AU2017346788A1 - Cytomegalovirus vectors eliciting T cells restricted by major histocompatibility complex E molecules - Google Patents

Cytomegalovirus vectors eliciting T cells restricted by major histocompatibility complex E molecules Download PDF

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Publication number
AU2017346788A1
AU2017346788A1 AU2017346788A AU2017346788A AU2017346788A1 AU 2017346788 A1 AU2017346788 A1 AU 2017346788A1 AU 2017346788 A AU2017346788 A AU 2017346788A AU 2017346788 A AU2017346788 A AU 2017346788A AU 2017346788 A1 AU2017346788 A1 AU 2017346788A1
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Prior art keywords
vector
antigen
cmv
mhc
cells
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AU2017346788A
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AU2017346788A8 (en
Inventor
Klaus Frueh
Meaghan HANCOCK
Scott Hansen
Daniel MALOULI
Jay Nelson
Louis Picker
Jonah SACHA
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Oregon Health and Science University
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Oregon Health and Science University
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Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/32—T-cell receptors [TCR]
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/46—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • C12N7/045—Pseudoviral particles; Non infectious pseudovirions, e.g. genetically engineered
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/141—MicroRNAs, miRNAs
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    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
    • C12N2710/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2710/16011—Herpesviridae
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    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
    • C12N2710/16141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/16143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
    • C12N2710/16171—Demonstrated in vivo effect
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AU2017346788A 2016-10-18 2017-10-18 Cytomegalovirus vectors eliciting T cells restricted by major histocompatibility complex E molecules Abandoned AU2017346788A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662409840P 2016-10-18 2016-10-18
US62/409,840 2016-10-18
PCT/US2017/057106 WO2018075591A1 (en) 2016-10-18 2017-10-18 Cytomegalovirus vectors eliciting t cells restricted by major histocompatibility complex e molecules

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AU2017346788A1 true AU2017346788A1 (en) 2019-05-02
AU2017346788A8 AU2017346788A8 (en) 2019-05-16

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US (2) US10532099B2 (enExample)
EP (1) EP3529363B1 (enExample)
JP (2) JP2019531745A (enExample)
KR (1) KR102604486B1 (enExample)
CN (1) CN110036112B (enExample)
AU (1) AU2017346788A1 (enExample)
BR (1) BR112019007982A2 (enExample)
CA (1) CA3040303A1 (enExample)
CL (1) CL2019001054A1 (enExample)
CO (1) CO2019004102A2 (enExample)
CR (1) CR20190205A (enExample)
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EA (1) EA201990937A1 (enExample)
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CN113950334B (zh) * 2019-06-07 2025-01-28 俄勒冈健康与科学大学 乙型肝炎病毒特异性t细胞应答
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