AU2017322552B2 - Proinsulin derivatives - Google Patents

Proinsulin derivatives Download PDF

Info

Publication number
AU2017322552B2
AU2017322552B2 AU2017322552A AU2017322552A AU2017322552B2 AU 2017322552 B2 AU2017322552 B2 AU 2017322552B2 AU 2017322552 A AU2017322552 A AU 2017322552A AU 2017322552 A AU2017322552 A AU 2017322552A AU 2017322552 B2 AU2017322552 B2 AU 2017322552B2
Authority
AU
Australia
Prior art keywords
amino acid
process according
chain
insulin
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2017322552A
Other languages
English (en)
Other versions
AU2017322552A1 (en
Inventor
Alexandra ANASTASIOU
Kleomenis Barlos
Dimitrios Gatos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chemical and Biopharmaceutical Laboratories of Patras SA
Original Assignee
Chemical and Biopharmaceutical Laboratories of Patras SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemical and Biopharmaceutical Laboratories of Patras SA filed Critical Chemical and Biopharmaceutical Laboratories of Patras SA
Publication of AU2017322552A1 publication Critical patent/AU2017322552A1/en
Application granted granted Critical
Publication of AU2017322552B2 publication Critical patent/AU2017322552B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
AU2017322552A 2016-09-06 2017-09-05 Proinsulin derivatives Active AU2017322552B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GR20160100458 2016-09-06
GR20160100458 2016-09-06
PCT/IB2017/055336 WO2018047062A1 (en) 2016-09-06 2017-09-05 Proinsulin derivatives

Publications (2)

Publication Number Publication Date
AU2017322552A1 AU2017322552A1 (en) 2019-03-28
AU2017322552B2 true AU2017322552B2 (en) 2021-12-02

Family

ID=59895344

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2017322552A Active AU2017322552B2 (en) 2016-09-06 2017-09-05 Proinsulin derivatives

Country Status (10)

Country Link
US (1) US11230585B2 (https=)
EP (1) EP3509625A1 (https=)
JP (1) JP2019530473A (https=)
KR (1) KR20190043609A (https=)
CN (1) CN110234339A (https=)
AU (1) AU2017322552B2 (https=)
BR (1) BR112019004314A2 (https=)
CA (1) CA3035850A1 (https=)
IL (1) IL265182A (https=)
WO (1) WO2018047062A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3756679A1 (en) 2019-06-28 2020-12-30 Université de Genève Compositions for use in the treatment of insulin deficiency conditions

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0518587A2 (en) * 1991-06-11 1992-12-16 Eli Lilly And Company A-C-B proinsulin, method of manufacturing and using same, and intermediates in insulin production
US6444641B1 (en) * 1997-10-24 2002-09-03 Eli Lilly Company Fatty acid-acylated insulin analogs
WO2002079251A2 (en) * 2001-04-02 2002-10-10 Novo Nordisk A/S Method for making human insulin precursors

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK58285D0 (da) 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
DK129385A (da) 1985-03-22 1986-09-23 Novo Industri As Peptider og fremstilling deraf
DK10191D0 (da) 1991-01-22 1991-01-22 Novo Nordisk As Hidtil ukendte peptider
WO1995016708A1 (en) 1993-12-17 1995-06-22 Novo Nordisk A/S Proinsulin-like compounds
BR9408638A (pt) 1994-12-29 2004-09-21 Bio Technology General Corp Geração de insulina humana
CN1231259C (zh) * 1994-12-29 2005-12-14 萨文特医药公司 生产人胰岛素
EP0741188A3 (en) 1995-05-05 1999-07-14 Eli Lilly And Company Single chain insulin with high bioactivity
JP2001521006A (ja) 1997-10-24 2001-11-06 イーライ・リリー・アンド・カンパニー 不溶性インシュリン組成物
GB9812675D0 (en) 1998-06-11 1998-08-12 Univ Edinburgh Peptides
EP1193272B1 (en) 2000-10-02 2004-06-30 Yonsei University Single-chain insulin analogs
KR100449454B1 (ko) * 2000-10-02 2004-09-21 이현철 단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터
EP1692168B1 (en) 2003-12-03 2011-07-20 Novo Nordisk A/S Single-chain insulin
JP2008533100A (ja) 2005-03-18 2008-08-21 ノボ ノルディスク アクティーゼルスカブ Ｐｅｇ化された単鎖インスリン
US20090069216A1 (en) 2006-02-21 2009-03-12 Novo Nordisk A/S Single-Chain Insulin Analogues and Pharmaceutical Formulations Thereof
JP2009530243A (ja) 2006-03-13 2009-08-27 ノボ・ノルデイスク・エー／エス アシル化単鎖インスリン
WO2008043033A2 (en) 2006-10-04 2008-04-10 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues
US10100098B2 (en) * 2006-12-13 2018-10-16 Stelis Biopharma Private Limited Insulin production methods and proinsulin constructs
GR1006941B (el) * 2009-06-01 2010-08-27 Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras), Πεπτιδικη συνθεση (peptide synthesis)
GR1007010B (el) 2009-10-08 2010-10-07 Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras), Ινσουλινοειδη πεπτιδια
GB201321489D0 (en) * 2013-12-05 2014-01-22 Chemical & Biopharmaceutical Lab Of Patras S A Biologically active insulin derivatives
US9982287B2 (en) * 2013-12-17 2018-05-29 Novo Nordisk A/S Enterokinase cleavable polypeptides

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0518587A2 (en) * 1991-06-11 1992-12-16 Eli Lilly And Company A-C-B proinsulin, method of manufacturing and using same, and intermediates in insulin production
US6444641B1 (en) * 1997-10-24 2002-09-03 Eli Lilly Company Fatty acid-acylated insulin analogs
WO2002079251A2 (en) * 2001-04-02 2002-10-10 Novo Nordisk A/S Method for making human insulin precursors

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
G. RAJPAL ET AL, "Single-Chain Insulins as Receptor Agonists", MOLECULAR ENDOCRINOLOGY, (2009-05-01), vol. 23, no. 5, doi:10.1210/me.2008-0349, ISSN 0888-8809, pages 679 - 688 *
HEATH W F ET AL, "(A-C-B) Human Proinsulin, a Novel Insulin Agonist and Intermediate in the Synthesis of Biosynthetic Human Insulin", J OF BIO CHE, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 267, no. 1, pages 419 - 425 *
THIM L ET AL, "Secretion and processing of insulin precursors in yeast", PROCEEDINGS NATIONAL ACADEMY OF SCIENCES PNAS, NATIONAL ACADEMY OF SCIENCES, US, (1986-09-01), vol. 83, no. 18, pages 6766 - 6770 *
WETZEL R ET AL, "Expression in escherichia coli of a chemically synthesized gene for a ''mini-c'' analog of human proinsulin", GENE, ELSEVIER, AMSTERDAM, NL, vol. 16, no. 1-3, pages 63 - 71, (1981-12-01) *

Also Published As

Publication number Publication date
AU2017322552A1 (en) 2019-03-28
CN110234339A (zh) 2019-09-13
EP3509625A1 (en) 2019-07-17
KR20190043609A (ko) 2019-04-26
IL265182A (en) 2019-05-30
WO2018047062A1 (en) 2018-03-15
BR112019004314A2 (pt) 2019-05-28
CA3035850A1 (en) 2018-03-15
JP2019530473A (ja) 2019-10-24
US20190263881A1 (en) 2019-08-29
US11230585B2 (en) 2022-01-25

Similar Documents

Publication Publication Date Title
FI79854B (fi) Foerfarande foer framstaellning av ett laekemedelspreparat som innehaoller ett insulinderivat.
EP2854838B1 (en) Pegylated oxm variants
KR880001107B1 (ko) 인체 인슐린 및 그의 유도체의 제조방법
CN106164088B (zh) 长效肾上腺髓质素衍生物
US20220106367A1 (en) Preparation and use of ginsentides and ginsentide-like peptides
US11168114B2 (en) Process for the manufacture of degarelix and its intermediates
AU2016273045B2 (en) Pegylated oxyntomodulin variants
AU2003236080B8 (en) A method for producing a modified peptide
AU2017322552B2 (en) Proinsulin derivatives
AU2017248496B2 (en) Biologically active insulin derivatives
CA2931439C (en) Biologically active insulin derivatives
EP0367463A1 (en) Calcitonin gene related peptide analogues

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)