MX2023007496A - Antifolatos poliglutamados y sus usos. - Google Patents

Antifolatos poliglutamados y sus usos.

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Publication number
MX2023007496A
MX2023007496A MX2023007496A MX2023007496A MX2023007496A MX 2023007496 A MX2023007496 A MX 2023007496A MX 2023007496 A MX2023007496 A MX 2023007496A MX 2023007496 A MX2023007496 A MX 2023007496A MX 2023007496 A MX2023007496 A MX 2023007496A
Authority
MX
Mexico
Prior art keywords
polyglutamated antifolates
polyglutamated
antifolates
formulations
disorders
Prior art date
Application number
MX2023007496A
Other languages
English (en)
Inventor
Clet Niyikiza
Victor Mandla Moyo
Original Assignee
L E A F Holdings Group Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/675,701 external-priority patent/US20180236098A1/en
Application filed by L E A F Holdings Group Llc filed Critical L E A F Holdings Group Llc
Publication of MX2023007496A publication Critical patent/MX2023007496A/es

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    • A61P35/00—Antineoplastic agents
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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Abstract

La descripción hace referencia, en términos generales, a antifolatos poliglutamados, formulaciones que contienen liposomas rellenos con los antifolatos poliglutamados, métodos para realizar las formulaciones que contienen liposomas y los antifolatos poliglutamados, así como métodos para utilizar las formulaciones que contienen liposomas y antifolatos poliglutamados para tratar trastornos hiperproliferativos (por ejemplo, cáncer) y trastornos del sistema inmunológico (por ejemplo, una enfermedad autoinmune, como artritis reumatoide).
MX2023007496A 2016-08-12 2019-02-11 Antifolatos poliglutamados y sus usos. MX2023007496A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662374458P 2016-08-12 2016-08-12
US201715675695A 2017-08-11 2017-08-11
US15/675,701 US20180236098A1 (en) 2016-08-12 2017-08-11 Alpha and gamma-d polyglutamated antifolates and uses thereof

Publications (1)

Publication Number Publication Date
MX2023007496A true MX2023007496A (es) 2023-07-05

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Family Applications (5)

Application Number Title Priority Date Filing Date
MX2019001756A MX2019001756A (es) 2016-08-12 2017-08-12 Antifolatos poliglutamados alfa y gamma-d y sus usos.
MX2019001755A MX2019001755A (es) 2016-08-12 2017-08-12 Antifolatos poliglutamados y sus usos.
MX2022009187A MX2022009187A (es) 2016-08-12 2019-02-11 Antifolatos poliglutamados alfa y gamma-d y sus usos.
MX2023007496A MX2023007496A (es) 2016-08-12 2019-02-11 Antifolatos poliglutamados y sus usos.
MX2023007726A MX2023007726A (es) 2016-08-12 2019-02-11 Antifolatos poliglutamados alfa y gamma-d y sus usos.

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MX2019001756A MX2019001756A (es) 2016-08-12 2017-08-12 Antifolatos poliglutamados alfa y gamma-d y sus usos.
MX2019001755A MX2019001755A (es) 2016-08-12 2017-08-12 Antifolatos poliglutamados y sus usos.
MX2022009187A MX2022009187A (es) 2016-08-12 2019-02-11 Antifolatos poliglutamados alfa y gamma-d y sus usos.

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Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2019001756A (es) 2016-08-12 2019-05-09 L E A F Holdings Group Llc Antifolatos poliglutamados alfa y gamma-d y sus usos.
WO2019157146A1 (en) * 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Alpha polyglutamated antifolates and uses thereof
US20210161899A1 (en) * 2018-02-07 2021-06-03 L.E.A.F. Holdings Group Llc Gamma polyglutamated pemetrexed and uses thereof
JP7490240B2 (ja) * 2018-02-07 2024-05-27 エル．イー．エー．エフ． ホールディングス グループ エルエルシー ガンマポリグルタミン酸化葉酸代謝拮抗薬およびその使用
EP3749316A4 (en) 2018-02-07 2021-10-27 L.E.A.F Holdings Group LLC PRALATREXATE ALPHA-POLYGLUTAMATE AND ASSOCIATED USES
US20210338675A1 (en) * 2018-02-07 2021-11-04 L.E.A.F. Holdings Group Llc Alpha polyglutamated lometrexol and uses thereof
WO2019157138A1 (en) * 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Alpha polyglutamated pemetrexed and uses thereof
WO2019157123A1 (en) * 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Alpha polyglutamated aminopterin and uses thereof
JP7491573B2 (ja) * 2018-02-07 2024-05-28 エル．イー．エー．エフ． ホールディングス グループ エルエルシー アルファポリグルタミン酸化メトトレキセートおよびその使用
WO2019160733A1 (en) * 2018-02-14 2019-08-22 L.E.A.F. Holdings Group Llc Gamma polyglutamated methotrexate and uses thereof
CA3090875A1 (en) 2018-02-14 2019-08-22 L.E.A.F. Holdings Group Llc Gamma polyglutamated lometrexol and uses thereof
WO2019160736A1 (en) * 2018-02-14 2019-08-22 L.E.A.F. Holdings Group Llc Gamma polyglutamated pralatrexate and uses thereof
WO2021026310A1 (en) * 2019-08-06 2021-02-11 L.E.A.F. Holdings Group Llc Processes of preparing polyglutamated antifolates and uses of their compositions
CN112010862B (zh) * 2020-10-23 2021-03-30 南京诺源医疗器械有限公司 一种主动靶向叶酸受体近红外荧光分子及其制备方法
WO2023180103A1 (en) * 2022-03-21 2023-09-28 Immundiagnostik Ag Kit of parts and microbiological method for assessment of the folate status in serum and red blood cells
JP2024060824A (ja) * 2022-10-20 2024-05-07 プレミアアンチエイジング株式会社 経口製剤及びその製造方法

Family Cites Families (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4584375A (en) * 1984-08-21 1986-04-22 Rensselaer Polytechnic Institute Fluorine-containing antifolates incapable of polyglutamate formation
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
EP0492316A1 (en) 1990-12-14 1992-07-01 Takeda Chemical Industries, Ltd. Condensed heterocyclic oligoglutamate derivatives, their production and pharmaceutical compositions containing them
US5646253A (en) 1994-03-08 1997-07-08 Memorial Sloan-Kettering Cancer Center Recombinant human anti-LK26 antibodies
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
US6569432B1 (en) 1995-02-24 2003-05-27 Sloan-Kettering Institute For Cancer Research Prostate-specific membrane antigen and uses thereof
CN1122456C (zh) 1996-01-31 2003-10-01 南亚拉巴马医学科学基金会 含有天然的还原叶酸盐异构体的食品和维生素制品
US5912251A (en) 1998-01-17 1999-06-15 Nair; Madhavan G. Metabolically inert anti-inflammatory and anti-tumor antifolates
US20050031679A1 (en) 1998-03-27 2005-02-10 Clemens Unger Method for producing liposomal formulations of active ingredients
EP1095077B1 (en) 1998-07-09 2005-04-06 Rhodia Chimie Water-soluble or water-dispersible grafted copolymers
WO2001005405A1 (en) 1999-07-16 2001-01-25 The General Hospital Corporation Folylpolyglutamyl synthetase gene transfer to enhance antifolate drug sensitivity
WO2001053331A2 (en) 2000-01-24 2001-07-26 Adherex Technologies, Inc. Peptidomimetic modulators of cell adhesion
CN1095472C (zh) 2000-04-17 2002-12-04 上海复康医药科技发展有限公司 叶酸－多聚糖复合物，其制备方法和以该复合物为活性成分的药物组合物
US6689381B2 (en) 2000-06-09 2004-02-10 Osi Pharmaceuticals, Inc. Liposomal benzoquinazoline thymidylate synthase inhibitor formulations
DE60127970T2 (de) 2000-06-30 2007-12-20 Eli Lilly And Co., Indianapolis Zusammensetzung, welche ein antifolate und ein methylmalonsäuresenkendes mittel enthält
CH696628A5 (de) 2002-02-26 2007-08-31 Eprova Ag Verwendung von Folaten zur Herstellung einer Zubereitung geeignet zur Vorbeugung und Behandlung von Entzündungen und entzündungsassoziierter Krankheiten, im Speziellen zur Beeinflussung der
US7563590B2 (en) 2002-08-30 2009-07-21 Cypress Bioscience Inc. Methods of quantifying methotrexate metabolites
US6921667B2 (en) * 2003-03-07 2005-07-26 Prometheus Laboratories, Inc. Methods for direct detection of individual methotrexate metabolites
NZ589967A (en) 2004-01-14 2012-07-27 Gilead Sciences Inc Lipid-based dispersions useful for drug delivery
WO2005080431A2 (en) 2004-02-12 2005-09-01 Morphotek, Inc. Monoclonal antibodies that specifically bind to folate receptor alpha
US7612071B2 (en) 2004-03-12 2009-11-03 Syntrix Biosystems, Inc. Compositions and methods employing aminopterin
US20080260812A1 (en) 2004-04-26 2008-10-23 Takami Matsuyama C/O Kagoshima University Therapeutic Medicine Containing Monoclonal Antibody Against Folate Receptor Beta (Fr-Beta)
UA86063C2 (ru) 2004-05-03 2009-03-25 Хермес Біосайенсез, Інк. Липосомы для снабжения лекарств
US7695908B2 (en) 2004-06-15 2010-04-13 Prometheus Laboratories Inc. Methods for predicting methotrexate polyglutamate levels using pharmacogenetics
WO2006029385A2 (en) 2004-09-08 2006-03-16 Chelsea Therapeutics, Inc. Quinazoline derivatives as metabolically inert antifolate compounds.
JPWO2006035876A1 (ja) 2004-09-29 2008-05-15 興和株式会社 関節リウマチの予防及び／又は治療薬
US8126089B2 (en) 2004-09-30 2012-02-28 Alcatel Lucent Method and apparatus for providing frame synchronization in a digital communication system that supports multiple modulation formats
US20100266709A1 (en) 2004-12-16 2010-10-21 Hicks Terry Lee Compositions and Methods for Treating Burns
WO2006074416A1 (en) * 2005-01-07 2006-07-13 Health Research Inc. 5-amino-4-imidazolecarboxamide riboside and its nucleobase as potentiators of antifolate transport and metabolism
JP2006248978A (ja) 2005-03-10 2006-09-21 Mebiopharm Co Ltd 新規なリポソーム製剤
WO2007023243A2 (en) 2005-08-24 2007-03-01 Protherics Medicines Development Limited Cleavage of antifolate compounds
EP1962796A2 (en) 2005-12-08 2008-09-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Methods for affecting liposome composition by ultrasound irradiation
WO2007098089A2 (en) * 2006-02-17 2007-08-30 Novacea, Inc. Treatment of hyperproliferative diseases with methotrexate n-oxide and analogs
US9265746B2 (en) 2006-05-31 2016-02-23 Merck & Cie Method for cell-specific targeting
WO2008030818A2 (en) 2006-09-05 2008-03-13 Mebiopharm Co., Ltd. Novel liposome compositions
EP1900752A1 (en) 2006-09-15 2008-03-19 DOMPE' pha.r.ma s.p.a. Human anti-folate receptor alpha antibodies and antibody fragments for the radioimmunotherapy of ovarian carcinoma
CA2674075C (en) * 2006-12-29 2012-10-30 Charles P. Theuer Antifolate agent combinations in the treatment of cancer
RU2423114C2 (ru) * 2006-12-29 2011-07-10 Тракон Фармасьютикалз, Инк. Комбинации антифолатного агента в лечении рака
JP2010516694A (ja) 2007-01-19 2010-05-20 チェルシー・セラピューティクス，インコーポレイテッド 新規な伝統的葉酸拮抗剤
ES2387334T3 (es) 2008-03-18 2012-09-20 Btg International Limited Derivados de ciclopenta[g]quinazolina para el tratamiento de la artritis reumatoide o la leucemia mielocítica aguda
GB0811360D0 (en) 2008-06-20 2008-07-30 Imp Innovations Ltd Methods
WO2010141711A1 (en) 2009-06-03 2010-12-09 Ex-Tek, Llc Skin treatment compositions
TW201118098A (en) 2009-08-13 2011-06-01 Reddy S Lab Liimited Dr Processes for preparing pemetrexed
KR101637138B1 (ko) 2010-02-24 2016-07-06 이뮤노젠 아이엔씨 엽산염 수용체 1 항체와 면역접합체 및 이들의 용도
AU2011227686B2 (en) 2010-03-19 2014-12-04 Massachusetts Institute Of Technology Lipid vesicle compositions and methods of use
US9770414B2 (en) * 2010-05-13 2017-09-26 Pacira Pharmaceuticals, Inc. Sustained release formulation of methotrexate as a disease-modifying antirheumatic drug (DMARD) and an anti-cancer agent
EP2394640A1 (en) 2010-05-21 2011-12-14 MediGene AG Improved liposomal formulations of lipophilic compounds
US20130071321A1 (en) 2010-05-28 2013-03-21 Purdue Research Foundation Delivery of agents to inflamed tissues using folate-targeted liposomes
EP2614084A4 (en) 2010-09-09 2014-02-19 Purdue Research Foundation HUMANE FOLAT RECEPTOR BETA ANTIBODIES AND METHOD FOR THEIR USE
US9261509B2 (en) 2010-09-13 2016-02-16 Thierry Dervieux Methods for monitoring methotrexate therapy
KR101931936B1 (ko) 2010-11-05 2018-12-26 에이자이 아이엔씨. 엽산 수용체 알파-발현 암에 대한 진단 및 예후 마커로서의 엽산 수용체 알파
WO2012078708A1 (en) 2010-12-07 2012-06-14 Chelsea Therapeutics, Inc. Combination comprising methotrexate and an antifolate compound
WO2012118806A2 (en) 2011-02-28 2012-09-07 The Regents Of The University Of California Compositions and methods for detecting and treating cancer
US9000003B2 (en) 2011-03-10 2015-04-07 National Science And Technology Development Agency Anti-folate antimalarials with dual-binding modes and their preparation
US8183227B1 (en) 2011-07-07 2012-05-22 Chemo S. A. France Compositions, kits and methods for nutrition supplementation
PL2731591T3 (pl) 2011-07-13 2021-05-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Liposomy zawierające bisfosfonian i środek amfipatyczny w wyniku ko-enkapsulacji
TR201802838T4 (tr) 2011-07-15 2018-03-21 Eisai R&D Man Co Ltd Anti-folat reseptör alfa antikorlar ve bunların kullanımı.
US20130122096A1 (en) 2011-11-14 2013-05-16 Silenseed Ltd. Compositions for drug delivery and methods of manufacturing and using same
JPWO2014003137A1 (ja) 2012-06-27 2016-06-02 旭化成メディカル株式会社 高アフィニティー抗体、及びその製造方法
US9440979B2 (en) 2012-07-23 2016-09-13 Fresenius Kabi Oncology Limited Process for the preparation of pralatrexate
WO2014046630A1 (en) 2012-09-19 2014-03-27 Keskin, Dilek Tumor targeted liposomal drug delivery system
US20140120157A1 (en) 2012-09-19 2014-05-01 Georgetown University Targeted liposomes
KR20150094617A (ko) 2012-12-07 2015-08-19 교와 핫꼬 기린 가부시키가이샤 항 ｆｏｌｒ１ 항체
CN103040748B (zh) * 2012-12-18 2014-07-02 海南圣欣医药科技有限公司 一种培美曲塞二钠脂质体注射剂
SG11201509043RA (en) 2013-05-14 2015-12-30 Immunogen Inc Anti-folr1 immunoconjugate dosing regimens
CN106794164A (zh) * 2014-08-14 2017-05-31 L.E.A.F.控股集团公司 脂质体包封的亲和性药物
CN104546723B (zh) * 2015-02-11 2017-07-18 上海交通大学医学院附属新华医院 一种培美曲塞脂质体及其制备方法
BR112018069133A2 (pt) 2016-04-29 2019-01-22 Univ Cornell composições e métodos para penetração direcionada de partículas, distribuição, e resposta em tumores cerebrais malignos
MX2019001756A (es) * 2016-08-12 2019-05-09 L E A F Holdings Group Llc Antifolatos poliglutamados alfa y gamma-d y sus usos.
WO2018031979A1 (en) 2016-08-12 2018-02-15 L.E.A.F. Holdings Group Llc Alpha and gamma-d polyglutamated antifolates and uses thereof
WO2018031968A1 (en) * 2016-08-12 2018-02-15 L.E.A.F. Holdings Group Llc Alpha and gamma-d polyglutamated antifolates and uses thereof
EP3706801A4 (en) 2017-11-08 2022-04-06 L.E.A.F Holdings Group LLC PLATINUM COMPLEXES AND THEIR USES
CN111936146A (zh) 2018-02-07 2020-11-13 L.E.A.F.控股集团公司 α聚谷氨酸化四氢叶酸及其用途
WO2019157138A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Alpha polyglutamated pemetrexed and uses thereof
JP7490240B2 (ja) 2018-02-07 2024-05-27 エル．イー．エー．エフ． ホールディングス グループ エルエルシー ガンマポリグルタミン酸化葉酸代謝拮抗薬およびその使用
WO2019157146A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Alpha polyglutamated antifolates and uses thereof
US20210338675A1 (en) 2018-02-07 2021-11-04 L.E.A.F. Holdings Group Llc Alpha polyglutamated lometrexol and uses thereof
EP3749316A4 (en) 2018-02-07 2021-10-27 L.E.A.F Holdings Group LLC PRALATREXATE ALPHA-POLYGLUTAMATE AND ASSOCIATED USES
WO2019157140A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Gamma polyglutamated raltitrexed and uses thereof
US20210161899A1 (en) 2018-02-07 2021-06-03 L.E.A.F. Holdings Group Llc Gamma polyglutamated pemetrexed and uses thereof
US20210169884A1 (en) 2018-02-07 2021-06-10 L.E.A.F. Holdings Group Llc Alpha polyglutamated raltitrexed and uses thereof
WO2019157123A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Alpha polyglutamated aminopterin and uses thereof
JP7491573B2 (ja) 2018-02-07 2024-05-28 エル．イー．エー．エフ． ホールディングス グループ エルエルシー アルファポリグルタミン酸化メトトレキセートおよびその使用
WO2019160736A1 (en) 2018-02-14 2019-08-22 L.E.A.F. Holdings Group Llc Gamma polyglutamated pralatrexate and uses thereof
CA3090992A1 (en) 2018-02-14 2019-08-22 L.E.A.F. Holdings Group Llc Gamma polyglutamated tetrahydrofolates and uses thereof
WO2019160733A1 (en) 2018-02-14 2019-08-22 L.E.A.F. Holdings Group Llc Gamma polyglutamated methotrexate and uses thereof
CA3090943A1 (en) 2018-02-14 2019-08-22 L.E.A.F. Holdings Group Llc Gamma polyglutamated aminopterin and uses thereof
CA3090875A1 (en) 2018-02-14 2019-08-22 L.E.A.F. Holdings Group Llc Gamma polyglutamated lometrexol and uses thereof
WO2021026310A1 (en) 2019-08-06 2021-02-11 L.E.A.F. Holdings Group Llc Processes of preparing polyglutamated antifolates and uses of their compositions

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MX2019001756A (es) 2019-05-09
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BR112019002497A2 (pt) 2019-05-14
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