AU2017324550B2 - Methods and compositions for modulating gene expression - Google Patents

Methods and compositions for modulating gene expression Download PDF

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AU2017324550B2
AU2017324550B2 AU2017324550A AU2017324550A AU2017324550B2 AU 2017324550 B2 AU2017324550 B2 AU 2017324550B2 AU 2017324550 A AU2017324550 A AU 2017324550A AU 2017324550 A AU2017324550 A AU 2017324550A AU 2017324550 B2 AU2017324550 B2 AU 2017324550B2
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sequence
anchor sequence
anchor
polypeptide
conjunction
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AU2017324550A1 (en
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David Arthur Berry
Rahul KARNIK
Laura Gabriela LANDE
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Flagship Pioneering Innovations V Inc
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Flagship Pioneering Innovations V Inc
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1007—Methyltransferases (general) (2.1.1.)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
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    • C12Y201/00—Transferases transferring one-carbon groups (2.1)
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    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01098—Histone deacetylase (3.5.1.98), i.e. sirtuin deacetylase
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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    • A01K2217/056—Animals comprising random inserted nucleic acids (transgenic) inducing loss of function due to mutation of coding region of the transgene (dominant negative)
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]

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AU2017324550A 2016-09-07 2017-09-07 Methods and compositions for modulating gene expression Active AU2017324550B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2024203956A AU2024203956A1 (en) 2016-09-07 2024-06-11 Methods and compositions for modulating gene expression

Applications Claiming Priority (9)

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US201662384603P 2016-09-07 2016-09-07
US62/384,603 2016-09-07
US201662416501P 2016-11-02 2016-11-02
US62/416,501 2016-11-02
US201662439327P 2016-12-27 2016-12-27
US62/439,327 2016-12-27
US201762542703P 2017-08-08 2017-08-08
US62/542,703 2017-08-08
PCT/US2017/050553 WO2018049073A1 (en) 2016-09-07 2017-09-07 Methods and compositions for modulating gene expression

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AU2017324550A1 AU2017324550A1 (en) 2019-03-21
AU2017324550B2 true AU2017324550B2 (en) 2024-03-14

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US (4) US20190255106A1 (enExample)
EP (1) EP3510152A4 (enExample)
JP (2) JP7682604B2 (enExample)
CN (1) CN109890962A (enExample)
AU (2) AU2017324550B2 (enExample)
CA (1) CA3035910A1 (enExample)
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