AU2017315781B2 - Use of pridopidine for treating dystonias - Google Patents

Use of pridopidine for treating dystonias Download PDF

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Publication number
AU2017315781B2
AU2017315781B2 AU2017315781A AU2017315781A AU2017315781B2 AU 2017315781 B2 AU2017315781 B2 AU 2017315781B2 AU 2017315781 A AU2017315781 A AU 2017315781A AU 2017315781 A AU2017315781 A AU 2017315781A AU 2017315781 B2 AU2017315781 B2 AU 2017315781B2
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AU
Australia
Prior art keywords
dystonia
pridopidine
bid
baseline
uhdrs
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AU2017315781A
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AU2017315781A1 (en
Inventor
Beth Borowsky
Eli Eyal
Mark Forrest GORDON
Igor D. GRACHEV
Michael Hayden
Spyridon Papapetropoulos
Juha-Matti Savola
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Prilenia Neurotherapeutics Ltd
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Prilenia Neurotherapeutics Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2017315781A 2016-08-24 2017-08-24 Use of pridopidine for treating dystonias Active AU2017315781B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662379175P 2016-08-24 2016-08-24
US62/379,175 2016-08-24
US201662395319P 2016-09-15 2016-09-15
US62/395,319 2016-09-15
PCT/US2017/048458 WO2018039475A1 (en) 2016-08-24 2017-08-24 Use of pridopidine for treating dystonias

Publications (2)

Publication Number Publication Date
AU2017315781A1 AU2017315781A1 (en) 2019-04-11
AU2017315781B2 true AU2017315781B2 (en) 2021-01-28

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2017315781A Active AU2017315781B2 (en) 2016-08-24 2017-08-24 Use of pridopidine for treating dystonias

Country Status (12)

Country Link
US (2) US11826361B2 (cg-RX-API-DMAC7.html)
EP (1) EP3503890B1 (cg-RX-API-DMAC7.html)
JP (2) JP7278210B2 (cg-RX-API-DMAC7.html)
CN (1) CN110012661A (cg-RX-API-DMAC7.html)
AU (1) AU2017315781B2 (cg-RX-API-DMAC7.html)
BR (1) BR112019003731A2 (cg-RX-API-DMAC7.html)
CA (1) CA3035099C (cg-RX-API-DMAC7.html)
DK (1) DK3503890T3 (cg-RX-API-DMAC7.html)
ES (1) ES3009437T3 (cg-RX-API-DMAC7.html)
MX (1) MX2019002190A (cg-RX-API-DMAC7.html)
PL (1) PL3503890T3 (cg-RX-API-DMAC7.html)
WO (1) WO2018039475A1 (cg-RX-API-DMAC7.html)

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JP2013536825A (ja) 2010-09-03 2013-09-26 イバックス・インターナショナル・ゲーエムベーハー ドパミン作動性安定化剤として有用なプリドピジンの重水素化類似体
US11090297B2 (en) 2013-06-21 2021-08-17 Prilenia Neurotherapeutics Ltd. Pridopidine for treating huntington's disease
UA122999C2 (uk) 2013-06-21 2021-02-03 Прайлінія Н'Юротерапьютікс Лтд. Застосування придопідину для лікування хвороби гантінгтона
US11471449B2 (en) 2015-02-25 2022-10-18 Prilenia Neurotherapeutics Ltd. Use of pridopidine to improve cognitive function and for treating Alzheimer's disease
EP4282479A3 (en) 2015-02-25 2024-02-21 Prilenia Neurotherapeutics Ltd. Use of pridopidine to treat depression or anxiety
EP3503890B1 (en) 2016-08-24 2024-12-18 Prilenia Neurotherapeutics Ltd. Use of pridopidine for treating dystonias
MX390627B (es) 2016-08-24 2025-03-21 Prilenia Neurotherapeutics Ltd Uso de pridopidina para el tratamiento de la disminucion funcional.
US12102627B2 (en) 2016-09-16 2024-10-01 Prilenia Neurotherapeutics Ltd. Use of pridopidine for treating rett syndrome
US12036213B2 (en) 2017-09-08 2024-07-16 Prilenia Neurotherapeutics Ltd. Pridopidine for treating drug induced dyskinesias
CN111343982A (zh) 2017-09-08 2020-06-26 普瑞尼亚神经治疗有限公司 用于治疗药物诱发的异动症的普利多匹定
BR112021015346A2 (pt) 2019-02-04 2021-10-05 Prilenia Neurotherapeutics Ltd. Uso de pridopidina de baixa dose para a doença de parkinson e outras doenças associadas ao parkinsonismo
JP7603713B2 (ja) * 2020-05-04 2024-12-20 プリレニア ニューロセラピューティクス リミテッド 選択的ｓ１ｒアゴニストを使用するウイルス感染、疾患、又は障害の治療
KR20250121149A (ko) * 2022-12-27 2025-08-11 프리레니아 뉴로테라퓨틱스 엘티디. 소아 헌팅턴병 치료를 위한 프리도피딘
WO2024258929A1 (en) * 2023-06-12 2024-12-19 Unravel Biosciences, Inc. Methods for treating diseases associated with taf1 loss of function
WO2025188979A1 (en) * 2024-03-06 2025-09-12 Ovid Therapeutics Inc. Fused amino pyrimidine compounds and pridopidine for treatment of huntington's disease

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WO2011107583A1 (en) * 2010-03-04 2011-09-09 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Substituted 4-phenyl-n-alkyl-piperidines for preventing onset or slowing progression of neurodegenerative disorders
US20130150406A1 (en) * 2011-12-08 2013-06-13 IVAX International GmbH Hydrobromide salt of pridopidine
US20140037850A1 (en) * 2012-08-06 2014-02-06 General Electric Company Corrosion and wear resistant organic coatings
US20140378508A1 (en) * 2013-06-21 2014-12-25 IVAX International GmbH Use of high dose pridopidine for treating huntington's disease
US20150202302A1 (en) * 2014-01-22 2015-07-23 IVAX International GmbH Modified release formulations of pridopidine

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BRPI0511907A8 (pt) * 2004-06-08 2018-05-02 A Carlsson Res Ab novos derivados de fenilpiperidinas/piperazinas dissubstituídos como moduladores da neurotransmissão de dopamina
SE0401465D0 (sv) * 2004-06-08 2004-06-08 Carlsson A Research Ab New substituted piperdines as modulators of dopamine neurotransmission
CA2584831C (en) 2004-10-13 2013-09-17 Neurosearch Sweden Ab Process for the synthesis of 4-(3-methanesulfonylphenyl)-1-n-propyl-piperidine
SE529246C2 (sv) * 2005-10-13 2007-06-12 Neurosearch Sweden Ab Nya disubstituerade fenyl-piperidiner som modulatorer för dopaminneurotransmission
WO2008127188A1 (en) 2007-04-12 2008-10-23 Allbay Ab N-oxide and/or di-n-oxide derivatives of dopamine receptor stabilizers/modulators displaying improved cardiovascular side-effects profiles
US8562488B2 (en) * 2009-10-05 2013-10-22 The Cleveland Clinic Foundation Systems and methods for improving motor function with assisted exercise
JP2013536825A (ja) 2010-09-03 2013-09-26 イバックス・インターナショナル・ゲーエムベーハー ドパミン作動性安定化剤として有用なプリドピジンの重水素化類似体
EP2753603B1 (en) 2011-09-07 2017-06-21 Teva Pharmaceuticals International GmbH Polymorphic form of pridopidine hydrochloride
US9744155B2 (en) 2012-03-28 2017-08-29 Ixcela, Inc. IPA as a therapeutic agent, as a protective agent, and as a biomarker of disease risk
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EP4282479A3 (en) 2015-02-25 2024-02-21 Prilenia Neurotherapeutics Ltd. Use of pridopidine to treat depression or anxiety
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MX390627B (es) 2016-08-24 2025-03-21 Prilenia Neurotherapeutics Ltd Uso de pridopidina para el tratamiento de la disminucion funcional.
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US20200375966A1 (en) 2016-09-15 2020-12-03 Prilenia Therapeutics Development Ltd Use of pridopidine for the treatment of anxiety and depression
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HUE068300T2 (hu) 2017-01-20 2024-12-28 Prilenia Neurotherapeutics Ltd Pridopidin törékeny X szindróma kezelésében történõ alkalmazásra
ES2938546T3 (es) 2017-08-14 2023-04-12 Prilenia Neurotherapeutics Ltd Método de tratamiento de la esclerosis lateral amiotrófica con pridopidina
CN111343982A (zh) 2017-09-08 2020-06-26 普瑞尼亚神经治疗有限公司 用于治疗药物诱发的异动症的普利多匹定

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WO2011107583A1 (en) * 2010-03-04 2011-09-09 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Substituted 4-phenyl-n-alkyl-piperidines for preventing onset or slowing progression of neurodegenerative disorders
US20130150406A1 (en) * 2011-12-08 2013-06-13 IVAX International GmbH Hydrobromide salt of pridopidine
US20140037850A1 (en) * 2012-08-06 2014-02-06 General Electric Company Corrosion and wear resistant organic coatings
US20140378508A1 (en) * 2013-06-21 2014-12-25 IVAX International GmbH Use of high dose pridopidine for treating huntington's disease
US20150202302A1 (en) * 2014-01-22 2015-07-23 IVAX International GmbH Modified release formulations of pridopidine

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Also Published As

Publication number Publication date
US11826361B2 (en) 2023-11-28
CA3035099C (en) 2023-01-17
EP3503890A1 (en) 2019-07-03
AU2017315781A1 (en) 2019-04-11
CA3035099A1 (en) 2018-03-01
US20240075021A1 (en) 2024-03-07
MX2019002190A (es) 2019-09-11
BR112019003731A2 (pt) 2019-07-16
WO2018039475A8 (en) 2018-10-04
JP7278210B2 (ja) 2023-05-19
DK3503890T3 (da) 2025-01-27
EP3503890B1 (en) 2024-12-18
JP2021119189A (ja) 2021-08-12
PL3503890T3 (pl) 2025-03-24
US20190192496A1 (en) 2019-06-27
EP3503890A4 (en) 2020-05-06
JP2019524897A (ja) 2019-09-05
ES3009437T3 (en) 2025-03-26
WO2018039475A1 (en) 2018-03-01
CN110012661A (zh) 2019-07-12
JP7278327B2 (ja) 2023-05-19

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