JP2019535734A/ja active Pending
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- 2017-11-21 AU AU2017361539A patent/AU2017361539B2/en active Active
- 2017-11-21 WO PCT/US2017/062838 patent/WO2018094404A1/fr unknown
- 2017-11-21 CA CA3043899A patent/CA3043899A1/fr active Pending
- 2017-11-21 EP EP17871296.4A patent/EP3541366A4/fr active Pending
- 2017-11-21 US US16/461,329 patent/US11020484B2/en active Active
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- 2023-06-22 US US18/339,305 patent/US20240042035A1/en active Pending
- 2023-09-28 AU AU2023237119A patent/AU2023237119A1/en active Pending
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| AU2017361539A1 (en) | 2019-07-04 |
| JP2022153624A (ja) | 2022-10-12 |
| CL2019001366A1 (es) | 2019-11-08 |
| US20210315995A1 (en) | 2021-10-14 |
| AU2023237119A1 (en) | 2023-10-19 |
| IL266568A (en) | 2019-07-31 |
| US11020484B2 (en) | 2021-06-01 |
| US20200069802A1 (en) | 2020-03-05 |
| EP3541366A4 (fr) | 2020-08-05 |
| US11738086B2 (en) | 2023-08-29 |
| CA3043899A1 (fr) | 2018-05-24 |
| US20240042035A1 (en) | 2024-02-08 |
| EP3541366A1 (fr) | 2019-09-25 |
| JP2019535734A (ja) | 2019-12-12 |
| IL266568B1 (en) | 2024-05-01 |
| WO2018094404A1 (fr) | 2018-05-24 |
| BR112019010236A2 (pt) | 2019-08-20 |
| CN110267648A (zh) | 2019-09-20 |
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