CN110234339A - 胰岛素原衍生物 - Google Patents

胰岛素原衍生物 Download PDF

Info

Publication number
CN110234339A
CN110234339A CN201780067797.9A CN201780067797A CN110234339A CN 110234339 A CN110234339 A CN 110234339A CN 201780067797 A CN201780067797 A CN 201780067797A CN 110234339 A CN110234339 A CN 110234339A
Authority
CN
China
Prior art keywords
amino acid
peptide
insulin
polypeptide compound
chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780067797.9A
Other languages
English (en)
Chinese (zh)
Inventor
季米特里奥斯·加托斯
亚历山德拉·阿纳斯塔西奥
克列奥梅尼斯·巴罗斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chemical and Biopharmaceutical Laboratories of Patras SA
Original Assignee
Chemical and Biopharmaceutical Laboratories of Patras SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemical and Biopharmaceutical Laboratories of Patras SA filed Critical Chemical and Biopharmaceutical Laboratories of Patras SA
Publication of CN110234339A publication Critical patent/CN110234339A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
CN201780067797.9A 2016-09-06 2017-09-05 胰岛素原衍生物 Pending CN110234339A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GR20160100458 2016-09-06
GR20160100458 2016-09-06
PCT/IB2017/055336 WO2018047062A1 (en) 2016-09-06 2017-09-05 Proinsulin derivatives

Publications (1)

Publication Number Publication Date
CN110234339A true CN110234339A (zh) 2019-09-13

Family

ID=59895344

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780067797.9A Pending CN110234339A (zh) 2016-09-06 2017-09-05 胰岛素原衍生物

Country Status (10)

Country Link
US (1) US11230585B2 (https=)
EP (1) EP3509625A1 (https=)
JP (1) JP2019530473A (https=)
KR (1) KR20190043609A (https=)
CN (1) CN110234339A (https=)
AU (1) AU2017322552B2 (https=)
BR (1) BR112019004314A2 (https=)
CA (1) CA3035850A1 (https=)
IL (1) IL265182A (https=)
WO (1) WO2018047062A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3756679A1 (en) 2019-06-28 2020-12-30 Université de Genève Compositions for use in the treatment of insulin deficiency conditions

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1068501A (zh) * 1991-06-11 1993-02-03 伊莱利利公司 A-c-b胰岛素原，其生产方法和应用，以及胰岛素生产中的中间体
CN1177928A (zh) * 1994-12-29 1998-04-01 生物技术通用公司 生产人胰岛素
US6444641B1 (en) * 1997-10-24 2002-09-03 Eli Lilly Company Fatty acid-acylated insulin analogs
US6630348B1 (en) * 2000-10-02 2003-10-07 Univ Yonsei Seoul Single-chain insulin analog and a polynucleotide sequence encoding the analog
CN105793283A (zh) * 2013-12-05 2016-07-20 佩特雷化学和生物制药学实验室有限公司 具有生物学活性的胰岛素衍生物
CN105829350A (zh) * 2013-12-17 2016-08-03 诺和诺德股份有限公司 肠激酶可切割的多肽

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK58285D0 (da) 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
DK129385A (da) 1985-03-22 1986-09-23 Novo Industri As Peptider og fremstilling deraf
DK10191D0 (da) 1991-01-22 1991-01-22 Novo Nordisk As Hidtil ukendte peptider
WO1995016708A1 (en) 1993-12-17 1995-06-22 Novo Nordisk A/S Proinsulin-like compounds
BR9408638A (pt) 1994-12-29 2004-09-21 Bio Technology General Corp Geração de insulina humana
EP0741188A3 (en) 1995-05-05 1999-07-14 Eli Lilly And Company Single chain insulin with high bioactivity
JP2001521006A (ja) 1997-10-24 2001-11-06 イーライ・リリー・アンド・カンパニー 不溶性インシュリン組成物
GB9812675D0 (en) 1998-06-11 1998-08-12 Univ Edinburgh Peptides
EP1193272B1 (en) 2000-10-02 2004-06-30 Yonsei University Single-chain insulin analogs
WO2002079251A2 (en) * 2001-04-02 2002-10-10 Novo Nordisk A/S Method for making human insulin precursors
EP1692168B1 (en) 2003-12-03 2011-07-20 Novo Nordisk A/S Single-chain insulin
JP2008533100A (ja) 2005-03-18 2008-08-21 ノボ ノルディスク アクティーゼルスカブ Ｐｅｇ化された単鎖インスリン
US20090069216A1 (en) 2006-02-21 2009-03-12 Novo Nordisk A/S Single-Chain Insulin Analogues and Pharmaceutical Formulations Thereof
JP2009530243A (ja) 2006-03-13 2009-08-27 ノボ・ノルデイスク・エー／エス アシル化単鎖インスリン
WO2008043033A2 (en) 2006-10-04 2008-04-10 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues
US10100098B2 (en) * 2006-12-13 2018-10-16 Stelis Biopharma Private Limited Insulin production methods and proinsulin constructs
GR1006941B (el) * 2009-06-01 2010-08-27 Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras), Πεπτιδικη συνθεση (peptide synthesis)
GR1007010B (el) 2009-10-08 2010-10-07 Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras), Ινσουλινοειδη πεπτιδια

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1068501A (zh) * 1991-06-11 1993-02-03 伊莱利利公司 A-c-b胰岛素原，其生产方法和应用，以及胰岛素生产中的中间体
CN1177928A (zh) * 1994-12-29 1998-04-01 生物技术通用公司 生产人胰岛素
US6444641B1 (en) * 1997-10-24 2002-09-03 Eli Lilly Company Fatty acid-acylated insulin analogs
US6630348B1 (en) * 2000-10-02 2003-10-07 Univ Yonsei Seoul Single-chain insulin analog and a polynucleotide sequence encoding the analog
CN105793283A (zh) * 2013-12-05 2016-07-20 佩特雷化学和生物制药学实验室有限公司 具有生物学活性的胰岛素衍生物
CN105829350A (zh) * 2013-12-17 2016-08-03 诺和诺德股份有限公司 肠激酶可切割的多肽

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GAUTAM RAJPAL等: "Single-chain insulins as receptor agonists", 《MOL ENDOCRINOL.》 *
W F HEATH等: "( A-C-B ) Human Proinsulin , a Novel Insulin Agonist and Intermediate in the Synthesis of Biosynthetic Human Insulin", 《J BIOL CHEM.》 *

Also Published As

Publication number Publication date
AU2017322552A1 (en) 2019-03-28
EP3509625A1 (en) 2019-07-17
KR20190043609A (ko) 2019-04-26
IL265182A (en) 2019-05-30
AU2017322552B2 (en) 2021-12-02
WO2018047062A1 (en) 2018-03-15
BR112019004314A2 (pt) 2019-05-28
CA3035850A1 (en) 2018-03-15
JP2019530473A (ja) 2019-10-24
US20190263881A1 (en) 2019-08-29
US11230585B2 (en) 2022-01-25

Similar Documents

Publication Publication Date Title
US20250188115A1 (en) Process for preparing a glucagon-like peptide
CN110003055B (zh) 含有肽修饰剂的氨基二酸
US8445433B2 (en) Synthesis of glucagon-like peptide
US20170226177A1 (en) Peptidomimetic macrocycles
US20110136724A1 (en) Analogues of glucose-dependent insulinotropic polypeptide
US20220411461A1 (en) Methods of making incretin analogs
WO2017023933A2 (en) Peptidomimetic macrocycles
US8709998B2 (en) Peptide vectors
KR20130127985A (ko) 글루코스-의존 인슐린 친화성 펩티드 유사체
US11168114B2 (en) Process for the manufacture of degarelix and its intermediates
US11377471B2 (en) Process for the preparation of a dodecapeptide
US20240209023A1 (en) Peptide compound, application thereof and composition containing same
US8846614B2 (en) Process for the synthesis of 37-mer peptide pramlintide
CN110234339A (zh) 胰岛素原衍生物
WO2007000118A1 (en) Exendin 4 polypeptide fragments and use thereof
JP6798883B2 (ja) 生物学的活性なインスリン誘導体
JP4927746B2 (ja) 樹脂上ペプチド環化

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20190913