AU2017308158B2 - Alpha and gamma-D polyglutamated antifolates and uses thereof - Google Patents

Alpha and gamma-D polyglutamated antifolates and uses thereof Download PDF

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Publication number
AU2017308158B2
AU2017308158B2 AU2017308158A AU2017308158A AU2017308158B2 AU 2017308158 B2 AU2017308158 B2 AU 2017308158B2 AU 2017308158 A AU2017308158 A AU 2017308158A AU 2017308158 A AU2017308158 A AU 2017308158A AU 2017308158 B2 AU2017308158 B2 AU 2017308158B2
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alpha
polyglutamated
gamma
cancer
pentaglutamated
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AU2017308158A1 (en
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Victor Mandla MOYO
Clet Niyikiza
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LEAF Holdings Group LLC
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LEAF Holdings Group LLC
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Priority claimed from US15/675,701 external-priority patent/US20180236098A1/en
Application filed by LEAF Holdings Group LLC filed Critical LEAF Holdings Group LLC
Priority claimed from PCT/US2017/046666 external-priority patent/WO2018031979A1/en
Publication of AU2017308158A1 publication Critical patent/AU2017308158A1/en
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
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    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C—CHEMISTRY; METALLURGY
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  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
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  • Biochemistry (AREA)
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  • Rheumatology (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
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AU2017308158A 2016-08-12 2017-08-12 Alpha and gamma-D polyglutamated antifolates and uses thereof Active AU2017308158B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2023263441A AU2023263441B2 (en) 2016-08-12 2023-11-07 Alpha And Gamma-D Polyglutamated Antifolates And Uses Thereof

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662374458P 2016-08-12 2016-08-12
US62/374,458 2016-08-12
US201715675695A 2017-08-11 2017-08-11
US15/675,701 2017-08-11
US15/675,695 2017-08-11
US15/675,701 US20180236098A1 (en) 2016-08-12 2017-08-11 Alpha and gamma-d polyglutamated antifolates and uses thereof
PCT/US2017/046666 WO2018031979A1 (en) 2016-08-12 2017-08-12 Alpha and gamma-d polyglutamated antifolates and uses thereof

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AU2017308158A1 AU2017308158A1 (en) 2019-02-07
AU2017308158B2 true AU2017308158B2 (en) 2023-08-10

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AU2017308158A Active AU2017308158B2 (en) 2016-08-12 2017-08-12 Alpha and gamma-D polyglutamated antifolates and uses thereof
AU2017308159A Active AU2017308159B2 (en) 2016-08-12 2017-08-12 Polyglutamated antifolates and uses thereof
AU2023263442A Active AU2023263442B2 (en) 2016-08-12 2023-11-07 Polyglutamated Antifolates And Uses Thereof
AU2023263441A Active AU2023263441B2 (en) 2016-08-12 2023-11-07 Alpha And Gamma-D Polyglutamated Antifolates And Uses Thereof

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AU2023263441A Active AU2023263441B2 (en) 2016-08-12 2023-11-07 Alpha And Gamma-D Polyglutamated Antifolates And Uses Thereof

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US (11) US11344628B2 (cg-RX-API-DMAC7.html)
EP (3) EP3496756A4 (cg-RX-API-DMAC7.html)
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CA (3) CA3177187A1 (cg-RX-API-DMAC7.html)
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WO2018031968A1 (en) 2016-08-12 2018-02-15 L.E.A.F. Holdings Group Llc Alpha and gamma-d polyglutamated antifolates and uses thereof
CA3177187A1 (en) 2016-08-12 2018-02-15 L.E.A.F Holdings Group Llc Alpha and gamma-d polyglutamated antifolates and uses thereof
CA3090505A1 (en) * 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Gamma polyglutamated antifolates and uses thereof
CA3090384A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Alpha polyglutamated aminopterin and uses thereof
EP3749318A4 (en) 2018-02-07 2022-07-06 L.E.A.F Holdings Group LLC GAMMA-POLYGLUTAMATED RALTITREXED AND ITS USES
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